|
.002 |
.001 |
.001 |
.177 |
.001 |
.0 |
.015 |
.845 |
.002 |
.0 |
.03 |
.001 |
.049 |
.293 |
.422 |
.0 |
.001 |
.002 |
.005 |
.019 |
.004 |
.005 |
.021 |
.045 |
.007 |
.176 |
.03 |
.002 |
.002 |
.001 |
.167 |
-- |
.008 |
.243 |
.001 |
.017 |
.019 |
.022 |
.007 |
.081 |
.049 |
.023 |
.011 |
.014 |
.0 |
-- |
.009 |
.002 |
-- |
.337 |
.0 |
.127 |
.004 |
.014 |
.059 |
.641 |
.578 |
-- |
.203 |
.001 |
.0 |
.011 |
.183 |
.0 |
.92 |
.272 |
.05 |
.0 |
.027 |
.207 |
.002 |
.024 |
.003 |
-- |
-- |
.053 |
.001 |
.018 |
.001 |
.01 |
.024 |
.025 |
.163 |
.044 |
.062 |
.004 |
-- |
.052 |
.347 |
.313 |
.005 |
.016 |
.023 |
.194 |
.129 |
.112 |
.001 |
.002 |
.003 |
.11 |
.117 |
.0 |
.031 |
-- |
-- |
-- |
.208 |
.008 |
.009 |
.048 |
.025 |
.016 |
.05 |
.272 |
.005 |
.024 |
.007 |
.03 |
.082 |
.0 |
.051 |
.001 |
.002 |
.051 |
.001 |
.011 |
.023 |
.0 |
.005 |
.172 |
.003 |
.993 |
.991 |
.174 |
.024 |
.003 |
.05 |
.115 |
.001 |
.187 |
.013 |
.015 |
.002 |
.0 |
.0 |
.009 |
.001 |
.053 |
.203 |
.0 |
.053 |
.008 |
.052 |
.016 |
.4 |
.0 |
.0 |
.017 |
.01 |
.032 |
.032 |
.069 |
.001 |
.001 |
.014 |
.0 |
.009 |
.01 |
.0 |
.004 |
.0 |
.073 |
.035 |
.024 |
.0 |
.0 |
.026 |
.0 |
.001 |
.001 |
.0 |
.006 |
-- |
.022 |
.004 |
.006 |
-- |
-- |
.0 |
.0 |
.0 |
.0 |
.005 |
.007 |
.005 |
.029 |
.01 |
.032 |
.001 |
.003 |
.071 |
.135 |
.012 |
.0 |
.094 |
.049 |
.008 |
.013 |
.48 |
.018 |
.095 |
.0 |
.001 |
.999 |
.937 |
.001 |
.083 |
.003 |
.003 |
.087 |
.075 |
.018 |
.038 |
.251 |
.154 |
.137 |
.042 |
.29 |
.258 |
.252 |
.007 |
.014 |
.022 |
.322 |
.08 |
.223 |
.949 |
.0 |
.051 |
.001 |
.022 |
.0 |
.0 |
.019 |
.01 |
.001 |
.009 |
.213 |
-- |
-- |
.435 |
.041 |
.091 |
.009 |
.165 |
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
Trpc4
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
G |
A |
T |
C |
A |
4 |
G |
T |
G |
T |
A |
2 |
C |
T |
A |
G |
A |
A |
T |
T |
G |
G |
A |
C |
C |
8 |
8 |
6 |
T |
G |
A |
T |
G |
T |
C |
A |
C |
G |
A |
A |
G |
G |
