CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: disulfiram
Accession: CHEBI:4659
browse the term
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Synonyms: exact_synonym: 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
related_synonym: 1,1'-dithiobis(N,N-diethylthioformamide); Antabuse; Formula=C10H20N2S4; InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3; InChIKey=AUZONCFQVSMFAP-UHFFFAOYSA-N; N,N,N',N'-tetraethylthiuram disulfide; SMILES=S(SC(N(CC)CC)=S)C(N(CC)CC)=S; bis(diethylthiocarbamoyl) disulfide; tetraethylthioperoxydicarbonic diamide; tetraethylthiuram disulfide; tetraethylthiuram disulphide
xref: CAS:97-77-8; DrugBank:DB00822; Drug_Central:928; HMDB:HMDB0014960; KEGG:C01692; KEGG:D00131; LINCS:LSM-5467
xref_mesh: MESH:D004221
xref: MetaCyc:DISULFIRAM; PMID:10841824; PMID:11005259; PMID:11716515; PMID:14978246; PMID:15325261; PMID:15709459; PMID:16426571; PMID:16661923; PMID:16666414; PMID:16880974; PMID:17079463; PMID:17579916; PMID:17667894; PMID:18579431; PMID:19720750; PMID:19782464; PMID:19787200; PMID:21471244; PMID:24496638; PMID:25133664; PMID:25445071; PMID:25464072; PMID:25476326; PMID:25495604; PMID:25557293; PMID:25565438; PMID:25657800; PMID:25777347; PMID:26033731; PMID:26224731; PMID:26235918; PMID:26239994; PMID:26314552; PMID:26517513; PMID:26550292; PMID:31151194; PMID:32963852; PMID:32971817; PMID:33731397; PMID:34012274; PMID:34045896; PMID:8442800; PMID:8572926; Pesticides:disulfiram; Reaxys:1712560; Wikipedia:Disulfiram
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AARS1
alanyl-tRNA synthetase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of AARS1 mRNA
CTD
PMID:24690739
NCBI chr16:70,252,298...70,289,506
Ensembl chr16:70,251,983...70,289,707
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ABAT
4-aminobutyrate aminotransferase
multiple interactions
ISO
[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein; [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA
CTD
PMID:9591243
NCBI chr16:8,674,617...8,784,570
Ensembl chr16:8,674,596...8,784,575
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ABCA1
ATP binding cassette subfamily A member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA
CTD
PMID:24690739
NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
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ABCA3
ATP binding cassette subfamily A member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ABCA3 mRNA
CTD
PMID:24690739
NCBI chr16:2,275,881...2,340,728
Ensembl chr16:2,275,881...2,340,746
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ABCB1
ATP binding cassette subfamily B member 1
multiple interactions decreases activity
EXP
Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidopine binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidoprazosin binds to ABCB1 protein] Disulfiram metabolite results in decreased activity of ABCB1 protein; Disulfiram results in decreased activity of ABCB1 protein
CTD
PMID:10841824 PMID:14978246 PMID:16028354
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ABCB11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
EXP
Disulfiram results in decreased activity of ABCB11 protein Disulfiram inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:24014644
NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
decreases activity multiple interactions
EXP
Disulfiram results in decreased activity of ABCC1 protein Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC1 protein]
CTD
PMID:14978246
NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
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ABCC4
ATP binding cassette subfamily C member 4 (PEL blood group)
multiple interactions
EXP
Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]
CTD
PMID:14978246
NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
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ABCG1
ATP binding cassette subfamily G member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA
CTD
PMID:24690739
NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,304,389
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ACAD11
acyl-CoA dehydrogenase family member 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ACAD11 mRNA
CTD
PMID:24690739
NCBI chr 3:132,558,141...132,659,809
Ensembl chr 3:132,558,138...132,660,082
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ACE2
angiotensin converting enzyme 2
decreases expression
EXP
Disulfiram results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236
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ACHE
acetylcholinesterase (Yt blood group)
decreases expression
ISO
Disulfiram results in decreased expression of ACHE protein
CTD
PMID:3868355
NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
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ACSS2
acyl-CoA synthetase short chain family member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA
CTD
PMID:24690739
NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962
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ACTA2
actin alpha 2, smooth muscle
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ACTA2 mRNA
CTD
PMID:24690739
NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
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ADAM9
ADAM metallopeptidase domain 9
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ADAM9 mRNA
CTD
PMID:24690739
NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445
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ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ADAMTS1 mRNA
CTD
PMID:24690739
NCBI chr21:26,835,755...26,845,409
Ensembl chr21:26,835,755...26,845,409
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ADARB1
adenosine deaminase RNA specific B1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA
CTD
PMID:24690739
NCBI chr21:45,074,578...45,226,563
Ensembl chr21:45,073,853...45,226,560
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ADCY3
adenylate cyclase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA
CTD
PMID:24690739
NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237
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ADGRE5
adhesion G protein-coupled receptor E5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ADGRE5 mRNA
CTD
PMID:24690739
NCBI chr19:14,381,444...14,408,723
Ensembl chr19:14,380,501...14,408,725
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ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases activity
ISO
Disulfiram results in decreased activity of ADH1 protein
CTD
PMID:15551062
NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
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ADM
adrenomedullin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA
CTD
PMID:24690739
NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
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AFAP1
actin filament associated protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA
CTD
PMID:24690739
NCBI chr 4:7,758,713...7,939,861
Ensembl chr 4:7,758,714...7,939,926
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AGXT
alanine--glyoxylate aminotransferase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA
CTD
PMID:24690739
NCBI chr 2:240,868,824...240,880,500
Ensembl chr 2:240,868,824...240,880,502
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AGXT2
alanine--glyoxylate aminotransferase 2
multiple interactions
ISO
[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein
CTD
PMID:9591243
NCBI chr 5:34,998,102...35,047,949
Ensembl chr 5:34,998,101...35,048,135
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AHSA1
activator of HSP90 ATPase activity 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA
CTD
PMID:24690739
NCBI chr14:77,457,867...77,469,472
Ensembl chr14:77,457,870...77,469,472
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AKR1B1
aldo-keto reductase family 1 member B
increases expression
EXP
Disulfiram results in increased expression of AKR1B1 mRNA
CTD
PMID:20566472
NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
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AKR1B10
aldo-keto reductase family 1 member B10
increases expression
EXP
Disulfiram results in increased expression of AKR1B10 mRNA
CTD
PMID:20566472
NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
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AKR1C1
aldo-keto reductase family 1 member C1
increases expression
EXP
Disulfiram results in increased expression of AKR1C1 mRNA
CTD
PMID:20566472
NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
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AKR1C3
aldo-keto reductase family 1 member C3
increases expression
EXP
Disulfiram results in increased expression of AKR1C3 mRNA
CTD
PMID:20566472
NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
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AKT1
AKT serine/threonine kinase 1
decreases phosphorylation
EXP
Disulfiram results in decreased phosphorylation of AKT1 protein
CTD
PMID:34182011
NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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ALAD
aminolevulinate dehydratase
multiple interactions
ISO
[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein
CTD
PMID:2748540
NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
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ALDH1A1
aldehyde dehydrogenase 1 family member A1
decreases activity decreases expression multiple interactions
ISO EXP
Disulfiram results in decreased activity of ALDH1A1 protein Disulfiram results in decreased expression of ALDH1A1 mRNA; Disulfiram results in decreased expression of ALDH1A1 protein Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide]
CTD
PMID:8562935 PMID:10998257 PMID:21035945 PMID:34242567
NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
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ALDH1A2
aldehyde dehydrogenase 1 family member A2
decreases activity
EXP
Disulfiram results in decreased activity of ALDH1A2 protein
CTD
PMID:22079344
NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866
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ALDH2
aldehyde dehydrogenase 2 family member
decreases activity decreases expression multiple interactions
ISO EXP
Disulfiram metabolite results in decreased activity of ALDH2 protein; Disulfiram results in decreased activity of ALDH2 protein Disulfiram results in decreased expression of ALDH2 mRNA [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde
CTD
PMID:9585485 PMID:10513990 PMID:11142365 PMID:21334317 PMID:21376711 PMID:22079344 PMID:24496638 More...
NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
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ALDH3A1
aldehyde dehydrogenase 3 family member A1
increases metabolic processing
EXP
ALDH3A1 protein results in increased metabolism of Disulfiram
CTD
PMID:18591790
NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943
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ANGPTL4
angiopoietin like 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA
CTD
PMID:24690739
NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370
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ANO6
anoctamin 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA
CTD
PMID:24690739
NCBI chr12:45,216,095...45,440,404
Ensembl chr12:45,215,987...45,482,280
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APAF1
apoptotic peptidase activating factor 1
increases expression
EXP
Disulfiram results in increased expression of APAF1 mRNA
CTD
PMID:34182011
NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433
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APBB3
amyloid beta precursor protein binding family B member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of APBB3 mRNA
CTD
PMID:24690739
NCBI chr 5:140,558,268...140,564,598
Ensembl chr 5:140,558,268...140,564,781
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APCDD1L
APC down-regulated 1 like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of APCDD1L mRNA
CTD
PMID:24690739
NCBI chr20:58,459,101...58,515,399
Ensembl chr20:58,459,101...58,515,399
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APP
amyloid beta precursor protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of APP mRNA
CTD
PMID:24690739
NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
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AR
androgen receptor
multiple interactions
EXP
[Disulfiram co-treated with cupric chloride] results in decreased expression of AR protein; Disulfiram inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:19789329 PMID:33049310
NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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ARC
activity regulated cytoskeleton associated protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ARC mRNA
CTD
PMID:24690739
NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
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ASGR1
asialoglycoprotein receptor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ASGR1 mRNA
CTD
PMID:24690739
NCBI chr17:7,173,431...7,179,370
Ensembl chr17:7,173,431...7,179,564
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ASMTL
acetylserotonin O-methyltransferase like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ASMTL mRNA
CTD
PMID:24690739
NCBI chr X:1,403,139...1,453,756 NCBI chr Y:1,403,139...1,453,756
Ensembl chr Y:1,403,139...1,453,762 Ensembl chr X:1,403,139...1,453,762
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ASNS
asparagine synthetase (glutamine-hydrolyzing)
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ASNS mRNA
CTD
PMID:24690739
NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
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ATF1
activating transcription factor 1
multiple interactions
EXP
[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein]
CTD
PMID:15367699
NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162
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ATF2
activating transcription factor 2
multiple interactions
EXP
[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]
CTD
PMID:15367699
NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
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ATF3
activating transcription factor 3
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATF3 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]
CTD
PMID:24690739 PMID:32661532
NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
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ATG101
autophagy related 101
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATG101 mRNA
CTD
PMID:24690739
NCBI chr12:52,065,300...52,077,495
Ensembl chr12:52,069,246...52,077,495
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ATP2B1
ATPase plasma membrane Ca2+ transporting 1
decreases expression
ISO
Disulfiram results in decreased expression of ATP2B1 mRNA
CTD
PMID:15003327
NCBI chr12:89,588,049...89,709,366
Ensembl chr12:89,588,049...89,709,366
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ATP5MK
ATP synthase membrane subunit k
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATP5MK mRNA
CTD
PMID:24690739
NCBI chr10:103,389,050...103,396,475
Ensembl chr10:103,389,041...103,396,492
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ATP6V0D1
ATPase H+ transporting V0 subunit d1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATP6V0D1 mRNA
CTD
PMID:24690739
NCBI chr16:67,438,019...67,481,157
Ensembl chr16:67,438,014...67,481,181
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ATP6V1G1
ATPase H+ transporting V1 subunit G1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATP6V1G1 mRNA
CTD
PMID:24690739
NCBI chr 9:114,587,769...114,598,879
Ensembl chr 9:114,587,706...114,598,915
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ATXN1L
ataxin 1 like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ATXN1L mRNA
CTD
PMID:24690739
NCBI chr16:71,845,976...71,857,328
Ensembl chr16:71,808,439...71,885,268
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ATXN3
ataxin 3
affects localization increases response to substance
EXP
Disulfiram affects the localization of ATXN3 protein alternative form ATXN3 protein alternative form results in increased susceptibility to Disulfiram
CTD
PMID:31378764
NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621
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BAD
BCL2 associated agonist of cell death
increases expression
EXP
Disulfiram results in increased expression of BAD mRNA
CTD
PMID:34182011
NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
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BAG3
BAG cochaperone 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA
CTD
PMID:24690739
NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,380...119,677,819
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BAK1
BCL2 antagonist/killer 1
multiple interactions
EXP
[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein
CTD
PMID:24126434
NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
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BAX
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
EXP
Disulfiram results in increased expression of BAX mRNA; Disulfiram results in increased expression of BAX protein [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [Copper co-treated with Disulfiram] results in increased expression of BAX protein
CTD
PMID:17079463 PMID:23033007 PMID:24126434 PMID:34182011
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BBC3
BCL2 binding component 3
increases expression
EXP
Disulfiram results in increased expression of BBC3 mRNA
CTD
PMID:34182011
NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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BBS2
Bardet-Biedl syndrome 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of BBS2 mRNA
CTD
PMID:24690739
NCBI chr16:56,470,403...56,520,024
Ensembl chr16:56,465,640...56,582,667
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BCCIP
BRCA2 and CDKN1A interacting protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of BCCIP mRNA
CTD
PMID:24690739
NCBI chr10:125,823,546...125,853,695
Ensembl chr10:125,823,546...125,853,695
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BCL2
BCL2 apoptosis regulator
multiple interactions decreases expression
EXP
[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Disulfiram co-treated with cupric chloride] results in decreased expression of BCL2 protein Disulfiram results in decreased expression of BCL2 mRNA
CTD
PMID:21911303 PMID:23033007 PMID:24126434 PMID:34182011
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BCL2L1
BCL2 like 1
decreases expression
EXP
Disulfiram results in decreased expression of BCL2L1 mRNA
CTD
PMID:34182011
NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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BCL2L11
BCL2 like 11
increases expression
EXP
Disulfiram results in increased expression of BCL2L11 mRNA
CTD
PMID:34182011
NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444
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BDNF
brain derived neurotrophic factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of BDNF mRNA
CTD
PMID:24690739
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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BECN1
beclin 1
increases expression
EXP
Disulfiram results in increased expression of BECN1 mRNA
CTD
PMID:34182011
NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
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BGLAP
bone gamma-carboxyglutamate protein
increases expression
ISO
Disulfiram results in increased expression of BGLAP mRNA
CTD
PMID:24496638
NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
G
BIRC5
baculoviral IAP repeat containing 5
increases expression
EXP
Disulfiram results in increased expression of BIRC5 protein
CTD
PMID:34182011
NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
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BMP7
bone morphogenetic protein 7
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]
CTD
PMID:22285649
NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641
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BNIP3
BCL2 interacting protein 3
increases expression
EXP
Disulfiram results in increased expression of BNIP3 mRNA
CTD
PMID:34182011
NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
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BRF2
BRF2 general transcription factor IIIB subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of BRF2 mRNA
CTD
PMID:24690739
NCBI chr 8:37,843,268...37,849,861
Ensembl chr 8:37,843,268...37,849,861
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BTK
Bruton tyrosine kinase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA
CTD
PMID:24690739
NCBI chr X:101,349,450...101,390,796
Ensembl chr X:101,349,338...101,390,796
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BTN3A2
butyrophilin subfamily 3 member A2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of BTN3A2 mRNA
CTD
PMID:24690739
NCBI chr 6:26,365,169...26,378,320
Ensembl chr 6:26,365,159...26,378,320
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C11orf96
chromosome 11 open reading frame 96
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of C11ORF96 mRNA
CTD
PMID:24690739
NCBI chr11:43,942,637...43,943,878
Ensembl chr11:43,942,637...43,943,878
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C1R
complement C1r
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of C1R mRNA
