|
.212 |
.103 |
.03 |
.748 |
-- |
-- |
.025 |
.004 |
.001 |
.024 |
.0 |
.003 |
.001 |
.001 |
.047 |
.0 |
.004 |
.988 |
.019 |
.033 |
.084 |
.005 |
.003 |
-- |
-- |
-- |
-- |
.97 |
.97 |
.242 |
.005 |
.015 |
.514 |
.065 |
.271 |
.001 |
.001 |
.001 |
.025 |
.011 |
.235 |
.028 |
.001 |
.007 |
.005 |
.008 |
.018 |
.784 |
.002 |
.062 |
.102 |
.086 |
.062 |
.051 |
.0 |
.001 |
.285 |
.385 |
.006 |
.001 |
.013 |
.977 |
.027 |
.0 |
.015 |
.162 |
.467 |
.309 |
.31 |
.046 |
.026 |
.056 |
.001 |
.034 |
.521 |
.002 |
.004 |
.021 |
.001 |
.01 |
.034 |
.066 |
.005 |
.021 |
.003 |
.031 |
.065 |
.045 |
.001 |
.0 |
.0 |
.009 |
.001 |
.033 |
.023 |
.001 |
.002 |
.131 |
.006 |
.07 |
.001 |
.009 |
.0 |
-- |
.187 |
.014 |
.001 |
-- |
.853 |
.101 |
.001 |
.187 |
.659 |
.176 |
.017 |
.027 |
.046 |
.174 |
.183 |
.0 |
.003 |
.037 |
.0 |
.003 |
.0 |
.0 |
.0 |
.0 |
.0 |
.0 |
.001 |
.007 |
.023 |
.609 |
.016 |
.018 |
.021 |
.13 |
.002 |
.002 |
.185 |
.335 |
.001 |
.005 |
.044 |
.0 |
.0 |
.003 |
.032 |
.001 |
.0 |
.0 |
.002 |
.172 |
.012 |
.075 |
.411 |
.062 |
.115 |
.455 |
.541 |
.608 |
.0 |
.042 |
.005 |
.003 |
.202 |
.002 |
.002 |
.001 |
.297 |
.799 |
.735 |
.676 |
.621 |
.694 |
.0 |
.003 |
.005 |
.022 |
.004 |
.002 |
.013 |
.209 |
.248 |
.091 |
.013 |
.002 |
.069 |
.0 |
.475 |
.004 |
.9 |
.989 |
.065 |
.003 |
.0 |
.001 |
.064 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.065 |
.0 |
.116 |
.001 |
.005 |
.204 |
.009 |
.001 |
.001 |
.001 |
.017 |
.002 |
.019 |
.003 |
.049 |
.08 |
.315 |
.01 |
.027 |
.001 |
.003 |
.001 |
.071 |
.004 |
.001 |
.3 |
.436 |
.012 |
.211 |
.237 |
.008 |
.001 |
.002 |
.0 |
.027 |
.012 |
-- |
.08 |
.044 |
.102 |
.001 |
.0 |
.043 |
.014 |
.001 |
.006 |
.0 |
.0 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
.044 |
.001 |
.003 |
.001 |
.001 |
.019 |
.001 |
.001 |
.003 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.029 |
.177 |
-- |
-- |
-- |
.084 |
.0 |
.013 |
.015 |
.04 |
.005 |
.001 |
.0 |
-- |
-- |
.135 |
.002 |
.0 |
.007 |
.008 |
.001 |
.0 |
.0 |
-- |
-- |
-- |
.021 |
.322 |
.001 |
.073 |
-- |
.006 |
.001 |
.188 |
.001 |
.075 |
.068 |
.013 |
.078 |
-- |
.094 |
.045 |
.001 |
.021 |
.0 |
.001 |
.003 |
.0 |
.021 |
.113 |
1.0 |
.002 |
.003 |
.01 |
.007 |
.581 |
.008 |
