|
.0 |
.003 |
.001 |
.078 |
.004 |
.0 |
.002 |
.365 |
-- |
-- |
.218 |
-- |
-- |
-- |
.0 |
.0 |
.004 |
.005 |
.007 |
.021 |
.003 |
.001 |
.001 |
.001 |
.061 |
.001 |
.002 |
.005 |
.001 |
.025 |
.483 |
.091 |
.013 |
.006 |
.003 |
.022 |
.049 |
.017 |
.035 |
.101 |
.062 |
.108 |
.098 |
.048 |
.048 |
.126 |
.153 |
.03 |
.126 |
.021 |
.032 |
.324 |
-- |
.01 |
.645 |
.331 |
.064 |
.186 |
.464 |
.004 |
.002 |
.093 |
.003 |
.058 |
.046 |
.036 |
.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.008 |
.033 |
.308 |
.066 |
.009 |
.062 |
.001 |
.015 |
.024 |
.025 |
.011 |
.042 |
.089 |
.113 |
.224 |
.003 |
.03 |
.035 |
-- |
-- |
.056 |
.005 |
.005 |
.003 |
.027 |
.116 |
-- |
.876 |
.042 |
.001 |
.088 |
.389 |
.234 |
.001 |
.442 |
.193 |
-- |
-- |
.068 |
.24 |
.008 |
.001 |
.003 |
.01 |
.856 |
.999 |
1.0 |
1.0 |
1.0 |
-- |
.001 |
.051 |
-- |
.065 |
.321 |
.088 |
-- |
-- |
.034 |
.855 |
.948 |
.154 |
.006 |
.028 |
.583 |
.022 |
.063 |
.153 |
.534 |
.107 |
.018 |
.635 |
.054 |
.186 |
.054 |
.0 |
.001 |
.226 |
.238 |
.117 |
.064 |
.02 |
.015 |
.001 |
.149 |
.17 |
.207 |
.011 |
.037 |
.035 |
.021 |
.401 |
.044 |
.003 |
.002 |
.032 |
.058 |
.001 |
-- |
-- |
.646 |
.019 |
-- |
.556 |
.03 |
.057 |
.007 |
.024 |
.453 |
.224 |
-- |
-- |
.024 |
.005 |
.03 |
.008 |
.014 |
.022 |
.031 |
.036 |
.036 |
.038 |
.034 |
.036 |
.024 |
.008 |
.007 |
.115 |
.125 |
.062 |
.14 |
.381 |
.094 |
.041 |
.047 |
.303 |
.004 |
.004 |
.002 |
.335 |
.036 |
.035 |
.002 |
.001 |
.42 |
.365 |
-- |
.211 |
-- |
-- |
.263 |
.265 |
.011 |
.011 |
.033 |
.005 |
.0 |
-- |
.0 |
.317 |
.646 |
.323 |
.01 |
.19 |
.191 |
.034 |
.006 |
.087 |
.2 |
.168 |
.204 |
.066 |
.006 |
-- |
-- |
.038 |
.013 |
.013 |
.06 |
-- |
.001 |
.0 |
.023 |
.019 |
.016 |
.004 |
.023 |
.005 |
.004 |
.0 |
.019 |
.014 |
.019 |
.001 |
.984 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
.021 |
.014 |
.146 |
-- |
.327 |
.037 |
.456 |
.003 |
.003 |
.005 |
.23 |
.133 |
.033 |
1.0 |
.0 |
.008 |
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
|
--
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--
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--
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--
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--
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--
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--
|
--
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--
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--
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--
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--
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--
|
--
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--
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--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
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--
|
--
|
--
|
--
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--
|
--
|
--
|
--
|
--
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--
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--
