|
1.0 |
.045 |
.0 |
.011 |
.0 |
.0 |
.006 |
.001 |
.005 |
.054 |
.0 |
.002 |
.004 |
.0 |
.001 |
.01 |
.003 |
.001 |
.028 |
.0 |
.002 |
.007 |
.021 |
.032 |
.255 |
.03 |
.003 |
.027 |
.15 |
.997 |
.0 |
.002 |
.969 |
.006 |
.363 |
.326 |
.002 |
.048 |
.006 |
.003 |
.002 |
.007 |
.0 |
.002 |
.583 |
.0 |
1.0 |
.009 |
.175 |
.001 |
.001 |
.002 |
.063 |
.003 |
.003 |
.019 |
.002 |
.007 |
-- |
.135 |
.061 |
.007 |
.063 |
.001 |
.007 |
.002 |
.03 |
.0 |
.022 |
.044 |
.042 |
.006 |
.218 |
.005 |
.021 |
.027 |
.031 |
.003 |
.006 |
.003 |
.044 |
.001 |
.07 |
.043 |
.033 |
.019 |
.069 |
.674 |
.012 |
.004 |
.986 |
.0 |
.005 |
.004 |
.049 |
.002 |
.148 |
.046 |
.053 |
.145 |
.02 |
.017 |
.0 |
.006 |
.022 |
.017 |
.007 |
.025 |
.0 |
.017 |
.005 |
.001 |
.0 |
.275 |
.009 |
.005 |
.0 |
.0 |
.0 |
.001 |
.002 |
.013 |
.002 |
.121 |
.255 |
.011 |
.107 |
.0 |
.026 |
.057 |
.001 |
.002 |
.002 |
.004 |
.017 |
.404 |
.003 |
.0 |
.0 |
.008 |
.0 |
.001 |
.005 |
.465 |
.011 |
.019 |
.031 |
.039 |
.055 |
.068 |
.174 |
.176 |
.139 |
.0 |
.001 |
.0 |
.0 |
.0 |
.024 |
.0 |
.003 |
.003 |
.009 |
.037 |
.0 |
.007 |
.0 |
.0 |
.001 |
.0 |
.016 |
.0 |
.0 |
.0 |
.0 |
.0 |
.0 |
.001 |
.009 |
.001 |
.0 |
.003 |
.001 |
.002 |
.0 |
.0 |
.002 |
.0 |
.0 |
.001 |
.01 |
.001 |
.024 |
.0 |
.001 |
.0 |
.009 |
.014 |
1.0 |
.081 |
.078 |
.048 |
.006 |
-- |
.154 |
.002 |
.004 |
.006 |
.002 |
.03 |
.0 |
.002 |
.01 |
.002 |
.675 |
.005 |
.003 |
.013 |
.003 |
.002 |
.001 |
.018 |
.163 |
.008 |
.022 |
.178 |
.001 |
.001 |
.0 |
.099 |
-- |
-- |
-- |
-- |
-- |
.002 |
.002 |
.0 |
.001 |
.013 |
.061 |
.005 |
.0 |
.161 |
.156 |
.194 |
.001 |
.017 |
.0 |
.028 |
.002 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
.134 |
.005 |
.007 |
.0 |
.05 |
.034 |
.015 |
.002 |
.0 |
.007 |
.009 |
-- |
.001 |
.017 |
.225 |
.038 |
.064 |
.133 |
.206 |
.04 |
.026 |
.003 |
-- |
-- |
-- |
.168 |
.199 |
.039 |
.002 |
.027 |
.001 |
.0 |
.031 |
.977 |
.058 |
.003 |
.015 |
.051 |
.007 |
.004 |
.001 |
.002 |
.0 |
.009 |
.037 |
.049 |
.038 |
.005 |
.077 |
.045 |
.049 |
.004 |
.001 |
.014 |
.0 |
.002 |
.0 |
.04 |
.003 |
.0 |
.0 |
.0 |
.0 |
.0 |
.0 |
.0 |
.025 |
.012 |
.435 |
.008 |
.005 |
.001 |
.995 |
.005 |
