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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Salidroside
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Accession:CHEBI:9009 term browser browse the term
Definition:A glycoside that has formula C14H20O7.
Synonyms:related_synonym: Formula=C14H20O7;   InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1;   InChIKey=ILRCGYURZSFMEG-RKQHYHRCSA-N;   SMILES=OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O;   Tyrosol glucoside;   p-Hydroxyphenethyl alcohol 1-O-beta-D-glucoside
 xref: CAS:10338-51-9;   KEGG:C06046
 xref_mesh: MESH:C009172


show annotations for term's descendants           Sort by:
Salidroside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [furan co-treated with rhodioloside] results in increased expression of ABCB11 mRNA CTD PMID:32251705 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP rhodioloside inhibits the reaction [Isoflurane results in increased activity of ACHE protein] CTD PMID:28084090 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein] CTD PMID:28465020 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression		 ISO rhodioloside results in increased activity of ALPL protein
rhodioloside results in increased expression of ALPL mRNA		 CTD PMID:24055767 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 decreases secretion ISO rhodioloside results in decreased secretion of AOC1 protein CTD PMID:37530723 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 rhodioloside inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [cobaltous chloride results in increased expression of BAX protein]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]; rhodioloside inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; rhodioloside inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]		 CTD PMID:21499890 PMID:24072175 PMID:28465020 PMID:28851138 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 rhodioloside results in increased expression of BCL2 mRNA
rhodioloside results in increased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]		 CTD PMID:24072175 PMID:28465020 PMID:28851138 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO rhodioloside results in increased expression of BMP2 mRNA CTD PMID:24055767 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO rhodioloside results in increased expression of BMP6 mRNA CTD PMID:24055767 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bmp7 bone morphogenetic protein 7 increases expression ISO rhodioloside results in increased expression of BMP7 mRNA CTD PMID:24055767 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [Glucose results in increased expression of CASP1 protein]
rhodioloside inhibits the reaction [furan results in increased cleavage of CASP1 protein]		 CTD PMID:29031534 PMID:34450210 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased cleavage of CASP12 protein] CTD PMID:34450210 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]; rhodioloside inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]
rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]		 CTD PMID:24072175 PMID:28465020 PMID:28851138 PMID:30991096 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression
multiple interactions		 ISO
EXP		 rhodioloside results in increased expression of CAT mRNA; rhodioloside results in increased expression of CAT protein
rhodioloside inhibits the reaction [furan results in decreased activity of CAT protein]; rhodioloside inhibits the reaction [furan results in decreased expression of CAT mRNA]; rhodioloside inhibits the reaction [Streptozocin results in decreased activity of CAT protein]		 CTD PMID:24072175 PMID:31682803 PMID:34450210 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO rhodioloside inhibits the reaction [Streptozocin results in decreased expression of CDH2 protein] CTD PMID:31682803 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cert1 ceramide transporter 1 multiple interactions EXP rhodioloside inhibits the reaction [Glucose results in increased expression of CERT1 mRNA] CTD PMID:29031534 NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP rhodioloside inhibits the reaction [Isoflurane results in decreased activity of CHAT protein] CTD PMID:28084090 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Cldn11 claudin 11 multiple interactions ISO rhodioloside inhibits the reaction [Streptozocin results in decreased expression of CLDN11 protein] CTD PMID:31682803 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CYBB protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CYBB protein]] CTD PMID:28851138 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of CYP2E1 protein] CTD PMID:34450210 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in decreased expression of CYP7A1 mRNA] CTD PMID:32251705 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of DDIT3 mRNA]; rhodioloside inhibits the reaction [furan results in increased expression of DDIT3 protein] CTD PMID:34450210 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 mRNA]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 protein] CTD PMID:24989011 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Eno2 enolase 2 multiple interactions
increases expression		 ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 protein]
rhodioloside results in increased expression of ENO2 mRNA; rhodioloside results in increased expression of ENO2 protein		 CTD PMID:24929042 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of ERN1 protein] CTD PMID:34450210 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [furan co-treated with rhodioloside] results in increased expression of FGF15 mRNA CTD PMID:32251705 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP rhodioloside inhibits the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:29031534 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO rhodioloside results in decreased expression of HES1 mRNA CTD PMID:24929042 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [rhodioloside co-treated with cobaltous chloride co-treated with NGF protein] results in decreased expression of HIF1A mRNA; R 59949 inhibits the reaction [rhodioloside promotes the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein]]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of HIF1A protein]; rhodioloside promotes the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein] CTD PMID:21499890 PMID:24989011 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of HSPA5 mRNA]; rhodioloside inhibits the reaction [furan results in increased expression of HSPA5 protein] CTD PMID:34450210 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of IL18 mRNA]; rhodioloside inhibits the reaction [furan results in increased expression of IL18 protein] CTD PMID:34450210 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [Isoflurane results in increased expression of IL1B protein]
rhodioloside inhibits the reaction [furan results in increased expression of IL1B mRNA]; rhodioloside inhibits the reaction [furan results in increased expression of IL1B protein]; rhodioloside results in decreased secretion of and results in decreased expression of IL1B protein		 CTD PMID:28084090 PMID:34450210 PMID:37530723 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of IL6 mRNA]; rhodioloside results in decreased secretion of and results in decreased expression of IL6 protein CTD PMID:34450210 PMID:37530723 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression		 ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 protein]