.957 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.018 |
.009 |
.009 |
.008 |
.052 |
.059 |
.027 |
-- |
.01 |
.017 |
.013 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.003 |
.001 |
.003 |
.003 |
.039 |
.001 |
.08 |
.0 |
.011 |
.006 |
.033 |
.005 |
.118 |
.11 |
.004 |
.007 |
.063 |
.004 |
.022 |
.011 |
.084 |
.001 |
.004 |
.002 |
.009 |
.588 |
.003 |
.003 |
.179 |
.0 |
.274 |
.001 |
.0 |
.0 |
.0 |
.005 |
.025 |
.002 |
.115 |
.085 |
.008 |
.006 |
.01 |
.0 |
.016 |
.095 |
.095 |
.097 |
.03 |
-- |
.022 |
.281 |
.08 |
.373 |
.034 |
.021 |
.065 |
.064 |
.009 |
.004 |
.265 |
.232 |
.004 |
.036 |
.031 |
.001 |
.002 |
.001 |
.001 |
.003 |
.0 |
.003 |
.0 |
.02 |
.0 |
.045 |
.05 |
.639 |
.02 |
-- |
.012 |
.065 |
.046 |
.024 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.003 |
.002 |
.004 |
.002 |
.054 |
.064 |
.001 |
.001 |
.0 |
.012 |
.445 |
.35 |
.041 |
.003 |
.001 |
.001 |
.002 |
.019 |
.251 |
.244 |
.029 |
.004 |
.068 |
.439 |
-- |
-- |
-- |
.44 |
.023 |
.019 |
.099 |
.021 |
.052 |
.001 |
.062 |
.0 |
.164 |
.004 |
.001 |
.004 |
.005 |
.015 |
.012 |
.07 |
.427 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
.043 |
.062 |
.009 |
.01 |
.074 |
.044 |
.001 |
.999 |
.001 |
.013 |
.0 |
.319 |
.004 |
.001 |
.008 |
.001 |
.003 |
.072 |
.001 |
.001 |
.016 |
.088 |
.011 |
.0 |
.0 |
.001 |
.001 |
.008 |
.004 |
.004 |
.001 |
-- |
.077 |
.417 |
.252 |
.508 |
.072 |
.0 |
.001 |
.011 |
.315 |
.639 |
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
Cdc14a
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
|
--
|
--
|
--
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--
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--
|
--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
G |
C |
A |
C |
T |
G |
2 |
C |
T |
A |
4 |
C |
A |
G |
G |
C |
G |
G |
T |
C |
C |
T |
G |
T |
2 |
T |
10 |
8 |
3 |
G |
C |
G |
A |
G |
A |
2 |
C |
2 |
C |
C |
T |
A |
C |
T |
T |
T |
2 |
A |
G |
G |
G |
A |
2 |
G |
3 |
C |
T |
T |
T |
A |
G |
C |
T |
G |
2 |
G |
A |
T |
A |
G |
T |
G |
A |
T |
T |
C |
A |
G |
G |
T |
G |
T |
T |
T |
C |
A |
G |
C |
T |
G |
C |
A |
T |
2 |
C |
T |
A |
T |
C |
C |
T |
A |
A |
G |
2 |
T |
4 |
4 |
T |
C |
2 |
A |
G |
T |
C |
G |
G |
A |
A |
C |
C |
G |
C |
C |
C |
2 |
G |
