|
.008 |
.207 |
.008 |
.001 |
.251 |
.138 |
.046 |
.002 |
.103 |
.002 |
.047 |
.004 |
.0 |
.063 |
.02 |
.011 |
.016 |
.015 |
.018 |
.016 |
.007 |
.004 |
.038 |
.0 |
.008 |
.0 |
.001 |
.006 |
.0 |
.0 |
.0 |
.343 |
.185 |
.036 |
.005 |
.0 |
.001 |
.023 |
.039 |
.0 |
.001 |
.029 |
.024 |
.001 |
.001 |
.002 |
.004 |
.0 |
.0 |
.519 |
.536 |
.583 |
.509 |
.037 |
.015 |
.011 |
.0 |
.001 |
.002 |
.0 |
.5 |
.013 |
.013 |
.003 |
.003 |
.006 |
.007 |
.091 |
.017 |
.003 |
.163 |
.0 |
.003 |
.014 |
.042 |
.007 |
.0 |
.046 |
.011 |
.021 |
.001 |
.347 |
.009 |
.003 |
.016 |
.003 |
.002 |
.102 |
.003 |
.035 |
.414 |
.002 |
.0 |
.009 |
.0 |
.0 |
.001 |
.0 |
.002 |
.0 |
.001 |
.001 |
.003 |
.014 |
.024 |
.0 |
.001 |
.012 |
.001 |
.027 |
.001 |
.027 |
.004 |
.089 |
.034 |
.975 |
.004 |
.004 |
.014 |
.0 |
.008 |
.047 |
.047 |
.0 |
.017 |
.0 |
.0 |
.006 |
.01 |
.0 |
.004 |
.001 |
.009 |
.007 |
.006 |
.0 |
.162 |
.774 |
.013 |
.015 |
.169 |
.084 |
.001 |
.442 |
.035 |
.009 |
.0 |
.362 |
.087 |
.002 |
.0 |
.006 |
.001 |
.011 |
.0 |
.001 |
.001 |
.12 |
.555 |
.036 |
.016 |
.136 |
.121 |
.001 |
.166 |
.017 |
-- |
.032 |
.233 |
.0 |
.0 |
.002 |
.032 |
.493 |
.008 |
-- |
.471 |
.012 |
.186 |
.072 |
.005 |
-- |
.01 |
-- |
-- |
-- |
-- |
-- |
-- |
.018 |
.017 |
.0 |
.998 |
.89 |
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
T |
C |
A |
T |
T |
G |
C |
C |
G |
G |
C |
T |
10 |
C |
G |
G |
A |
T |
T |
A |
C |
G |
C |
T |
A |
A |
C |
G |
C |
C |
C |
2 |
C |
A |
T |
T |
T |
A |
C |
A |
11 |
T |
G |
T |
A |
C |
G |
T |
T |
T |
G |
G |
C |
C |
C |
G |
G |
G |
G |
G |
C |
G |
G |
A |
T |
A |
C |
T |
G |
A |
T |
A |
A |
G |
C |
A |
C |
T |
C |
C |
A |
G |
A |
A |
G |
A |
C |
C |
G |
A |
T |
5 |
2 |
T |
C |
A |
C |
C |
A |
A |
A |
C |
A |
T |
C |
A |
C |
C |
5 |
C |
A |
C |
C |
C |
G |
G |
T |
C |
G |
C |
G |
G |
A |
T |
C |
G |
A |
A |
C |
C |
G |
T |
T |
C |
G |
A |
43 |
A |
C |
A |
G |
T |
G |
C |
G |
G |
25 |
G |
C |
T |
C |
C |
C |
C |
G |
C |
A |
C |
T |
C |
2 |
G |
6 |
T |
G |
T |
2 |
A |
C |
A |
G |
C |
T |
8 |
C |
A |
C |
T |
A |
T |
C |
A |
T |
T |
G |
G |
A |
8 |
T |
A |
A |
A |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T
|
C
|
T
|
G
|
C
|
G
|
C
|
-
|
T
|
-
|
A
|
T
|
-
|
-
|
T
|
A
|
C
|
G
|
C
|
2
|
T
|
8
|
T
|
T
|
C
|
G
|
G
|
C/2
|
A
|
T
|
T
|
-
|
-
|
7
|
G
|
-
|
-
|
3
|
13
|
T
|
T
|
-
|
-
|
T
|
2
|
G
|
T
|
C
|
C
|
T/A
|
A
|
T
|
2
|
T
|
T
|
11
|
A
|
A
|
A
|
A
|
T
|
T
|
A
|
A
|
9
|
G
|
T
|
2
|
-
|
A
|
G
|
C
|
G
|
G
|
2
|
A
|
T
|
T
|
C
|
T
|
A
|
T
|
A
|
T
|
G
|
A
|
C
|
A
|
T
|
13
|
G
|
C
|
-
|
-
|
C
|
7/5
|
G
|
T
|
T
|
C
|
G
|
G
|
T
|
2
|
C
|
T
|
G
|
T
|
G
|
-
|
2
|
C
|
T
|
T
|
T
|
C
|
A
|
G
|
T
|
A
|
T
|
A
|
A
|
G
|
G
|
A
|
C
|
C
|
C
|
G
|
A
|
C
|
C
|
C
|
2
|
A
|
G
|
-
|
2
|
T
|
G
|
A
|
G
|
A
|
2
|
A
|
A
|
-
|
A
|
A
|
C
|
-
|
T
|
T
|
T
|
A
|
T
|
G
|
A
|
G
|
T
|
-
|
2
|
-
|
A
|
G/3
|
C
|
-
|
G
|
T
|
G
|
-
|
T
|
C
|
-
|
C/3
|
A/-
|
T
|
C
|
14
|
C
|
19
|
G
|
-
|
G
|
A
|
A
|
-
|
-
|
-
|
G
|
4
|
G
|
-
|
|