|
.002 |
.842 |
.0 |
.001 |
.003 |
.001 |
.053 |
.0 |
.009 |
.835 |
.0 |
.0 |
.032 |
.0 |
.003 |
.003 |
.001 |
-- |
.015 |
.01 |
.008 |
.184 |
.007 |
.002 |
-- |
-- |
-- |
-- |
.003 |
.021 |
.001 |
.004 |
.001 |
.006 |
.001 |
.763 |
.005 |
.0 |
.001 |
.002 |
.178 |
.0 |
.001 |
.0 |
.008 |
.017 |
.07 |
.001 |
.0 |
.0 |
.001 |
.029 |
.006 |
.0 |
.044 |
.004 |
.0 |
.39 |
.73 |
.017 |
.002 |
.017 |
.001 |
.349 |
.089 |
.417 |
.0 |
.003 |
.112 |
.002 |
.185 |
.036 |
.009 |
.001 |
.049 |
.021 |
.017 |
.001 |
.016 |
.0 |
.003 |
.003 |
.004 |
.048 |
.0 |
.003 |
.169 |
.001 |
.001 |
.128 |
.0 |
.187 |
.927 |
.047 |
.003 |
.05 |
.001 |
.0 |
.036 |
.067 |
.001 |
.0 |
.001 |
.0 |
.0 |
.777 |
.105 |
.168 |
.001 |
.015 |
.007 |
.005 |
.029 |
.294 |
.1 |
.005 |
.007 |
.135 |
.064 |
.009 |
.24 |
.036 |
.585 |
.593 |
.614 |
.014 |
.353 |
.019 |
.763 |
.015 |
.612 |
.005 |
.008 |
.003 |
.201 |
.137 |
.068 |
.29 |
-- |
.981 |
.277 |
-- |
-- |
-- |
.04 |
.012 |
.003 |
.001 |
.001 |
.002 |
.08 |
.0 |
.0 |
.06 |
.002 |
.0 |
.033 |
.414 |
.009 |
.006 |
.007 |
.002 |
.004 |
.19 |
.001 |
.0 |
.0 |
.003 |
.008 |
.015 |
.001 |
.187 |
.002 |
.018 |
.01 |
-- |
.0 |
-- |
-- |
.018 |
.0 |
.041 |
.031 |
.002 |
.036 |
.998 |
.006 |
.516 |
.001 |
.005 |
.011 |
.001 |
.002 |
.0 |
.092 |
.003 |
.0 |
.0 |
.273 |
.257 |
.994 |
.001 |
.0 |
.048 |
.018 |
.0 |
.01 |
.002 |
.001 |
.006 |
.001 |
.013 |
.072 |
.001 |
.002 |
.055 |
.003 |
.056 |
.008 |
.002 |
.046 |
.065 |
.021 |
.048 |
.002 |
.001 |
.035 |
.604 |
.001 |
.0 |
.0 |
.003 |
.13 |
.001 |
.001 |
.884 |
.011 |
.054 |
.0 |
.925 |
.004 |
.048 |
.008 |
.006 |
.022 |
.001 |
.001 |
.068 |
-- |
.047 |
.083 |
.006 |
.212 |
.002 |
.013 |
.003 |
.275 |
.049 |
.038 |
.007 |
.01 |
-- |
.51 |
.258 |
.004 |
.018 |
.255 |
.074 |
.0 |
.02 |
.001 |
.001 |
.001 |
.001 |
.0 |
.0 |
.005 |
.001 |
.034 |
.0 |
.0 |
.004 |
.001 |
.109 |
.001 |
.053 |
.003 |
.0 |
.0 |
.009 |
.001 |
.206 |
.01 |
.006 |
.001 |
.005 |
.0 |
.291 |
.446 |
.002 |
.021 |
.295 |
.062 |
.0 |
.006 |
.013 |
.215 |
.001 |
.015 |
.003 |
.0 |
.022 |
.007 |
.276 |
.511 |
.012 |
.0 |
.012 |
.001 |
.0 |
.24 |
.061 |
.131 |
.337 |
.048 |
.009 |
.037 |
.003 |
.009 |
.0 |
.007 |
.067 |
.001 |
.0 |
.0 |
.002 |
.003 |
.031 |
.001 |
.027 |
.007 |
.671 |
.0 |
.002 |
.016 |
.019 |
.0 |
.003 |
.014 |
.022 |
.022 |
.001 |
.099 |
.006 |
.052 |
.0 |
.0 |
.001 |
.0 |
.003 |
.0 |
.0 |
.0 |
.465 |
.446 |
.999 |
.0 |
.07 |
.003 |
.019 |
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
Pde4b
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
A |
G |
A |
T |
T |
T |
C |
C |
T |
C |
C |
A |
T |
G |
G |
C |
G |
T |
A |
T |
A |
T |
T |
T |
A |
A |
C |
T |
C |
A |
C |
C |
C |
A |
G |
2 |
A |
T |
T |
G |
G |
C |
C |
C |
T |
G |
G |
A |
T |
C |
C |
T |
C |
A |
G |
T |
A |
C |
2 |
G |
A |
A |
T |
2 |
A |
A |
T |
T |
G |
A |
C |
A |
G |
