Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nalidixic acid
go back to main search page
Accession:CHEBI:100147 term browser browse the term
Definition:A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.
Synonyms:related_synonym: 1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure;   1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;   1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid;   3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;   Formula=C12H12N2O3;   InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17);   InChIKey=MHWLWQUZZRMNGJ-UHFFFAOYSA-N;   SMILES=CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12;   acide nalidixique;   acido nalidixico;   acidum nalidixicum
 alt_id: CHEBI:7456
 xref: CAS:389-08-2;   DrugBank:DB00779;   Drug_Central:1875;   KEGG:C05079;   KEGG:D00183;   LINCS:LSM-5590
 xref_mesh: MESH:D009268
 xref: PDBeChem:NIX;   PMID:11321869;   PMID:12002106;   PMID:12399485;   PMID:12702698;   PMID:14107587;   PMID:16107187;   PMID:16423473;   PMID:16667857;   PMID:16803589;   PMID:17132068;   PMID:17631104;   PMID:18788798;   PMID:19071706;   PMID:28166217;   Patent:BE612258;   Patent:US3590036;   Reaxys:750515;   VSDB:1880;   Wikipedia:Nalidixic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62070


show annotations for term's descendants           Sort by:
nalidixic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression		 ISO Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Nalidixic Acid results in decreased expression of MMP13 mRNA		 CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        antimicrobial agent 18062
          nalidixic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic molecule 19764
                              organic cyclic compound 19572
                                organic heterocyclic compound 18905
                                  organic heteropolycyclic compound 18317
                                    organic heterobicyclic compound 17257
                                      mancude organic heterobicyclic parent 8278
                                        naphthyridine 2295
                                          1,8-naphthyridine 1909
                                            1,8-naphthyridine derivative 1909
                                              nalidixic acid 2
paths to the root