|
.001 |
.562 |
.009 |
.0 |
.002 |
.032 |
.005 |
.012 |
.666 |
.045 |
.0 |
.001 |
.041 |
.006 |
.008 |
.006 |
.014 |
.003 |
.0 |
.0 |
.003 |
.001 |
.001 |
.0 |
.002 |
.0 |
.0 |
.0 |
.636 |
.001 |
.021 |
.0 |
.034 |
.0 |
.0 |
.012 |
.004 |
.002 |
.0 |
.002 |
.002 |
.0 |
.0 |
.23 |
.226 |
.324 |
.99 |
.008 |
.0 |
.0 |
.0 |
.0 |
.0 |
.028 |
.003 |
.012 |
.003 |
.005 |
.019 |
.038 |
.039 |
.001 |
.001 |
.117 |
.008 |
.0 |
.0 |
.295 |
.0 |
.001 |
.005 |
.01 |
.0 |
.012 |
.0 |
.002 |
.038 |
.0 |
.0 |
.151 |
.002 |
.049 |
.0 |
.004 |
.003 |
.006 |
.0 |
.001 |
.0 |
.0 |
.0 |
.001 |
.0 |
.001 |
.076 |
.012 |
.001 |
.009 |
.007 |
.001 |
.001 |
.002 |
.001 |
.004 |
.012 |
.013 |
.011 |
.684 |
.001 |
.024 |
.004 |
.0 |
.007 |
.012 |
.03 |
.0 |
.001 |
.0 |
.0 |
.001 |
.006 |
.0 |
.024 |
.003 |
.002 |
.004 |
.006 |
.0 |
.032 |
.02 |
.001 |
.368 |
.066 |
.0 |
.396 |
.017 |
.019 |
.0 |
.031 |
.007 |
.0 |
.0 |
.0 |
.001 |
.059 |
.004 |
.0 |
.004 |
.266 |
.312 |
.012 |
.034 |
.031 |
.007 |
.012 |
.001 |
.008 |
.0 |
.001 |
.002 |
.001 |
.003 |
.043 |
.032 |
.004 |
.0 |
-- |
.009 |
.004 |
.003 |
.067 |
.01 |
.007 |
.015 |
.006 |
.0 |
.984 |
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
Smad1
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
T |
C |
A |
T |
T |
G |
C |
C |
G |
C |
T |
10 |
C |
G |
G |
A |
T |
- |
- |
G |
C |
T |
A |
A |
G |
C |
C |
C |
A |
T |
- |
- |
C |
A |
11 |
T |
G |
- |
A |
C |
G |
T |
T |
T |
G |
- |
C |
C |
G |
G |
G |
G |
G |
C |
G |
G |
- |
T |
A |
- |
T |
G |
A |
T |
A |
A |
- |
C |
C |
T |
C |
C |
A |
G |
A |
A |
G |
A |
C |
C |
A |
T |
5 |
2 |
T |
T |
A |
C |
C |
A |
A |
A |
C |
- |
T |
119 |
C |
A |
C |
C |
5 |
- |
A |
C |
C |
C |
G |
G |
T |
C |
G |
C |
G |
G |
A |
T |
C |
G |
A |
A |
C |
C |
G |
T |
T |
- |
G |
A |
- |
C |
A |
G |
T |
G |
- |
G |
G |
25 |
G |
C |
T |
C |
C |
C |
C |
G |
C |
A |
C |
T |
C |
2 |
- |
T |
T |
A |
C |
A |
G |
C |
T |
C |
T |
T |
T |
- |
A |
T |
T |
G |
G |
A |
T |
A |
- |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T
|
C
|
T
|
G
|
C
|
G
|
C
|
-
|
T
|
A
|
T
|
-
|
-
|
T
|
A
|
C
|
G
|
C
|
G/T
|
7
|
T
|
T
|
C
|
G
|
G
|
A
|
T
|
T
|
-
|
G
|
-
|
2
|
12
|
T
|
T
|
-
|
-
|
T
|
G
|
G
|
T
|
C
|
C
|
A
|
A
|
T
|
T
|
T
|
T
|
A
|
A
|
A
|
A
|
T
|
T
|
A
|
A
|
8
|
G
|
T
|
T
|
-
|
A
|
G
|
C
|
G
|
G
|
A
|
A
|
T
|
C
|
T
|
A
|
T
|
A
|
T
|
G
|
A
|
C
|
A
|
T
|
G
|
C
|
-
|
-
|
A
|
C
|
G
|
T
|
T
|
C
|
G
|
G
|
T
|
T
|
C
|
-
|
T
|
G
|
T
|
G
|
-
|
A
|
C
|
T
|
T
|
T
|
C
|
A
|
G
|
T
|
A
|
T
|
A
|
A
|
G
|
G
|
A
|
C
|
C
|
C
|
G
|
A
|
C
|
C
|
C
|
G
|
A
|
G
|
C
|
T
|
G
|
A
|
G
|
A
|
A
|
A
|
A
|
-
|
A
|
A
|
C
|
-
|
T
|
T
|
T
|
A
|
T
|
G
|
A
|
G
|
T
|
-
|
C
|
A
|
C
|
G
|
T
|
G
|
-
|
T
|
C
|
T
|
C
|
C
|
C
|
18
|
G
|
-
|
G
|
A
|
A
|
-
|
-
|
G
|
3
|
G
|
|