CTD
PMID:24690739
NCBI chr12:7,080,219...7,092,445
Ensembl chr12:7,080,214...7,092,540
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C1S
complement C1s
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of C1S mRNA
CTD
PMID:24690739
NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032
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C2orf42
chromosome 2 open reading frame 42
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of C2ORF42 mRNA
CTD
PMID:24690739
NCBI chr 2:70,149,885...70,191,019
Ensembl chr 2:70,149,885...70,248,615
G
C2orf49
chromosome 2 open reading frame 49
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of C2ORF49 mRNA
CTD
PMID:24690739
NCBI chr 2:105,337,540...105,385,899
Ensembl chr 2:105,337,532...105,350,712
G
C3orf52
chromosome 3 open reading frame 52
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of C3ORF52 mRNA
CTD
PMID:24690739
NCBI chr 3:112,086,389...112,136,381
Ensembl chr 3:112,086,335...112,131,004
G
CA2
carbonic anhydrase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA
CTD
PMID:24690739
NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
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CA7
carbonic anhydrase 7
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CA7 mRNA
CTD
PMID:24690739
NCBI chr16:66,844,414...66,854,147
Ensembl chr16:66,844,414...66,854,153
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CACYBP
calcyclin binding protein
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of CACYBP mRNA Disulfiram results in increased expression of CACYBP mRNA; Disulfiram results in increased expression of CACYBP protein
CTD
PMID:24690739 PMID:34182011
NCBI chr 1:174,999,435...175,012,027
Ensembl chr 1:174,999,163...175,012,027
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CALCB
calcitonin related polypeptide beta
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CALCB mRNA
CTD
PMID:24690739
NCBI chr11:15,073,593...15,078,637
Ensembl chr11:14,904,997...15,082,342
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CALD1
caldesmon 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA
CTD
PMID:24690739
NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729
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CALM1
calmodulin 1
decreases expression
EXP
Disulfiram results in decreased expression of CALM1 mRNA
CTD
PMID:34182011
NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
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CALM2
calmodulin 2
increases expression
EXP
Disulfiram results in increased expression of CALM2 mRNA
CTD
PMID:34182011
NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921
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CALM3
calmodulin 3
decreases expression
EXP
Disulfiram results in decreased expression of CALM3 mRNA
CTD
PMID:34182011
NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
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CASP3
caspase 3
multiple interactions increases activity
ISO EXP
[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein] [Disulfiram binds to Copper] which results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein] Disulfiram results in increased activity of CASP3 protein
CTD
PMID:11239917 PMID:17026967 PMID:17079463 PMID:24193513 PMID:24690739
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP7
caspase 7
increases activity
EXP
Disulfiram results in increased activity of CASP7 protein
CTD
PMID:17026967
NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
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CASP9
caspase 9
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in increased activity of CASP9 protein Disulfiram results in increased expression of CASP9 mRNA
CTD
PMID:24690739 PMID:34182011
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CAT
catalase
increases expression multiple interactions decreases expression
EXP
Disulfiram results in increased expression of CAT mRNA Zinc Sulfate inhibits the reaction [Disulfiram results in decreased expression of CAT mRNA]
CTD
PMID:20566472 PMID:32712770 PMID:34182011
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
G
CCAR1
cell division cycle and apoptosis regulator 1
multiple interactions
ISO EXP
[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein
CTD
PMID:24690739
NCBI chr10:68,721,239...68,792,377
Ensembl chr10:68,721,012...68,792,377
G
CCDC59
coiled-coil domain containing 59
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CCDC59 mRNA
CTD
PMID:24690739
NCBI chr12:82,352,303...82,358,805
Ensembl chr12:82,223,681...82,358,805
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CCDC92
coiled-coil domain containing 92
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CCDC92 mRNA
CTD
PMID:24690739
NCBI chr12:123,935,626...123,972,831
Ensembl chr12:123,918,660...123,972,831
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CCK
cholecystokinin
decreases expression multiple interactions
ISO EXP
Disulfiram results in decreased expression of CCK protein alternative form [Disulfiram binds to Copper] which results in decreased expression of CCK mRNA
CTD
PMID:8246921 PMID:24690739
NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
G
CCL2
C-C motif chemokine ligand 2
multiple interactions decreases secretion
EXP
[Disulfiram binds to Copper] which results in increased expression of CCL2 mRNA; [Zinc Sulfate co-treated with Disulfiram] inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Disulfiram results in decreased secretion of CCL2 protein
CTD
PMID:24690739 PMID:32712770
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CCL26
C-C motif chemokine ligand 26
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CCL26 mRNA
CTD
PMID:24690739
NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896
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CCL5
C-C motif chemokine ligand 5
multiple interactions
ISO EXP
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] [Disulfiram binds to Copper] which results in increased expression of CCL5 mRNA
CTD
PMID:19016906 PMID:24690739
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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CCNA2
cyclin A2
multiple interactions decreases expression
EXP
[Disulfiram co-treated with Copper] results in decreased expression of CCNA2 protein Disulfiram results in decreased expression of CCNA2 mRNA
CTD
PMID:15367699 PMID:34182011
NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
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CCND1
cyclin D1
decreases expression
EXP
Disulfiram results in decreased expression of CCND1 mRNA
CTD
PMID:34182011
NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
G
CCND2
cyclin D2
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]
CTD
PMID:22285649
NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
G
CCNK
cyclin K
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CCNK mRNA
CTD
PMID:24690739
NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
G
CCPG1
cell cycle progression 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CCPG1 mRNA
CTD
PMID:24690739
NCBI chr15:55,355,239...55,408,359
Ensembl chr15:55,340,032...55,408,510
G
CCR2
C-C motif chemokine receptor 2
increases expression
EXP
Disulfiram results in increased expression of CCR2 protein
CTD
PMID:32712770
NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
G
CCR5
C-C motif chemokine receptor 5
multiple interactions
ISO
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]
CTD
PMID:19016906
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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CD163
CD163 molecule
multiple interactions decreases expression
EXP
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA Disulfiram results in decreased expression of CD163 mRNA
CTD
PMID:32712770
NCBI chr12:7,470,811...7,503,777
Ensembl chr12:7,470,811...7,503,893
G
CD36
CD36 molecule (CD36 blood group)
multiple interactions decreases expression
EXP
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD36 mRNA Disulfiram results in decreased expression of CD36 mRNA
CTD
PMID:32712770
NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
G
CD46
CD46 molecule
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA
CTD
PMID:24690739
NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,037...207,795,513
G
CD47
CD47 molecule
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA
CTD
PMID:24690739
NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862
G
CD9
CD9 molecule
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA
CTD
PMID:24690739
NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271
G
CDC42EP5
CDC42 effector protein 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CDC42EP5 mRNA
CTD
PMID:24690739
NCBI chr19:54,465,026...54,473,296
Ensembl chr19:54,465,026...54,473,296
G
CDH11
cadherin 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA
CTD
PMID:24690739
NCBI chr16:64,943,753...65,123,744
Ensembl chr16:64,943,753...65,126,112
G
CDH2
cadherin 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA
CTD
PMID:24690739
NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946
G
CDK2
cyclin dependent kinase 2
decreases expression
EXP
Disulfiram results in decreased expression of CDK2 mRNA
CTD
PMID:34182011
NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
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CDK4
cyclin dependent kinase 4
decreases expression
EXP
Disulfiram results in decreased expression of CDK4 mRNA
CTD
PMID:34182011
NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
G
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA
CTD
PMID:24690739
NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253
G
CDK5RAP3
CDK5 regulatory subunit associated protein 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA
CTD
PMID:24690739
NCBI chr17:47,967,904...47,981,781
Ensembl chr17:47,967,810...47,981,781
G
CDK6
cyclin dependent kinase 6
decreases expression
EXP
Disulfiram results in decreased expression of CDK6 mRNA
CTD
PMID:34182011
NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
G
CDKN1A
cyclin dependent kinase inhibitor 1A
increases expression
EXP
Disulfiram results in increased expression of CDKN1A mRNA
CTD
PMID:34182011
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
G
CDKN1B
cyclin dependent kinase inhibitor 1B
increases expression multiple interactions
EXP ISO
Disulfiram results in increased expression of CDKN1B mRNA; Disulfiram results in increased expression of CDKN1B protein [Disulfiram binds to Copper] which results in increased expression of CDKN1B protein
CTD
PMID:17079463 PMID:24690739 PMID:34182011
NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
G
CDKN1C
cyclin dependent kinase inhibitor 1C
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA
CTD
PMID:24690739
NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
G
CDKN2AIP
CDKN2A interacting protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA
CTD
PMID:24690739
NCBI chr 4:183,444,636...183,449,064
Ensembl chr 4:183,444,635...183,449,064
G
CDKN2B
cyclin dependent kinase inhibitor 2B
increases expression
EXP
Disulfiram results in increased expression of CDKN2B mRNA
CTD
PMID:34182011
NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305
G
CEMIP
cell migration inducing hyaluronidase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA
CTD
PMID:24690739
NCBI chr15:80,779,370...80,951,771
Ensembl chr15:80,779,343...80,951,776
G
CENPW
centromere protein W
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CENPW mRNA
CTD
PMID:24690739
NCBI chr 6:126,340,115...126,483,320
Ensembl chr 6:126,340,115...126,348,875
G
CFAP53
cilia and flagella associated protein 53
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CFAP53 mRNA
CTD
PMID:24690739
NCBI chr18:50,227,193...50,266,495
Ensembl chr18:50,227,193...50,266,495
G
CFB
complement factor B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CFB mRNA
CTD
PMID:24690739
NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086
G
CFL1
cofilin 1
increases expression
EXP
Disulfiram results in increased expression of CFL1 protein
CTD
PMID:34182011
NCBI chr11:65,854,673...65,858,180
Ensembl chr11:65,823,022...65,862,026
G
CHGA
chromogranin A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA
CTD
PMID:24690739
NCBI chr14:92,922,664...92,935,285
Ensembl chr14:92,923,150...92,935,285
G
CHMP1B
charged multivesicular body protein 1B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CHMP1B mRNA
CTD
PMID:24690739
NCBI chr18:11,851,413...11,854,444
Ensembl chr18:11,851,413...11,854,444
G
CHORDC1
cysteine and histidine rich domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CHORDC1 mRNA
CTD
PMID:24690739
NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077
G
CIDECP1
CIDEC pseudogene 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CIDECP1 mRNA
CTD
PMID:24690739
NCBI chr 3:10,017,553...10,026,136
Ensembl chr 3:10,017,490...10,023,747
G
CILP
cartilage intermediate layer protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CILP mRNA
CTD
PMID:24690739
NCBI chr15:65,194,760...65,211,473
Ensembl chr15:65,194,760...65,211,473
G
CIRBP
cold inducible RNA binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CIRBP mRNA
CTD
PMID:24690739
NCBI chr19:1,269,332...1,274,880
Ensembl chr19:1,259,384...1,274,880
G
CKAP4
cytoskeleton associated protein 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CKAP4 mRNA
CTD
PMID:24690739
NCBI chr12:106,237,881...106,248,020
Ensembl chr12:106,237,881...106,304,279
G
CLDN1
claudin 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA
CTD
PMID:24690739
NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
G
CLEC7A
C-type lectin domain containing 7A
increases expression
EXP
Disulfiram results in increased expression of CLEC7A protein
CTD
PMID:32712770
NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258
G
CLP1
cleavage factor polyribonucleotide kinase subunit 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CLP1 mRNA
CTD
PMID:24690739
NCBI chr11:57,657,762...57,661,865
Ensembl chr11:57,648,188...57,661,865
G
CLTA
clathrin light chain A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CLTA mRNA
CTD
PMID:24690739
NCBI chr 9:36,190,874...36,212,059
Ensembl chr 9:36,190,856...36,304,781
G
CMKLR2
chemerin chemokine-like receptor 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CMKLR2 mRNA
CTD
PMID:24690739
NCBI chr 2:206,175,316...206,217,912
Ensembl chr 2:206,175,316...206,218,047
G
CNTNAP1
contactin associated protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CNTNAP1 mRNA
CTD
PMID:24690739
NCBI chr17:42,682,531...42,699,993
Ensembl chr17:42,682,531...42,699,993
G
COL12A1
collagen type XII alpha 1 chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of COL12A1 mRNA
CTD
PMID:24690739
NCBI chr 6:75,084,326...75,206,053
Ensembl chr 6:75,084,326...75,206,267
G
COL1A1
collagen type I alpha 1 chain
decreases expression
EXP
Disulfiram results in decreased expression of COL1A1 protein
CTD
PMID:34182011
NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
G
COL1A2
collagen type I alpha 2 chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of COL1A2 mRNA
CTD
PMID:24690739
NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
G
COL3A1
collagen type III alpha 1 chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA
CTD
PMID:24690739
NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
G
COL4A1
collagen type IV alpha 1 chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA
CTD
PMID:24690739
NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202
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COL5A1
collagen type V alpha 1 chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of COL5A1 mRNA
CTD
PMID:24690739
NCBI chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843
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COMMD9
COMM domain containing 9
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of COMMD9 mRNA
CTD
PMID:24690739
NCBI chr11:36,272,292...36,289,424
Ensembl chr11:36,269,284...36,289,449
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CRABP2
cellular retinoic acid binding protein 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CRABP2 mRNA
CTD
PMID:24690739
NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816
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CREB1
cAMP responsive element binding protein 1
multiple interactions
EXP
[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein]
CTD
PMID:15367699
NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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CRELD2
cysteine rich with EGF like domains 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CRELD2 mRNA
CTD
PMID:24690739
NCBI chr22:49,918,634...49,927,537
Ensembl chr22:49,918,167...49,927,540
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CRIM1
cysteine rich transmembrane BMP regulator 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CRIM1 mRNA
CTD
PMID:24690739
NCBI chr 2:36,355,778...36,551,135
Ensembl chr 2:36,355,778...36,551,135
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CRIPT
CXXC repeat containing interactor of PDZ3 domain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CRIPT mRNA
CTD
PMID:24690739
NCBI chr 2:46,617,215...46,630,176
Ensembl chr 2:46,616,416...46,685,037
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CRISPLD2
cysteine rich secretory protein LCCL domain containing 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CRISPLD2 mRNA
CTD
PMID:24690739
NCBI chr16:84,819,985...84,909,508
Ensembl chr16:84,819,985...84,920,768
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CRYAB
crystallin alpha B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CRYAB mRNA
CTD
PMID:24690739
NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
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CSE1L
chromosome segregation 1 like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CSE1L mRNA
CTD
PMID:24690739
NCBI chr20:49,046,312...49,096,949
Ensembl chr20:49,046,246...49,096,960
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CSNK1E
casein kinase 1 epsilon
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CSNK1E mRNA
CTD
PMID:24690739
NCBI chr22:38,290,691...38,318,084
Ensembl chr22:38,290,691...38,318,084
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CSRNP1
cysteine and serine rich nuclear protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of AXUD1 mRNA
CTD
PMID:24690739
NCBI chr 3:39,141,855...39,154,641
Ensembl chr 3:39,141,855...39,154,562
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CSRP2
cysteine and glycine rich protein 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CSRP2 mRNA
CTD
PMID:24690739
NCBI chr12:76,858,709...76,879,019
Ensembl chr12:76,858,709...76,879,023
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CST6
cystatin E/M
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA
CTD
PMID:24690739
NCBI chr11:66,012,008...66,013,505
Ensembl chr11:66,012,008...66,013,505
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CT45A3
cancer/testis antigen family 45 member A3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CT45A3 mRNA
CTD
PMID:24690739
NCBI chr X:135,760,044...135,768,191
Ensembl chr X:135,759,846...135,768,191
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CTH
cystathionine gamma-lyase
increases expression
EXP
Disulfiram results in increased expression of CTH protein
CTD
PMID:34242567
NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851
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CWC25
CWC25 spliceosome associated protein homolog
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CWC25 mRNA
CTD
PMID:24690739
NCBI chr17:38,800,441...38,825,321
Ensembl chr17:38,800,441...38,825,355
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CXCR4
C-X-C motif chemokine receptor 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA
CTD
PMID:24690739
NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
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CYP17A1
cytochrome P450 family 17 subfamily A member 1
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]
CTD
PMID:22285649
NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
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CYP19A1
cytochrome P450 family 19 subfamily A member 1
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]
CTD
PMID:22285649
NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
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CYP1A1
cytochrome P450 family 1 subfamily A member 1
decreases activity
EXP
Disulfiram results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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CYP1B1
cytochrome P450 family 1 subfamily B member 1
decreases activity
EXP
Disulfiram results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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CYP2C18
cytochrome P450 family 2 subfamily C member 18
decreases expression decreases activity
ISO
Disulfiram results in decreased expression of CYP2C11 protein Disulfiram results in decreased activity of CYP2C11 protein
CTD
PMID:9393675
NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
multiple interactions decreases activity decreases expression
EXP ISO
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane] Disulfiram results in decreased expression of CYP2E1 mRNA; Disulfiram results in decreased expression of CYP2E1 protein Disulfiram binds to and results in decreased activity of CYP2E1 protein
CTD
PMID:1664256 PMID:8637342 PMID:9393675 PMID:10805064 PMID:18754103 PMID:20470765 PMID:21915887 PMID:23669205 More...
