|
.001 |
.106 |
.038 |
.001 |
.004 |
.001 |
.073 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.897 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.001 |
.013 |
.717 |
.009 |
-- |
.0 |
.104 |
.026 |
.005 |
.0 |
.009 |
.001 |
.015 |
.031 |
.089 |
.04 |
.0 |
.003 |
.001 |
.004 |
.022 |
.003 |
.004 |
.29 |
.003 |
.123 |
.001 |
.02 |
.777 |
.011 |
.019 |
.022 |
.002 |
.028 |
.02 |
.261 |
-- |
-- |
-- |
.009 |
.001 |
-- |
-- |
-- |
.007 |
.001 |
.001 |
.046 |
.261 |
.001 |
.002 |
.023 |
.001 |
.074 |
.022 |
.005 |
.0 |
.032 |
.005 |
.002 |
.036 |
.024 |
.338 |
.234 |
.007 |
.012 |
.947 |
.061 |
.039 |
.0 |
.013 |
-- |
-- |
.005 |
.203 |
.377 |
.019 |
.009 |
.022 |
.048 |
.531 |
.004 |
.702 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.288 |
.03 |
.599 |
.048 |
.075 |
.0 |
.003 |
.004 |
.001 |
.0 |
.002 |
.001 |
.005 |
.0 |
.0 |
.001 |
.0 |
.0 |
.001 |
.011 |
.001 |
.006 |
.989 |
.855 |
.997 |
.027 |
.001 |
.0 |
.057 |
.005 |
.002 |
.028 |
.193 |
.124 |
.176 |
.272 |
.002 |
.008 |
.031 |
.014 |
.006 |
.131 |
.004 |
.096 |
.04 |
.048 |
.015 |
.023 |
.002 |
.003 |
.0 |
.013 |
.007 |
.005 |
.011 |
.014 |
.133 |
.079 |
.011 |
.034 |
.032 |
.016 |
.005 |
.001 |
.004 |
.013 |
.283 |
.027 |
.002 |
.049 |
.001 |
.0 |
.005 |
.182 |
.161 |
-- |
-- |
.098 |
.02 |
.023 |
-- |
.004 |
.003 |
.0 |
.001 |
.002 |
.001 |
.329 |
.002 |
.001 |
.025 |
.012 |
.005 |
.993 |
.003 |
.88 |
.016 |
.461 |
.104 |
-- |
-- |
-- |
-- |
.01 |
-- |
-- |
.012 |
.016 |
.079 |
.109 |
.09 |
.023 |
.001 |
.001 |
.145 |
.017 |
.0 |
.032 |
.478 |
-- |
.054 |
.0 |
.043 |
.003 |
.869 |
.001 |
.004 |
.002 |
.0 |
.002 |
.0 |
.001 |
.003 |
.045 |
.024 |
.015 |
.003 |
.0 |
.036 |
.0 |
.003 |
.539 |
.132 |
.0 |
.004 |
.122 |
.003 |
.007 |
.06 |
.0 |
.044 |
.133 |
.0 |
.023 |
.0 |
.013 |
.026 |
.19 |
.001 |
.001 |
.04 |
.194 |
.052 |
.804 |
.0 |
.001 |
.0 |
.016 |
.0 |
.011 |
.013 |
.052 |
.033 |
.001 |
.0 |
.046 |
.011 |
.0 |
.0 |
.0 |
.001 |
.0 |
.001 |
.0 |
.0 |
.001 |
.166 |
.007 |
.046 |
.087 |
.456 |
.028 |
.078 |
.372 |
.407 |
.052 |
-- |
-- |
.01 |
.077 |
.079 |
.036 |
.089 |
.0 |
.03 |
.021 |
.827 |
.08 |
.01 |
.002 |
.008 |
.007 |
.17 |
.618 |
.54 |
.184 |
.025 |
.046 |
.014 |
.018 |
.115 |
.092 |
.171 |
.029 |
.0 |
.01 |
.001 |
.006 |
.002 |
.0 |
.0 |
.001 |
.005 |
.103 |
.012 |
.001 |
.006 |
.0 |
.0 |
.001 |
.034 |
.005 |
.001 |
.086 |
.004 |
.14 |
.272 |
.292 |
.295 |
.284 |
.016 |
.002 |
.194 |
.023 |
.716 |
.183 |
.067 |
.332 |
.362 |
.008 |
.331 |
.938 |
.991 |
.514 |
.026 |
.004 |
.018 |
.415 |
.319 |
.002 |
.012 |
.002 |
.952 |
.109 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.037 |
.001 |
.003 |
.302 |
.265 |
.004 |
.12 |
.519 |
.016 |
.0 |
.094 |
-- |
.328 |
-- |
.29 |
.0 |
.001 |
.0 |
.0 |
.0 |
.034 |
.001 |
.004 |
.004 |
.218 |
.313 |
.169 |
.057 |
.063 |
.057 |
-- |
.019 |
.021 |
.058 |
.07 |
.075 |
.009 |
.001 |
.016 |
-- |
-- |
.0 |
.022 |
.003 |
.813 |
.692 |
