|
.059 |
.0 |
.024 |
.268 |
.002 |
.001 |
.004 |
.0 |
.026 |
.001 |
.003 |
.0 |
.044 |
1.0 |
1.0 |
.998 |
.013 |
.263 |
.026 |
-- |
.334 |
.0 |
.001 |
.033 |
.066 |
.106 |
.035 |
.006 |
.007 |
.004 |
.003 |
.002 |
.052 |
.002 |
.035 |
.003 |
.045 |
.001 |
.004 |
.161 |
.181 |
.185 |
.901 |
.858 |
.009 |
.0 |
.003 |
.003 |
.004 |
.004 |
.011 |
.0 |
.0 |
.0 |
.057 |
.001 |
.002 |
.005 |
.0 |
.004 |
.011 |
.001 |
.041 |
.312 |
.003 |
.072 |
.002 |
.001 |
.0 |
.004 |
.009 |
.144 |
.008 |
.909 |
.033 |
.075 |
.082 |
.039 |
.147 |
.136 |
-- |
-- |
.038 |
.0 |
.001 |
.024 |
1.0 |
.55 |
.257 |
.991 |
.002 |
.0 |
.005 |
.099 |
.0 |
.001 |
.006 |
.208 |
.001 |
.003 |
.0 |
.001 |
.001 |
.0 |
.005 |
.029 |
.033 |
.033 |
.02 |
.003 |
-- |
-- |
-- |
-- |
.0 |
.284 |
.0 |
.043 |
-- |
-- |
-- |
-- |
-- |
.033 |
1.0 |
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
Smad2
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
A |
A |
G |
T |
A |
T |
C |
A |
A |
T |
T |
G |
G |
G |
T |
18 |
T |
T |
- |
C |
T |
C |
G |
C |
2 |
T |
12 |
T |
T |
7 |
G |
C |
G |
A |
C |
C |
A |
C |
C |
G |
C |
A |
C |
T |
T |
T |
- |
G |
T |
A |
G |
G |
C |
G |
A |
G |
T |
G |
- |
C |
C |
T |
A |
A |
G |
A |
G |
G |
G |
C |
G |
A |
T |
A |
- |
C |
T |
- |
G |
G |
C |
A |
5 |
G |
A |
A |
C |
G |
T |
A |
A |
A |
C |
G |
C |
A |
G |
G |
- |
- |
- |
- |
- |
G |
A |
A |
4 |
- |
A |
G |
A |
- |
- |
G |
C |
C |
C |
T |
G |
2 |
G |
6 |
G |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
T
|
G
|
A
|
C
|
G
|
A
|
T
|
C
|
T
|
-
|
A
|
A
|
A
|
T
|
A
|
-
|
C
|
C
|
5
|
T
|
C
|
T
|
T
|
T
|
-
|
C
|
-
|
-
|
A
|
-
|
A
|
-
|
C
|
T
|
G
|
G
|
G
|
T
|
A
|
T
|
A
|
T
|
-
|
A
|
C
|
C
|
-/T
|
A
|
G
|
T
|
A
|
A
|
T
|
T
|
G
|
A
|
-
|
A
|
2
|
-
|
T
|
C
|
T
|
G
|
A
|
T
|
A
|
T
|
T/A
|
T
|
T
|
T
|
G
|
G
|
T
|
T
|
G
|
T/T
|
A
|
A
|
T
|
G
|
5/-
|
A
|
-
|
-
|
T
|
T
|
C
|
G
|
G
|
T
|
T
|
A
|
-
|
-
|
A
|
A
|
4
|
A
|
5
|
4
|
27
|
C
|
G
|
-
|
-
|
4
|
G
|
A
|
G
|
5
|
4
|
A
|
A
|
T
|
G
|
-
|
A
|
-
|
C
|
-
|
A
|
C
|
|