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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CYP2R1
cytochrome P450 family 2 subfamily R member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CYP2R1 mRNA
CTD
PMID:24690739
NCBI chr11:14,877,440...14,892,443
Ensembl chr11:14,877,440...14,892,231
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CYP3A4
cytochrome P450 family 3 subfamily A member 4
increases response to substance decreases expression decreases activity
EXP ISO
CYP3A4 protein results in increased susceptibility to Disulfiram Disulfiram results in decreased expression of CYP3A2 mRNA Disulfiram results in decreased activity of CYP3A2 protein
CTD
PMID:9393675 PMID:21540358
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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DAG1
dystroglycan 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA
CTD
PMID:24690739
NCBI chr 3:49,468,948...49,535,615
Ensembl chr 3:49,468,713...49,535,618
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DBH
dopamine beta-hydroxylase
decreases activity affects response to substance
EXP ISO
Disulfiram results in decreased activity of DBH protein DBH gene SNP affects the susceptibility to Disulfiram DBH gene polymorphism affects the susceptibility to Disulfiram
CTD
PMID:90468 PMID:16163519 PMID:19462300
NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329
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DCAF13
DDB1 and CUL4 associated factor 13
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DCAF13 mRNA
CTD
PMID:24690739
NCBI chr 8:103,415,386...103,443,453
Ensembl chr 8:103,414,714...103,443,453
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DCXR
dicarbonyl and L-xylulose reductase
multiple interactions
EXP
[Disulfiram co-treated with NADP] binds to DCXR protein
CTD
PMID:25526675
NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
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DDIT3
DNA damage inducible transcript 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DDIT3 mRNA
CTD
PMID:24690739
NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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DDX39A
DExD-box helicase 39A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DDX39A mRNA
CTD
PMID:24690739
NCBI chr19:14,408,798...14,419,383
Ensembl chr19:14,408,798...14,419,383
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DDX60
DExD/H-box helicase 60
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA
CTD
PMID:24690739
NCBI chr 4:168,216,294...168,325,979
Ensembl chr 4:168,216,291...168,318,883
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DEDD2
death effector domain containing 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA
CTD
PMID:24690739
NCBI chr19:42,198,598...42,220,134
Ensembl chr19:42,198,598...42,220,140
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DEFB103B
defensin beta 103B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DEFB103B mRNA
CTD
PMID:24690739
NCBI chr 8:7,428,888...7,430,348
Ensembl chr 8:7,881,392...7,882,663 Ensembl chr 8:7,881,392...7,882,663
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DHDH
dihydrodiol dehydrogenase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA
CTD
PMID:24690739
NCBI chr19:48,932,795...48,944,969
Ensembl chr19:48,933,699...48,944,969
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DHRS2
dehydrogenase/reductase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DHRS2 mRNA
CTD
PMID:24690739
NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639
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DHRS3
dehydrogenase/reductase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DHRS3 mRNA
CTD
PMID:24690739
NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133
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DKK3
dickkopf WNT signaling pathway inhibitor 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA
CTD
PMID:24690739
NCBI chr11:11,963,036...12,009,745
Ensembl chr11:11,956,207...12,009,769
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DLL1
delta like canonical Notch ligand 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DLL1 mRNA
CTD
PMID:24690739
NCBI chr 6:170,282,206...170,291,078
Ensembl chr 6:170,282,206...170,306,565
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DNAJA1
DnaJ heat shock protein family (Hsp40) member A1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DNAJA1 mRNA
CTD
PMID:24690739
NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
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DNAJA4
DnaJ heat shock protein family (Hsp40) member A4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA
CTD
PMID:24690739
NCBI chr15:78,264,145...78,282,191
Ensembl chr15:78,264,086...78,282,196
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DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA
CTD
PMID:24690739
NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,513,789...14,560,391
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DNAJB6
DnaJ heat shock protein family (Hsp40) member B6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DNAJB6 mRNA
CTD
PMID:24690739
NCBI chr 7:157,337,004...157,417,439
Ensembl chr 7:157,335,381...157,417,439
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DNAJC3
DnaJ heat shock protein family (Hsp40) member C3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DNAJC3 mRNA
CTD
PMID:24690739
NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988
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DPH3
diphthamide biosynthesis 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DPH3 mRNA
CTD
PMID:24690739
NCBI chr 3:16,257,061...16,264,943
Ensembl chr 3:16,257,061...16,264,969
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DRAM1
DNA damage regulated autophagy modulator 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA
CTD
PMID:24690739
NCBI chr12:101,877,580...101,923,612
Ensembl chr12:101,877,580...102,012,130
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DSE
dermatan sulfate epimerase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of DSE mRNA
CTD
PMID:24690739
NCBI chr 6:116,254,171...116,444,861
Ensembl chr 6:116,254,173...116,444,861
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DUSP2
dual specificity phosphatase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA
CTD
PMID:24690739
NCBI chr 2:96,143,169...96,145,440
Ensembl chr 2:96,143,166...96,145,440
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DUSP5
dual specificity phosphatase 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DUSP5 mRNA
CTD
PMID:24690739
NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533
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DYNLL2
dynein light chain LC8-type 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of DYNLL2 mRNA
CTD
PMID:24690739
NCBI chr17:58,083,419...58,095,542
Ensembl chr17:58,083,419...58,095,542
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EAF1
ELL associated factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of EAF1 mRNA
CTD
PMID:24690739
NCBI chr 3:15,427,598...15,442,613
Ensembl chr 3:15,427,598...15,450,635
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EDIL3
EGF like repeats and discoidin domains 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA
CTD
PMID:24690739
NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880
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EED
embryonic ectoderm development
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of EED mRNA
CTD
PMID:24690739
NCBI chr11:86,244,753...86,287,615
Ensembl chr11:86,201,212...86,279,807
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EFEMP1
EGF containing fibulin extracellular matrix protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA
CTD
PMID:24690739
NCBI chr 2:55,865,967...55,923,782
Ensembl chr 2:55,865,967...55,924,139
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EGR1
early growth response 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of EGR1 mRNA
CTD
PMID:24690739
NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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EIF4A3
eukaryotic translation initiation factor 4A3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of EIF4A3 mRNA
CTD
PMID:24690739
NCBI chr17:80,134,369...80,147,128
Ensembl chr17:80,134,369...80,147,151
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ELL2
elongation factor for RNA polymerase II 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ELL2 mRNA
CTD
PMID:24690739
NCBI chr 5:95,885,098...95,961,851
Ensembl chr 5:95,885,098...95,961,851
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ELOF1
elongation factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ELOF1 mRNA
CTD
PMID:24690739
NCBI chr19:11,553,046...11,559,230
Ensembl chr19:11,551,147...11,559,230
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ESR1
estrogen receptor 1
multiple interactions
EXP
Disulfiram binds to and results in decreased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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ETS1
ETS proto-oncogene 1, transcription factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ETS1 mRNA
CTD
PMID:24690739
NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558
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F12
coagulation factor XII
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA
CTD
PMID:24690739
NCBI chr 5:177,402,141...177,409,564
Ensembl chr 5:177,402,133...177,416,583
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FAM210A
family with sequence similarity 210 member A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FAM210A mRNA
CTD
PMID:24690739
NCBI chr18:13,663,347...13,726,558
Ensembl chr18:13,663,347...13,726,663
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FAM234A
family with sequence similarity 234 member A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of FAM234A mRNA
CTD
PMID:24690739
NCBI chr16:234,821...269,963
Ensembl chr16:234,521...272,183
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FAM32A
family with sequence similarity 32 member A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FAM32A mRNA
CTD
PMID:24690739
NCBI chr19:16,185,410...16,192,046
Ensembl chr19:16,185,380...16,192,046
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FASLG
Fas ligand
increases expression
EXP
Disulfiram results in increased expression of FASLG mRNA
CTD
PMID:34182011
NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
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FECH
ferrochelatase
increases expression
EXP
Disulfiram results in increased expression of FECH mRNA
CTD
PMID:20566472
NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732
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FKBP1A
FKBP prolyl isomerase 1A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FKBP1A mRNA
CTD
PMID:24690739
NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164
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FLCN
folliculin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA
CTD
PMID:24690739
NCBI chr17:17,212,212...17,237,330
Ensembl chr17:17,212,212...17,237,188
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FNDC11
fibronectin type III domain containing 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FNDC11 mRNA
CTD
PMID:24690739
NCBI chr20:63,553,020...63,556,708
Ensembl chr20:63,547,891...63,556,695
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FOS mRNA
CTD
PMID:24690739
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
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FOSB
FosB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA
CTD
PMID:24690739
NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
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FOXA3
forkhead box A3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FOXA3 mRNA
CTD
PMID:24690739
NCBI chr19:45,864,326...45,873,797
Ensembl chr19:45,863,989...45,873,797
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FOXJ1
forkhead box J1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA
CTD
PMID:24690739
NCBI chr17:76,136,333...76,141,245
Ensembl chr17:76,136,333...76,141,245
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FOXO1
forkhead box O1
increases expression
EXP
Disulfiram results in increased expression of FOXO1 mRNA
CTD
PMID:34182011
NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
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FOXO3
forkhead box O3
increases expression
EXP
Disulfiram results in increased expression of FOXO3 mRNA
CTD
PMID:34182011
NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
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FOXO4
forkhead box O4
increases expression
EXP
Disulfiram results in increased expression of FOXO4 mRNA
CTD
PMID:34182011
NCBI chr X:71,095,851...71,103,532
Ensembl chr X:71,095,851...71,103,535
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FRG1
FSHD region gene 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FRG1 mRNA
CTD
PMID:24690739
NCBI chr 4:189,940,872...189,963,192
Ensembl chr 4:189,940,855...189,963,202
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FSHB
follicle stimulating hormone subunit beta
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
G
FSHR
follicle stimulating hormone receptor
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]
CTD
PMID:22285649
NCBI chr 2:48,962,157...49,154,515
Ensembl chr 2:48,962,157...49,154,527
G
FSTL1
follistatin like 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA
CTD
PMID:24690739
NCBI chr 3:120,392,293...120,450,992
Ensembl chr 3:120,392,293...120,451,016
G
FTCD
formimidoyltransferase cyclodeaminase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA
CTD
PMID:24690739
NCBI chr21:46,136,262...46,155,579
Ensembl chr21:46,136,160...46,155,579
G
FTH1P20
ferritin heavy chain 1 pseudogene 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of FTH1P20 mRNA
CTD
PMID:24690739
NCBI chr 2:180,872,705...180,873,565
Ensembl chr 2:180,872,867...180,873,414
G
FTL
ferritin light chain
increases expression
EXP
Disulfiram results in increased expression of FTL mRNA
CTD
PMID:20566472
NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,967,896
G
G6PD
glucose-6-phosphate dehydrogenase
increases expression
EXP
Disulfiram results in increased expression of G6PD mRNA
CTD
PMID:20566472
NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
G
GADD45A
growth arrest and DNA damage inducible alpha
increases expression
EXP
Disulfiram results in increased expression of GADD45A mRNA
CTD
PMID:34182011
NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
G
GADD45B
growth arrest and DNA damage inducible beta
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GADD45B mRNA
CTD
PMID:24690739
NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,805
G
GALNT10
polypeptide N-acetylgalactosaminyltransferase 10
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA
CTD
PMID:24690739
NCBI chr 5:154,190,733...154,420,984
Ensembl chr 5:154,190,730...154,420,984
G
GAS6
growth arrest specific 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA
CTD
PMID:24690739
NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076
G
GATA2
GATA binding protein 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA
CTD
PMID:24690739
NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
G
GBP4
guanylate binding protein 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GBP4 mRNA
CTD
PMID:24690739
NCBI chr 1:89,181,144...89,198,942
Ensembl chr 1:89,181,144...89,198,942
G
GCC1
GRIP and coiled-coil domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GCC1 mRNA
CTD
PMID:24690739
NCBI chr 7:127,580,628...127,585,596
Ensembl chr 7:127,580,628...127,593,611
G
GCGR
glucagon receptor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GCGR mRNA
CTD
PMID:24690739
NCBI chr17:81,804,150...81,814,008
Ensembl chr17:81,804,132...81,814,008
G
GCLC
glutamate-cysteine ligase catalytic subunit
increases expression
EXP
Disulfiram results in increased expression of GCLC mRNA
CTD
PMID:20566472
NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
G
GCLM
glutamate-cysteine ligase modifier subunit
increases expression
EXP
Disulfiram results in increased expression of GCLM mRNA
CTD
PMID:20566472
NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
G
GCNA
germ cell nuclear acidic peptidase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GCNA mRNA
CTD
PMID:24690739
NCBI chr X:71,578,437...71,613,583
Ensembl chr X:71,578,437...71,613,583
G
GEM
GTP binding protein overexpressed in skeletal muscle
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA
CTD
PMID:24690739
NCBI chr 8:94,249,253...94,262,319
Ensembl chr 8:94,249,253...94,262,350
G
GEMIN6
gem nuclear organelle associated protein 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA
CTD
PMID:24690739
NCBI chr 2:38,778,210...38,785,002
Ensembl chr 2:38,751,534...38,785,002
G
GH1
growth hormone 1
multiple interactions
ISO
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]; GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]
CTD
PMID:8390837
NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
G
GLG1
golgi glycoprotein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GLG1 mRNA
CTD
PMID:24690739
NCBI chr16:74,447,440...74,607,114
Ensembl chr16:74,447,427...74,607,144
G
GLRX2
glutaredoxin 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA
CTD
PMID:24690739
NCBI chr 1:193,096,465...193,106,114
Ensembl chr 1:193,090,866...193,106,114
G
GOSR2
golgi SNAP receptor complex member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GOSR2 mRNA
CTD
PMID:24690739
NCBI chr17:46,923,160...46,975,890
Ensembl chr17:46,923,075...46,975,524
G
GPSM1
G protein signaling modulator 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GPSM1 mRNA
CTD
PMID:24690739
NCBI chr 9:136,327,539...136,359,601
Ensembl chr 9:136,327,476...136,359,605
G
GPT2
glutamic--pyruvic transaminase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GPT2 mRNA
CTD
PMID:24690739
NCBI chr16:46,884,362...46,931,289
Ensembl chr16:46,884,362...46,931,289
G
GPX3
glutathione peroxidase 3
increases expression
EXP
Disulfiram results in increased expression of GPX3 mRNA
CTD
PMID:20566472
NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
G
GRAMD1A
GRAM domain containing 1A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GRAMD1A mRNA
CTD
PMID:24690739
NCBI chr19:34,994,727...35,026,469
Ensembl chr19:34,994,784...35,026,471
G
GRAMD2B
GRAM domain containing 2B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GRAMD2B mRNA
CTD
PMID:24690739
NCBI chr 5:126,360,120...126,494,364
Ensembl chr 5:126,360,132...126,496,494
G
GRWD1
glutamate rich WD repeat containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GRWD1 mRNA
CTD
PMID:24690739
NCBI chr19:48,445,983...48,457,022
Ensembl chr19:48,445,841...48,457,022
G
GSDMD
gasdermin D
decreases cleavage multiple interactions
EXP
Disulfiram results in decreased cleavage of GSDMD protein Disulfiram binds to and results in decreased activity of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]
CTD
PMID:32367036 PMID:33851234
NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062
G
GSDME
gasdermin E
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of GSDME mRNA
CTD
PMID:24690739
NCBI chr 7:24,698,355...24,795,539
Ensembl chr 7:24,698,355...24,757,940
G
GSR
glutathione-disulfide reductase
increases expression
EXP
Disulfiram results in increased expression of GSR mRNA
CTD
PMID:20566472
NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
G
GTF2B
general transcription factor IIB
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of GTF2B mRNA
CTD
PMID:24690739
NCBI chr 1:88,852,633...88,891,567
Ensembl chr 1:88,852,633...88,891,944
