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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6alpha-methylprednisolone
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Accession:CHEBI:6888 term browser browse the term
Definition:The 6alpha-stereoisomer of 6-methylprednisolone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione;   1-dehydro-6alpha-methylhydrocortisone;   6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione;   Delta(1)-6alpha-methylhydrocortisone;   Formula=C22H30O5;   InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1;   InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N;   Medrate;   Medrol;   Medrone;   Methylprednisolon;   SMILES=C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12;   Solomet;   Urbason;   methylprednisolone;   methylprednisolonum;   metilprednisolona
 xref: CAS:83-43-2;   DrugBank:DB00959;   Drug_Central:1768;   HMDB:HMDB0015094;   KEGG:D00407
 xref_mesh: MESH:D008775
 xref: PMID:25232411;   Patent:US2897218;   Patent:US3053832;   Reaxys:2340300;   VSDB:1936;   Wikipedia:Methylprednisolone



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6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression
increases secretion
EXP ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein
CTD PMID:16932953 PMID:22079615 PMID:22464980 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions EXP Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACKR3 atypical chemokine receptor 3 decreases expression EXP Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 2:236,537,122...236,582,354
Ensembl chr 2:236,567,787...236,582,354
JBrowse link
G ADORA2A adenosine A2a receptor decreases expression EXP Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]
CTD PMID:15187100 PMID:30878453 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions
increases secretion
ISO Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G AMIGO2 adhesion molecule with Ig like domain 2 decreases expression EXP Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr12:47,075,707...47,079,959
Ensembl chr12:47,075,707...47,079,959
JBrowse link
G ANTXR1 ANTXR cell adhesion molecule 1 increases expression EXP Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 2:69,013,144...69,249,327
Ensembl chr 2:69,013,176...69,249,327
JBrowse link
G AOX1 aldehyde oxidase 1 increases expression EXP Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 2:200,586,014...200,682,241
Ensembl chr 2:200,586,014...200,677,064
JBrowse link
G AR androgen receptor multiple interactions EXP Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061 PMID:26093215 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 decreases expression EXP Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein decreases secretion
decreases expression
multiple interactions
ISO Methylprednisolone results in decreased secretion of BGLAP protein
Methylprednisolone results in decreased expression of BGLAP mRNA; Methylprednisolone results in decreased expression of BGLAP protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP protein]; [Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]; Methylprednisolone inhibits the reaction [2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of BGLAP mRNA]; Methylprednisolone inhibits the reaction [2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of BGLAP protein]
CTD PMID:30291735 PMID:37659742 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BST2 bone marrow stromal cell antigen 2 decreases expression EXP Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630
JBrowse link
G CAPN2 calpain 2 multiple interactions ISO Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase multiple interactions
decreases activity
increases activity
ISO [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein
CTD PMID:1942778 PMID:30291735 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL20 C-C motif chemokine ligand 20 decreases expression EXP Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCN1 cellular communication network factor 1 increases expression EXP Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589
JBrowse link
G CCN2 cellular communication network factor 2 increases expression EXP Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CCN5 cellular communication network factor 5 increases expression EXP Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr20:44,714,861...44,727,811
Ensembl chr20:44,714,844...44,728,509
JBrowse link
G CLGN calmegin decreases expression EXP Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr 4:140,388,453...140,427,648
Ensembl chr 4:140,388,453...140,427,661
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA
CTD PMID:19192274 PMID:26093215 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions ISO Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202
JBrowse link
G CTSD cathepsin D multiple interactions ISO Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression EXP Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression EXP Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 decreases expression EXP Methylprednisolone results in decreased expression of CXCL3 mRNA CTD PMID:19192274 NCBI chr 4:74,036,589...74,038,689
Ensembl chr 4:74,036,589...74,038,807
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP [Methylprednisolone co-treated with Lidocaine] results in decreased expression of CXCL8 protein
Methylprednisolone results in decreased expression of CXCL8 mRNA; Methylprednisolone results in decreased expression of CXCL8 protein
CTD PMID:11280320 PMID:19192274 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 decreases expression EXP Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity
decreases expression
EXP Methylprednisolone results in increased activity of CYP3A4 protein
Methylprednisolone results in decreased expression of CYP3A4 mRNA
CTD PMID:15964336 PMID:16837568 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression
multiple interactions
ISO Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]
CTD PMID:21931329 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
JBrowse link
G DIO2 iodothyronine deiodinase 2 increases expression EXP Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757
JBrowse link
G DMD dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:31,119,222...33,339,388
Ensembl chr  X:31,097,677...33,339,609
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr13:77,895,487...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G EFEMP1 EGF containing fibulin extracellular matrix protein 1 increases expression EXP Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr 2:55,865,967...55,923,782
Ensembl chr 2:55,865,967...55,924,139
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G F8 coagulation factor VIII increases expression EXP Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr  X:154,835,792...155,022,723
Ensembl chr  X:154,835,788...155,026,940
JBrowse link
G FABP4 fatty acid binding protein 4 increases expression
multiple interactions
ISO Methylprednisolone results in increased expression of FABP4 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in increased expression of FABP4 mRNA]
CTD PMID:37659742 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FBLN1 fibulin 1 increases expression EXP Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr22:45,502,883...45,601,135
