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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nalidixic acid
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Accession:CHEBI:100147 term browser browse the term
Definition:A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.
Synonyms:related_synonym: 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;   1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure;   1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid;   3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;   Formula=C12H12N2O3;   InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17);   InChIKey=MHWLWQUZZRMNGJ-UHFFFAOYSA-N;   SMILES=CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12;   acide nalidixique;   acido nalidixico;   acidum nalidixicum
 alt_id: CHEBI:7456
 xref: CAS:389-08-2;   DrugBank:DB00779;   Drug_Central:1875;   KEGG:C05079;   KEGG:D00183;   LINCS:LSM-5590
 xref_mesh: MESH:D009268
 xref: PDBeChem:NIX;   PMID:11321869;   PMID:12002106;   PMID:12399485;   PMID:12702698;   PMID:14107587;   PMID:16107187;   PMID:16423473;   PMID:16667857;   PMID:16803589;   PMID:17132068;   PMID:17631104;   PMID:18788798;   PMID:19071706;   PMID:28166217;   Patent:BE612258;   Patent:US3590036;   Reaxys:750515;   VSDB:1880;   Wikipedia:Nalidixic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62070


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nalidixic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Nalidixic Acid results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          nalidixic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      mancude organic heterobicyclic parent 5190
                                        naphthyridine 765
                                          1,8-naphthyridine 382
                                            1,8-naphthyridine derivative 382
                                              nalidixic acid 2
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