|
1.0 |
.005 |
.001 |
.0 |
.003 |
.001 |
.001 |
.0 |
.0 |
.0 |
.021 |
.021 |
.0 |
.0 |
.001 |
.002 |
.014 |
.0 |
.001 |
.0 |
.0 |
.003 |
.0 |
.001 |
.217 |
.031 |
.007 |
.022 |
.0 |
.921 |
.994 |
.035 |
.036 |
.02 |
.001 |
.0 |
.006 |
.002 |
.013 |
.0 |
.023 |
.004 |
.002 |
.461 |
.006 |
.025 |
.001 |
.054 |
.007 |
.068 |
.023 |
.036 |
.0 |
.001 |
.008 |
.007 |
.01 |
.001 |
.001 |
.002 |
.002 |
1.0 |
1.0 |
1.0 |
.631 |
.883 |
.996 |
.992 |
.978 |
.999 |
.996 |
.356 |
.0 |
.007 |
.029 |
.001 |
.129 |
.019 |
.007 |
.015 |
.003 |
.01 |
.012 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.048 |
.047 |
.099 |
.372 |
.034 |
.018 |
.004 |
.078 |
.102 |
.006 |
.03 |
.2 |
.19 |
.184 |
.04 |
.025 |
.036 |
.009 |
.0 |
.001 |
.0 |
.181 |
.023 |
.082 |
.145 |
.039 |
.096 |
.145 |
.003 |
.008 |
.006 |
.019 |
.072 |
.01 |
.018 |
.032 |
.003 |
.038 |
.019 |
.008 |
.019 |
.004 |
.017 |
.011 |
.008 |
.014 |
.079 |
.119 |
.079 |
.036 |
.054 |
.01 |
.004 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.02 |
.454 |
.612 |
.812 |
.975 |
.764 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.062 |
.039 |
.038 |
.018 |
.043 |
.002 |
.042 |
.001 |
.001 |
.001 |
.0 |
.001 |
.009 |
.04 |
.13 |
.076 |
.012 |
.004 |
.068 |
.429 |
.387 |
.699 |
.11 |
.1 |
.179 |
.005 |
.012 |
.008 |
.002 |
.01 |
.001 |
.0 |
.002 |
.01 |
-- |
-- |
.026 |
.003 |
.045 |
.746 |
.317 |
.327 |
.003 |
.025 |
.145 |
.924 |
.049 |
.141 |
.01 |
.005 |
.007 |
.002 |
.012 |
.017 |
-- |
.004 |
.001 |
.072 |
.079 |
.11 |
.0 |
.008 |
.014 |
.002 |
.024 |
.023 |
.458 |
.167 |
.0 |
.02 |
.139 |
.005 |
.0 |
.001 |
.0 |
.0 |
.01 |
.002 |
.0 |
.0 |
.004 |
.004 |
.001 |
.001 |
.0 |
.0 |
.001 |
.001 |
.008 |
.025 |
.0 |
.043 |
.08 |
.135 |
.002 |
.001 |
.008 |
.078 |
.136 |
.152 |
.086 |
.089 |
.0 |
.021 |
.043 |
.004 |
.051 |
.005 |
.001 |
.0 |
.0 |
.001 |
.295 |
.0 |
.001 |
.022 |
.092 |
.015 |
.039 |
.023 |
.001 |
.176 |
.002 |
.0 |
.034 |
.977 |
.002 |
.0 |
.001 |
.999 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
.844 |
.968 |
.0 |
.0 |
.012 |
.004 |
.0 |
.048 |
1.0 |
1.0 |
.129 |
.006 |
.003 |
.0 |
.0 |
.0 |
.008 |
.001 |
.0 |
.0 |
.001 |
.002 |
.002 |
.003 |
.002 |
.001 |
.773 |
.438 |
.198 |
.449 |
.548 |
.798 |
.002 |
.001 |
.262 |
.0 |
.001 |
.0 |
.004 |
.001 |
.028 |
.055 |
.001 |
.002 |
.0 |
.003 |
.0 |
.003 |
.004 |
.0 |
.008 |
.031 |
.001 |
.003 |
.019 |
.003 |
.0 |
.002 |
.004 |
.007 |
.028 |
.023 |
-- |
.004 |
.024 |
.071 |
.004 |
.165 |
.004 |
.0 |
.291 |
.736 |
.02 |
.001 |
.001 |
.017 |
-- |
.035 |
.003 |
.026 |
.008 |
.155 |
.113 |
.001 |
.024 |
.001 |
.001 |
.017 |
.01 |
.042 |
.016 |
.027 |
.042 |
.057 |
.005 |
.05 |
.007 |
.018 |
.006 |
.007 |
.014 |
.02 |
.023 |
.026 |
-- |
-- |
.953 |
.012 |
-- |
-- |
-- |
-- |
-- |
.0 |
-- |
-- |
-- |
-- |
.027 |
.003 |
.025 |
.003 |
.15 |
-- |
-- |
-- |
.012 |
.033 |
.007 |
.0 |
.05 |
.003 |
.004 |
-- |
.002 |
.141 |
.036 |
.01 |
.62 |
-- |
-- |
.0 |
.001 |
.172 |
.066 |
.994 |
.447 |
.031 |
.033 |
.033 |
.025 |
.017 |
.005 |
.008 |
.001 |
.005 |
.0 |
.002 |
.002 |
.029 |
.14 |
.011 |
.007 |
.033 |
.072 |
.001 |
.004 |
.049 |
.034 |
.002 |
.354 |
.143 |
.772 |
.02 |
.784 |
.0 |
.872 |