4 |
A |
G |
A |
6 |
C |
A |
C |
T |
C |
A |
2 |
2 |
T |
C |
T |
C |
G |
G |
A |
A |
C |
6 |
G |
C |
G |
A |
C |
T |
T |
G |
C |
C |
C |
T |
2 |
G |
T |
T |
2 |
3 |
C |
T |
A |
A |
G |
G |
A |
8 |
6 |
A |
T |
G |
20 |
T |
C |
2 |
2 |
A |
A |
G |
C |
A |
A |
C |
T |
G |
A |
G |
A |
T |
C |
A |
G |
G |
C |
G |
C |
C |
C |
C |
T |
A |
A |
A |
2 |
A |
C |
C |
G |
G |
T |
G |
G |
T |
A |
C |
T |
C |
T |
C |
T |
A |
G |
T |
A |
A |
T |
T |
C |
C |
T |
T |
T |
G |
T |
G |
G |
T |
2 |
A |
G |
T |
C |
5 |
2 |
G |
T |
T |
G |
A |
G |
C |
G |
A |
C |
A |
C |
A |
G |
2 |
A |
A |
C |
C |
T |
A |
A |
T |
T |
T |
C |
G |
C |
A |
T |
G |
T |
G |
C |
C |
2 |
6 |
4 |
40 |
G |
T |
C |
G |
C |
A |
T |
C |
A |
C |
G |
C |
63 |
T |
C |
A |
T |
T |
C |
A |
T |
G |
C |
G |
C |
T |
12 |
A |
C |
G |
G |
G |
G |
A |
T |
A |
G |
T |
G |
A |
6 |
5 |
G |
T |
T |
4 |
12 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
A
|
G
|
C
|
T
|
G
|
-
|
A
|
C
|
2
|
C
|
A/7
|
2/-
|
T
|
G
|
G
|
C
|
T
|
G
|
C
|
C
|
A
|
T
|
G
|
T
|
T
|
-
|
8/-
|
6/-
|
C
|
C
|
C
|
C
|
T
|
2
|
T
|
G
|
T
|
T
|
G
|
2
|
A
|
C
|
-
|
3/5
|
10
|
G
|
-
|
T
|
G
|
T
|
-
|
A
|
-
|
-
|
2/-
|
-
|
T
|
C
|
T
|
A
|
A
|
4
|
G
|
T
|
-
|
T
|
T
|
A
|
G
|
T
|
A
|
A
|
T
|
T
|
-
|
-
|
G
|
-
|
2
|
T/2
|
2
|
-
|
-
|
T
|
-
|
3
|
G
|
2
|
T
|
C
|
-
|
6/-
|
3
|
C
|
A
|
-
|
C
|
C/3
|
2/-
|
2/-
|
C
|
G
|
4
|
G
|
2
|
G
|
T
|
C
|
A
|
G
|
T
|
G
|
G
|
T
|
G
|
T
|
A
|
4
|
A
|
T
|
T
|
T
|
A
|
C
|
G
|
T
|
G
|
-
|
G
|
4
|
T
|
A
|
A
|
C
|
2
|
A
|
C
|
G
|
T
|
A
|
6
|
C
|
T
|
G
|
G
|
A
|
C
|
G
|
C
|
C
|
C
|
T
|
T
|
C
|
C
|
C
|
A
|
G
|
A
|
A
|
C
|
2/-
|
A/-
|
C
|
C
|
T
|
-
|
-
|
T
|
G
|
C
|
A
|
G
|
A
|
3
|
3
|
T
|
T
|
-
|
T
|
19
|
A
|
-
|
C
|
C
|
T
|
T
|
C
|
G
|
G
|
A
|
A
|
G
|
T
|
A
|
G
|
T
|
2
|
A
|
G
|
A
|
-
|
2
|
-
|
-
|
-
|
-
|
-
|
A
|
T
|
T
|
A
|
2
|
G
|
T
|
-
|
17
|
C
|
T
|
-
|
C
|
T
|
G
|
3
|
-
|
T
|
G
|
C
|
A
|
T
|
A
|
T
|
C
|
-
|
4
|
T
|
A
|
3
|
A
|
C
|
G
|
11
|
T
|
C
|
C
|
G/3
|
7
|
6/-
|
-
|
2
|
-
|
15
|
-
|
-
|
|