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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tunicamycin
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Accession:CHEBI:29699 term browser browse the term
Definition:A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Synonyms:related_synonym: Formula=C25H38N4O16;   SMILES=[H][C@@](O)(C[C@H]1O[C@@H](OC2O[C@H]([*]O)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC([*])=O)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O
 xref: CAS:11089-65-9;   KEGG:C12063
 xref_mesh: MESH:D014415
 xref: PMID:11478581;   PMID:11514096;   PMID:11732194;   PMID:11798249;   PMID:12093793;   PMID:12106388;   PMID:12136966;   PMID:12232600;   PMID:12232799;   PMID:12515321;   PMID:160437;   PMID:1624425;   PMID:3018444;   PMID:315774;   PMID:34700340;   PMID:34979291;   PMID:35233582;   PMID:35370192;   PMID:4624615;   PMID:4630978;   PMID:5103138;   PMID:5103535;   PMID:5168706;   PMID:6153524;   PMID:6813319;   PMID:6975776;   PMID:6992777;   PMID:701277;   PMID:7142115;   PMID:7144800;   PMID:7766032;   Wikipedia:Tunicamycin


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tunicamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Tunicamycin results in increased expression of HSP90B1 protein CTD PMID:15049342 PMID:17416481 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases response to substance
increases expression		 EXP HSPA5 results in decreased susceptibility to Tunicamycin
Tunicamycin results in increased expression of HSPA5 protein		 CTD PMID:15049342 PMID:16920763 PMID:17416481 PMID:17464326 PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5163
    role 5116
      biological role 5130
        antimicrobial agent 290
          tunicamycin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 5163
    subatomic particle 5140
      composite particle 5154
        hadron 5154
          baryon 5154
            nucleon 5154
              atomic nucleus 5154
                atom 5154
                  main group element atom 5113
                    p-block element atom 5110
                      carbon group element atom 5028
                        carbon atom 5027
                          organic molecular entity 5027
                            heteroorganic entity 4873
                              organochalcogen compound 4827
                                organooxygen compound 4791
                                  carbohydrates and carbohydrate derivatives 123
                                    carbohydrate 123
                                      carbohydrate derivative 112
                                        glycosyl compound 50
                                          N-glycosyl compound 27
                                            nucleoside 27
                                              tunicamycin A0 2
                                                tunicamycin 2
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