G
H2AC19
H2A clustered histone 19
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H2AC19 mRNA
CTD
PMID:24690739
NCBI chr 1:149,851,061...149,851,594
Ensembl chr 1:149,851,061...149,851,594
G
H2AC20
H2A clustered histone 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H2AC20 mRNA
CTD
PMID:24690739
NCBI chr 1:149,886,918...149,887,411
Ensembl chr 1:149,886,918...149,887,411
G
H2AX
H2A.X variant histone
multiple interactions increases expression
EXP
Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein] Disulfiram results in increased expression of H2AX protein
CTD
PMID:28300663 PMID:29722447 PMID:34830855 PMID:35279910
NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
G
H2BC12
H2B clustered histone 12
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA
CTD
PMID:24690739
NCBI chr 6:27,138,293...27,146,858
Ensembl chr 6:27,137,298...27,146,855
G
H2BC8
H2B clustered histone 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H2BC8 mRNA
CTD
PMID:24690739
NCBI chr 6:26,216,200...26,216,688
Ensembl chr 6:26,216,200...26,216,688
G
H3-4
H3.4 histone, cluster member
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA
CTD
PMID:24690739
NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,360
G
H3C12
H3 clustered histone 12
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of H3C12 mRNA
CTD
PMID:24690739
NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,315...27,893,106
G
H6PD
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of H6PD mRNA
CTD
PMID:24690739
NCBI chr 1:9,234,774...9,271,337
Ensembl chr 1:9,234,774...9,271,337
G
HBA1
hemoglobin subunit alpha 1
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA Disulfiram results in increased expression of HBA1 protein
CTD
PMID:24690739 PMID:34182011
NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
G
HBEGF
heparin binding EGF like growth factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA
CTD
PMID:24690739
NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
G
HBG2
hemoglobin subunit gamma 2
increases expression multiple interactions
EXP
Disulfiram results in increased expression of HBG2 protein Disulfiram promotes the reaction [Primaquine results in increased expression of HBG2 protein]
CTD
PMID:19616568
NCBI chr11:5,253,188...5,254,781
Ensembl chr11:5,253,188...5,505,605
G
HES1
hes family bHLH transcription factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HES1 mRNA
CTD
PMID:24690739
NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
G
HES6
hes family bHLH transcription factor 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HES6 mRNA
CTD
PMID:24690739
NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662
G
HLA-B
major histocompatibility complex, class I, B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of HLA-B mRNA
CTD
PMID:24690739
NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
G
HLA-F
major histocompatibility complex, class I, F
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of HLA-F mRNA
CTD
PMID:24690739
NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528
G
HMOX1
heme oxygenase 1
increases expression multiple interactions
EXP
Disulfiram results in increased expression of HMOX1 mRNA [Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA; [Disulfiram co-treated with Zinc Sulfate] results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]
CTD
PMID:20566472 PMID:24690739 PMID:32661532 PMID:32712770
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
G
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of HNRNPA2B1 mRNA
CTD
PMID:24690739
NCBI chr 7:26,189,927...26,200,746
Ensembl chr 7:26,171,151...26,201,529
G
HOXA1
homeobox A1
multiple interactions
ISO
Disulfiram inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]
CTD
PMID:23696197
NCBI chr 7:27,092,993...27,096,000
Ensembl chr 7:27,092,993...27,096,000
G
HOXD1
homeobox D1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HOXD1 mRNA
CTD
PMID:24690739
NCBI chr 2:176,188,668...176,190,907
Ensembl chr 2:176,188,668...176,190,907
G
HRK
harakiri, BCL2 interacting protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA
CTD
PMID:24690739
NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441
G
HS3ST2
heparan sulfate-glucosamine 3-sulfotransferase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HS3ST2 mRNA
CTD
PMID:24690739
NCBI chr16:22,814,162...22,916,338
Ensembl chr16:22,814,162...22,916,338
G
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
multiple interactions
EXP
[Disulfiram co-treated with NAD] binds to HSD11B1 protein
CTD
PMID:25526675
NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
G
HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity
EXP
Disulfiram results in decreased activity of HSD11B2 protein
CTD
PMID:22796344
NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
G
HSP90AA1
heat shock protein 90 alpha family class A member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA
CTD
PMID:24690739
NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
G
HSP90AB1
heat shock protein 90 alpha family class B member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSP90AB1 mRNA
CTD
PMID:24690739
NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
G
HSPA1A
heat shock protein family A (Hsp70) member 1A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPA1A mRNA
CTD
PMID:24690739
NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
G
HSPA1B
heat shock protein family A (Hsp70) member 1B
increases expression multiple interactions
EXP
Disulfiram results in increased expression of HSPA1B mRNA [Disulfiram binds to Copper] which results in decreased expression of HSPA1B mRNA
CTD
PMID:20566472 PMID:24690739
NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
G
HSPA1L
heat shock protein family A (Hsp70) member 1 like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPA1L mRNA
CTD
PMID:24690739
NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283
G
HSPA4
heat shock protein family A (Hsp70) member 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPA4 mRNA
CTD
PMID:24690739
NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
G
HSPA6
heat shock protein family A (Hsp70) member 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA
CTD
PMID:24690739
NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
G
HSPA8
heat shock protein family A (Hsp70) member 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPA8 mRNA
CTD
PMID:24690739
NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230
G
HSPB1
heat shock protein family B (small) member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA
CTD
PMID:24690739
NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813
G
HSPB8
heat shock protein family B (small) member 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA
CTD
PMID:24690739
NCBI chr12:119,178,931...119,194,746
Ensembl chr12:119,171,555...119,224,855
G
HSPH1
heat shock protein family H (Hsp110) member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA
CTD
PMID:24690739
NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
G
HTR2B
5-hydroxytryptamine receptor 2B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA
CTD
PMID:24690739
NCBI chr 2:231,108,230...231,125,042
Ensembl chr 2:231,108,230...231,125,042
G
ID2
inhibitor of DNA binding 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA
CTD
PMID:24690739
NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
G
IER5
immediate early response 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of IER5 mRNA
CTD
PMID:24690739
NCBI chr 1:181,088,700...181,092,900
Ensembl chr 1:181,088,700...181,092,900
G
IFIT1
interferon induced protein with tetratricopeptide repeats 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IFIT1 mRNA
CTD
PMID:24690739
NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487
G
IFIT2
interferon induced protein with tetratricopeptide repeats 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IFIT2 mRNA
CTD
PMID:24690739
NCBI chr10:89,302,046...89,309,271
Ensembl chr10:89,283,694...89,309,271
G
IFIT3
interferon induced protein with tetratricopeptide repeats 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IFIT3 mRNA
CTD
PMID:24690739
NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473
G
IFNGR2
interferon gamma receptor 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA
CTD
PMID:24690739
NCBI chr21:33,402,882...33,437,516
Ensembl chr21:33,403,413...33,479,348
G
IGF2-AS
IGF2 antisense RNA
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of IGF2-AS mRNA
CTD
PMID:24690739
NCBI chr11:2,140,512...2,148,666
Ensembl chr11:2,140,501...2,148,666
G
IGF2R
insulin like growth factor 2 receptor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA
CTD
PMID:24690739
NCBI chr 6:159,969,082...160,111,504
Ensembl chr 6:159,969,082...160,113,507
G
IGFBP7
insulin like growth factor binding protein 7
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in increased expression of IGFBP7 mRNA; [Disulfiram binds to Copper] which results in increased expression of IGFBP7 protein [Disulfiram cotreated with copper(+2)] increases expression of IGFBP7 mRNA in malignant pleural mesothelioma cells
CTD RGD
PMID:24690739 PMID:24690739
RGD:401960877
NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385
G
IL18
interleukin 18
multiple interactions
EXP
[Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]
CTD
PMID:33579316 PMID:33851234
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
G
IL1A
interleukin 1 alpha
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IL1A mRNA
CTD
PMID:24690739
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
G
IL1B
interleukin 1 beta
multiple interactions
EXP ISO
[Disulfiram binds to Copper] which results in increased expression of IL1B mRNA; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [Nigericin results in increased secretion of IL1B protein] Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:24690739 PMID:32367036 PMID:32712770 PMID:33579316 PMID:33851234
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL6
interleukin 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]
CTD
PMID:24690739 PMID:32712770 PMID:33851234
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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INSIG1
insulin induced gene 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA
CTD
PMID:24690739
NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
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IRF8
interferon regulatory factor 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA
CTD
PMID:24690739
NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606
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ISY1
ISY1 splicing factor homolog
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ISY1 mRNA
CTD
PMID:24690739
NCBI chr 3:129,127,415...129,161,063
Ensembl chr 3:129,127,415...129,161,063
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ITGA11
integrin subunit alpha 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA
CTD
PMID:24690739
NCBI chr15:68,296,532...68,432,163
Ensembl chr15:68,296,532...68,432,163
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ITGA3
integrin subunit alpha 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ITGA3 mRNA
CTD
PMID:24690739
NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481
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ITGAM
integrin subunit alpha M
increases expression
EXP
Disulfiram results in increased expression of ITGAM protein
CTD
PMID:32712770
NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
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ITGAV
integrin subunit alpha V
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ITGAV mRNA
CTD
PMID:24690739
NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901
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ITGB1
integrin subunit beta 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA
CTD
PMID:24690739
NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
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ITGB5
integrin subunit beta 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA
CTD
PMID:24690739
NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418
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JAG2
jagged canonical Notch ligand 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA
CTD
PMID:24690739
NCBI chr14:105,140,995...105,168,776
Ensembl chr14:105,140,982...105,168,824
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JSRP1
junctional sarcoplasmic reticulum protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of JSRP1 mRNA
CTD
PMID:24690739
NCBI chr19:2,252,252...2,256,417
Ensembl chr19:2,252,252...2,269,759
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JUN
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein; [Copper co-treated with Disulfiram] results in increased expression of and results in increased phosphorylation of JUN protein; [Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]
CTD
PMID:21911303 PMID:23033007
NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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KCNG1
potassium voltage-gated channel modifier subfamily G member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA
CTD
PMID:24690739
NCBI chr20:51,003,656...51,023,107
Ensembl chr20:51,003,656...51,023,107
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KHDRBS3
KH RNA binding domain containing, signal transduction associated 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA
CTD
PMID:24690739
NCBI chr 8:135,457,456...135,656,516
Ensembl chr 8:135,457,456...135,656,722
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KLF10
KLF transcription factor 10
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA
CTD
PMID:24690739
NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
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KLHL22
kelch like family member 22
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA
CTD
PMID:24690739
NCBI chr22:20,441,519...20,495,795
Ensembl chr22:20,441,519...20,495,844
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KLHL5
kelch like family member 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of KLHL5 mRNA
CTD
PMID:24690739
NCBI chr 4:39,044,827...39,143,101
Ensembl chr 4:39,045,039...39,126,857
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KRT1
keratin 1
increases expression
EXP
Disulfiram results in increased expression of KRT1 mRNA; Disulfiram results in increased expression of KRT1 protein
CTD
PMID:34182011
NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407
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KRT75
keratin 75
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of KRT75 mRNA
CTD
PMID:24690739
NCBI chr12:52,424,070...52,434,371
Ensembl chr12:52,424,070...52,434,371
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LAMC1
laminin subunit gamma 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LAMC1 mRNA
CTD
PMID:24690739
NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592
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LAMTOR3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LAMTOR3 mRNA
CTD
PMID:24690739
NCBI chr 4:99,878,336...99,894,546
Ensembl chr 4:99,878,336...99,894,428
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LEMD2
LEM domain nuclear envelope protein 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA
CTD
PMID:24690739
NCBI chr 6:33,771,213...33,789,130
Ensembl chr 6:33,771,202...33,789,130
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LHB
luteinizing hormone subunit beta
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
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LHCGR
luteinizing hormone/choriogonadotropin receptor
multiple interactions
ISO
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]
CTD
PMID:22285649
NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730
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LIMCH1
LIM and calponin homology domains 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA
CTD
PMID:24690739
NCBI chr 4:41,359,607...41,700,044
Ensembl chr 4:41,359,607...41,700,044
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LINC01554
long intergenic non-protein coding RNA 1554
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LINC01554 mRNA
CTD
PMID:24690739
NCBI chr 5:95,852,232...95,860,133
Ensembl chr 5:95,838,244...95,860,141
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LIPT1
lipoyltransferase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LIPT1 mRNA
CTD
PMID:24690739
NCBI chr 2:99,154,967...99,163,137
Ensembl chr 2:99,154,955...99,163,157
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LMCD1
LIM and cysteine rich domains 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LMCD1 mRNA
CTD
PMID:24690739
NCBI chr 3:8,501,823...8,574,668
Ensembl chr 3:8,501,807...8,574,668
G
LMTK2
lemur tyrosine kinase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA
CTD
PMID:24690739
NCBI chr 7:98,106,862...98,209,638
Ensembl chr 7:98,106,862...98,209,638
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LORICRIN
loricrin cornified envelope precursor protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LORICRIN mRNA
CTD
PMID:24690739
NCBI chr 1:153,259,687...153,262,124
Ensembl chr 1:153,259,687...153,262,124
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LRATD2
LRAT domain containing 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LRATD2 mRNA
CTD
PMID:24690739
NCBI chr 8:126,552,443...126,558,478
Ensembl chr 8:126,552,443...126,558,478
G
LRP8
LDL receptor related protein 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA
CTD
PMID:24690739
NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469
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LSMEM1
leucine rich single-pass membrane protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of LSMEM1 mRNA
CTD
PMID:24690739
NCBI chr 7:112,480,304...112,491,062
Ensembl chr 7:112,480,853...112,491,062
G
LTB4R
leukotriene B4 receptor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA
CTD
PMID:24690739
NCBI chr14:24,311,502...24,318,036
Ensembl chr14:24,311,450...24,318,036
G
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of CROP mRNA
CTD
PMID:24690739
NCBI chr17:50,719,603...50,756,219
Ensembl chr17:50,719,565...50,756,219
G
MACF1
microtubule actin crosslinking factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MACF1 mRNA
CTD
PMID:24690739
NCBI chr 1:39,084,167...39,487,138
Ensembl chr 1:39,081,316...39,487,177
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MAD2L1BP
MAD2L1 binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAD2L1BP mRNA
CTD
PMID:24690739
NCBI chr 6:43,629,540...43,640,941
Ensembl chr 6:43,629,540...43,640,941
G
MAFB
MAF bZIP transcription factor B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAFB mRNA
CTD
PMID:24690739
NCBI chr20:40,685,848...40,689,236
Ensembl chr20:40,685,848...40,689,236
G
MAFF
MAF bZIP transcription factor F
increases expression
EXP
Disulfiram results in increased expression of MAFF mRNA
CTD
PMID:20566472
NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
G
MAFG
MAF bZIP transcription factor G
increases expression
EXP
Disulfiram results in increased expression of MAFG mRNA
CTD
PMID:20566472
NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735
G
MAFK
MAF bZIP transcription factor K
increases expression
EXP
Disulfiram results in increased expression of MAFK mRNA
CTD
PMID:20566472
NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
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MAGOH
mago homolog, exon junction complex subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAGOH mRNA
CTD
PMID:24690739
NCBI chr 1:53,226,900...53,238,518
Ensembl chr 1:53,226,900...53,238,518
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MAN1B1
