|
.603 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.01 |
.015 |
.003 |
.001 |
.002 |
.091 |
.51 |
.0 |
.001 |
.016 |
.001 |
.044 |
.0 |
.0 |
.273 |
.003 |
.002 |
.006 |
.003 |
.057 |
.0 |
.119 |
.001 |
.006 |
.007 |
.011 |
.015 |
-- |
-- |
-- |
-- |
-- |
-- |
.014 |
.045 |
.004 |
.017 |
.001 |
-- |
-- |
-- |
-- |
.001 |
.002 |
.375 |
.006 |
.114 |
.145 |
.002 |
.748 |
.0 |
.019 |
.075 |
.015 |
.005 |
.001 |
.0 |
.0 |
.004 |
.23 |
.585 |
.405 |
.001 |
.002 |
.0 |
.001 |
.0 |
.164 |
.031 |
.107 |
.075 |
.0 |
.005 |
.007 |
.0 |
1.0 |
.002 |
-- |
.001 |
-- |
.997 |
.005 |
.004 |
.0 |
.002 |
.012 |
.001 |
.064 |
.001 |
.001 |
.001 |
.0 |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
.02 |
.18 |
.103 |
.041 |
.013 |
.005 |
.16 |
.168 |
.019 |
.01 |
.034 |
.156 |
.042 |
.676 |
.146 |
.038 |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
-- |
-- |
-- |
.017 |
.0 |
.0 |
.002 |
.01 |
.011 |
.049 |
-- |
.001 |
.005 |
.008 |
.042 |
.122 |
.002 |
.008 |
.022 |
.002 |
.027 |
.0 |
.0 |
.003 |
.017 |
.045 |
.0 |
.091 |
.084 |
.0 |
.002 |
.005 |
.0 |
.033 |
.0 |
.0 |
.001 |
.021 |
.082 |
.167 |
.053 |
.038 |
.042 |
.001 |
.006 |
.004 |
.015 |
.0 |
.969 |
.0 |
-- |
-- |
-- |
.026 |
.013 |
.0 |
.013 |
.001 |
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
Pde6a
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
A |
T |
G |
2 |
G |
T |
C |
C |
T |
C |
T |
C |
C |
A |
T |
A |
G |
T |
A |
C |
T |
A |
- |
G |
T |
T |
G |
A |
C |
A |
T |
C |
G |
T |
A |
C |
C |
A |
T |
A |
- |
T |
G |
C |
C |
G |
A |
G |
C |
96 |
T |
T |
A |
T |
A |
T |
G |
T |
T |
T |
T |
A |
9 |
C |
C |
C |
111 |
T |
- |
- |
T |
G |
A |
G |
C |
C |
G |
A |
122 |
A |
G |
T |
A |
- |
C |
T |
C |
C |
T |
3 |
T |
G |
- |
A |
G |
9 |
G |
G |
G |
T |
T |
A |
A |
A |
A |
T |
A |
A |
C |
T |
A |
C |
A |
C |
G |
A |
T |
G |
C |
C |
C |
G |
T |
C |
T |
T |
- |
T |
A |
- |
T |
T |
C |
G |
T |
T |
- |
C |
C |
C |
G |
C |
T |
G |
G |
A |
T |
G |
A |
C |
A |
C |
C |
- |
C |
- |
T |
A |
G |
8 |
T |
A |
G |
T |
C |
T |
C |
G |
C |
C |
A |
C |
T |
T |
G |
G |
A |
2 |
T |
T |
- |
C |
C |
C |
C |
A |
- |
G |
G |
C |
A |
- |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
T/C
|
G/A
|
2/-
|
G/T
|
T/A
|
C/T
|
C/G
|
T/C
|
C/T
|
T/C
|
C/T
|
C/A
|
G
|
G
|
G
|
A
|
C
|
-
|
G
|
C
|
G
|
T
|
C
|
C
|
C
|
A
|
G
|
G
|
T
|
A
|
T
|
A
|
G
|
G
|
G
|
T
|
G
|
-
|
G
|
C
|
C
|
A
|
T
|
T
|
A
|
T
|
A
|
T
|
-
|
C
|
C
|
G
|
A
|
G
|
G
|
A
|
C
|
G
|
C
|
C
|
T
|
-
|
T
|
T
|
T
|
-
|
A
|
-/3
|
-/2
|
C
|
A
|
G
|
T
|
T
|
T
|
A
|
T
|
-
|
T
|
A
|
G
|
G
|
C
|
T
|
C
|
T
|
T
|
C
|
-
|
C
|
A
|
9
|
G
|
A
|
-
|
A
|
A
|
A
|
-
|
G
|
G
|
G
|
C
|
G
|
-
|
T
|
T
|
G
|
C
|
C
|
G
|
G
|
T
|
T
|
G
|
-
|
A
|
T
|
T
|
G
|
T
|
A
|
T
|
C
|
C
|
4
|
C
|
C
|
T
|
C
|
C
|
A
|
A
|
C
|
C
|
A
|
G
|
T
|
G
|
A
|
A
|
C
|
A
|
A
|
C
|
G
|
A
|
G
|
T
|
G
|
T
|
A
|
C
|
T
|
3
|
C
|
C
|
A
|
-
|
C
|
G
|
C
|
C
|
T
|
C
|
T
|
C
|
T
|
T
|
C
|
G
|
C
|
C
|
A
|
A
|
G
|
-
|
G
|
G
|
30
|
T
|
T
|
A
|
A
|
G
|
2
|
C
|
A
|
G
|
G
|
4
|
C
|
|