|
.0 |
.001 |
.0 |
.011 |
.041 |
.0 |
.0 |
.001 |
.064 |
.707 |
.009 |
.001 |
.0 |
.027 |
.067 |
.006 |
.008 |
.001 |
.013 |
.001 |
.0 |
.032 |
.001 |
-- |
.019 |
.06 |
.05 |
.66 |
.004 |
.124 |
.054 |
.14 |
-- |
-- |
.074 |
.001 |
.017 |
.061 |
-- |
.057 |
-- |
-- |
-- |
-- |
.123 |
.115 |
.17 |
-- |
.006 |
.001 |
.15 |
.01 |
.097 |
.022 |
.033 |
.018 |
.002 |
.0 |
.0 |
.019 |
.05 |
.016 |
.0 |
.007 |
.0 |
.056 |
-- |
-- |
.027 |
-- |
-- |
.015 |
.012 |
.013 |
.01 |
.017 |
.034 |
.004 |
-- |
.002 |
.068 |
.188 |
.0 |
.012 |
.988 |
.158 |
.304 |
.254 |
.255 |
.254 |
.229 |
.015 |
.123 |
.0 |
.106 |
.0 |
.0 |
.0 |
.0 |
.0 |
.003 |
.001 |
.037 |
.016 |
.959 |
.0 |
.042 |
.001 |
.001 |
.015 |
.032 |
.332 |
.005 |
.013 |
-- |
-- |
-- |
.13 |
-- |
.01 |
-- |
.0 |
.015 |
.002 |
.0 |
.998 |
.0 |
.002 |
.002 |
.02 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.762 |
.008 |
.001 |
.0 |
.0 |
.123 |
.401 |
-- |
-- |
.001 |
.735 |
.0 |
.0 |
.001 |
.001 |
.001 |
.011 |
-- |
-- |
.062 |
.025 |
.009 |
.009 |
.35 |
.367 |
.381 |
.002 |
.0 |
.008 |
.006 |
.002 |
.0 |
.023 |
.169 |
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
A |
C |
A |
A |
A |
C |
T |
T |
C |
C |
4 |
C |
C |
A |
C |
C |
G |
A |
T |
G |
A |
C |
A |
A |
A |
A |
T |
C |
2 |
A |
G |
A |
T |
T |
C |
C |
C |
A |
C |
A |
G |
G |
G |
C |
G |
A |
G |
C |
A |
2 |
A |
G |
G |
G |
A |
A |
T |
C |
C |
G |
G |
A |
A |
C |
C |
G |
6 |
G |
T |
5 |
A |
G |
A |
A |
T |
3 |
A |
C |
T |
T |
G |
C |
A |
A |
G |
C |
C |
C |
C |
A |
G |
T |
A |
T |
A |
A |
C |
C |
C |
G |
G |
G |
A |
T |
A |
T |
T |
A |
A |
G |
T |
T |
A |
A |
G |
C |
A |
T |
A |
G |
A |
G |
A |
A |
C |
C |
G |
T |
T |
T |
C |
T |
C |
C |
T |
C |
A |
A |
T |
T |
C |
T |
A |
G |
T |
C |
C |
A |
C |
C |
T |
A |
T |
T |
T |
T |
A |
3 |
C |
C |
C |
T |
T |
G |
A |
A |
T |
G |
C |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C
|
2
|
-
|
T
|
G
|
T
|
3
|
C
|
C
|
T
|
T
|
-
|
T
|
T
|
G
|
A
|
G
|
C
|
G
|
-
|
-
|
G
|
T
|
T
|
G
|
G
|
-
|
C
|
A
|
-
|
G
|
A
|
C
|
-
|
C
|
-
|
A
|
T
|
G
|
C/A
|
G
|
G/C
|
G/C
|
C
|
2
|
2
|
2
|
G/A
|
T
|
G
|
-
|
G
|
T
|
A
|
A
|
C
|
G
|
C
|
T
|
G
|
A
|
T
|
G
|
C
|
T
|
G
|
2
|
-
|
T
|
A
|
-
|
G
|
T
|
G
|
G
|
C
|
3/-
|
G
|
T
|
3
|
C
|
C
|
3
|
G
|
C
|
A
|
C/G
|
C/G
|
C/G
|
C/G
|
T
|
A
|
C
|
G
|
C
|
G
|
T
|
T
|
A
|
-
|
A
|
A
|
C
|
G
|
C
|
T
|
C
|
C
|
G
|
T
|
T
|
2
|
C
|
G
|
2
|
4
|
T
|
G
|
C
|
G
|
G/2
|
G
|
T
|
G
|
G
|
T
|
T
|
T
|
C
|
G
|
T/3
|
C/2
|
T/C
|
C/4
|
C/T
|
T/2
|
T
|
C
|
T
|
C
|
C
|
T
|
5
|
G
|
T
|
C
|
T
|
T
|
G
|
-
|
T
|
C
|
C
|
C
|
T/C
|
C
|
G
|
T
|
-
|
G
|
G
|
A
|
G
|
3
|
A
|
G
|
G
|
-
|
4
|
T
|
5
|
|