Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Withanone
go back to main search page
Accession:CHEBI:231685 term browser browse the term
Synonyms:exact_synonym: (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-5,15-dihydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one
 related_synonym: Formula=C28H38O6;   InChI=1S/C28H38O6/c1-14-13-19(33-24(30)15(14)2)16(3)27(31)12-9-17-21-18(8-11-25(17,27)4)26(5)20(29)7-6-10-28(26,32)23-22(21)34-23/h6-7,16-19,21-23,31-32H,8-13H2,1-5H3/t16-,17+,18+,19-,21+,22+,23+,25+,26+,27+,28+/m1/s1;   InChIKey=FAZIYUIDUNHZRG-PCTWTJKKSA-N;   SMILES=O1[C@H]2[C@]3([C@]4([C@@]([C@](O)(CC4)[C@@H]([C@@]5(OC(=O)C(=C(C5)C)C)[H])C)(CC[C@@]3([C@@]6([C@@](O[H])([C@@H]12)CC=CC6=O)C)[H])C)[H])[H]
 xref_mesh: MESH:C560597


show annotations for term's descendants           Sort by:
Withanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A multiple interactions ISO withanone inhibits the reaction [TPX2 protein binds to AURKA protein] CTD PMID:22303466 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO withanone binds to and results in decreased activity of BIRC5 protein CTD PMID:23994265 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO withanone results in increased expression of CDKN1A mRNA
withanone inhibits the reaction [methoxyacetic acid results in increased expression of CDKN1A protein]; withanone results in increased expression of and affects the localization of and results in increased activity of CDKN1A protein		 CTD PMID:21573189 PMID:22973447 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO withanone inhibits the reaction [methoxyacetic acid results in increased expression of CDKN2A protein] CTD PMID:21573189 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ezr ezrin multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein] CTD PMID:22096544 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein] CTD PMID:22096544 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withanone binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; [withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withanone inhibits the reaction [HSPA9 protein binds to TP53 protein] CTD PMID:22155302 PMID:25236891 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein] CTD PMID:22096544 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein CTD PMID:25236891 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein CTD PMID:25236891 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nefh neurofilament heavy chain multiple interactions ISO withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein] CTD PMID:22096544 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO withanone results in increased expression of NFE2L2 protein
withanone inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]; withanone inhibits the reaction [methoxyacetic acid results in decreased expression of NFE2L2 protein]		 CTD PMID:21573189 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO withanone inhibits the reaction [methoxyacetic acid results in increased phosphorylation of RB1 protein] CTD PMID:21573189 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO [withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]; withanone inhibits the reaction [methoxyacetic acid results in increased expression of TP53 protein]
withanone results in increased expression of TP53 mRNA		 CTD PMID:21573189 PMID:22155302 PMID:22973447 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor multiple interactions ISO withanone inhibits the reaction [TPX2 protein binds to AURKA protein] CTD PMID:22303466 NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein CTD PMID:25236891 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          carbon atom 19772
            organic molecular entity 19772
              lipid 18003
                steroid 14738
                  steroid lactone 481
                    Withanone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19536
                              organochalcogen compound 19296
                                organooxygen compound 19214
                                  ester 17563
                                    carboxylic ester 16937
                                      lactone 13317
                                        steroid lactone 481
                                          Withanone 19
paths to the root