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--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
|
--
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--
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--
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--
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--
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--
|
--
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--
|
--
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--
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--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
C |
A |
T |
G |
A |
2 |
C |
G |
G |
T |
G |
C |
A |
A |
A |
T |
C |
A |
C |
A |
C |
G |
G |
A |
A |
C |
C |
T |
C |
C |
T |
3 |
T |
3 |
G |
C |
A |
A |
C |
G |
A |
T |
G |
T |
C |
C |
A |
C |
5 |
G |
A |
G |
2 |
G |
T |
C |
A |
47 |
A |
T |
C |
8 |
C |
C |
A |
T |
A |
G |
3 |
C |
T |
A |
C |
C |
C |
G |
C |
T |
A |
G |
A |
T |
A |
3 |
A |
G |
A |
2 |
A |
G |
T |
T |
T |
T |
G |
C |
C |
2 |
T |
C |
G |
A |
G |
C |
T |
G |
A |
G |
C |
T |
3 |
T |
C |
C |
C |
C |
T |
A |
A |
T |
G |
T |
2 |
A |
G |
A |
G |
G |
C |
C |
C |
C |
A |
T |
C |
A |
T |
A |
G |
G |
T |
T |
G |
T |
A |
C |
G |
3 |
C |
T |
G |
C |
A |
A |
42 |
C |
C |
A |
C |
G |
C |
T |
T |
C |
T |
12 |
2 |
2 |
C |
4 |
10 |
C |
6 |
T |
C |
G |
G |
T |
C |
A |
C |
20 |
T |
G |
2 |
T |
G |
12 |
C |
5 |
A |
T |
T |
G |
T |
3 |
G |
A |
G |
C |
A |
6 |
T |
6 |
A |
A |
T |
C |
G |
T |
A |
C |
C |
C |
G |
G |
10 |
8 |
3 |
A |
C |
A |
G |
T |
G |
A |
C |
A |
A |
G |
T |
T |
A |
76 |
C |
G |
G |
G |
G |
T |
T |
C |
T |
A |
2 |
A |
16 |
A |
4 |
12 |
C |
T |
A |
14 |
T |
T |
T |
A |
108 |
G |
T |
2 |
C |
C |
G |
A |
C |
A |
A |
T |
G |
A |
T |
A |
T |
T |
G |
C |
T |
G |
C |
T |
10 |
T |
G |
T |
A |
A |
C |
C |
A |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C
|
A
|
G
|
2
|
G/5
|
A/G
|
2/-
|
G
|
17
|
A
|
T/-
|
A
|
T
|
5
|
G
|
C
|
A
|
G
|
C
|
T
|
G
|
T
|
A
|
A
|
G
|
G
|
A
|
G
|
G
|
T
|
T
|
C
|
3/-
|
T/-
|
-
|
T
|
T
|
G
|
-
|
A
|
A
|
G
|
C
|
A
|
14
|
T
|
T
|
G
|
T
|
-
|
A
|
T
|
T
|
-
|
A
|
C
|
2
|
48
|
-
|
C
|
C
|
T
|
-
|
T
|
T
|
C
|
C
|
G
|
2
|
-
|
T
|
C
|
C
|
T
|
A
|
T
|
A
|
T
|
C
|
G
|
A
|
G
|
C
|
G
|
-
|
G
|
A
|
-
|
-
|
2
|
A
|
C
|
C
|
G
|
C
|
A
|
T
|
C/5
|
2/-
|
C
|
14
|
T
|
G
|
A
|
G
|
C
|
A
|
G
|
A
|
T
|
C
|
-
|
T/-
|
-
|
4
|
T
|
A
|
C
|
2
|
T
|
C
|
2
|
C
|
-
|
G
|
T
|
2
|
4
|
T
|
T
|
T
|
G
|
T
|
G
|
C
|
A
|
G
|
C
|
5/3
|
A
|
6
|
A
|
C
|
A
|
C
|
T
|
T
|
4
|
-
|
A
|
G
|
C
|
T
|
T
|
G
|
-
|
G
|
A
|
G
|
T
|
T
|
T
|
G
|
C
|
-
|
-
|
-
|
-
|
-
|
5
|
-
|
-
|
5
|
-
|
C
|
T
|
A
|
3
|
-
|
T
|
2
|
T
|
-
|
C
|
T
|
2/-
|
T/-
|
A
|
-
|
T
|
-
|
6
|
4
|
6
|
T
|
C
|
-
|
A
|
G
|
A
|
T
|
G
|
-
|
G
|
-
|
G
|
G
|
C
|
T
|
A
|
2
|
G
|
T
|
A
|
T
|
A
|
A
|
10/-
|
8/-
|
-
|
5
|
C/41
|
G
|
A
|
C
|
G/27
|
A/G
|
A
|
-
|
C
|
A
|
G
|
C
|
G
|
-
|
T
|
A
|
A
|
2
|
4
|
C
|
2
|
-
|
-
|
G
|
-
|
G
|
-
|
-
|
-
|
-
|
T
|
A
|
G
|
-
|
2
|
C
|
C
|
G
|
-
|
C
|
C
|
2/-
|
C/-
|
G
|
T
|
G
|
T
|
C
|
G
|
G
|
G/11
|
4
|
C
|
G
|
C
|
C
|
A
|
T
|
C
|
A
|
T
|
C
|
-
|
2
|
A
|
C
|
G
|
-
|
T
|
T
|
G
|
A
|
|