G |
C |
A |
T |
T |
T |
C |
A |
G |
G |
C |
C |
A |
A |
T |
T |
A |
T |
G |
T |
C |
C |
G |
G |
T |
A |
C |
A |
2 |
C |
T |
T |
T |
2 |
T |
C |
G |
G |
T |
A |
T |
G |
C |
G |
G |
G |
G |
G |
C |
T |
G |
A |
G |
2 |
T |
T |
G |
A |
A |
A |
C |
C |
A |
A |
G |
A |
G |
2 |
C |
T |
G |
G |
A |
A |
A |
T |
C |
C |
A |
A |
C |
C |
A |
A |
C |
3 |
2 |
A |
G |
G |
A |
C |
4 |
A |
T |
G |
G |
G |
G |
T |
11 |
14 |
G |
G |
A |
A |
G |
C |
C |
C |
G |
G |
A |
C |
3 |
C |
G |
A |
C |
T |
G |
A |
G |
A |
T |
T |
C |
T |
C |
8 |
A |
A |
4 |
A |
A |
A |
4 |
4 |
10 |
5 |
A |
T |
T |
T |
6 |
5 |
G |
G |
2 |
A |
C |
C |
G |
G |
C |
G |
G |
A |
G |
2 |
G |
A |
C |
T |
C |
C |
C |
A |
C |
G |
C |
C |
G |
C |
A |
2 |
A |
C |
A |
T |
C |
2 |
C |
4 |
C |
G |
C |
T |
T |
A |
T |
T |
G |
C |
A |
T |
A |
A |
A |
T |
A |
G |
A |
A |
C |
T |
C |
T |
A |
A |
C |
T |
G |
G |
A |
G |
G |
T |
4 |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
A |
G |
2 |
C |
G |
T |
T |
C |
T |
G |
C |
G |
G |
T |
A |
T |
C |
C |
2 |
2 |
4 |
T |
T |
3 |
A |
T |
C |
T |
A |
C |
T |
A |
G |
C |
G |
G |
C |
G |
8 |
7 |
4 |
G |
G |
G |
A |
C |
G |
G |
A |
T |
T |
T |
T |
C |
A |
C |
T |
G |
A |
C |
T |
T |
6 |
G |
T |
C |
A |
A |
C |
A |
G |
G |
C |
A |
A |
A |
G |
C |
T |
C |
T |
T |
C |
G |
4 |
10 |
2 |
C |
C |
4 |
A |
G |
A |
A |
G |
C |
A |
G |
C |
T |
C |
5 |
G |
C |
T |
C |
T |
C |
A |
C |
C |
A |
A |
T |
C |
A |
T |
C |
G |
T |
T |
A |
T |
T |
G |
G |
A |
T |
2 |
G |
C |
G |
A |
2 |
A |
4 |
A |
A |
G |
T |
G |
6 |
T |
C |
A |
6 |
T |
A |
T |
6 |
4 |
C |
T |
7 |
G |
G |
A |
T |
C |
T |
A |
C |
G |
C |
A |
T |
C |
A |
G |
9 |
G |
8 |
T |
G |
2 |
C |
T |
2 |
2 |
2 |
4 |
2 |
4 |
C |
G |
C |
T |
T |
C |
A |
A |
G |
C |
C |
T |
T |
G |
G |
G |
T |
G |
G |
T |
C |
C |
A |
A |
A |
G |
C |
A |
G |
A |
4 |
2 |
2 |
C |
G |
A |
T |
A |
T |
C |
C |
T |
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5
|
-
|
C/5
|
3
|
G
|
A
|
2
|
-
|
T
|
C
|
G
|
4/-
|
3
|
G
|
A
|
A
|
A
|
A
|
GT/3
|
T/-
|
T
|
T
|
2
|
5
|
T/A
|
-
|
7
|
10/-
|
8/-
|
-
|
A
|
A
|
2
|
G
|
C
|
2
|
2/-
|
3
|
-
|
?
|
2
|
C
|
G
|
T
|
5
|
G
|
G
|
-
|
2
|
3
|
T/GT
|
A
|
2
|
-
|
3/GA
|
-
|
T
|
T/2
|
C
|
G
|
G
|
A
|
T
|
C
|
A
|
2/-
|
A
|
-
|
C
|
G
|
A
|
C
|
-
|
C
|
C
|
C
|
T
|
A/5
|