mannosidase alpha class 1B member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MAN1B1 mRNA
CTD
PMID:24690739
NCBI chr 9:137,086,985...137,109,183
Ensembl chr 9:137,086,857...137,109,189
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MAOA
monoamine oxidase A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA
CTD
PMID:24690739
NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817
G
MAP1LC3B
microtubule associated protein 1 light chain 3 beta
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAP1LC3B mRNA Disulfiram results in increased expression of MAP1LC3B mRNA
CTD
PMID:24690739 PMID:34182011
NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
G
MAP2K3
mitogen-activated protein kinase kinase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAP2K3 mRNA
CTD
PMID:24690739
NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232
G
MAP3K13
mitogen-activated protein kinase kinase kinase 13
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAP3K13 mRNA
CTD
PMID:24690739
NCBI chr 3:185,282,961...185,489,094
Ensembl chr 3:185,282,941...185,489,094
G
MAP3K20
mitogen-activated protein kinase kinase kinase 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MAP3K20 mRNA
CTD
PMID:24690739
NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015
G
MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK1 protein
CTD
PMID:23033007
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
G
MAPK3
mitogen-activated protein kinase 3
multiple interactions
EXP
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK3 protein
CTD
PMID:23033007
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MAPK8
mitogen-activated protein kinase 8
multiple interactions
ISO EXP
[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein] [Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein
CTD
PMID:11239917 PMID:24690739
NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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MAPK9
mitogen-activated protein kinase 9
multiple interactions
EXP ISO
[Disulfiram binds to Copper] which results in increased phosphorylation of MAPK9 protein
CTD
PMID:24690739
NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
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MAPRE2
microtubule associated protein RP/EB family member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA
CTD
PMID:24690739
NCBI chr18:34,977,027...35,143,470
Ensembl chr18:34,976,928...35,143,470
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MCM2
minichromosome maintenance complex component 2
multiple interactions decreases expression
EXP
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]
CTD
PMID:19789329
NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,223...127,622,436
G
MCM5
minichromosome maintenance complex component 5
multiple interactions decreases expression
EXP
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA]
CTD
PMID:19789329
NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431
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ME1
malic enzyme 1
increases expression
EXP
Disulfiram results in increased expression of ME1 mRNA
CTD
PMID:20566472
NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051
G
MFSD3
major facilitator superfamily domain containing 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MFSD3 mRNA
CTD
PMID:24690739
NCBI chr 8:144,509,070...144,511,213
Ensembl chr 8:144,509,070...144,511,213
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MGMT
O-6-methylguanine-DNA methyltransferase
multiple interactions decreases activity increases degradation
EXP ISO
[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein; [Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein; bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]; Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]; Disulfiram results in decreased expression of and results in decreased activity of MGMT protein Disulfiram results in decreased activity of MGMT protein
CTD
PMID:24193513
NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
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MGST1
microsomal glutathione S-transferase 1
increases expression
EXP
Disulfiram results in increased expression of MGST1 mRNA
CTD
PMID:20566472
NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
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MIDN
midnolin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA
CTD
PMID:24690739
NCBI chr19:1,248,583...1,259,143
Ensembl chr19:1,248,553...1,259,143
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MIF
macrophage migration inhibitory factor
increases expression
EXP
Disulfiram results in increased expression of MIF protein
CTD
PMID:34182011
NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
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MIX23
mitochondrial matrix import factor 23
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MIX23 mRNA
CTD
PMID:24690739
NCBI chr 3:122,359,591...122,383,231
Ensembl chr 3:122,359,591...122,383,231
G
MMP10
matrix metallopeptidase 10
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA
CTD
PMID:24690739
NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
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MMP2
matrix metallopeptidase 2
decreases expression
EXP
Disulfiram results in decreased expression of MMP2
CTD
PMID:18047805
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
G
MMP3
matrix metallopeptidase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA
CTD
PMID:24690739
NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
G
MMP9
matrix metallopeptidase 9
decreases expression
EXP
Disulfiram results in decreased expression of MMP9
CTD
PMID:18047805
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
G
MPPE1
metallophosphoesterase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MPPE1 mRNA
CTD
PMID:24690739
NCBI chr18:11,882,622...11,908,317
Ensembl chr18:11,882,622...11,908,366
G
MRPL10
mitochondrial ribosomal protein L10
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MRPL10 mRNA
CTD
PMID:24690739
NCBI chr17:47,823,272...47,831,541
Ensembl chr17:47,823,272...47,831,541
G
MRPL18
mitochondrial ribosomal protein L18
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MRPL18 mRNA
CTD
PMID:24690739
NCBI chr 6:159,789,812...159,798,429
Ensembl chr 6:159,789,812...159,798,436
G
MRPL45
mitochondrial ribosomal protein L45
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MRPL45 mRNA
CTD
PMID:24690739
NCBI chr17:38,297,168...38,323,211
Ensembl chr17:38,297,023...38,323,217
G
MST1
macrophage stimulating 1
increases expression
EXP
Disulfiram results in increased expression of MST1 mRNA
CTD
PMID:34182011
NCBI chr 3:49,683,947...49,689,474
Ensembl chr 3:49,683,947...49,689,501
G
MT-CO1
mitochondrially encoded cytochrome c oxidase I
affects activity affects expression
ISO
Disulfiram affects the activity of COX1 protein Disulfiram affects the expression of COX1 mRNA
CTD
PMID:17936468
NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
G
MT1A
metallothionein 1A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MT1A mRNA
CTD
PMID:24690739
NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
G
MT1B
metallothionein 1B
increases expression multiple interactions
EXP
Disulfiram results in increased expression of MT1B mRNA [Disulfiram binds to Copper] which results in decreased expression of MT1B mRNA; cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1B mRNA]
CTD
PMID:19789329 PMID:24690739
NCBI chr16:56,651,886...56,653,204
Ensembl chr16:56,651,886...56,653,204
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MT1F
metallothionein 1F
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of MT1F mRNA; cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1F mRNA]
CTD
PMID:19789329 PMID:24690739
NCBI chr16:56,657,959...56,659,303
Ensembl chr16:56,657,731...56,660,698
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MT1G
metallothionein 1G
multiple interactions increases expression
EXP
[Disulfiram binds to Copper] which results in decreased expression of MT1G mRNA; cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1G mRNA]
CTD
PMID:19789329 PMID:24690739
NCBI chr16:56,666,730...56,668,065
Ensembl chr16:56,666,730...56,668,065
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MT1L
metallothionein 1L (pseudogene)
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MT1L mRNA
CTD
PMID:24690739
NCBI chr16:56,617,461...56,618,818
Ensembl chr16:56,617,563...56,618,680
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MT1M
metallothionein 1M
increases expression multiple interactions
EXP
Disulfiram results in increased expression of MT1M mRNA MTF1 protein affects the reaction [Disulfiram results in increased expression of MT1M mRNA]
CTD
PMID:32661532
NCBI chr16:56,632,659...56,633,981
Ensembl chr16:56,632,659...56,633,981
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MT1X
metallothionein 1X
increases expression multiple interactions
EXP
Disulfiram results in increased expression of MT1X mRNA [Disulfiram binds to Copper] which results in decreased expression of MT1X mRNA; cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1X mRNA]
CTD
PMID:19789329 PMID:20566472 PMID:24690739
NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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MT2A
metallothionein 2A
multiple interactions increases expression
EXP
cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]
CTD
PMID:19789329 PMID:32661532
NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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MT3
metallothionein 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA
CTD
PMID:24690739
NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
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MTF1
metal regulatory transcription factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT1M mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]
CTD
PMID:24690739 PMID:32661532
NCBI chr 1:37,809,574...37,859,592
Ensembl chr 1:37,809,574...37,859,592
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MX1
MX dynamin like GTPase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA
CTD
PMID:24690739
NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071
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MYC
MYC proto-oncogene, bHLH transcription factor
decreases expression
EXP
Disulfiram results in decreased expression of MYC mRNA
CTD
PMID:34182011
NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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MYLIP
myosin regulatory light chain interacting protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of MYLIP mRNA
CTD
PMID:24690739
NCBI chr 6:16,129,086...16,163,887
Ensembl chr 6:16,129,086...16,151,367
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MYLK
myosin light chain kinase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA
CTD
PMID:24690739
NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332
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NAT14
N-acetyltransferase 14 (putative)
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NAT14 mRNA
CTD
PMID:24690739
NCBI chr19:55,485,188...55,487,566
Ensembl chr19:55,485,188...55,487,568
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NBPF3
NBPF member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NBPF3 mRNA
CTD
PMID:24690739
NCBI chr 1:21,436,789...21,484,900
Ensembl chr 1:21,440,128...21,485,005
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NCEH1
neutral cholesterol ester hydrolase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NCEH1 mRNA
CTD
PMID:24690739
NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218
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NCOA7
nuclear receptor coactivator 7
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NCOA7 mRNA
CTD
PMID:24690739
NCBI chr 6:125,781,115...125,932,034
Ensembl chr 6:125,781,161...125,932,034
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NCSTN
nicastrin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NCSTN mRNA
CTD
PMID:24690739
NCBI chr 1:160,343,383...160,358,949
Ensembl chr 1:160,343,294...160,358,952
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NEFH
neurofilament heavy chain
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA
CTD
PMID:24690739
NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
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NFE2L3
NFE2 like bZIP transcription factor 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NFE2L3 mRNA
CTD
PMID:24690739
NCBI chr 7:26,152,198...26,187,137
Ensembl chr 7:26,152,198...26,187,137
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NFKB1
nuclear factor kappa B subunit 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA
CTD
PMID:24690739
NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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NFKBIA
NFKB inhibitor alpha
decreases degradation multiple interactions
ISO EXP
Disulfiram results in decreased degradation of NFKBIA protein [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein
CTD
PMID:10418820 PMID:24690739
NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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NFKBIB
NFKB inhibitor beta
multiple interactions
EXP ISO
[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein
CTD
PMID:24690739
NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893
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NGDN
neuroguidin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NGDN mRNA
CTD
PMID:24690739
NCBI chr14:23,469,703...23,478,826
Ensembl chr14:23,469,679...23,509,862
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NIBAN1
niban apoptosis regulator 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NIBAN1 mRNA
CTD
PMID:24690739
NCBI chr 1:184,791,032...184,974,508
Ensembl chr 1:184,790,724...184,974,508
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NME1-NME2
NME1-NME2 readthrough
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NME1-NME2 mRNA
CTD
PMID:24690739
NCBI chr17:51,153,559...51,171,744
Ensembl chr17:51,153,590...51,171,744
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NOL12
nucleolar protein 12
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NOL12 mRNA
CTD
PMID:24690739
NCBI chr22:37,686,343...37,693,474
Ensembl chr22:37,681,673...37,693,476
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NOS2
nitric oxide synthase 2
affects expression
ISO
Disulfiram affects the expression of NOS2 mRNA
CTD
PMID:17936468
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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NOSIP
nitric oxide synthase interacting protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NOSIP mRNA
CTD
PMID:24690739
NCBI chr19:49,555,468...49,580,556
Ensembl chr19:49,555,468...49,590,262
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NPEPL1
aminopeptidase like 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NPEPL1 mRNA
CTD
PMID:24690739
NCBI chr20:58,689,131...58,715,844
Ensembl chr20:58,689,131...58,719,238
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NPPB
natriuretic peptide B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA
CTD
PMID:24690739
NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
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NPTX2
neuronal pentraxin 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA
CTD
PMID:24690739
NCBI chr 7:98,617,285...98,629,869
Ensembl chr 7:98,617,285...98,629,869
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NQO1
NAD(P)H quinone dehydrogenase 1
increases expression increases activity
EXP ISO
Disulfiram results in increased expression of NQO1 mRNA Disulfiram results in increased activity of NQO1 protein
CTD
PMID:16045903 PMID:20566472
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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NR1I2
nuclear receptor subfamily 1 group I member 2
multiple interactions
ISO EXP
Disulfiram binds to and affects the activity of NR1I2 protein Disulfiram binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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NRARP
NOTCH regulated ankyrin repeat protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NRARP mRNA
CTD
PMID:24690739
NCBI chr 9:137,299,631...137,302,271
Ensembl chr 9:137,299,631...137,302,271
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NRAS
NRAS proto-oncogene, GTPase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NRAS mRNA
CTD
PMID:24690739
NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
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NRP1
neuropilin 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA
CTD
PMID:24690739
NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262
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NSUN5P2
NSUN5 pseudogene 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NSUN5P2 mRNA
CTD
PMID:24690739
NCBI chr 7:72,948,293...72,954,763
Ensembl chr 7:72,947,581...72,954,790 Ensembl chr 7:72,947,581...72,954,790
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NT5E
5'-nucleotidase ecto
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of NT5E mRNA
CTD
PMID:24690739
NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
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NUBP1
NUBP iron-sulfur cluster assembly factor 1, cytosolic
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NUBP1 mRNA
CTD
PMID:24690739
NCBI chr16:10,743,842...10,769,351
Ensembl chr16:10,743,786...10,769,351
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NXF1
nuclear RNA export factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NXF1 mRNA
CTD
PMID:24690739
NCBI chr11:62,792,130...62,805,440
Ensembl chr11:62,792,123...62,806,302
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NXT2
nuclear transport factor 2 like export factor 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA
CTD
PMID:24690739
NCBI chr X:109,535,824...109,544,698
Ensembl chr X:109,535,781...109,544,698
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OASL
2'-5'-oligoadenylate synthetase like
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of OASL mRNA
CTD
PMID:24690739
NCBI chr12:121,017,761...121,039,246
Ensembl chr12:121,017,763...121,039,246
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OSMR
oncostatin M receptor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of OSMR mRNA
CTD
PMID:24690739
NCBI chr 5:38,846,012...38,945,579
Ensembl chr 5:38,845,858...38,945,596
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P3H3
prolyl 3-hydroxylase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of P3H3 mRNA
CTD
PMID:24690739
NCBI chr12:6,828,407...6,839,847
Ensembl chr12:6,828,407...6,839,847
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P3H4
prolyl 3-hydroxylase family member 4 (inactive)
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA
CTD
PMID:24690739
NCBI chr17:41,801,953...41,811,949
Ensembl chr17:41,801,947...41,812,604
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PAM
peptidylglycine alpha-amidating monooxygenase
increases activity
ISO
Disulfiram results in increased activity of PAM protein
CTD
PMID:8246921 PMID:10347250
NCBI chr 5:102,754,783...103,031,105
Ensembl chr 5:102,753,981...103,029,730
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PARP1
poly(ADP-ribose) polymerase 1
multiple interactions increases cleavage
EXP ISO
[Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein; [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein; [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein] Disulfiram results in increased cleavage of PARP1 protein
CTD
PMID:17079463 PMID:19789329 PMID:23033007 PMID:24193513 PMID:24690739 PMID:34182011 More...
NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA
CTD
PMID:24690739
NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598
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PCNX4
pecanex 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PCNX4 mRNA
CTD
PMID:24690739
NCBI chr14:60,091,911...60,148,221
Ensembl chr14:60,091,911...60,169,133
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PDE5A
phosphodiesterase 5A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA
CTD
PMID:24690739
NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804
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PDGFRB
platelet derived growth factor receptor beta
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA
CTD
PMID:24690739
NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
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PDLIM5
PDZ and LIM domain 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA
CTD
PMID:24690739
NCBI chr 4:94,451,942...94,668,223
Ensembl chr 4:94,451,857...94,668,227
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PDPN
podoplanin
multiple interactions
ISO EXP
[Disulfiram binds to Copper] which results in increased expression of PDPN protein [Disulfiram binds to Copper] which results in increased expression of and results in increased phosphorylation of and results in increased ubiquitination of PDPN protein
CTD
PMID:24690739
NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957
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PDRG1
p53 and DNA damage regulated 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PDRG1 mRNA
CTD
PMID:24690739
NCBI chr20:31,944,337...31,952,046
Ensembl chr20:31,944,337...31,952,046
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PGD
phosphogluconate dehydrogenase
increases expression
EXP
Disulfiram results in increased expression of PGD mRNA
CTD
PMID:20566472
NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
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PHLDA2
pleckstrin homology like domain family A member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA
CTD
PMID:24690739
NCBI chr11:2,928,273...2,929,420
Ensembl chr11:2,928,273...2,929,420
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PHLDB2
pleckstrin homology like domain family B member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PHLDB2 mRNA
CTD
PMID:24690739
NCBI chr 3:111,732,496...111,976,517
Ensembl chr 3:111,732,497...111,976,517
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PIGQ
phosphatidylinositol glycan anchor biosynthesis class Q
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PIGQ mRNA
CTD
PMID:24690739
NCBI chr16:569,968...584,109
Ensembl chr16:566,995...584,109
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PIK3IP1
phosphoinositide-3-kinase interacting protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA
CTD
PMID:24690739
NCBI chr22:31,281,593...31,292,534
Ensembl chr22:31,281,594...31,292,534
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PIN4P1
peptidylprolyl cis/trans isomerase, NIMA-interacting 4 pseudogene 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PIN4P1 mRNA
CTD
PMID:24690739
NCBI chr15:43,875,806...43,878,171
Ensembl chr15:43,875,849...43,876,244
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PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PIP4K2A mRNA
CTD
PMID:24690739
NCBI chr10:22,534,854...22,714,578
Ensembl chr10:22,534,854...22,714,578
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PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PLOD2 mRNA
CTD
PMID:24690739
NCBI chr 3:146,069,440...146,161,184
Ensembl chr 3:146,035,139...146,163,725
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PLPBP
pyridoxal phosphate binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PLPBP mRNA
CTD
PMID:24690739
NCBI chr 8:37,762,546...37,779,768
Ensembl chr 8:37,762,595...37,779,768
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PLSCR4
phospholipid scramblase 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PLSCR4 mRNA
CTD
PMID:24690739
NCBI chr 3:146,192,335...146,251,105
Ensembl chr 3:146,192,335...146,251,179
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PLXNB2
plexin B2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PLXNB2 mRNA
CTD
PMID:24690739
NCBI chr22:50,274,979...50,307,646
Ensembl chr22:50,274,979...50,307,646
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PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
EXP
Disulfiram results in increased expression of PMAIP1 mRNA
CTD
PMID:34182011
NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
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PNLDC1
PARN like ribonuclease domain containing exonuclease 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PNLDC1 mRNA
CTD
PMID:24690739
NCBI chr 6:159,799,455...159,820,704
Ensembl chr 6:159,800,249...159,820,704
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PNMA2
PNMA family member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PNMA2 mRNA
CTD
PMID:24690739
NCBI chr 8:26,504,701...26,513,872
Ensembl chr 8:26,504,701...26,514,092
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POLR2C
RNA polymerase II subunit C
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of POLR2C mRNA
CTD
PMID:24690739
NCBI chr16:57,462,679...57,472,009
Ensembl chr16:57,462,660...57,472,009
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POLR2M
RNA polymerase II subunit M
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA
CTD
PMID:24690739
NCBI chr15:57,706,714...57,717,557
Ensembl chr15:57,706,695...57,782,762
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POMC
proopiomelanocortin
decreases expression
ISO
Disulfiram results in decreased expression of POMC protein alternative form
CTD
PMID:8246921
NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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POP4
POP4 homolog, ribonuclease P/MRP subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of POP4 mRNA
CTD
PMID:24690739
NCBI chr19:29,606,283...29,617,237
Ensembl chr19:29,606,283...29,617,237
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POSTN
periostin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of POSTN mRNA
CTD
PMID:24690739
NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844
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PPARG
peroxisome proliferator activated receptor gamma
affects expression multiple interactions
EXP ISO
Disulfiram affects the expression of PPARG mRNA Disulfiram binds to and results in increased activity of PPARG protein
CTD
PMID:32712770 PMID:33049310
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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PPIA
peptidylprolyl isomerase A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PPIA mRNA
CTD
PMID:24690739
NCBI chr 7:44,796,681...44,803,117
Ensembl chr 7:44,796,680...44,824,564
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PPP1R15A
protein phosphatase 1 regulatory subunit 15A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PPP1R15A mRNA
CTD
PMID:24690739
NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059
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PPP1R3C
protein phosphatase 1 regulatory subunit 3C
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PPP1R3C mRNA
CTD
PMID:24690739
NCBI chr10:91,628,442...91,633,071
Ensembl chr10:91,628,442...91,633,071
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PPP2R2B
protein phosphatase 2 regulatory subunit Bbeta
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA
CTD
PMID:24690739
NCBI chr 5:146,580,742...147,081,520
Ensembl chr 5:146,580,742...147,084,784
G
PRDX1
peroxiredoxin 1
increases expression
EXP
Disulfiram results in increased expression of PRDX1 mRNA; Disulfiram results in increased expression of PRDX1 protein
CTD
PMID:34182011
NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
G
PROK2
prokineticin 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PROK2 mRNA
CTD
PMID:24690739
NCBI chr 3:71,771,655...71,785,148
Ensembl chr 3:71,771,655...71,785,206
G
PRSS8
serine protease 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA
CTD
PMID:24690739
NCBI chr16:31,131,433...31,135,727
Ensembl chr16:31,131,433...31,135,727
G
PSAT1
phosphoserine aminotransferase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PSAT1 mRNA
CTD
PMID:24690739
NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093
G
PSG11
pregnancy specific beta-1-glycoprotein 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PSG11 mRNA
CTD
PMID:24690739
NCBI chr19:43,007,656...43,026,469
Ensembl chr19:43,007,656...43,026,474
G
PSG5
pregnancy specific beta-1-glycoprotein 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PSG5 mRNA
CTD
PMID:24690739
NCBI chr19:43,167,743...43,186,536
Ensembl chr19:43,166,256...43,186,536
G
PSG9
pregnancy specific beta-1-glycoprotein 9
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PSG9 mRNA
CTD
PMID:24690739
NCBI chr19:43,253,282...43,269,530
Ensembl chr19:43,211,791...43,269,530
G
PSMC4
proteasome 26S subunit, ATPase 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PSMC4 mRNA
CTD
PMID:24690739
NCBI chr19:39,971,165...39,981,764
Ensembl chr19:39,971,165...39,981,764
G
PSPN
persephin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA
CTD
PMID:24690739
NCBI chr19:6,375,148...6,375,933
Ensembl chr19:6,375,148...6,379,058
G
PTEN
phosphatase and tensin homolog
multiple interactions increases expression
EXP
[Copper co-treated with Disulfiram] results in decreased expression of PTEN protein Disulfiram results in increased expression of PTEN mRNA
CTD
PMID:20424113 PMID:34182011
NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
G
PTGES3
prostaglandin E synthase 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA
CTD
PMID:24690739
NCBI chr12:56,663,349...56,688,284
Ensembl chr12:56,663,341...56,688,408
G
PTGR1
prostaglandin reductase 1
increases expression
EXP
Disulfiram results in increased expression of PTGR1 mRNA
CTD
PMID:20566472
NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893
G
PTGS2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Disulfiram results in decreased expression of PTGS2 mRNA
CTD
PMID:10418820
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
G
PTMA
prothymosin alpha
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of PTMA mRNA
CTD
PMID:24690739
NCBI chr 2:231,708,525...231,713,551
Ensembl chr 2:231,706,895...231,713,551
G
PTX3
pentraxin 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA
CTD
PMID:24690739
NCBI chr 3:157,436,850...157,443,633
Ensembl chr 3:157,436,850...157,443,633
G
RAB40A
RAB40A, member RAS oncogene family
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RAB40A mRNA
CTD
PMID:24690739
NCBI chr X:103,493,266...103,519,489
Ensembl chr X:103,499,130...103,519,489
G
RAB5C
RAB5C, member RAS oncogene family
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RAB5C mRNA
CTD
PMID:24690739
NCBI chr17:42,124,979...42,154,989
Ensembl chr17:42,124,978...42,155,044
G
RAC1
Rac family small GTPase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RAC1 mRNA
CTD
PMID:24690739
NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
G
RAI2
retinoic acid induced 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RAI2 mRNA
CTD
PMID:24690739
NCBI chr X:17,800,049...17,861,298
Ensembl chr X:17,800,049...17,861,337
G
RAMAC
RNA guanine-7 methyltransferase activating subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RAMAC mRNA
CTD
PMID:24690739
NCBI chr15:82,986,210...82,991,057
Ensembl chr15:82,986,210...82,991,057
G
RASA1
RAS p21 protein activator 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA
CTD
PMID:24690739
NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931
G
RASD1
ras related dexamethasone induced 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RASD1 mRNA
CTD
PMID:24690739
NCBI chr17:17,494,437...17,496,395
Ensembl chr17:17,494,437...17,496,395
G
RASL11B
RAS like family 11 member B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RASL11B mRNA
CTD
PMID:24690739
NCBI chr 4:52,862,317...52,866,835
Ensembl chr 4:52,862,317...52,866,835
G
RBIS
ribosomal biogenesis factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RBIS mRNA
CTD
PMID:24690739
NCBI chr 8:85,214,048...85,220,374
Ensembl chr 8:85,214,048...85,220,421
G
RBM18
RNA binding motif protein 18
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RBM18 mRNA
CTD
PMID:24690739
NCBI chr 9:122,237,622...122,264,840
Ensembl chr 9:122,237,622...122,264,840
G
RBM48
RNA binding motif protein 48
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RBM48 mRNA
CTD
PMID:24690739
NCBI chr 7:92,528,795...92,540,481
Ensembl chr 7:92,528,773...92,540,481
G
REP15
RAB15 effector protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of REP15 mRNA
CTD
PMID:24690739
NCBI chr12:27,696,447...27,697,596
Ensembl chr12:27,696,447...27,697,596
G
RFTN1
raftlin, lipid raft linker 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RFTN1 mRNA
CTD
PMID:24690739
NCBI chr 3:16,315,845...16,513,699
Ensembl chr 3:16,313,574...16,514,026
G
RFTN2
raftlin family member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RFTN2 mRNA
CTD
PMID:24690739
NCBI chr 2:197,568,224...197,675,587
Ensembl chr 2:197,568,224...197,676,045
G
RGCC
regulator of cell cycle
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RGCC mRNA
CTD
PMID:24690739
NCBI chr13:41,457,550...41,470,871
Ensembl chr13:41,457,550...41,470,871
G
RGS11
regulator of G protein signaling 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RGS11 mRNA
CTD
PMID:24690739
NCBI chr16:268,307...275,944
Ensembl chr16:268,301...275,980
G
RGS16
regulator of G protein signaling 16
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RGS16 mRNA
CTD
PMID:24690739
NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389
G
RGS2
regulator of G protein signaling 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RGS2 mRNA
CTD
PMID:24690739
NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
G
RHBDF1
rhomboid 5 homolog 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RHBDF1 mRNA
CTD
PMID:24690739
NCBI chr16:58,059...76,360
Ensembl chr16:58,059...76,355
G
RHBDF2
rhomboid 5 homolog 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RHBDF2 mRNA
CTD
PMID:24690739
NCBI chr17:76,470,893...76,501,427
Ensembl chr17:76,470,891...76,501,790
G
RHOB
ras homolog family member B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RHOB mRNA
CTD
PMID:24690739
NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440
G
RNF207
ring finger protein 207
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RNF207 mRNA
CTD
PMID:24690739
NCBI chr 1:6,206,119...6,221,299
Ensembl chr 1:6,205,475...6,221,299
G
RPL23
ribosomal protein L23
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPL23 mRNA
CTD
PMID:24690739
NCBI chr17:38,847,860...38,853,721
Ensembl chr17:38,847,860...38,868,644
G
RPL29
ribosomal protein L29
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPL29 mRNA
CTD
PMID:24690739
NCBI chr 3:51,993,522...51,995,895
Ensembl chr 3:51,993,522...51,995,895
G
RPL38
ribosomal protein L38
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPL38 mRNA
CTD
PMID:24690739
NCBI chr17:74,203,678...74,210,655
Ensembl chr17:74,203,582...74,210,655
G
RPLP1
ribosomal protein lateral stalk subunit P1
increases expression
EXP
Disulfiram results in increased expression of RPLP1 protein
CTD
PMID:34182011
NCBI chr15:69,452,818...69,456,205
Ensembl chr15:69,452,814...69,456,205
G
RPLP2P3
ribosomal protein lateral stalk subunit P2 pseudogene 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPLP2P3 mRNA
CTD
PMID:24690739
NCBI chr11:107,908,347...107,908,802
G
RPS15
ribosomal protein S15
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPS15 mRNA
CTD
PMID:24690739
NCBI chr19:1,438,396...1,440,495
Ensembl chr19:1,438,358...1,440,495
G
RPS26P35
ribosomal protein S26 pseudogene 35
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPS26P35 mRNA
CTD
PMID:24690739
NCBI chr 8:118,761,783...118,762,232
Ensembl chr 8:118,761,856...118,762,201
G
RPS27P29
ribosomal protein S27 pseudogene 29
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPS27P29 mRNA
CTD
PMID:24690739
NCBI chr19:23,597,307...23,597,649
Ensembl chr19:23,597,341...23,597,592
G
RPS7
ribosomal protein S7
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RPS7 mRNA
CTD
PMID:24690739
NCBI chr 2:3,575,260...3,580,920
Ensembl chr 2:3,575,260...3,580,920
G
RRAD
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA
CTD
PMID:24690739
NCBI chr16:66,921,685...66,925,535
Ensembl chr16:66,921,685...66,925,535
G
RRAGD
Ras related GTP binding D
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RRAGD mRNA
CTD
PMID:24690739
NCBI chr 6:89,364,616...89,412,273
Ensembl chr 6:89,364,616...89,412,273
G
RRAS
RAS related
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RRAS mRNA
CTD
PMID:24690739
NCBI chr19:49,635,292...49,640,143
Ensembl chr19:49,635,292...49,640,143
G
RSAD2
radical S-adenosyl methionine domain containing 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of RSAD2 mRNA