.003 |
.011 |
.001 |
.0 |
.001 |
.331 |
.002 |
.015 |
.054 |
.005 |
.273 |
.029 |
.0 |
.0 |
.001 |
.0 |
.002 |
.0 |
.0 |
.009 |
.032 |
.021 |
.0 |
.012 |
.012 |
.001 |
1.0 |
.0 |
.004 |
.005 |
.0 |
.001 |
.023 |
.014 |
.0 |
.001 |
.001 |
.002 |
.045 |
.007 |
.0 |
.0 |
.067 |
.16 |
.002 |
.0 |
.007 |
.0 |
.002 |
.001 |
1.0 |
.001 |
.165 |
.001 |
.014 |
.0 |
.001 |
.0 |
.012 |
.01 |
.006 |
.023 |
.004 |
.002 |
.003 |
.603 |
.02 |
.0 |
.271 |
.007 |
.0 |
.0 |
.001 |
.002 |
.002 |
.002 |
.004 |
.241 |
.001 |
.0 |
.028 |
.014 |
.701 |
.002 |
-- |
.497 |
.552 |
.594 |
-- |
-- |
.001 |
.001 |
.577 |
.009 |
.009 |
.0 |
.072 |
.15 |
.157 |
.003 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.001 |
.0 |
.001 |
.004 |
.012 |
.503 |
.001 |
.002 |
.0 |
.0 |
.191 |
.0 |
.003 |
.003 |
.005 |
.003 |
.002 |
.001 |
.0 |
.014 |
.002 |
.061 |
.228 |
.863 |
.387 |
.001 |
.0 |
.001 |
.0 |
.0 |
.001 |
.001 |
.009 |
.444 |
.077 |
.132 |
.233 |
.019 |
.001 |
.003 |
.04 |
.01 |
.0 |
.022 |
.003 |
.01 |
.011 |
.0 |
.001 |
.0 |
.026 |
.149 |
.052 |
.001 |
.01 |
.0 |
.025 |
.021 |
.438 |
.432 |
.998 |
.998 |
.002 |
.03 |
.067 |
.011 |
.001 |
.031 |
.001 |
.009 |
.013 |
.002 |
.0 |
.012 |
.0 |
.2 |
.259 |
.001 |
.0 |
.004 |
.0 |
.001 |
.01 |
.265 |
.005 |
.227 |
.0 |
.003 |
.002 |
.002 |
.0 |
.028 |
.006 |
.014 |
.0 |
.0 |
.003 |
.003 |
.002 |
.001 |
.03 |
.015 |
.002 |
.0 |
-- |
.001 |
.075 |
.034 |
.001 |
.0 |
.021 |
.001 |
.003 |
.006 |
.182 |
.206 |
.003 |
.034 |
.006 |
.001 |
.0 |
.001 |
-- |
-- |
-- |
-- |
.0 |
.001 |
.01 |
.002 |
.006 |
.006 |
.006 |
.002 |
.005 |
.003 |
.0 |
.4 |
.001 |
.012 |
.0 |
.035 |
.003 |
.0 |
.055 |
.001 |
.003 |
.003 |
.002 |
.045 |
.001 |
.007 |
.003 |
.47 |
.001 |
.0 |
.038 |
.018 |
.004 |
.005 |
.007 |
.03 |
.006 |
.029 |
.001 |
.756 |
.001 |
.017 |
.001 |
.0 |
.0 |
.002 |
.007 |
.106 |
.002 |
.0 |
.349 |
.041 |
.125 |
.004 |
.002 |
.081 |
.012 |
.02 |
.001 |
.072 |
.0 |
.26 |
.082 |
.0 |
.011 |
.191 |
-- |
-- |
.0 |
.6 |
.107 |
.042 |
.026 |
.006 |
1.0 |
.025 |
.003 |
.0 |
.206 |
.339 |
.398 |
.003 |
.006 |
.006 |
.001 |
.18 |
.063 |
.001 |
.009 |
.0 |
.002 |
.999 |
1.0 |
.173 |
.001 |
.001 |
.012 |
.429 |
.001 |
