|
.002 |
.002 |
.008 |
.003 |
.004 |
.594 |
.001 |
.001 |
.001 |
.309 |
.002 |
.046 |
.116 |
.0 |
.0 |
.0 |
.025 |
.058 |
.006 |
.001 |
.116 |
.004 |
.006 |
.571 |
.562 |
.013 |
.005 |
.328 |
.008 |
.072 |
.003 |
.016 |
.01 |
.027 |
.004 |
.004 |
.062 |
.057 |
-- |
-- |
.502 |
-- |
.006 |
.015 |
.181 |
.001 |
.011 |
.044 |
.001 |
.001 |
-- |
-- |
.174 |
.004 |
-- |
-- |
-- |
-- |
-- |
.02 |
.017 |
.535 |
-- |
.006 |
.022 |
.33 |
.002 |
.688 |
.692 |
.15 |
.035 |
.096 |
-- |
.075 |
.058 |
.028 |
.072 |
.001 |
.0 |
.0 |
.0 |
.005 |
.006 |
.003 |
.003 |
.001 |
.004 |
.001 |
.007 |
.039 |
.013 |
.001 |
.139 |
.812 |
.029 |
.141 |
.047 |
.015 |
.001 |
.15 |
.021 |
.12 |
.011 |
.012 |
.004 |
.183 |
.001 |
.008 |
.056 |
.22 |
.052 |
.143 |
.119 |
.034 |
.019 |
.001 |
.065 |
.298 |
.259 |
.066 |
.001 |
.0 |
.003 |
.019 |
.709 |
.723 |
.726 |
.005 |
.036 |
.018 |
.004 |
.0 |
.417 |
.022 |
.157 |
.262 |
.002 |
.0 |
.001 |
.0 |
.003 |
.782 |
.001 |
.076 |
.001 |
.621 |
.054 |
.019 |
.002 |
.064 |
.0 |
.001 |
.004 |
.006 |
.253 |
.012 |
.001 |
.135 |
.104 |
.114 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.0 |
.012 |
.012 |
.004 |
.068 |
.007 |
.021 |
.001 |
.0 |
.002 |
.004 |
.021 |
.001 |
.009 |
.002 |
.0 |
.056 |
.06 |
.088 |
.0 |
.003 |
.0 |
.002 |
.023 |
.017 |
.348 |
.002 |
.015 |
.013 |
.375 |
.003 |
.059 |
.0 |
.002 |
.022 |
.044 |
.075 |
.152 |
.012 |
.0 |
.002 |
.427 |
.98 |
.001 |
.024 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.003 |
.002 |
.001 |
.002 |
.011 |
.016 |
.011 |
.001 |
.005 |
.014 |
.0 |
.011 |
.0 |
.99 |
.0 |
.003 |
.205 |
.001 |
.111 |
.003 |
.018 |
.0 |
.283 |
.015 |
.0 |
1.0 |
.993 |
.161 |
.386 |
.022 |
.048 |
.001 |
.001 |
.001 |
.012 |
.003 |
.003 |
.001 |
.28 |
.019 |
-- |
-- |
-- |
.028 |
.0 |
.111 |
.707 |
.107 |
.122 |
.405 |
.319 |
.366 |
.11 |
.006 |
.4 |
.578 |
.059 |
.074 |
.024 |
.125 |
.11 |
.022 |
.443 |
.006 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.025 |
.023 |
.023 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.008 |
.006 |
.012 |
.02 |
.009 |
.049 |
.008 |
.095 |
.0 |
.003 |
.02 |
.561 |
.001 |
.046 |
.005 |
.808 |
.001 |
.008 |
.001 |
.005 |
.004 |
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
Pde5a
|
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
C |
C |
G |
A |
T |
C |
T |
G |
G |
A |
A |
G |
A |
T |
T |
G |
2 |
T |
4 |
G |
T |
A |
2 |
A |
T |
A |
T |
G |
A |
T |
G |
A |
G |
T |
T |
C |
C |
2 |
20 |
A |
C |
G |
G |
T |
C |
T |
A |
G |
A |
G |
T |
A |
T |
A |
T |
A |
A |
T |
C |
C |
A |
A |
C |
G |
A |
T |
2 |
T |
G |
A |
C |
G |
A |
T |
C |
T |
A |
A |
C |
A |
G |
T |
T |
