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ONTOLOGY REPORT - ANNOTATIONS


Term:nalidixic acid
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Accession:CHEBI:100147 term browser browse the term
Definition:A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.
Synonyms:related_synonym: 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;   1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure;   1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid;   3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;   Formula=C12H12N2O3;   InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17);   InChIKey=MHWLWQUZZRMNGJ-UHFFFAOYSA-N;   SMILES=CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12;   acide nalidixique;   acido nalidixico;   acidum nalidixicum
 alt_id: CHEBI:7456
 xref: CAS:389-08-2 "ChemIDplus";   CAS:389-08-2 "KEGG COMPOUND";   DrugBank:DB00779;   Drug_Central:1875 "DrugCentral";   KEGG:C05079;   KEGG:D00183;   LINCS:LSM-5590
 xref_mesh: MESH:D009268
 xref: PDBeChem:NIX;   PMID:11321869 "Europe PMC";   PMID:12002106 "Europe PMC";   PMID:12399485 "Europe PMC";   PMID:12702698 "Europe PMC";   PMID:14107587 "Europe PMC";   PMID:16107187 "Europe PMC";   PMID:16423473 "Europe PMC";   PMID:16667857 "Europe PMC";   PMID:16803589 "Europe PMC";   PMID:17132068 "Europe PMC";   PMID:17631104 "Europe PMC";   PMID:18788798 "Europe PMC";   PMID:19071706 "Europe PMC";   PMID:28166217 "Europe PMC";   Patent:BE612258;   Patent:US3590036;   Reaxys:750515 "Reaxys";   VSDB:1880;   Wikipedia:Nalidixic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62070


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nalidixic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 8 5,522,739 5,533,018 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          nalidixic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterobicyclic compound 15905
                                      mancude organic heterobicyclic parent 5175
                                        naphthyridine 760
                                          1,8-naphthyridine 381
                                            1,8-naphthyridine derivative 381
                                              nalidixic acid 2
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