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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Moxestrol
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Accession:CHEBI:34857 term browser browse the term
Definition:A 3-hydroxy steroid that has formula C21H26O3.
Synonyms:related_synonym: 11beta-Methoxy-17alpha-ethinylestradiol;   17alpha-Ethinyl-11beta-methoxy-1,3,5(10)-estratrien-3,17-diol;   Formula=C21H26O3;   InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1;   InChIKey=MTMZZIPTQITGCY-OLGWUGKESA-N;   RU-16117;   SMILES=CO[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#C)[C@@H]2CCc3cc(O)ccc3[C@@H]12;   moxesterol;   moxestrel
 xref: CAS:34816-55-2;   Drug_Central:3366;   KEGG:C14757
 xref_mesh: MESH:C011310


show annotations for term's descendants           Sort by:
Moxestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions ISO alisol B 23-acetate inhibits the reaction [moxestrol results in increased secretion of ALPL protein] CTD PMID:26040663 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
increases activity		 EXP moxestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein]
moxestrol results in increased activity of ESR1 protein		 CTD PMID:9048584 PMID:10875235 PMID:14617632 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
affects binding		 ISO moxestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
Moxestrol binds to Esr2 protein		 CTD
RGD		 PMID:9048584 PMID:9048584 RGD:8694130 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP IL1B protein inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA] CTD PMID:12177049 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G PRL prolactin increases expression ISO moxestrol analog results in increased expression of PRL protein CTD PMID:3780563 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G SERPINB9 serpin family B member 9 multiple interactions
increases expression		 EXP Cycloheximide promotes the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; fulvestrant inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; IL1B protein inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]; moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; Tamoxifen analog inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]
moxestrol results in increased expression of SERPINB9 mRNA; moxestrol results in increased expression of SERPINB9 protein		 CTD PMID:10681578 PMID:12177049 PMID:14617632 NCBI chr 6:2,887,270...2,903,309
Ensembl chr 6:2,887,173...2,903,309 		JBrowse link
G SHBG sex hormone binding globulin affects binding EXP moxestrol binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G TFF1 trefoil factor 1 multiple interactions
increases expression		 EXP moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein]
moxestrol results in increased expression of TFF1 mRNA		 CTD PMID:14617632 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26502
    chemical entity 26474
      molecular entity 26456
        polyatomic entity 26290
          heteroatomic molecular entity 25925
            hydroxides 24106
              organic hydroxy compound 22148
                hydroxy steroid 15573
                  3-hydroxy steroid 13578
                    Moxestrol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 26502
    subatomic particle 26470
      composite particle 26478
        hadron 26478
          baryon 26478
            nucleon 26470
              atomic nucleus 26478
                atom 26478
                  main group element atom 26206
                    p-block element atom 26206
                      carbon group element atom 25649
                        carbon atom 25611
                          organic molecular entity 25611
                            organic molecule 25362
                              organic cyclic compound 24410
                                organic polycyclic compound 18988
                                  steroid 15894
                                    hydroxy steroid 15573
                                      3-hydroxy steroid 13578
                                        Moxestrol 8
paths to the root