T |
A |
C |
C |
G |
T |
T |
T |
C |
T |
G |
C |
G |
T |
C |
C |
T |
T |
A |
T |
C |
T |
T |
A |
G |
T |
A |
A |
G |
A |
T |
G |
C |
G |
G |
T |
G |
2 |
G |
C |
T |
C |
A |
A |
A |
T |
C |
G |
A |
T |
A |
T |
C |
A |
G |
A |
T |
C |
T |
T |
T |
T |
C |
A |
C |
T |
3 |
C |
A |
A |
C |
C |
2 |
A |
T |
2 |
A |
A |
C |
G |
C |
G |
G |
A |
C |
G |
2 |
3 |
2 |
A |
T |
C |
G |
T |
A |
C |
2 |
G |
T |
T |
T |
G |
G |
A |
G |
G |
T |
A |
C |
A |
T |
T |
T |
T |
3 |
G |
A |
G |
A |
C |
A |
G |
G |
A |
G |
G |
A |
G |
4 |
T |
C |
G |
A |
A |
T |
C |
G |
A |
T |
C |
T |
G |
G |
C |
C |
G |
G |
T |
G |
4 |
T |
C |
T |
T |
C |
T |
C |
C |
T |
T |
T |
T |
T |
A |
A |
A |
A |
A |
G |
G |
2 |
C |
T |
T |
A |
T |
T |
A |
G |
G |
A |
A |
T |
A |
A |
C |
C |
G |
T |
A |
A |
T |
A |
A |
G |
C |
C |
A |
T |
C |
G |
A |
A |
A |
G |
A |
C |
A |
G |
T |
T |
T |
G |
22 |
4 |
T |
C |
T |
T |
T |
G |
C |
T |
T |
G |
G |
G |
T |
T |
C |
C |
T |
T |
C |
C |
C |
A |
C |
2 |
A |
T |
C |
G |
T |
A |
A |
C |
T |
A |
A |
A |
10 |
C |
T |
5 |
A |
C |
C |
A |
C |
G |
C |
A |
G |
A |
G |
C |
A |
C |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C
|
G
|
T
|
A
|
-
|
2
|
13
|
C
|
A
|
T
|
2
|
C
|
A
|
G
|
C
|
-
|
A
|
-
|
C
|
-
|
A
|
C
|
G
|
2/-
|
A/-
|
G
|
G
|
3
|
GT/3
|
-
|
G
|
2
|
G
|
C
|
G
|
C
|
C/3
|
T
|
-
|
-
|
T
|
2
|
4
|
A
|
C
|
G
|
-
|
17
|
A
|
G
|
5
|
3
|
G
|
C
|
T
|
C
|
G
|
G
|
-
|
T
|
T
|
A/3
|
2
|
T
|
5/7
|
-
|
C
|
-
|
A
|
2
|
G
|
T
|
A
|
T
|
A
|
3
|
9
|
G
|
G
|
T
|
15
|
T
|
C
|
C
|
T/C
|
3/4
|
T
|
15
|
A
|
C
|
5
|
A
|
T
|
C
|
A
|
T
|
A
|
A
|
T
|
T
|
A
|
C
|
G
|
C
|
T
|
C
|
C
|
2
|
T
|
T/-
|
T
|
2
|
A
|
G
|
C
|
C
|
T
|
A
|
A
|
C
|
A
|
-
|
2
|
T
|
55
|
29
|
30
|
G
|
G
|
-
|
T
|
A
|
2
|
A
|
-
|
C
|
T
|
T
|
G/2
|
G
|
C
|
G
|
A
|
C
|
G
|
G
|
8
|
G
|
T
|
C
|
-
|
A
|
T
|
G
|
5
|
T
|
-
|
G
|
G
|
-
|
T
|
T
|
T
|
A
|
A
|
T
|
T
|
G
|
T
|
T
|
-
|
3/-
|
2/-
|
G
|
G
|
T
|
A
|
C
|
G
|
T
|
-
|
3
|
C
|
C
|
G
|
21
|
A
|
G
|
-
|
-
|
A
|
G
|
A
|
-
|
C
|
C
|
C
|
C
|
-
|
T
|
G
|
A
|
G
|
T
|
A/11
|
T
|
C
|
C
|
A
|
A
|
G
|
A
|
-
|
C
|
T
|
A
|
G
|
G
|
A
|
A
|
C
|
G
|
2
|
T
|
C
|
A
|
2
|
A
|
T
|
T
|
T
|
C
|
2
|
-
|
A
|
G
|
C
|
4
|
4
|
29
|
7
|
10
|
C
|
C
|
C
|
C
|
A
|
G
|
-
|
G
|
-
|
20
|
G/3
|
G/2
|
--/-
|
T
|
C
|
C
|
G
|
C
|
C
|
G
|
A
|
A
|
G
|
2
|
C
|
A/17
|
G
|
G
|
T
|
C
|
C
|
G
|
G
|
C
|
G
|
G
|
C
|
T
|
T
|
G
|
C
|
T
|
A
|
G
|
G
|
2
|
A
|
G
|
G
|
G
|
T
|
C
|
A
|
A
|
A
|
22/-
|
-
|
C
|
T
|
4/3
|
A
|
C
|
10
|
T
|
C
|
G
|
A
|
-
|
C
|
C
|
C
|
T
|
G
|
G
|
C
|
G
|
T
|
T
|
G
|
A
|
-
|
G
|
C
|
C/15
|
A
|
C
|
2
|
G
|
T
|
A
|
C
|
G
|
G
|
-
|
2
|
A
|
-
|
C
|
-
|
T
|
G
|
T
|
T
|
T
|
-
|
C
|
T
|
A
|
2
|
C
|
?
|
G
|
|