CTD
PMID:24690739
NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239
G
RUNX2
RUNX family transcription factor 2
increases expression
ISO
Disulfiram results in increased expression of RUNX2 mRNA
CTD
PMID:24496638
NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
G
RYBP
RING1 and YY1 binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA
CTD
PMID:24690739
NCBI chr 3:72,374,597...72,446,623
Ensembl chr 3:72,371,825...72,446,621
G
S100P
S100 calcium binding protein P
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of S100P mRNA
CTD
PMID:24690739
NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
G
SAP18
Sin3A associated protein 18
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SAP18 mRNA
CTD
PMID:24690739
NCBI chr13:21,140,119...21,149,097
Ensembl chr13:21,140,119...21,149,097
G
SAR1B
secretion associated Ras related GTPase 1B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SAR1B mRNA
CTD
PMID:24690739
NCBI chr 5:134,601,149...134,632,828
Ensembl chr 5:134,601,149...134,649,271
G
SAT1
spermidine/spermine N1-acetyltransferase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SAT1 mRNA
CTD
PMID:24690739
NCBI chr X:23,783,173...23,786,210
Ensembl chr X:23,783,173...23,786,210
G
SBDS
SBDS ribosome maturation factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA
CTD
PMID:24690739
NCBI chr 7:66,987,680...66,995,586
Ensembl chr 7:66,987,680...66,995,693
G
SCARF2
scavenger receptor class F member 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SCARF2 mRNA
CTD
PMID:24690739
NCBI chr22:20,424,584...20,437,825
Ensembl chr22:20,424,584...20,437,826
G
SCNM1
sodium channel modifier 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SCNM1 mRNA
CTD
PMID:24690739
NCBI chr 1:151,166,144...151,170,296
Ensembl chr 1:151,156,664...151,170,296
G
SEC61B
SEC61 translocon subunit beta
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA
CTD
PMID:24690739
NCBI chr 9:99,222,282...99,230,615
Ensembl chr 9:99,222,064...99,230,615
G
SEL1L3
SEL1L family member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SEL1L3 mRNA
CTD
PMID:24690739
NCBI chr 4:25,713,964...25,863,566
Ensembl chr 4:25,747,433...25,863,760
G
SEM1
SEM1 26S proteasome subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SEM1 mRNA
CTD
PMID:24690739
NCBI chr 7:96,481,626...96,709,846
Ensembl chr 7:96,481,626...96,709,880
G
SERTAD1
SERTA domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SERTAD1 mRNA
CTD
PMID:24690739
NCBI chr19:40,421,589...40,425,992
Ensembl chr19:40,421,589...40,425,992
G
SF3B4
splicing factor 3b subunit 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SF3B4 mRNA
CTD
PMID:24690739
NCBI chr 1:149,923,317...149,927,803
Ensembl chr 1:149,923,317...149,927,803
G
SGTA
small glutamine rich tetratricopeptide repeat co-chaperone alpha
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SGTA mRNA
CTD
PMID:24690739
NCBI chr19:2,754,715...2,783,273
Ensembl chr19:2,754,715...2,783,362
G
SH3PXD2A
SH3 and PX domains 2A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SH3PXD2A mRNA
CTD
PMID:24690739
NCBI chr10:103,594,027...103,855,576
Ensembl chr10:103,594,027...103,855,584
G
SIK1
salt inducible kinase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SIK1 mRNA
CTD
PMID:24690739
NCBI chr21:43,414,483...43,427,131
Ensembl chr21:43,414,483...43,427,131
G
SIRT1
sirtuin 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA
CTD
PMID:24690739
NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
G
SIRT6
sirtuin 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA
CTD
PMID:24690739
NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566
G
SKI
SKI proto-oncogene
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA
CTD
PMID:24690739
NCBI chr 1:2,228,319...2,310,213
Ensembl chr 1:2,227,388...2,310,213
G
SKIL
SKI like proto-oncogene
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SKIL mRNA
CTD
PMID:24690739
NCBI chr 3:170,357,715...170,396,849
Ensembl chr 3:170,357,342...170,396,835
G
SLC16A10
solute carrier family 16 member 10
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SLC16A10 mRNA
CTD
PMID:24690739
NCBI chr 6:111,087,503...111,231,194
Ensembl chr 6:111,087,503...111,231,194
G
SLC25A37
solute carrier family 25 member 37
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA
CTD
PMID:24690739
NCBI chr 8:23,528,956...23,575,463
Ensembl chr 8:23,528,956...23,575,463
G
SLC30A1
solute carrier family 30 member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SLC30A1 mRNA
CTD
PMID:24690739
NCBI chr 1:211,571,568...211,579,161
Ensembl chr 1:211,571,568...211,579,161
G
SLC44A1
solute carrier family 44 member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SLC44A1 mRNA
CTD
PMID:24690739
NCBI chr 9:105,244,651...105,438,504
Ensembl chr 9:105,244,622...105,439,171
G
SLC44A2
solute carrier family 44 member 2 (CTL2 blood group)
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SLC44A2 mRNA
CTD
PMID:24690739
NCBI chr19:10,602,455...10,644,557
Ensembl chr19:10,602,457...10,644,557
G
SLC6A9
solute carrier family 6 member 9
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA
CTD
PMID:24690739
NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467
G
SLC7A1
solute carrier family 7 member 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SLC7A1 mRNA
CTD
PMID:24690739
NCBI chr13:29,509,414...29,595,688
Ensembl chr13:29,509,414...29,595,688
G
SLC7A6OS
solute carrier family 7 member 6 opposite strand
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SLC7A6OS mRNA
CTD
PMID:24690739
NCBI chr16:68,298,034...68,310,946
Ensembl chr16:68,284,503...68,310,946
G
SLFN11
schlafen family member 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SLFN11 mRNA
CTD
PMID:24690739
NCBI chr17:35,350,305...35,373,621
Ensembl chr17:35,350,305...35,373,701
G
SLU7
SLU7 homolog, splicing factor
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SLU7 mRNA
CTD
PMID:24690739
NCBI chr 5:160,401,641...160,419,081
Ensembl chr 5:160,401,641...160,421,711
G
SMAD3
SMAD family member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA
CTD
PMID:24690739
NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
G
SMOX
spermine oxidase
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA
CTD
PMID:24690739
NCBI chr20:4,148,828...4,187,727
Ensembl chr20:4,120,980...4,187,747
G
SNAI1
snail family transcriptional repressor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA
CTD
PMID:24690739
NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
G
SNAR-A1
small NF90 (ILF3) associated RNA A1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SNAR-A1 mRNA
CTD
PMID:24690739
NCBI chr19:47,918,429...47,918,550
G
SNIP1
Smad nuclear interacting protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SNIP1 mRNA
CTD
PMID:24690739
NCBI chr 1:37,534,449...37,554,293
Ensembl chr 1:37,534,449...37,554,293
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SNORA70
small nucleolar RNA, H/ACA box 70
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SNORA70 mRNA
CTD
PMID:24690739
NCBI chr X:154,400,281...154,400,415
Ensembl chr X:154,400,281...154,400,415
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SNRPB2
small nuclear ribonucleoprotein polypeptide B2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SNRPB2 mRNA
CTD
PMID:24690739
NCBI chr20:16,730,026...16,742,564
Ensembl chr20:16,729,961...16,742,564
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SOD1
superoxide dismutase 1
increases expression decreases activity
EXP ISO
Disulfiram results in increased expression of SOD1 mRNA Disulfiram results in decreased activity of SOD1 protein
CTD
PMID:19016906 PMID:20566472
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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SOD2
superoxide dismutase 2
increases expression multiple interactions
EXP
Disulfiram results in increased expression of SOD2 mRNA [Disulfiram co-treated with Zinc Sulfate] results in increased expression of SOD2 mRNA
CTD
PMID:20566472 PMID:32712770 PMID:34182011
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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SOD3
superoxide dismutase 3
increases expression
EXP
Disulfiram results in increased expression of SOD3 mRNA
CTD
PMID:20566472
NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842
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SOX8
SRY-box transcription factor 8
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SOX8 mRNA
CTD
PMID:24690739
NCBI chr16:981,770...986,979
Ensembl chr16:981,444...986,979
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SPACDR
sperm acrosome developmental regulator
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SPACDR mRNA
CTD
PMID:24690739
NCBI chr 7:100,456,620...100,464,260
Ensembl chr 7:100,456,620...100,464,260
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SPANXN1
SPANX family member N1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SPANXN1 mRNA
CTD
PMID:24690739
NCBI chr X:145,247,503...145,256,208
Ensembl chr X:145,247,503...145,256,208
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SPANXN5
SPANX family member N5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SPANXN5 mRNA
CTD
PMID:24690739
NCBI chr X:52,796,144...52,797,427
Ensembl chr X:52,796,144...52,797,427
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SPATA20
spermatogenesis associated 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SPATA20 mRNA
CTD
PMID:24690739
NCBI chr17:50,547,174...50,555,852
Ensembl chr17:50,543,058...50,555,852
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SPG7
SPG7 matrix AAA peptidase subunit, paraplegin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SPG7 mRNA
CTD
PMID:24690739
NCBI chr16:89,508,388...89,557,768
Ensembl chr16:89,490,719...89,557,766
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SPIRE1
spire type actin nucleation factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SPIRE1 mRNA
CTD
PMID:24690739
NCBI chr18:12,446,512...12,662,091
Ensembl chr18:12,446,512...12,658,107
G
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
EXP
Disulfiram results in increased expression of SPSB1 mRNA
CTD
PMID:20566472
NCBI chr 1:9,292,894...9,369,532
Ensembl chr 1:9,292,894...9,369,532
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SPTBN1
spectrin beta, non-erythrocytic 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SPTBN1 mRNA
CTD
PMID:24690739
NCBI chr 2:54,456,327...54,671,446
Ensembl chr 2:54,456,327...54,671,446
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SPTY2D1
SPT2 chromatin protein domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SPTY2D1 mRNA
CTD
PMID:24690739
NCBI chr11:18,606,403...18,634,342
Ensembl chr11:18,606,403...18,634,791
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SQSTM1
sequestosome 1
decreases expression
EXP
Disulfiram results in decreased expression of SQSTM1 protein
CTD
PMID:34182011
NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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SREBF1
sterol regulatory element binding transcription factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA
CTD
PMID:24690739
NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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SRXN1
sulfiredoxin 1
increases expression
EXP
Disulfiram results in increased expression of SRXN1 mRNA
CTD
PMID:20566472
NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200
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SSX3
SSX family member 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SSX3 mRNA
CTD
PMID:24690739
NCBI chr X:48,346,427...48,356,703
Ensembl chr X:48,346,427...48,356,707
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STC2
stanniocalcin 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of STC2 mRNA
CTD
PMID:24690739
NCBI chr 5:173,314,723...173,328,414
Ensembl chr 5:173,314,723...173,328,447
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STEEP1
STING1 ER exit protein 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of STEEP1 mRNA
CTD
PMID:24690739
NCBI chr X:119,538,149...119,565,409
Ensembl chr X:119,538,149...119,565,409
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STX3
syntaxin 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of STX3 mRNA
CTD
PMID:24690739
NCBI chr11:59,754,188...59,805,878
Ensembl chr11:59,713,456...59,805,882
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SULF1
sulfatase 1
multiple interactions
EXP ISO
[Disulfiram binds to Copper] which results in increased expression of SULF1 mRNA; [Disulfiram binds to Copper] which results in increased expression of SULF1 protein
CTD
PMID:24690739
NCBI chr 8:69,466,781...69,660,912
Ensembl chr 8:69,466,624...69,660,915
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SUMO2
small ubiquitin like modifier 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA
CTD
PMID:24690739
NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959
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SUN1
Sad1 and UNC84 domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SUN1 mRNA
CTD
PMID:24690739
NCBI chr 7:815,557...874,934
Ensembl chr 7:816,615...896,435
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SUN2
Sad1 and UNC84 domain containing 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA
CTD
PMID:24690739
NCBI chr22:38,734,734...38,755,998
Ensembl chr22:38,733,290...38,794,143
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SUPT4H1
SPT4 homolog, DSIF elongation factor subunit
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA
CTD
PMID:24690739
NCBI chr17:58,345,178...58,352,201
Ensembl chr17:58,345,175...58,353,093
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SYNJ1
synaptojanin 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SYNJ1 mRNA
CTD
PMID:24690739
NCBI chr21:32,628,759...32,728,394
Ensembl chr21:32,628,759...32,728,040
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SZRD1
SUZ RNA binding domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of SZRD1 mRNA
CTD
PMID:24690739
NCBI chr 1:16,367,242...16,398,145
Ensembl chr 1:16,352,575...16,398,145
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TAF13
TATA-box binding protein associated factor 13
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TAF13 mRNA
CTD
PMID:24690739
NCBI chr 1:109,064,140...109,076,003
Ensembl chr 1:109,062,496...109,076,012
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TAF7
TATA-box binding protein associated factor 7
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TAF7 mRNA
CTD
PMID:24690739
NCBI chr 5:141,318,490...141,320,784
Ensembl chr 5:141,259,884...141,320,784
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TAMALIN
trafficking regulator and scaffold protein tamalin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TAMALIN mRNA
CTD
PMID:24690739
NCBI chr12:52,006,946...52,015,889
Ensembl chr12:52,006,946...52,015,889
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TANC1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA
CTD
PMID:24690739
NCBI chr 2:158,968,640...159,232,659
Ensembl chr 2:158,968,640...159,232,659
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TAP2
transporter 2, ATP binding cassette subfamily B member
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TAP2 mRNA
CTD
PMID:24690739
NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739
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TAPBP
TAP binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TAPBP mRNA
CTD
PMID:24690739
NCBI chr 6:33,299,694...33,314,078
Ensembl chr 6:33,299,694...33,314,284
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TAT
tyrosine aminotransferase
multiple interactions
ISO
[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein
CTD
PMID:9591243
NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
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TCEA2
transcription elongation factor A2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TCEA2 mRNA
CTD
PMID:24690739
NCBI chr20:64,055,596...64,072,347
Ensembl chr20:64,049,836...64,072,347
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TCP1
t-complex 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TCP1 mRNA
CTD
PMID:24690739
NCBI chr 6:159,778,498...159,789,602
Ensembl chr 6:159,778,498...159,789,703
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TENT5B
terminal nucleotidyltransferase 5B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TENT5B mRNA
CTD
PMID:24690739
NCBI chr 1:27,005,020...27,012,850
Ensembl chr 1:27,005,020...27,012,850
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TENT5C
terminal nucleotidyltransferase 5C
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA
CTD
PMID:24690739
NCBI chr 1:117,606,048...117,628,389
Ensembl chr 1:117,606,048...117,628,389
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TFIP11
tuftelin interacting protein 11
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TFIP11 mRNA
CTD
PMID:24690739
NCBI chr22:26,491,240...26,512,473
Ensembl chr22:26,491,225...26,512,505
