|
.002 |
.0 |
.015 |
.003 |
.008 |
.002 |
.007 |
.012 |
.008 |
.011 |
.0 |
.001 |
.007 |
.995 |
.003 |
.001 |
.0 |
.001 |
.001 |
.001 |
.004 |
.011 |
.009 |
.011 |
.001 |
.0 |
.0 |
.0 |
.004 |
.002 |
.975 |
.006 |
.196 |
.0 |
.51 |
.049 |
.828 |
.001 |
.001 |
.0 |
.002 |
.0 |
.277 |
.407 |
.002 |
.007 |
.016 |
.074 |
.016 |
.02 |
.39 |
.368 |
.059 |
.003 |
.001 |
.148 |
.184 |
.215 |
.0 |
-- |
.017 |
.011 |
.014 |
.79 |
.951 |
.015 |
.018 |
.001 |
.002 |
.005 |
.003 |
.003 |
.0 |
.001 |
.001 |
.998 |
.034 |
.001 |
.002 |
.001 |
.974 |
.004 |
.008 |
.032 |
.0 |
.0 |
.0 |
.1 |
.003 |
.318 |
.001 |
.044 |
.107 |
.193 |
.005 |
.001 |
.0 |
.032 |
.006 |
.079 |
.005 |
.982 |
.004 |
.006 |
.002 |
.0 |
.004 |
.001 |
.028 |
.116 |
.045 |
.001 |
.003 |
.004 |
.001 |
.001 |
.007 |
.013 |
.008 |
.002 |
.012 |
.001 |
.001 |
.001 |
.001 |
.004 |
.02 |
.075 |
.098 |
.001 |
.001 |
.019 |
.002 |
.002 |
.001 |
.002 |
.019 |
.004 |
.001 |
.0 |
.012 |
.0 |
.0 |
.002 |
.014 |
.0 |
.001 |
.001 |
.001 |
.001 |
.001 |
.004 |
.002 |
.0 |
.0 |
.003 |
.0 |
.015 |
.672 |
.0 |
.4 |
.047 |
.168 |
.004 |
.763 |
.872 |
.0 |
.005 |
.158 |
.998 |
.0 |
.006 |
.015 |
.001 |
.001 |
.0 |
.04 |
.028 |
.01 |
.617 |
.0 |
.015 |
.025 |
.002 |
.009 |
.096 |
.018 |
.153 |
.06 |
.138 |
.792 |
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
Lgr4
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
- |
G |
C |
C |
T |
T |
T |
- |
C |
- |
4 |
- |
C |
G |
4 |
T |
G |
G |
C |
12 |
C |
- |
G |
A |
A |
A |
T |
- |
A |
- |
A |
T |
T |
C |
- |
G |
8 |
- |
T |
A |
C |
C |
A |
G |
G |
G |
A |
A |
22 |
C |
C |
G |
6 |
A |
4 |
G |
C |
G |
C |
T |
T |
T |
C |
G |
- |
- |
G |
A |
C |
G |
C |
2 |
G |
C |
C |
A |
C |
C |
T |
T |
G |
T |
- |
T |
C |
T |
T |
A |
- |
C |
C |
C |
G |
T |
A |
T |
A |
T |
A |
3 |
- |
A |
- |
C |
A |
- |
A |
2 |
A |
C |
2 |
- |
T |
C |
2 |
- |
2 |
A |
G |
6 |
A |
A |
- |
A |
T |
3 |
T |
4 |
2 |
C |
- |
C |
A |
A |
3 |
T |
- |
- |
G |
- |
G |
T |
G |
2 |
C |
G |
C |
G |
2 |
C |
C |
- |
C |
T |
G |
C |
G |
- |
T |
A |
T |
- |
G |
G |
T |
C |
A |
A |
G |
A |
T |
C |
C |
C |
- |
G |
3 |
G |
9 |
C |
- |
T |
C |
T |
A |
A |
A |
A |
T |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-
|
14
|
G/-
|
T
|
T
|
C
|
C
|
G
|
T
|
T
|
A
|
-
|
2
|
T
|
A
|
-
|
A
|
A
|
A
|
T
|
-
|
T
|
C
|
A
|
G
|
-
|
T
|
G
|
2
|
G
|
T
|
T
|
-
|
G
|
T
|
2
|
A
|
-
|
4
|
C
|
-
|
T
|
G
|
G
|
C
|
A
|
C
|
G
|
G
|
-
|
C/G
|
C/G
|
A
|
-
|
G
|
-
|
A
|
G
|
C
|
T
|
-
|
C
|
C
|
T
|
-
|
8
|
5
|
A
|
G
|
T
|
A
|
T
|
-
|
-
|
G
|
G
|
G
|
A
|
G
|
G
|
G
|
C
|
C
|
-/2
|
C
|
T
|
C
|
G
|
G
|
6
|
T
|
G
|
G
|
C
|
C
|
C
|
A
|
G
|
G
|
G
|
-
|
3
|
-
|
T
|
-
|
G
|
3
|
-
|
-
|
-
|
-
|
-
|
C
|
-
|
-
|
-
|
C
|
-
|
-
|
-
|
-
|
C
|
C
|
2
|
T
|
A
|
-
|
A
|
-
|
-
|
-
|
3
|
A
|
C
|
G/5
|
-
|
-
|
A
|
G
|
T
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
C
|
G
|
G
|
A
|
T
|
T
|
6
|
G
|
G
|
C
|
112
|
C
|
A
|
-
|
A
|
T
|
C
|
A
|
G
|
C
|
T
|
T
|
T
|
3
|
C
|
-
|
A
|
-
|
G
|
G
|
G
|
T
|
C
|
A/-
|
T
|
G
|
C
|
A
|
G
|
|