Ensembl chr22:45,502,238...45,601,135
JBrowse link
G FBXO32 F-box protein 32 increases expression
multiple interactions
ISO Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein]
CTD PMID:21931329 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G FCER2 Fc epsilon receptor II multiple interactions EXP Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr19:7,688,776...7,702,131
Ensembl chr19:7,688,758...7,702,146
JBrowse link
G FOXO1 forkhead box O1 increases expression
multiple interactions
ISO Methylprednisolone results in increased expression of FOXO1 protein
echinacoside inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]; Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]
CTD PMID:21931329 PMID:38336255 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G GBP1 guanylate binding protein 1 decreases expression EXP Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression EXP Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GPM6B glycoprotein M6B increases expression EXP Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:13,770,939...13,938,638
Ensembl chr  X:13,770,939...13,938,638
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
increases activity
ISO [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein
CTD PMID:1942778 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSDME gasdermin E decreases expression EXP Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 7:24,698,355...24,795,539
Ensembl chr 7:24,698,355...24,757,940
JBrowse link
G HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 decreases expression EXP Methylprednisolone results in decreased expression of HERC5 mRNA CTD PMID:19192274 NCBI chr 4:88,457,119...88,506,163
Ensembl chr 4:88,457,119...88,506,163
JBrowse link
G HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression EXP Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,378,852...88,443,097
Ensembl chr 4:88,378,739...88,443,097
JBrowse link
G HILPDA hypoxia inducible lipid droplet associated decreases expression EXP Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 7:128,455,878...128,458,418
Ensembl chr 7:128,455,849...128,458,418
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
EXP [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein
CTD PMID:15329590 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313
JBrowse link
G ID3 inhibitor of DNA binding 3 increases expression EXP Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IFI27 interferon alpha inducible protein 27 decreases expression EXP Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr14:94,105,894...94,116,690
Ensembl chr14:94,104,836...94,116,695
JBrowse link
G IFI35 interferon induced protein 35 decreases expression EXP Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr17:43,006,784...43,014,456
Ensembl chr17:43,006,740...43,014,456
JBrowse link
G IFI44 interferon induced protein 44 decreases expression EXP Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 1:78,649,789...78,664,078
Ensembl chr 1:78,649,796...78,664,078
JBrowse link
G IFI44L interferon induced protein 44 like decreases expression EXP Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145
JBrowse link
G IFI6 interferon alpha inducible protein 6 decreases expression EXP Methylprednisolone results in decreased expression of IFI6 mRNA CTD PMID:19192274 NCBI chr 1:27,666,064...27,672,192
Ensembl chr 1:27,666,064...27,672,212
JBrowse link
G IFIH1 interferon induced with helicase C domain 1 decreases expression EXP Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684
JBrowse link
G IFIT1 interferon induced protein with tetratricopeptide repeats 1 decreases expression EXP Methylprednisolone results in decreased expression of IFIT1 mRNA CTD PMID:19192274 NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487
JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 decreases expression EXP Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473
JBrowse link
G IL10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist decreases expression EXP Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
JBrowse link
G IL23A interleukin 23 subunit alpha decreases expression EXP Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein
CTD PMID:7988651 PMID:11997017 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL4R interleukin 4 receptor multiple interactions EXP Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
JBrowse link
G IL5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein
CTD PMID:19192274 PMID:26093215 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO cobaltiprotoporphyrin inhibits the reaction [Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:15919478 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G IRF7 interferon regulatory factor 7 decreases expression EXP Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983
JBrowse link
G ISG15 ISG15 ubiquitin like modifier decreases expression EXP Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 decreases expression EXP Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483
JBrowse link
G JAK1 Janus kinase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754
JBrowse link
G LAMB1 laminin subunit beta 1 multiple interactions ISO Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213
JBrowse link
G LAMB2 laminin subunit beta 2 multiple interactions ISO Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118
JBrowse link
G LAMB3 laminin subunit beta 3 decreases expression EXP Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425
JBrowse link
G LY6E lymphocyte antigen 6 family member E decreases expression EXP Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 8:143,018,529...143,022,409
Ensembl chr 8:143,017,982...143,023,832
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate decreases expression EXP Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr 6:113,857,345...113,863,475
Ensembl chr 6:113,857,345...113,863,475
JBrowse link
G MBP myelin basic protein decreases expression EXP Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase decreases expression EXP Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G MMP10 matrix metallopeptidase 10 decreases expression EXP Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
JBrowse link
G MMP12 matrix metallopeptidase 12 decreases expression EXP Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MPO myeloperoxidase multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
CTD PMID:26093215 PMID:28557239 PMID:30891624 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G MX1 MX dynamin like GTPase 1 decreases expression EXP Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071
JBrowse link
G NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 decreases expression EXP Methylprednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr12:57,234,903...57,240,762
Ensembl chr12:57,234,903...57,240,715
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NID2 nidogen 2 increases expression EXP Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr14:52,004,809...52,069,059
Ensembl chr14:52,004,809...52,069,059
JBrowse link
G NMB neuromedin B decreases expression EXP Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr15:84,655,132...84,658,199