rhodioloside results in increased expression of MAP2 mRNA; rhodioloside results in increased expression of MAP2 protein		 CTD PMID:24929042 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of MAP3K5 protein] CTD PMID:34450210 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of MAPK1 protein] CTD PMID:34450210 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of MAPK3 protein] CTD PMID:34450210 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of MAPK8 protein] CTD PMID:34450210 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein] CTD PMID:24989011 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased phosphorylation of NFKBIA protein] CTD PMID:34450210 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [rhodioloside co-treated with cobaltous chloride co-treated with NGF protein] results in decreased expression of HIF1A mRNA; Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]; Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 mRNA]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of DDIT4 protein]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in increased expression of HIF1A protein] CTD PMID:24989011 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
rhodioloside inhibits the reaction [furan results in increased expression of NLRP3 protein]		 CTD PMID:29031534 PMID:34450210 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 protein]; NOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 protein]; NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 protein] CTD PMID:24929042 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO rhodioloside results in decreased expression of NOTCH1 mRNA CTD PMID:24929042 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO
EXP		 rhodioloside inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:24072175 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of NR0B2 mRNA] CTD PMID:32251705 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO rhodioloside affects the reaction [furan affects the expression of NR1H4 mRNA] CTD PMID:32251705 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Ocln occludin multiple interactions ISO rhodioloside affects the reaction [furan results in decreased expression of OCLN protein]; rhodioloside inhibits the reaction [Streptozocin results in decreased expression of OCLN protein] CTD PMID:31682803 PMID:32251705 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO rhodioloside results in increased phosphorylation of [PRKAA1 protein binds to PRKAA2 protein] CTD PMID:37530723 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO rhodioloside results in increased phosphorylation of [PRKAA1 protein binds to PRKAA2 protein] CTD PMID:37530723 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta multiple interactions EXP rhodioloside inhibits the reaction [[Oxygen co-treated with Glucose deficiency] results in decreased expression of PRKAR2B protein] CTD PMID:24726522 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [Glucose results in increased expression of PYCARD protein]
rhodioloside inhibits the reaction [furan results in increased expression of PYCARD protein]		 CTD PMID:29031534 PMID:34450210 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [cobaltous chloride results in increased expression of RELA protein]
rhodioloside inhibits the reaction [furan results in increased phosphorylation of RELA protein]		 CTD PMID:21499890 PMID:34450210 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]; rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:24989011 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
increases activity		 ISO rhodioloside results in increased expression of RUNX2 mRNA
rhodioloside results in increased activity of RUNX2 protein		 CTD PMID:24055767 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:28851138 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Smad1 SMAD family member 1 multiple interactions
increases expression		 ISO rhodioloside results in increased phosphorylation of and results in increased expression of SMAD1 protein
rhodioloside results in increased expression of SMAD1 mRNA		 CTD PMID:24929042 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad5 SMAD family member 5 increases expression
multiple interactions		 ISO rhodioloside results in increased expression of SMAD5 mRNA
rhodioloside results in increased phosphorylation of and results in increased expression of SMAD5 protein		 CTD PMID:24929042 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smad9 SMAD family member 9 increases expression
multiple interactions		 ISO rhodioloside results in increased expression of SMAD9 mRNA
rhodioloside results in increased phosphorylation of and results in increased expression of SMAD9 protein		 CTD PMID:24929042 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in decreased expression of SOD1 mRNA] CTD PMID:34450210 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO
EXP		 rhodioloside results in increased expression of SOD2 mRNA; rhodioloside results in increased expression of SOD2 protein CTD PMID:24072175 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO rhodioloside results in increased expression of SP7 mRNA CTD PMID:24055767 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO rhodioloside results in increased expression of SPP1 mRNA CTD PMID:24055767 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP rhodioloside inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; rhodioloside inhibits the reaction [Paraquat results in increased expression of TGFB1 protein] CTD PMID:25674253 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in decreased expression of TJP1 protein]; rhodioloside inhibits the reaction [Streptozocin results in decreased expression of TJP1 protein] CTD PMID:31682803 PMID:32251705 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 rhodioloside inhibits the reaction [Isoflurane results in increased expression of TNF protein]
rhodioloside inhibits the reaction [furan results in increased expression of TNF mRNA]; rhodioloside results in decreased secretion of and results in decreased expression of TNF protein		 CTD PMID:28084090 PMID:34450210 PMID:37530723 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of TRAF2 protein] CTD PMID:34450210 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions
increases expression		 ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 mRNA]; NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 protein]
rhodioloside results in increased expression of TUBB3 mRNA; rhodioloside results in increased expression of TUBB3 protein		 CTD PMID:24929042 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions
decreases expression		 EXP
ISO		 rhodioloside inhibits the reaction [Glucose results in increased expression of TXNIP protein]
rhodioloside results in decreased expression of TXNIP protein		 CTD PMID:29031534 PMID:37530723 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO rhodioloside inhibits the reaction [furan results in increased expression of XBP1 protein] CTD PMID:34450210 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      atom 19888
        nonmetal atom 19789
          oxygen atom 19549
            oxygen molecular entity 19529
              organooxygen compound 19180
                carbohydrates and carbohydrate derivatives 15283
                  carbohydrate derivative 14317
                    glycosyl compound 13080
                      glycoside 11832
                        Salidroside 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbohydrates and carbohydrate derivatives 15283
                                    carbohydrate 15304
                                      carbohydrate derivative 14317
                                        glycosyl compound 13080
                                          glycoside 11832
                                            Salidroside 71
paths to the root