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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Riluzole
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Accession:CHEBI:8863 term browser browse the term
Definition:A benzothiazole that has formula C8H5F3N2OS.
Synonyms:related_synonym: 6-Trifluoromethoxybenzothiazol-2-ylamine;   Formula=C8H5F3N2OS;   InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13);   InChIKey=FTALBRSUTCGOEG-UHFFFAOYSA-N;   RP-54274;   RP54274;   SMILES=Nc1nc2ccc(OC(F)(F)F)cc2s1;   rilutek;   rilutor;   riluzole HCl;   riluzole hydrochloride
 xref: CAS:1744-22-5;   Drug_Central:2382;   HMDB:HMDB0014878;   KEGG:C07937;   KEGG:D00775;   LINCS:LSM-2471
 xref_mesh: MESH:D019782



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Riluzole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]; Riluzole promotes the reaction [AR protein binds to SQSTM1 protein]; Riluzole results in increased degradation of and results in decreased expression of AR protein; Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form; Riluzole results in increased degradation of and results in decreased expression of AR protein mutant form; STF 083010 inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] CTD PMID:30280407 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Riluzole results in increased expression of ATF6 protein CTD PMID:30280407 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Riluzole results in increased expression of BCL2 protein CTD PMID:20885006 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] CTD PMID:19528481 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases activity ISO Riluzole results in increased activity of CASP4 protein CTD PMID:19528481 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Riluzole results in increased activity of CASP8 protein CTD PMID:19528481 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Riluzole results in increased activity of CASP9 protein CTD PMID:19528481 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Riluzole results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Riluzole results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] CTD PMID:19615351 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Riluzole results in increased expression of HSPA5 protein CTD PMID:30280407 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP Riluzole results in decreased phosphorylation of JUN protein CTD PMID:10067977 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression ISO Riluzole results in decreased expression of KLK3 mRNA CTD PMID:30280407 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Nefh neurofilament heavy chain decreases phosphorylation EXP Riluzole results in decreased phosphorylation of NEFH protein CTD PMID:19429076 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefm neurofilament medium chain affects localization
decreases phosphorylation
EXP Riluzole affects the localization of NEFM protein
Riluzole results in decreased phosphorylation of NEFM protein
CTD PMID:19429076 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Riluzole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] CTD PMID:16303979 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Slc17a7 solute carrier family 17 member 7 decreases expression EXP Riluzole results in decreased expression of SLC17A7 protein CTD PMID:17507170 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA]
Riluzole results in increased expression of SLC1A2 mRNA; Riluzole results in increased expression of SLC1A2 protein
CTD PMID:19615351 PMID:22966415 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc1a3 solute carrier family 1 member 3 multiple interactions
increases expression
EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA]
Riluzole results in increased expression of SLC1A3 mRNA; Riluzole results in increased expression of SLC1A3 protein
CTD PMID:19615351 PMID:22966415 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Riluzole promotes the reaction [AR protein binds to SQSTM1 protein] CTD PMID:30280407 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Utrn utrophin increases expression ISO Riluzole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] CTD PMID:16303979 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Riluzole results in increased expression of XBP1 protein CTD PMID:30280407 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      atom 19888
        nonmetal atom 19789
          nitrogen atom 18971
            nitrogen molecular entity 18971
              organonitrogen compound 18845
                organonitrogen heterocyclic compound 18167
                  benzothiazoles 151
                    Riluzole 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            organic molecule 19714
                              organic cyclic compound 19485
                                organic heterocyclic compound 18881
                                  organic heteropolycyclic compound 18290
                                    organic heterobicyclic compound 17234
                                      benzothiazoles 151
                                        Riluzole 28
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