|
.002 |
.048 |
.261 |
.02 |
.003 |
.001 |
.299 |
.022 |
.32 |
.106 |
.0 |
.0 |
.021 |
.002 |
.001 |
.001 |
.002 |
.006 |
.047 |
.021 |
.002 |
.0 |
.001 |
.014 |
.002 |
.009 |
.015 |
.155 |
.137 |
.092 |
.02 |
.012 |
.013 |
.009 |
.01 |
.056 |
.191 |
.057 |
.016 |
.003 |
.021 |
.046 |
.017 |
.011 |
.09 |
.065 |
.061 |
.033 |
.031 |
.038 |
.055 |
.002 |
.045 |
.007 |
-- |
-- |
.001 |
.001 |
.001 |
.005 |
.011 |
.001 |
.001 |
.001 |
.232 |
.0 |
.0 |
.008 |
.006 |
.005 |
.009 |
.106 |
.008 |
.252 |
.011 |
.002 |
.005 |
.002 |
.001 |
.001 |
.08 |
.228 |
.191 |
.014 |
.001 |
.001 |
.006 |
.012 |
.001 |
.001 |
.005 |
.018 |
.044 |
.036 |
.008 |
.041 |
.085 |
.199 |
.049 |
.15 |
.324 |
.325 |
.253 |
.01 |
.015 |
.03 |
.084 |
.069 |
.19 |
.005 |
.004 |
.004 |
.001 |
.001 |
.005 |
.006 |
.037 |
.069 |
.036 |
.033 |
.041 |
.055 |
.259 |
.119 |
.065 |
.003 |
.006 |
.003 |
.0 |
.004 |
.008 |
.004 |
.028 |
.077 |
.022 |
.016 |
.025 |
.033 |
.033 |
.001 |
.005 |
.007 |
.132 |
.088 |
.05 |
.043 |
.007 |
.008 |
.006 |
.003 |
.001 |
.003 |
.001 |
.002 |
.008 |
.006 |
.001 |
.001 |
.004 |
.003 |
.004 |
.034 |
.011 |
.016 |
.025 |
.025 |
.004 |
.001 |
.003 |
.0 |
.001 |
.012 |
.007 |
.016 |
.005 |
.023 |
.008 |
.002 |
.027 |
.035 |
.04 |
.001 |
.001 |
.004 |
.018 |
.015 |
.091 |
.117 |
.007 |
.002 |
.009 |
.007 |
.99 |
1.0 |
1.0 |
.992 |
.634 |
.753 |
.545 |
.0 |
.895 |
1.0 |
.724 |
.946 |
.982 |
1.0 |
.921 |
.997 |
.995 |
.001 |
.0 |
.0 |
.009 |
.009 |
.006 |
.003 |
.803 |
.598 |
.031 |
.018 |
.99 |
.117 |
.001 |
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
|
- |
C |
- |
T |
- |
T |
T |
T |
A |
C |
A |
T |
C |
2 |
- |
C |
A |
- |
- |
T |
C |
- |
G |
C |
G |
T |
G |
G |
A |
T |
G |
C |
G |
G |
C |
- |
C |
G |
G |
- |
2 |
G |
C |
G |
T |
T |
G |
G |
G |
- |
- |
- |
- |
C |
- |
C |
- |
G |
- |
G |
- |
C |
C |
T |
- |
- |
T |
G |
- |
T |
C |
G |
G |
- |
T |
G |
- |
2 |
G |
A |
2 |
G |
A |
- |
- |
2 |
- |
2 |
2 |
- |
G |
G |
A |
G |
2 |
C |
4 |
G |
C |
G |
- |
G |
G |
- |
2 |
G |
T |
C |
C |
T |
G |
- |
G |
A |
G |
G |
G |
C |
C |
T |
T |
2 |
- |
C |
2 |
- |
G |
G |
G |
G |
T |
A |
G |
C |
T |
T |
G |
- |
G |
C |
- |
G |
G |
T |
C |
A |
- |
C |
- |
C |
G |
T |
A |
G |
T |
G |
C |
G |
2 |
C |
C |
- |
T |
2 |
T |
G |
T |
G |
C |
- |
2 |
G |
C |
G |
G |
C |
A |
- |
G |
A |
- |
G |
G |
- |
G |
2 |
C |
- |
A |
C |
- |
- |
2 |
- |
- |
- |
- |
G |
- |
A |
- |
- |
A |
- |
T |
3 |
- |
G |
C |
C |
C |
- |
T |
A |
A |
G |
- |
- |
- |
- |
- |
- |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-/T
|
-
|
A
|
C
|
C
|
-
|
-
|
-
|
-
|
-
|
T
|
A
|
-
|
-
|
G
|
-
|
-
|
105
|
4
|
-
|
-
|
A
|
-
|
-
|
T
|
C
|
T
|
-
|
-
|
-
|
-
|
A
|
C
|
C
|
T
|
G
|
-
|
-
|
-
|
C
|
-
|
-
|
-
|
A
|
-
|
G
|
T
|
-
|
T
|
A
|
C
|
T
|
C
|
-
|
T
|
-
|
2
|
-
|
C
|
-
|
A
|
-
|
T
|
C
|
G
|
3
|
A/AC
|
-
|
G
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
T
|
-
|
-
|
C
|
-
|
-
|
-
|
C
|
2
|
-
|
T
|
-
|
-
|
T
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
C
|
-
|
-
|
T
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
A
|
-
|
T
|
C
|
T
|
-
|
-
|
-
|
C
|
-
|
-
|
T
|
G
|
-
|
T
|
-
|
-
|
C
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
3
|
A
|
-
|
T
|
-
|
-
|
-
|
T
|
-
|
A
|
A
|
T
|
T
|
C
|
-
|
-
|
-
|
G
|
T
|
-
|
-
|
-
|
-
|
A
|
A
|
-
|
-
|
G
|
T
|
-
|
-
|
-
|
C
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
3
|
A
|
-
|
4
|
-
|
T
|
T
|
-
|
-
|
-
|
C
|
-
|
-
|
C
|
G
|
-
|
T
|
C
|
C
|
G
|
-
|
2
|
-
|
G
|
G
|
-
|
4
|
G
|
-
|
C
|
C
|
-
|
-
|
-
|
G
|
-
|
G
|
-
|
A
|
C
|
A
|
T
|
A
|
G
|
C
|
-
|
|