.084 |
.005 |
.017 |
.153 |
.192 |
.001 |
.02 |
.006 |
.084 |
.07 |
.395 |
.123 |
.002 |
.001 |
.001 |
.027 |
.009 |
.025 |
.084 |
.048 |
.012 |
.194 |
.062 |
.02 |
.0 |
.0 |
.19 |
.184 |
.012 |
.007 |
.02 |
.029 |
.046 |
.011 |
.007 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.001 |
.003 |
.0 |
.032 |
.003 |
.0 |
.001 |
.001 |
.001 |
.001 |
-- |
.409 |
.301 |
.342 |
.135 |
.003 |
.061 |
.007 |
.028 |
.02 |
.992 |
.0 |
.162 |
-- |
.208 |
.014 |
.002 |
-- |
.002 |
.001 |
.0 |
.01 |
.026 |
.59 |
.002 |
.008 |
.641 |
.0 |
.001 |
.048 |
.004 |
.027 |
.089 |
.003 |
.034 |
-- |
.033 |
-- |
-- |
-- |
.075 |
.017 |
.01 |
.175 |
.0 |
.001 |
.024 |
.875 |
.002 |
-- |
.006 |
.013 |
.03 |
.096 |
.002 |
.019 |
.026 |
.0 |
.005 |
.028 |
.013 |
.694 |
.095 |
-- |
-- |
.069 |
.173 |
.112 |
.036 |
.055 |
.018 |
-- |
-- |
.095 |
.194 |
.144 |
.153 |
.001 |
.006 |
.001 |
1.0 |
.0 |
.002 |
.289 |
.258 |
.322 |
.001 |
.001 |
.002 |
.0 |
.0 |
.048 |
.064 |
.004 |
.002 |
.001 |
.0 |
.004 |
.004 |
.001 |
.038 |
.09 |
.002 |
.001 |
.0 |
.73 |
.723 |
.001 |
.0 |
.003 |
.001 |
.017 |
.003 |
.997 |
.003 |
.002 |
.659 |
.002 |
.0 |
.0 |
.012 |
.0 |
.0 |
.003 |
.017 |
.012 |
.026 |
.09 |
.0 |
.003 |
.0 |
.001 |
.001 |
.019 |
.021 |
.86 |
.004 |
.003 |
.0 |
.001 |
.347 |
.997 |
.001 |
.007 |
.05 |
.003 |
.003 |
.004 |
.001 |
.021 |
-- |
-- |
.011 |
.015 |
.0 |
.0 |
.005 |
.073 |
.0 |
.214 |
.001 |
.01 |
.014 |
.004 |
.162 |
.015 |
.002 |
.01 |
.019 |
-- |
-- |
-- |
-- |
-- |
-- |
.006 |
-- |
-- |
-- |
-- |
.106 |
.236 |
.002 |
.006 |
.132 |
.003 |
.277 |
.228 |
.028 |
.036 |
.243 |
.156 |
.048 |
.288 |
.003 |
.008 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.991 |
1.0 |
.99 |
.921 |
.521 |
.003 |
.001 |
.002 |
.0 |
.0 |
.004 |
.009 |
.001 |
.0 |
.0 |
.001 |
.004 |
.012 |
.248 |
.004 |
.0 |
.036 |
.021 |
.034 |
.068 |
.083 |
.01 |
.001 |
.008 |
.0 |
.015 |
.006 |
.049 |
.008 |
.006 |
-- |
.096 |
.002 |
.007 |
.004 |
.084 |
-- |
-- |
.036 |
.203 |
.031 |
.017 |
.579 |
.565 |
.048 |
.179 |
.144 |
.018 |
.001 |
.13 |
.015 |
|
Pcsk5
|
Pcsk5
|
Pcsk5
|
Pcsk5
|
Pcsk5
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Pcsk5
|
Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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Pcsk5
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--
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|
|
|
T
|
C
|
A
|
T
|
A
|
C
|
G
|
5
|
G
|
3
|
C
|
G
|
A
|
C/15
|
-
|
A
|
A
|
G
|
T
|
C
|
5
|
T
|
C
|
T
|
2
|
A
|
7
|
T
|
G
|
6/-
|
T
|
A
|
-
|
T/10
|
-
|
G
|
C
|
T
|
G
|
G
|
T
|
G
|
A
|
C
|
A
|
G
|
G
|
A
|
-
|
G
|
G
|
42
|
-
|
2
|
A
|
A
|
C
|
G
|
T
|
C
|
-
|
6
|
T
|
C
|
G
|
A
|
G
|
G
|
G
|
2
|
T
|
C
|
-
|
C
|
T
|
G
|
-
|
A
|
C
|
C
|
T/3
|
T
|
C/3
|
T/3
|
3
|
-
|
-
|
G
|
G
|
T
|
T
|
-
|
C
|
T
|
T
|
G
|
C
|
C
|
C
|
T
|
T
|
T
|
-
|
-
|
A
|
T
|
A
|
C
|
-
|
T
|
A
|
C
|
C
|
A
|
C
|
T
|
T
|
A
|
G
|
C
|
T
|
C
|
A
|
G
|
C
|
A
|
G
|
11
|
A
|
A
|
A
|
G
|
2
|
-
|
C
|
G
|
A
|
T
|
T
|
T
|
C
|
A
|
A
|
2
|
2
|
4
|
T
|
G
|
4
|
T
|
4
|
2
|
12
|
G
|
-
|
C
|
T
|
G
|
A
|
A
|
-
|
T
|
G
|
T
|
G
|
-
|
C
|
T
|
C
|
A
|
G
|
T
|
2
|
C
|
2
|
2
|
T
|
2
|
G
|
5
|
-
|
2
|
2
|
2
|
2
|
2
|
3
|
2
|
2
|
2
|
2
|
T
|
2
|
G
|
C
|
4
|
A
|
G
|
C
|
T
|
G
|
5
|
3
|
T
|
-
|
C
|
G
|
C
|
G
|
G
|
T
|
-
|
G
|
A
|
5
|
T
|
A
|
T
|
T
|
A
|
G
|
C
|
T/7
|
C
|
A
|
C
|
G
|
A/2
|
T
|
C
|
-
|
C
|
2
|
-
|
G
|
T
|
G
|
C
|
C
|
T
|
G
|
C
|
C
|
A
|
A
|
A
|
C
|
G
|
T
|
C
|
C
|
G
|
G
|
C
|
A
|
-
|
A
|
-
|
-
|
-
|
2
|
C
|
C
|
A
|
G
|
-
|
A
|
T
|
A
|
G
|
G
|
A
|
C
|
-
|
C
|
G
|
A
|
A
|
2
|
T
|
C
|
3
|
10
|
123
|
-
|
-
|
C
|
T
|
G
|
G
|
3
|
A/5
|
2/-
|
A
|
G
|
A
|
C
|
C
|
-
|
C
|
-
|
A
|
-
|
T
|
-
|
A
|
G
|
-
|
C
|
-
|
G
|
A
|
A
|
G
|
A
|
G
|
T
|
C
|
A
|
C
|
A
|
A
|
C
|
G
|
-
|
-
|
-
|
-
|
T
|
C
|
T
|
C
|
A
|
2
|
A
|
G
|
C
|
A
|
T
|
T
|
C
|
G
|
A
|
T
|
T
|
13
|
T
|
T
|
A
|
G
|
C
|
T
|
G
|
T
|
T
|
T
|
A
|
C
|
A
|
T
|
A
|
A
|
T
|
T
|
3
|
9
|
T
|
C
|
C
|
-
|
G
|
39
|
2
|
G
|
68
|
A
|
T
|
T
|
A
|
C
|
C
|
C
|
3
|
9
|
2
|
G
|
T
|
A
|
G
|
T
|
A
|
A
|
2
|
A
|
3
|
G
|
A
|
C
|
-
|
2
|
C
|
2
|
A
|
-
|
A
|
G
|
C
|
T
|
2
|
A
|
G
|
C
|
C
|
G/11
|
G/44
|
G
|
-
|
2
|
T
|
C
|
G
|
6
|
G
|
T
|
A
|
12/-
|
10/-
|
8/-
|
2/-
|
2/-
|
A
|
A
|
-
|
-
|
A/-
|
A
|
A
|
9
|
4
|
A
|
T
|
C
|
T
|
A
|
4
|
A
|
A
|
2
|
G
|
C
|
C
|
C
|
C
|
C
|
A
|
G
|
T
|
G
|
C
|
A
|
T
|
C
|
-
|
A
|
G
|
C
|
7
|
A
|
A
|
G
|
C
|
A
|
A
|
T
|
G
|
A
|
C
|
A
|
C
|