.002 |
.041 |
.769 |
.026 |
.01 |
.058 |
.023 |
.204 |
.299 |
.408 |
.317 |
.003 |
.272 |
.016 |
-- |
.124 |
.382 |
.229 |
.231 |
.006 |
.005 |
.015 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.592 |
.243 |
.075 |
.12 |
.084 |
.005 |
.391 |
.0 |
.004 |
.0 |
.112 |
.0 |
.198 |
.297 |
.185 |
.133 |
.038 |
-- |
-- |
.003 |
.081 |
.144 |
.019 |
.003 |
.003 |
.034 |
.092 |
.114 |
.14 |
.151 |
.159 |
-- |
.842 |
.002 |
.021 |
.001 |
.129 |
.134 |
.019 |
.004 |
.031 |
.019 |
.0 |
.797 |
.004 |
.043 |
.044 |
.041 |
.008 |
.043 |
.011 |
.017 |
.006 |
.022 |
.001 |
.008 |
.004 |
.0 |
.096 |
.072 |
.002 |
.379 |
.002 |
.033 |
.998 |
.972 |
.043 |
.56 |
.003 |
.01 |
.395 |
.001 |
.014 |
.025 |
.111 |
.206 |
.005 |
.313 |
.009 |
.266 |
.001 |
.082 |
.001 |
.027 |
.0 |
.0 |
.002 |
.007 |
-- |
.005 |
.008 |
.002 |
.001 |
.001 |
.003 |
-- |
-- |
-- |
.017 |
.006 |
.0 |
.033 |
.0 |
.004 |
.034 |
.443 |
.525 |
.036 |
.001 |
.009 |
.002 |
.025 |
.078 |
.0 |
.007 |
.004 |
.002 |
.005 |
.445 |
-- |
.118 |
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
|
--
|
--
|
--
|
--
|
--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Wbp4-ps1
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
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|
--
|
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|
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|
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--
|
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|
--
|
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|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
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|
--
|
--
|
--
|
--
|
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|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
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|
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|
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|
--
|
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|
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|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
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|
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|
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|
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|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
--
|
--
|
--
|
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|
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|
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|
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|
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|
--
|
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|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
--
|
--
|
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|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