G |
C |
G |
T |
T |
G |
T |
T |
G |
C |
T |
G |
C |
C |
G |
G |
G |
T |
G |
A |
G |
A |
C |
C |
3 |
C |
6 |
G |
A |
G |
A |
C |
T |
T |
A |
G |
G |
G |
G |
A |
G |
T |
G |
C |
14 |
A |
T |
C |
A |
A |
T |
A |
C |
G |
A |
A |
T |
C |
G |
A |
T |
G |
G |
A |
G |
C |
T |
A |
C |
C |
A |
G |
T |
A |
A |
A |
G |
C |
C |
A |
T |
T |
C |
C |
T |
G |
C |
T |
C |
T |
G |
A |
10 |
A |
G |
A |
C |
A |
G |
165 |
C |
A |
T |
A |
A |
A |
C |
G |
G |
A |
C |
A |
C |
C |
G |
T |
G |
G |
G |
A |
G |
7 |
T |
T |
2 |
A |
C |
T |
A |
C |
C |
C |
G |
G |
C |
G |
C |
C |
C |
G |
T |
C |
C |
A |
T |
T |
T |
15 |
G |
A |
C |
T |
A |
G |
A |
A |
C |
C |
T |
A |
C |
G |
G |
T |
T |
C |
G |
G |
T |
C |
G |
G |
G |
T |
G |
T |
C |
A |
4 |
A |
A |
G |
A |
A |
G |
A |
T |
A |
A |
G |
C |
A |
T |
A |
G |
A |
G |
A |
A |
C |
T |
C |
C |
C |
2 |
G |
G |
C |
A |
G |
C |
T |
4 |
G |
A |
T |
C |
A |
A |
T |
C |
C |
T |
T |
2 |
C |
C |
C |
T |
T |
C |
G |
5 |
G |
T |
A |
T |
T |
T |
T |
C |
G |
T |
A |
T |
A |
A |
T |
T |
C |
G |
T |
G |
T |
T |
C |
T |
T |
A |
A |
A |
C |
T |
A |
A |
4 |
3 |
T |
T |
T |
A |
G |
T |
G |
T |
C |
C |
G |
T |
A |
C |
G |
T |
G |
G |
T |
C |
T |
A |
T |
C |
T |
C |
C |
16 |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
G
|
A
|
G
|
G
|
C
|
G
|
C/T
|
C/A
|
T/2
|
C/T
|
C/6
|
2
|
C
|
A
|
T
|
T
|
G/A
|
C
|
G
|
C
|
2
|
G
|
3
|
C
|
G
|
G
|
T
|
C
|
3
|
C
|
T
|
G
|
C/A
|
G
|
A
|
-
|
C
|
C
|
A
|
G/4
|
3
|
G
|
T
|
A
|
A
|
A
|
A
|
G
|
-
|
4
|
-
|
-
|
-
|
A/2
|
A
|
-
|
G
|
A
|
-
|
G/C
|
A/G
|
T
|
C
|
-
|
G
|
G
|
C
|
G
|
A
|
G
|
T
|
G
|
A
|
A
|
T
|
A
|
C
|
A
|
A
|
C
|
-
|
23
|
A
|
G
|
A
|
T
|
T
|
A
|
A
|
A
|
G
|
-
|
G
|
G/A
|
G
|
G
|
T
|
-
|
A
|
6/-
|
A
|
A/G
|
A
|
C
|
T
|
-
|
-
|
G
|
A
|
A
|
C
|
A
|
4
|
A
|
C
|
A
|
C/G
|
-
|
G
|
C
|
C/3
|
T
|
A/T
|
2
|
T
|
T
|
A
|
G
|
G
|
A
|
T
|
G/T
|
G
|
T/A
|
A
|
A
|
G
|
A
|
C/3
|
15
|
A/-
|
A
|
T
|
G
|
T
|
C
|
T
|
G
|
G
|
G/T
|
T
|
G
|
G
|
C
|
C
|
T
|
T
|
T/C
|
A
|
T
|
C
|
G
|
G
|
A
|
2
|
10/-
|
G
|
A
|
T
|
T
|
C
|
G/T
|
-
|
G
|
-
|
A
|
5
|
G
|
G
|
G
|
A
|
A
|
G
|
T
|
-
|
T
|
T
|
A
|
G/-
|
G/A
|
A
|
A
|
G
|
C
|
7/-
|
C
|
C
|
2/-
|
A/-
|
3
|
-
|
G
|
A
|
C/T
|
T
|
A
|
G/T
|
A
|
A
|
G
|
T
|
C/T
|
C
|
A
|
T
|
T
|
2
|
C
|
C
|
C
|
-
|
A
|
G
|
T
|
C
|
G
|
T
|
G
|
G
|
T
|
T
|
C
|
A/G
|
T
|
C
|
A
|
C
|
C
|
T
|
A
|
A
|
C
|
T
|
A
|
C
|
A
|
C
|
2
|
G
|
A
|
G
|
-
|
G
|
G
|
C
|
C
|
G
|
T
|
G
|
A
|
G
|
-
|
A
|
T
|
G
|
-
|
A/-
|
A
|
G
|
A
|
C
|
G
|
C/2
|
A
|
A
|
G
|
T
|
-
|
A
|
A
|
T
|
G
|
C
|
T
|
G
|
4/-
|
G/A
|
G
|
T/2
|
G
|
G
|
G
|
C
|
A
|
G
|
T/2
|
C
|
-
|
A
|
G
|
T
|
3
|
C
|
A
|
T
|
-
|
A
|
C
|
A/3
|
-
|
C
|
C
|
-
|
T
|
A
|
C
|
G
|
A
|
G
|
A/G
|
2
|
A
|
C/A
|
A
|
C
|
C
|
3
|
A
|
-
|
A
|
T/9
|
A/2
|
T
|
C
|
G
|
C
|
C
|
A/G
|
-
|
3/-
|
C
|
T/C
|
C
|
2
|
G/2
|
A
|
G/2
|
T/C
|
C/3
|
C/G
|
G/C
|
C
|
G
|
T
|
A
|
C
|
A
|
A
|
A
|
T
|
C
|
G
|
T/A
|
T
|
C
|
T
|
T
|
16/-
|
5
|
|