2
|
A
|
C
|
A
|
G
|
G
|
C
|
G
|
G
|
A
|
T
|
G
|
A
|
T
|
G
|
TG/6
|
-
|
-/CT
|
T/A
|
A/-
|
C
|
2
|
3/4
|
G
|
G
|
A/3
|
T
|
-
|
C
|
-
|
-
|
C
|
2
|
-
|
G
|
A
|
C
|
4
|
A
|
7
|
A/G
|
G
|
T
|
T
|
T
|
T
|
T
|
T
|
-
|
A
|
A
|
T
|
G
|
-
|
G
|
C
|
T
|
G
|
2
|
A
|
A
|
T
|
G
|
G
|
C
|
C
|
G
|
2
|
2
|
G
|
T
|
T
|
C
|
T
|
C
|
-
|
T
|
2
|
-
|
T
|
5
|
T/3
|
T/C
|
2/-
|
C
|
T
|
5
|
C
|
G
|
G
|
C
|
A
|
T
|
A
|
G/A
|
G/A
|
G/A
|
2
|
T
|
A
|
A
|
G
|
2
|
2/-
|
-
|
C
|
T
|
C
|
G
|
G
|
T
|
T
|
G
|
2
|
T
|
G
|
C
|
-
|
T
|
C
|
T
|
G/5
|
G
|
A/G
|
2
|
T/2
|
T
|
T
|
G
|
G
|
T
|
T
|
T
|
G
|
T
|
-
|
2/-
|
4
|
T
|
T
|
T
|
A
|
-
|
A/C
|
C
|
C
|
A/5
|
T
|
A
|
C
|
-
|
14/-
|
A
|
T
|
C
|
T
|
A
|
T
|
A
|
T
|
A
|
C
|
G
|
T
|
-
|
T
|
A
|
G
|
G
|
C
|
A
|
G
|
A
|
G
|
C
|
3
|
5
|
T/C
|
-/5
|
8/-
|
A/2
|
2
|
-
|
A/2
|
A/-
|
T/AT
|
4/-
|
-
|
10/-
|
-
|
A/G
|
7
|
T/5
|
C
|
-
|
-
|
3/5
|
G/-
|
2/-
|
3
|
3
|
5
|
G/3
|
G/C
|
C/A
|
G/-
|
G/3
|
A/3
|
G/C
|
2/-
|
C
|
2
|
T
|
T/C
|
C/T
|
C/T
|
T
|
G
|
T
|
6
|
T
|
-
|
A
|
T
|
-
|
-
|
-
|
T
|
G
|
C
|
T
|
2/-
|
C/-
|
-
|
T
|
T
|
T
|
A
|
C
|
G
|
A
|
A
|
A
|
G
|
T
|
-
|
G
|
G
|
G
|
C
|
G
|
A
|
G
|
T
|
T
|
C
|
G
|
G
|
2
|
T
|
T
|
C
|
T
|
A
|
G
|
2
|
4
|
C
|
4/-
|
2
|
-/AC
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
2
|
-/AT
|
2
|
4
|
4
|
G/T
|
2/-
|
C/T
|
G/-
|
T/C
|
T/C
|
A
|
C
|
T
|
T
|
C
|
C
|
2
|
-
|
2
|
2
|
2
|
-
|
-
|
-
|
-
|
T/-
|
3/-
|
9
|
T/-
|
T
|
-
|
G
|
T
|
C
|
T
|
A
|
3
|
C
|
T
|
G
|
G/2
|
-
|
-
|
-
|
A
|
2
|
A
|
-
|
T
|
T
|
A
|
2
|
C
|
-
|
C
|
C
|
T
|
C
|
T
|
-
|
A
|
G
|
-
|
C
|
C
|
-
|
A
|
T/3
|
T
|
G
|
G
|
A
|
G
|
A
|
A
|
A
|
G
|
C
|
G
|
A
|
T
|
C
|
T
|
G
|
C
|
T
|
A
|
-
|
10/-
|
-
|
3
|
C/G
|
-
|
G
|
T
|
5
|
G
|
C
|
T
|
G
|
C
|
G
|
G
|
T
|
-
|
A
|
A
|
C
|
G
|
A
|
G
|
G
|
G
|
G
|
8
|
G
|
2
|
G
|
G
|
C
|
T
|
A
|
G
|
A
|
4
|
3
|
2
|
G/A
|
G/T
|
A/G
|
T/C
|
-
|
-
|
C/A
|
A
|
G
|
2/-
|
A/-
|
4/-
|
A/-
|
G
|
T
|
C
|
A
|
-
|
C
|
G
|
G
|
-
|
T/C
|
A/G
|
C
|
6/-
|
-
|
T
|
T/-
|
7/-
|
G/3
|
A
|
G
|
C
|
T
|
C
|
C
|
-
|
T
|
C/-
|
G
|
C
|
G
|
G
|
C
|
-
|
C
|
8/-
|
C
|
A
|
-
|
3
|
C
|
2/-
|
-
|
-
|
-
|
2/-
|
4/-
|
T
|
T
|
T
|
A
|
C
|
T
|
G
|
G
|
A
|
A
|
T
|
-
|
C
|
C
|
A
|
C
|
G
|
A
|
T
|
A
|
3
|
T
|
G
|
G
|
G
|
A
|
G
|
C
|
A
|
2
|
-
|
-
|
-
|
T
|
A
|
G
|
A
|
G
|
C
|
G
|
T
|
2
|
|