--
|
--
|
--
|
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|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
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|
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|
--
|
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|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
--
|
--
|
--
|
--
|
--
|
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|
--
|
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|
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|
--
|
--
|
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|
--
|
--
|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
A |
G |
G |
T |
2 |
T |
C |
A |
A |
T |
T |
G |
G |
A |
T |
T |
T |
T |
G |
T |
G |
C |
A |
G |
G |
A |
C |
C |
T |
T |
T |
C |
C |
A |
A |
A |
G |
C |
C |
G |
T |
T |
T |
8 |
C |
G |
A |
A |
G |
G |
C |
6 |
C |
22 |
C |
C |
G |
C |
G |
G |
A |
C |
A |
C |
C |
A |
C |
G |
G |
A |
A |
T |
T |
G |
G |
C |
G |
24 |
A |
A |
T |
C |
T |
G |
G |
T |
C |
A |
A |
G |
12 |
C |
C |
C |
C |
A |
C |
G |
T |
T |
C |
G |
A |
C |
16 |
C |
T |
G |
40 |
T |
T |
44 |
C |
A |
G |
T |
G |
T |
2 |
G |
C |
G |
T |
C |
G |
C |
A |
G |
T |
G |
T |
A |
G |
G |
C |
A |
T |
C |
A |
T |
A |
A |
G |
A |
T |
G |
G |
A |
G |
G |
T |
A |
A |
G |
C |
T |
C |
G |
A |
5 |
A |
G |
A |
A |
G |
C |
G |
A |
G |
10 |
T |
G |
T |
C |
A |
A |
G |
A |
A |
T |
C |
T |
A |
T |
G |
T |
C |
T |
A |
T |
C |
C |
A |
T |
G |
G |
C |
G |
T |
G |
C |
2 |
A |
A |
A |
C |
T |
12 |
10 |
8 |
A |
T |
C |
T |
C |
C |
G |
T |
C |
C |
A |
A |
T |
A |
C |
G |
T |
T |
A |
T |
A |
2 |
A |
T |
C |
A |
A |
T |
C |
T |
A |
A |
A |
T |
T |
A |
A |
8 |
C |
A |
C |
A |
T |
G |
A |
G |
C |
C |
A |
C |
A |
C |
C |
T |
G |
T |
C |
G |
T |
C |
C |
A |
T |
C |
T |
C |
C |
A |
C |
G |
C |
G |
T |
T |
C |
C |
T |
G |
G |
A |
T |
C |
G |
A |
T |
G |
G |
G |
T |
G |
A |
G |
G |
G |
A |
C |
G |
C |
A |
C |
T |
5 |
A |
A |
T |
C |
T |
C |
A |
G |
G |
T |
2 |
A |
A |
G |
G |
C |
C |
T |
3 |
A |
G |
G |
A |
A |
2 |
C |
3 |
2 |
C |
C |
A |
A |
A |
T |
G |
G |
G |
C |
C |
A |
4 |
2 |
G |
G |
4 |
12 |
A |
T |
G |
G |
C |
A |
T |
T |
G |
T |
8 |
2 |
2 |
14 |
12 |
A |
A |
G |
T |
C |
14 |
A |
A |
G |
A |
T |
G |
A |
C |
G |
27 |
C |
T |
A |
C |
A |
T |
C |
2 |
G |
A |
G |
T |
C |
A |
2 |
G |
C |
G |
A |
C |
A |
A |
G |
C |
T |
G |
A |
C |
A |
A |
T |
C |
A |
15 |
G |
T |
T |
G |
T |
A |
T |
C |
A |
T |
T |
G |
T |
C |
A |
T |
T |
G |
A |
C |
T |
G |
A |
T |
T |
G |
C |
T |
C |
T |
A |
C |
T |
T |
C |
T |
6 |
T |
A |
T |
16 |
C |
A |
2 |
T |
C |
A |
A |
C |
C |
T |
A |
T |
G |
G |
T |
G |
C |
A |
A |
T |
C |
T |
T |
C |
4 |
A |
C |
G |
T |
C |
A |
10 |
A |
A |
2 |
15 |
G |
A |
G |
C |
G |
A |
A |
T |
A |
A |
C |
C |
G |
T |
A |
T |
G |
C |
G |
G |
A |
10 |
6 |
G |
G |
T |
A |
C |
G |
G |
T |
C |
2 |
C |
A |
A |
A |
A |
G |
G |
G |
C |
C |
C |
C |
G |
T |
G |
T |
T |
C |
C |
G |
G |
T |