Ensembl chr15:84,655,129...84,658,563
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891
JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 decreases expression EXP Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219
JBrowse link
G OAS3 2'-5'-oligoadenylate synthetase 3 decreases expression EXP Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:112,938,474...112,973,251
Ensembl chr12:112,938,051...112,976,460
JBrowse link
G OASL 2'-5'-oligoadenylate synthetase like decreases expression EXP Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:121,017,761...121,039,246
Ensembl chr12:121,017,763...121,039,246
JBrowse link
G PHGDH phosphoglycerate dehydrogenase decreases expression EXP Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 1:119,711,934...119,744,215
Ensembl chr 1:119,648,411...119,744,218
JBrowse link
G PLA1A phospholipase A1 member A multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr 3:119,597,885...119,629,811
Ensembl chr 3:119,597,875...119,629,811
JBrowse link
G PLA2G4A phospholipase A2 group IVA multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
JBrowse link
G PLPP3 phospholipid phosphatase 3 decreases expression EXP Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in increased expression of PPARG mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in increased expression of PPARG protein]; Methylprednisolone inhibits the reaction [2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of PPARG mRNA]; Methylprednisolone inhibits the reaction [2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of PPARG protein]
Methylprednisolone results in increased expression of PPARG mRNA; Methylprednisolone results in increased expression of PPARG protein
CTD PMID:37659742 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRELP proline and arginine rich end leucine rich repeat protein increases expression EXP Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr 1:203,475,806...203,491,352
Ensembl chr 1:203,475,806...203,491,352
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G REN renin increases activity
multiple interactions
ISO Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:235222 PMID:6277579 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G RGS4 regulator of G protein signaling 4 decreases expression EXP Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G RIGI RNA sensor RIG-I decreases expression EXP Methylprednisolone results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 9:32,455,302...32,526,196
Ensembl chr 9:32,455,302...32,526,348
JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 decreases expression EXP Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064
JBrowse link
G RNF19B ring finger protein 19B decreases expression EXP Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 1:32,929,036...32,964,809
Ensembl chr 1:32,936,445...32,964,809
JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 decreases expression EXP Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions
decreases expression
ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 protein]; Methylprednisolone inhibits the reaction [2,2-bis(4-glycidyloxyphenyl)propane results in increased expression of RUNX2 protein]
Methylprednisolone results in decreased expression of RUNX2 mRNA; Methylprednisolone results in decreased expression of RUNX2 protein
CTD PMID:37659742 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC43A3 solute carrier family 43 member 3 decreases expression EXP Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr11:57,406,954...57,427,580
Ensembl chr11:57,406,954...57,427,580
JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SMS spermine synthase decreases expression EXP Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases expression
increases activity
ISO
EXP
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA
Methylprednisolone results in increased activity of SOD2 protein
CTD PMID:1942778 PMID:19192274 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STAT1 signal transducer and activator of transcription 1 decreases expression EXP Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT4 signal transducer and activator of transcription 4 decreases expression EXP Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,178,435
JBrowse link
G STAT6 signal transducer and activator of transcription 6 multiple interactions EXP Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
JBrowse link
G STS steroid sulfatase increases expression EXP Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THBS1 thrombospondin 1 increases expression EXP Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TLR2 toll like receptor 2 decreases expression EXP Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
[Cyclophosphamide co-treated with Methylprednisolone] inhibits the reaction [Paraquat results in increased expression of TNF protein]
Methylprednisolone results in decreased expression of TNF protein
CTD PMID:8384958 PMID:26093215 PMID:28557239 PMID:33737140 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP2 TNF alpha induced protein 2 decreases expression EXP Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr14:103,121,469...103,137,439
Ensembl chr14:103,121,476...103,137,439
JBrowse link
G TRIM63 tripartite motif containing 63 increases expression
multiple interactions
ISO Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein]
CTD PMID:21931329 NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436
JBrowse link
G TXNIP thioredoxin interacting protein increases expression EXP Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G VWF von Willebrand factor decreases expression
increases expression
EXP Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein
CTD PMID:7491699 PMID:20405515 NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    role 26326
      biological role 26305
        xenobiotic 20407
          6alpha-methylprednisolone 135
            methylprednisolone 21-suleptanic acid ester 0
            methylprednisolone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    p-block element atom 26217
                      carbon group element atom 25660
                        carbon atom 25622
                          organic molecular entity 25622
                            heteroorganic entity 25005
                              organochalcogen compound 24601
                                organooxygen compound 24195
                                  carbonyl compound 23670
                                    ketone 19584
                                      oxo steroid 11056
                                        3-oxo steroid 10450
                                          3-oxo-Delta(4) steroid 9660
                                            progesterone 2909
                                              Delta(1)-progesterone 259
                                                prednisolone 248
                                                  6-methylprednisolone 135
                                                    6alpha-methylprednisolone 135
                                                      methylprednisolone 21-suleptanic acid ester 0
                                                      methylprednisolone acetate 0
paths to the root