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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trichlormethiazide
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Accession:CHEBI:9683 term browser browse the term
Definition:A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
Synonyms:exact_synonym: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Formula=C8H8Cl3N3O4S2;   InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16);   InChIKey=LMJSLTNSBFUCMU-UHFFFAOYSA-N;   SMILES=C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O;   hydrotrichlorothiazide;   trichlormethiazidum;   triclormetiazida
 xref: CAS:133-67-5;   DrugBank:DB01021;   Drug_Central:2733;   KEGG:C07767;   KEGG:D00658;   LINCS:LSM-4383
 xref_mesh: MESH:D014237
 xref: PMID:21605415;   PMID:24678944;   PMID:25692026;   PMID:25938807;   PMID:28089902;   PMID:28166217;   PMID:29438107;   Wikipedia:Trichlormethiazide


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trichlormethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a7 solute carrier family 12, member 7 decreases activity EXP Trichlormethiazide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr13:73,881,172...73,964,873
Ensembl chr13:73,881,213...73,964,873 		JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Trichlormethiazide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171 		JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Trichlormethiazide affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686 		JBrowse link
G Tpmt thiopurine methyltransferase decreases activity ISO Trichlormethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr13:47,175,463...47,196,833
Ensembl chr13:47,175,958...47,198,213 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22308
    role 22292
      biological role 22291
        antimicrobial agent 19680
          sulfonamide antibiotic 2912
            trichlormethiazide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 22308
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22183
                    p-block element atom 22183
                      chalcogen 21520
                        oxygen atom 21498
                          oxygen molecular entity 21498
                            hydroxides 20866
                              oxoacid 20151
                                chalcogen oxoacid 14404
                                  sulfur oxoacid 14190
                                    sulfonic acid 12046
                                      sulfonic acid derivative 12046
                                        sulfonamide 5324
                                          sulfonamide antibiotic 2912
                                            trichlormethiazide 4
paths to the root