T |
A |
A |
G |
G |
G |
G |
T |
T |
T |
T |
T |
T |
A |
A |
C |
T |
G |
T |
A |
A |
T |
T |
A |
G |
T |
C |
C |
A |
C |
G |
G |
G |
T |
15 |
A |
T |
A |
G |
T |
T |
C |
A |
C |
T |
C |
T |
A |
T |
T |
A |
C |
T |
G |
A |
A |
T |
G |
15 |
G |
G |
T |
A |
T |
C |
G |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
-
|
T
|
C
|
2
|
-
|
C
|
T
|
G
|
G
|
G
|
C
|
A
|
A
|
G
|
A
|
-
|
-
|
C
|
C
|
C
|
A
|
T
|
G
|
C
|
A
|
G
|
T
|
A
|
C
|
C
|
C
|
-
|
A
|
T
|
G
|
C
|
A
|
T
|
T
|
T
|
C
|
C
|
C
|
8/-
|
A
|
A
|
G
|
C
|
A
|
C
|
T
|
-
|
T
|
-
|
T
|
T
|
A
|
T
|
A
|
4
|
G
|
T
|
G
|
T
|
T
|
-
|
A
|
-
|
A
|
G
|
C
|
-
|
C
|
A
|
A
|
G
|
A
|
24/-
|
G
|
-
|
C
|
T
|
-
|
A
|
T
|
C
|
G
|
G
|
G
|
A
|
-
|
T
|
4
|
T
|
G
|
G
|
T
|
T
|
C
|
3
|
13/9
|
T
|
C
|
T
|
-
|
T
|
-
|
T
|
-
|
C
|
-
|
-
|
3
|
A/-
|
A
|
C
|
T
|
C
|
-
|
A
|
-
|
A
|
89
|
T
|
A
|
T
|
T
|
T
|
A
|
A
|
C
|
G
|
A
|
A
|
T
|
G
|
C
|
G
|
T
|
G
|
C
|
G
|
A
|
G
|
A
|
A
|
T
|
G
|
4/3
|
A
|
C
|
G
|
G
|
A
|
T
|
C
|
T
|
3
|
G
|
-
|
6
|
C
|
G
|
T
|
T
|
T
|
A
|
G
|
A
|
-
|
C
|
2
|
G
|
T
|
G
|
G
|
A
|
C
|
G
|
C
|
A
|
C
|
T
|
2
|
-
|
-
|
-
|
-
|
4
|
-
|
G
|
T
|
G
|
3
|
C
|
A
|
T
|
A
|
2
|
A
|
7
|
2/-
|
A/-
|
G
|
G
|
G
|
C
|
12/-
|
10/-
|
8/-
|
A/-
|
-
|
G
|
C
|
A
|
T
|
C
|
3/TA
|
T
|
T
|
-
|
2
|
C
|
C
|
G
|
A
|
G
|
G
|
7/8
|
C
|
G
|
-
|
G
|
C
|
T
|
C
|
T
|
3
|
T
|
A
|
G
|
T
|
G
|
A
|
C
|
G
|
G
|
8/-
|
T
|
G
|
G
|
G
|
C
|
A
|
G
|
A
|
A
|
A
|
2
|
T
|
4
|
A
|
T
|
C
|
-
|
C
|
C/19
|
T
|
C
|
T
|
13
|
G
|
A
|
A
|
2
|
T
|
T
|
G
|
T
|
A
|
T
|
A
|
C
|
C
|
T
|
T
|
A
|
A
|
A
|
G
|
G
|
T
|
A
|
T
|
-
|
T
|
C
|
C
|
A
|
C
|
C
|
A
|
C
|
C
|
C
|
A
|
C
|
T
|
T
|
T
|
2
|
-
|
G
|
G
|
C
|
G
|
A
|
T
|
-
|
9
|
3
|
A
|
2/-
|
A/-
|
G
|
A
|
A
|
23
|
T
|
A
|
-
|
G
|
A
|
C
|
G
|
T
|
-
|
2
|
-
|
2/-
|
A
|
T
|
C
|
C
|
C
|
2
|
T
|
A
|
C
|
T
|
T
|
G
|
4/-
|
-
|
A
|
A
|
-
|
-
|
G
|
A
|
A
|
A
|
T
|
G
|
G
|
2
|
A
|
43
|
8/-
|
2/-
|
-
|
14/-
|
12/-
|
T
|
G
|
4
|
C
|
A
|
-
|
G
|
G
|
A
|
G
|
C
|
A
|
G
|
9
|
T
|
27/-
|
G
|
G
|
-
|
T
|
7/5
|
C
|
T
|
2/-
|
A
|
G
|
A
|
A
|
3
|
2
|
-
|
-
|
-
|
-
|
-
|
-
|
A/2
|
A/-
|
13
|
T
|
G
|
A
|
2
|
A
|
G
|
15
|
C
|
T
|
G
|
-
|
-
|
-
|
30
|
G/2
|
-
|
G
|
G
|
T
|
G
|
C
|
C
|
C
|
C
|
T
|
C
|
C
|
A
|
A
|
C
|
G
|
C
|
A
|
G
|
C
|
G
|
T
|
A
|
G
|
C/2
|
C
|
G
|
T
|
G
|
C
|
A
|
C
|
6/-
|
C
|
G
|
A
|
-
|
T
|
-
|
-
|
C
|
A
|
G
|
G
|
2
|
2
|
T/4
|
7/-
|
A
|
A
|
3
|
G
|
A
|
T
|
G
|
G
|
C
|
T
|
2
|
G
|
T
|
-
|
T
|
T
|
A
|
A
|
G
|
T
|
10/-
|
A/C
|
A/G
|
2/-
|
-
|
A
|
G
|
A
|
T
|
26
|
C
|
2
|
2
|
G
|
G
|
T
|
T
|
T
|
G
|
G
|
G
|
A
|
A
|
A
|
A
|
G
|
-
|
6/-
|
A
|
A
|
G
|
G
|
3
|
A
|
A
|
A
|
2
|
-
|
G
|
C
|
T
|
G
|
G
|
A
|
5
|
A
|
T
|
T
|
T
|
G
|
A
|
C
|
T
|
C
|
C
|
A
|
T
|
A
|
T
|
C
|
A
|
G
|
T
|
A
|
A
|
A
|
A
|
-
|
C
|
3/TA
|
C
|
4
|
G
|
10
|
5
|
A
|
C
|
T
|
C
|
A/-
|
G
|
C
|
C
|
6
|
A
|
C
|
T
|
T
|
2
|
19
|
T
|
A
|
A
|
2
|
15/-
|
G
|
G
|
T
|
T
|
A
|
G
|
T
|
2
|
5
|
C
|
T
|
C
|
G
|
C
|
G
|
G
|
T
|
-
|
A
|
G
|
G
|
A
|
A
|
-
|
A
|
A
|
C
|
C
|
C
|
T
|
2
|
-
|
|