G
|
C
|
3/GT
|
T
|
G
|
-
|
-
|
-
|
A
|
T
|
C
|
A
|
-
|
G
|
T
|
C
|
T
|
A
|
A
|
T
|
T
|
G
|
T
|
15/AC
|
A
|
G
|
G
|
C
|
3
|
-
|
A
|
T/7
|
-
|
G
|
2/-
|
A
|
G
|
C
|
A
|
A
|
T
|
G
|
A
|
T
|
C
|
C
|
G
|
G
|
C
|
G
|
G
|
A
|
A
|
A
|
C
|
-
|
T
|
G
|
T
|
A
|
2
|
5
|
-
|
G
|
C
|
G
|
4/-
|
-
|
C
|
A
|
2
|
A
|
T
|
T
|
A
|
-
|
-
|
21
|
G
|
C
|
T
|
T
|
-
|
-
|
3
|
90/-
|
4
|
T
|
G
|
C
|
-
|
A
|
3
|
8/-
|
T
|
C
|
C
|
A
|
T
|
-
|
-
|
A
|
G
|
A
|
G
|
4
|
G
|
-
|
A
|
-
|
A
|
A
|
G
|
C
|
C
|
T
|
A
|
G
|
A
|
3
|
T
|
T
|
5
|
A
|
G
|
-
|
-
|
3
|
G
|
C
|
C
|
T
|
3
|
G
|
C
|
T
|
G
|
C
|
C
|
A
|
T
|
G
|
G
|
A
|
A
|
C
|
T
|
A
|
T
|
-
|
C
|
A
|
A
|
C
|
A
|
G
|
C
|
T
|
G
|
G
|
G
|
-
|
C
|
-
|
-
|
-
|
A
|
G
|
T
|
G
|
C
|
2
|
-
|
10/-
|
8/-
|
2
|
2
|
-
|
A
|
-
|
-
|
3
|
T
|
A
|
C
|
2
|
G
|
-
|
4
|
C
|
A
|
T
|
-
|
A
|
T
|
G
|
A
|
-
|
T
|
A
|
C
|
T
|
G
|
A
|
-
|
C
|
A
|
T
|
T
|
-
|
G
|
5
|
3
|
A
|
A
|
21
|
A
|
G
|
C
|
2
|
4
|
A
|
C
|
G
|
T
|
C
|
G
|
A
|
-
|
-
|
G
|
A
|
A
|
A
|
-
|
T
|
C
|
A
|
G
|
T
|
A
|
T
|
G
|
C
|
C
|
T
|
A
|
C
|
G
|
-
|
G
|
C
|
T
|
A
|
2
|
A
|
A
|
-
|
2
|
T
|
C
|
A
|
A
|
A
|
G
|
G
|
2
|
T
|
G
|
G
|
A
|
2
|
G
|
C
|
-
|
C
|
7
|
A
|
C
|
C
|
9
|
A
|
-
|
-
|
A
|
2
|
C
|
G
|
2
|
A
|
A
|
G/-
|
-
|
C
|
G
|
T
|
T
|
T
|
A
|
T
|
A
|
G
|
-
|
T
|
2
|
C
|
A
|
2
|
2
|
C
|
C/2
|
-
|
-
|
A
|
G
|
C
|
G
|
G
|
12/-
|
A
|
T
|
2
|
C
|
2
|
G
|
11
|
T
|
A
|
C
|
2
|
T
|
C
|
C
|
G
|
A
|
T
|
C
|
6/-
|
4/-
|
C
|
A
|
T
|
A
|
G
|
C
|
G
|
12/-
|
10/-
|
2/-
|
-
|
T
|
T
|
G
|
T
|
T
|
T
|
-
|
A
|
A
|
C
|
A
|
G
|
G
|
-
|
A
|
G
|
A
|
T
|
G
|
C
|
-
|
C
|
C
|
C
|
G
|
T
|
C
|
2
|
G
|
A
|
A
|
T
|
A
|
G
|
G
|
A
|
C
|
-
|
G
|
G
|
G
|
T
|
A
|
A
|
A/-
|
G
|
A
|
-
|
A
|
T
|
C
|
T
|
T
|
2
|
T
|
G
|
G
|
C
|
15/13
|
G
|
A
|
G
|
T
|
T
|
A
|
A
|
T
|
A
|
A
|
G
|
T
|
G
|
G
|
A
|
-
|
-
|
C
|
G
|
2
|
G
|
A
|
A
|
T
|
T
|
G
|
A
|
A
|
C
|
A
|
G
|
2
|
C
|
A
|
A
|
T
|
A
|
T
|
-
|
G
|
-
|
A
|
-
|
A
|
A
|
-
|
-
|
T
|
C/-
|
11/-
|
C
|
2
|
C
|
3
|
A
|
C
|
-
|
T/2
|
2
|
-
|
-
|
C
|
C
|
A
|
3
|
T
|
A
|
A
|
A
|
T
|
A
|
G
|
G
|
C
|
C
|
T
|
G
|
T
|
C
|
G
|
2
|
C
|
A
|
C
|
T
|
-
|
4/-
|
-
|
A
|
6/-
|
4/-
|
C/2
|
T/-
|
T
|
-
|
A
|
T
|
T
|
7/9
|
G
|
3/GA
|
G
|
2
|
T
|
-
|
2
|
A/11
|
5
|
A
|
4
|
C
|
G
|
9
|
-
|
|