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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pluronic P-123
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Accession:CHEBI:53515 term browser browse the term
Definition:A triblock copolymer composed of a central hydrophobic chain of poly(propylene oxide) (70 units) flanked by two hydrophilic chains of poly(ethylene oxide) (20 units each). A polymer with the formula HO[CH2CH2O]2O[CH2CH(CH3)O]70[CH2CH2O]2OH.
Synonyms:related_synonym: Block polyethylene-polypropylene glycol;   Block polyoxyethylene-polyoxypropylene;   Ethylene glycol-propylene glycol block copolymer;   Pluronic P123;   Poloxamer;   Polyoxypropylene-polyoxyethylene block copolymer;   Propylene oxide ethylene oxide block polymer
 xref: Beilstein:10779434;   CAS:106392-12-5
 xref_mesh: MESH:D020442


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pluronic P-123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases secretion
multiple interactions		 ISO Poloxamer results in decreased secretion of ADIPOQ protein
carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]		 CTD PMID:29071762 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Afp alpha fetoprotein multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO Poloxamer results in increased expression of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]		 CTD PMID:29071762 PMID:32961231 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein] CTD PMID:29071762 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]] CTD PMID:32961231 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd68 CD68 antigen multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979 		JBrowse link
G Ckm creatine kinase, muscle multiple interactions
increases secretion		 ISO carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein] CTD PMID:29071762 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr19:61,205,629...61,221,141
Ensembl chr19:61,212,395...61,216,867 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]] CTD PMID:32961231 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]] CTD PMID:32961231 NCBI chr11:69,891,418...69,900,935
Ensembl chr11:69,891,421...69,903,127 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]] CTD PMID:32961231 NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nickel monoxide co-treated with Poloxamer] results in increased expression of HMOX1 mRNA CTD PMID:25964212 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr11:106,268,482...106,278,948
Ensembl chr11:106,268,482...106,278,901 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA] CTD PMID:32169474 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgam integrin alpha M multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:32169474 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Lep leptin multiple interactions
increases secretion		 ISO carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] CTD PMID:32961231 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]] CTD PMID:32961231 NCBI chr 6:134,423,439...134,543,876
Ensembl chr 6:134,423,439...134,543,928 		JBrowse link
G Mb myoglobin increases secretion
multiple interactions		 ISO Poloxamer results in increased secretion of MB protein
carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein]		 CTD PMID:29071762 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870 		JBrowse link
G Notch1 notch 1 multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Pnlip pancreatic lipase decreases activity EXP Poloxamer results in decreased activity of PNLIP protein CTD PMID:16872557 NCBI chr19:58,658,797...58,670,231
Ensembl chr19:58,640,930...58,670,220 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Poloxamer inhibits the reaction [Nanotubes, Carbon inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]] CTD PMID:17709331 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA] CTD PMID:32169474 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions ISO Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]] CTD PMID:32961231 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22298
    role 22264
      chemical role 21505
        emulsifier 7596
          surfactant 7604
            nonionic surfactant 36
              pluronic P-123 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 22298
    subatomic particle 22274
      composite particle 22292
        hadron 22292
          baryon 22292
            nucleon 22274
              atomic nucleus 22292
                atom 22292
                  group 22126
                    polyatomic entity 22126
                      macromolecule 9340
                        copolymer macromolecule 61
                          block copolymer 27
                            triblock copolymer 27
                              pluronic 27
                                pluronic P-123 27
paths to the root