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TGFB1
transforming growth factor beta 1
decreases activity
EXP
Disulfiram results in decreased activity of TGFB1 protein
CTD
PMID:31652400
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
G
THAP1
THAP domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA
CTD
PMID:24690739
NCBI chr 8:42,836,674...42,843,325
Ensembl chr 8:42,836,674...42,843,325
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THEM6
thioesterase superfamily member 6
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of THEM6 mRNA
CTD
PMID:24690739
NCBI chr 8:142,727,223...142,736,927
Ensembl chr 8:142,727,223...142,736,927
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THRA
thyroid hormone receptor alpha
multiple interactions
EXP
Disulfiram binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
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TICAM2
TIR domain containing adaptor molecule 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TICAM2 mRNA
CTD
PMID:24690739
NCBI chr 5:115,578,496...115,602,479
Ensembl chr 5:115,578,496...115,602,479
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TMEM167A
transmembrane protein 167A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TMEM167A mRNA
CTD
PMID:24690739
NCBI chr 5:83,052,846...83,077,394
Ensembl chr 5:83,052,846...83,077,863
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TMEM175
transmembrane protein 175
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TMEM175 mRNA
CTD
PMID:24690739
NCBI chr 4:932,460...958,656
Ensembl chr 4:932,387...958,656
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TMEM208
transmembrane protein 208
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TMEM208 mRNA
CTD
PMID:24690739
NCBI chr16:67,227,130...67,229,278
Ensembl chr16:67,227,103...67,229,278
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TMEM35B
transmembrane protein 35B
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TMEM35B mRNA
CTD
PMID:24690739
NCBI chr 1:34,981,380...34,985,347
Ensembl chr 1:34,981,380...34,985,347
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TMEM42
transmembrane protein 42
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TMEM42 mRNA
CTD
PMID:24690739
NCBI chr 3:44,861,912...44,865,664
Ensembl chr 3:44,861,904...44,865,670
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TMEM43
transmembrane protein 43
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA
CTD
PMID:24690739
NCBI chr 3:14,125,052...14,143,680
Ensembl chr 3:14,125,015...14,143,680
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TMEM44
transmembrane protein 44
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TMEM44 mRNA
CTD
PMID:24690739
NCBI chr 3:194,587,678...194,633,419
Ensembl chr 3:194,587,673...194,633,689
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TNF
tumor necrosis factor
decreases expression multiple interactions increases secretion
ISO EXP
Disulfiram results in decreased expression of TNF mRNA [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; Disulfiram promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Disulfiram results in increased secretion of TNF protein Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]
CTD
PMID:10418820 PMID:19016906 PMID:32712770 PMID:33851234
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFRSF6B
TNF receptor superfamily member 6b
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TNFRSF6B mRNA
CTD
PMID:24690739
NCBI chr20:63,696,652...63,698,684
Ensembl chr20:63,696,652...63,698,684
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TNFSF10
TNF superfamily member 10
increases expression
EXP
Disulfiram results in increased expression of TNFSF10 mRNA
CTD
PMID:34182011
NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
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TNIP1
TNFAIP3 interacting protein 1
multiple interactions
ISO EXP
[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein
CTD
PMID:24690739
NCBI chr 5:151,029,943...151,087,685
Ensembl chr 5:151,029,945...151,093,577
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TNIP2
TNFAIP3 interacting protein 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TNIP2 protein
CTD
PMID:24690739
NCBI chr 4:2,741,648...2,756,336
Ensembl chr 4:2,741,648...2,756,342
G
TNS3
tensin 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TNS3 mRNA
CTD
PMID:24690739
NCBI chr 7:47,275,154...47,582,586
Ensembl chr 7:47,275,154...47,582,558
G
TPRKB
TP53RK binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TPRKB mRNA
CTD
PMID:24690739
NCBI chr 2:73,729,873...73,737,345
Ensembl chr 2:73,729,104...73,737,400
G
TPSAB1
tryptase alpha/beta 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TPSAB1 mRNA
CTD
PMID:24690739
NCBI chr16:1,240,705...1,242,554
Ensembl chr16:1,239,266...1,242,554
G
TRA2B
transformer 2 beta homolog
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TRA2B mRNA
CTD
PMID:24690739
NCBI chr 3:185,914,558...185,938,014
Ensembl chr 3:185,914,558...185,938,103
G
TRABD
TraB domain containing
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TRABD mRNA
CTD
PMID:24690739
NCBI chr22:50,185,913...50,199,595
Ensembl chr22:50,185,913...50,199,598
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TRH
thyrotropin releasing hormone
multiple interactions increases expression decreases expression
ISO
Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] Disulfiram results in increased expression of TRH mRNA alternative form
CTD
PMID:9681491
NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935
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TSHB
thyroid stimulating hormone subunit beta
multiple interactions decreases secretion
ISO
Dexamethasone promotes the reaction [Disulfiram results in decreased secretion of TSHB protein]
CTD
PMID:9681491
NCBI chr 1:115,029,826...115,034,309
Ensembl chr 1:115,029,826...115,034,302
G
TSPYL2
TSPY like 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TSPYL2 mRNA
CTD
PMID:24690739
NCBI chr X:53,082,367...53,088,540
Ensembl chr X:53,082,367...53,088,540
G
TTC13
tetratricopeptide repeat domain 13
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of TTC13 mRNA
CTD
PMID:24690739
NCBI chr 1:230,906,243...230,978,861
Ensembl chr 1:230,906,243...230,978,875
G
TTF1
transcription termination factor 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TTF1 mRNA
CTD
PMID:24690739
NCBI chr 9:132,375,548...132,406,840
Ensembl chr 9:132,375,548...132,406,851
G
TUBA4A
tubulin alpha 4a
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TUBA4A mRNA
CTD
PMID:24690739
NCBI chr 2:219,249,710...219,254,740
Ensembl chr 2:219,249,710...219,277,902
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TUBB2A
tubulin beta 2A class IIa
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TUBB2A mRNA
CTD
PMID:24690739
NCBI chr 6:3,153,666...3,157,544
Ensembl chr 6:3,153,497...3,157,544
G
TUBB2B
tubulin beta 2B class IIb
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TUBB2B mRNA
CTD
PMID:24690739
NCBI chr 6:3,224,277...3,227,653
Ensembl chr 6:3,223,324...3,231,730
G
TUBB3
tubulin beta 3 class III
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TUBB3 mRNA
CTD
PMID:24690739
NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
G
TUBB7P
tubulin beta 7 pseudogene
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TUBB7P mRNA
CTD
PMID:24690739
NCBI chr 4:189,982,335...189,984,929
Ensembl chr 4:189,982,523...189,984,871
G
TXN2
thioredoxin 2
increases expression
EXP
Disulfiram results in increased expression of TXN2 mRNA
CTD
PMID:20566472
NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640
G
TXNL1
thioredoxin like 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of TXNL1 mRNA
CTD
PMID:24690739
NCBI chr18:56,597,209...56,638,592
Ensembl chr18:56,597,209...56,651,600
G
TXNRD1
thioredoxin reductase 1
increases expression
EXP
Disulfiram results in increased expression of TXNRD1 mRNA
CTD
PMID:20566472
NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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TXNRD2
thioredoxin reductase 2
increases expression
EXP
Disulfiram results in increased expression of TXNRD2 mRNA
CTD
PMID:20566472
NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
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UBFD1
ubiquitin family domain containing 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UBFD1 mRNA
CTD
PMID:24690739
NCBI chr16:23,557,727...23,574,389
Ensembl chr16:23,557,721...23,574,389
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UGT1A6
UDP glucuronosyltransferase family 1 member A6
increases expression
EXP
Disulfiram results in increased expression of UGT1A6 mRNA
CTD
PMID:20566472
NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
G
ULK1
unc-51 like autophagy activating kinase 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ULK1 mRNA
CTD
PMID:24690739
NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150
G
UQCC4
ubiquinol-cytochrome c reductase complex assembly factor 4
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UQCC4 mRNA
CTD
PMID:24690739
NCBI chr16:1,419,752...1,420,747
Ensembl chr16:1,419,752...1,420,756
G
UQCRB
ubiquinol-cytochrome c reductase binding protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UQCRB mRNA
CTD
PMID:24690739
NCBI chr 8:96,222,947...96,235,545
Ensembl chr 8:96,222,947...96,235,546
G
UQCRH
ubiquinol-cytochrome c reductase hinge protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UQCRH mRNA
CTD
PMID:24690739
NCBI chr 1:46,303,698...46,316,776
Ensembl chr 1:46,303,698...46,316,776
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USP17L30
ubiquitin specific peptidase 17 like family member 30
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of USP17L30 mRNA
CTD
PMID:24690739
NCBI chr 4:9,363,129...9,364,721
Ensembl chr 4:9,363,129...9,364,721
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USPL1
ubiquitin specific peptidase like 1
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of USPL1 mRNA
CTD
PMID:24690739
NCBI chr13:30,617,920...30,660,766
Ensembl chr13:30,617,693...30,660,770
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UTP11
UTP11 small subunit processome component
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UTP11 mRNA
CTD
PMID:24690739
NCBI chr 1:38,012,734...38,024,820
Ensembl chr 1:38,009,258...38,024,820
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UTP3
UTP3 small subunit processome component
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of UTP3 mRNA
CTD
PMID:24690739
NCBI chr 4:70,688,532...70,690,551
Ensembl chr 4:70,688,532...70,690,551
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VCAN
versican
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of VCAN mRNA
CTD
PMID:24690739
NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
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VCL
vinculin
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of VCL mRNA
CTD
PMID:24690739
NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363
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VDAC1
voltage dependent anion channel 1
multiple interactions
EXP
VDAC1 protein results in increased susceptibility to [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram]
CTD
PMID:24126434
NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
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VEGFC
vascular endothelial growth factor C
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of VEGFC mRNA
CTD
PMID:24690739
NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
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VGF
VGF nerve growth factor inducible
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of VGF mRNA
CTD
PMID:24690739
NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569
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VIM
vimentin
multiple interactions
EXP ISO
[Disulfiram binds to Copper] which results in increased cleavage of VIM protein
CTD
PMID:24690739
NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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VPS37B
VPS37B subunit of ESCRT-I
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of VPS37B mRNA
CTD
PMID:24690739
NCBI chr12:122,865,330...122,896,124
Ensembl chr12:122,865,330...122,896,127
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WDR20
WD repeat domain 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of WDR20 mRNA
CTD
PMID:24690739
NCBI chr14:102,139,423...102,224,839
Ensembl chr14:102,139,503...102,224,847
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XYLT2
xylosyltransferase 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of XYLT2 mRNA
CTD
PMID:24690739
NCBI chr17:50,346,126...50,361,185
Ensembl chr17:50,346,126...50,363,138
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YJU2
YJU2 splicing factor homolog
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of YJU2 mRNA
CTD
PMID:24690739
NCBI chr19:4,247,080...4,269,088
Ensembl chr19:4,247,080...4,269,088
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ZBTB43
zinc finger and BTB domain containing 43
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZBTB43 mRNA
CTD
PMID:24690739
NCBI chr 9:126,804,072...126,838,210
Ensembl chr 9:126,805,006...126,838,210
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ZFAND2A
zinc finger AN1-type containing 2A
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZFAND2A mRNA
CTD
PMID:24690739
NCBI chr 7:1,148,850...1,160,196
Ensembl chr 7:1,151,903...1,160,759
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ZFP36
ZFP36 ring finger protein
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZFP36 mRNA
CTD
PMID:24690739
NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,407
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ZHX3
zinc fingers and homeoboxes 3
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ZHX3 mRNA
CTD
PMID:24690739
NCBI chr20:41,178,455...41,317,731
Ensembl chr20:41,178,448...41,317,731
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ZKSCAN5
zinc finger with KRAB and SCAN domains 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZKSCAN5 mRNA
CTD
PMID:24690739
NCBI chr 7:99,504,662...99,534,700
Ensembl chr 7:99,504,662...99,534,700
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ZMAT2
zinc finger matrin-type 2
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZMAT2 mRNA
CTD
PMID:24690739
NCBI chr 5:140,700,447...140,706,686
Ensembl chr 5:140,698,680...140,706,686
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ZMAT5
zinc finger matrin-type 5
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZMAT5 mRNA
CTD
PMID:24690739
NCBI chr22:29,730,956...29,767,007
Ensembl chr22:29,730,956...29,767,011
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ZNF143
zinc finger protein 143
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF143 mRNA
CTD
PMID:24690739
NCBI chr11:9,461,012...9,528,524
Ensembl chr11:9,460,319...9,528,524
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ZNF20
zinc finger protein 20
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF20 mRNA
CTD
PMID:24690739
NCBI chr19:12,131,350...12,140,350
Ensembl chr19:12,092,843...12,140,355
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ZNF217
zinc finger protein 217
multiple interactions
EXP
[Disulfiram binds to Copper] which results in increased expression of ZNF217 mRNA
CTD
PMID:24690739
NCBI chr20:53,567,071...53,597,702
Ensembl chr20:53,567,071...53,609,907
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ZNF34
zinc finger protein 34
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF34 mRNA
CTD
PMID:24690739
NCBI chr 8:144,772,224...144,787,317
Ensembl chr 8:144,772,224...144,787,348
G
ZNF35
zinc finger protein 35
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF35 mRNA
CTD
PMID:24690739
NCBI chr 3:44,646,506...44,660,791
Ensembl chr 3:44,648,732...44,660,791
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ZNF408
zinc finger protein 408
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF408 mRNA
CTD
PMID:24690739
NCBI chr11:46,701,031...46,705,912
Ensembl chr11:46,701,030...46,705,912
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ZNF622
zinc finger protein 622
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF622 mRNA
CTD
PMID:24690739
NCBI chr 5:16,451,519...16,465,800
Ensembl chr 5:16,451,519...16,465,800
G
ZNF77
zinc finger protein 77
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF77 mRNA
CTD
PMID:24690739
NCBI chr19:2,933,218...2,944,971
Ensembl chr19:2,933,218...2,944,971
G
ZNF778
zinc finger protein 778
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZNF778 mRNA
CTD
PMID:24690739
NCBI chr16:89,217,703...89,237,141
Ensembl chr16:89,217,703...89,237,141
G
ZSCAN26
zinc finger and SCAN domain containing 26
multiple interactions
EXP
[Disulfiram binds to Copper] which results in decreased expression of ZSCAN26 mRNA
CTD
PMID:24690739
NCBI chr 6:28,267,143...28,278,204
Ensembl chr 6:28,267,058...28,278,224
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