.004 |
.029 |
.006 |
.066 |
.002 |
.008 |
.285 |
.038 |
.0 |
.001 |
.0 |
.001 |
.006 |
.004 |
.001 |
.0 |
.003 |
.002 |
.005 |
.002 |
.004 |
.0 |
.0 |
.0 |
.009 |
.0 |
.0 |
.017 |
.0 |
.006 |
.001 |
.011 |
.001 |
.0 |
.667 |
.0 |
.01 |
.007 |
.019 |
.009 |
.005 |
.028 |
.005 |
.156 |
.045 |
-- |
.05 |
.001 |
.0 |
.009 |
.002 |
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
Kdm2b
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
- |
C |
A |
A |
G |
G |
2 |
- |
A |
G |
C |
T |
C |
2 |
G |
4 |
- |
C |
T |
3 |
G |
G |
2 |
G |
T |
G |
G |
G |
- |
A |
G |
G |
G |
G |
T |
C |
G |
C |
A |
- |
- |
C |
- |
G |
G |
A |
G |
A |
G |
G |
- |
C |
A |
T |
T |
T |
C |
G |
G |
T |
- |
- |
- |
C |
A |
9 |
C |
- |
G |
C |
22 |
A |
C |
T |
C |
A |
A |
G |
C |
T |
T |
C |
6 |
C |
- |
- |
- |
A |
G |
G |
G |
C |
T |
A |
C |
G |
T |
A |
C |
3 |
A |
A |
C |
C |
T |
T |
T |
- |
G |
C |
3 |
- |
- |
- |
G |
T |
T |
G |
A |
A |
C |
C |
A |
A |
C |
T |
- |
A |
C |
A |
T |
21 |
4 |
9 |
- |
C |
- |
- |
C |
C |
C |
2 |
- |
C |
- |
- |
G |
3 |
C |
A |
C |
C |
T |
C |
G |
C |
A |
G |
C |
G |
- |
T |
C |
A |
2 |
T |
G |
2 |
G |
C |
A |
G |
A |
C |
A |
C |
G |
- |
G |
G |
3 |
G |
3 |
2 |
- |
T |
10 |
4 |
- |
- |
T |
C |
G |
- |
A |
G |
- |
C |
T |
- |
C |
T |
T |
C |
C |
- |
- |
C |
A |
C |
C |
C |
7 |
G |
- |
C |
C |
C |
- |
- |
- |
C |
- |
- |
T |
- |
- |
- |
A |
- |
- |
- |
- |
- |
T |
- |
A |
C |
G |
C |
- |
C |
A |
G |
G |
- |
A |
C |
C |
G |
A |
- |
C |
T |
- |
C |
C |
2 |
A |
- |
G |
C |
- |
- |
A |
T |
- |
- |
2 |
C |
A |
G |
T |
- |
A |
G |
- |
C |
- |
- |
- |
- |
- |
G |
- |
- |
- |
- |
- |
- |
C |
- |
- |
4 |
A |
C |
3 |
C |
2 |
C |
- |
- |
- |
C |
- |
T |
A |
- |
- |
2 |
- |
- |
C |
C |
A |
C |
- |
2 |
C |
- |
- |
8 |
T |
- |
G |
C |
- |
- |
16 |
T |
T |
T |
A |
A |
G |
T |
T |
T |
C |
G |
T |
C |
C |
C |
C |
G |
- |
- |
- |
T |
C |
C |
A |
A |
- |
A |
- |
- |
T |
A |
C |
- |
T |
A |
A |
A |
A |
- |
T |
- |
T |
G |
T |
T |
T |
T |
A |
- |
T |
T |
- |
A |
T |
- |
T |
T |
- |
A |
T |
C |
- |
C |
G |
A |
T |
C |
A |
T |
C |
T |
T |
T |
A |
G |
A |
T |
A |
C |
G |
T |
T |
C |
A |
T |
T |
T |
T |
A |
G |
C |
T |
G |
- |
C |
A |
G |
G |
C |
G |
- |
T |
2 |
G |
G |
- |
A |
A |
- |
18 |
T |
C |
T |
A |
- |
G |
C |
G |
G |
G |
C |
- |
A |
G |
C |
2 |
C |
- |
G |
C |
A |
G |
T |
A |
A |
G |
A |
C |
2 |
G |
C |
2 |
2 |
G |
- |
A |
- |
G |
G |
2 |
C |
A |
A |
G |
- |
- |
T |
T |
T |
A |
A |
T |
A |
C |
T |
G |
13 |
- |
- |
T |
T |
G |
- |
G |
C |
G |
G |
G |
T |
C |
G |
2 |
T |
4 |
C |
A |
A |
T |
A |
A |
T |
T |
G |
A |
G |
A |
T |
T |
T |
A |
2 |
T |
C |
G |
C |
- |
A |
7 |
A |
- |
C |
C |
2 |
- |
C |
C |
A |
|
|
|
|
|
|
|
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|
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|
|
|
|
|
|
|
|
|
|
|
|
T
|
C
|
G
|
C/T
|
-
|
C
|
-
|
-
|
A
|
-
|
-
|
-
|
C
|
T
|
-
|
-
|
-
|
7
|
T
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
2
|
-
|
-
|
-
|
-
|
-
|
G
|
T
|
A
|
T
|
G
|
T
|
4
|
T
|
7
|
A
|
A
|
G
|
A
|
C
|
A
|
T
|
3
|
-
|
C
|
C
|
G
|
G
|
T
|
A
|
A
|
C
|
6
|
2
|
2
|
T
|
G
|
-
|
T
|
4
|
C
|
T
|
22/-
|
G
|
T
|
C
|
T
|
G
|
G
|
A
|
T
|
C
|
A
|
-
|
-
|
-
|
2
|
A
|
T
|
T
|
C
|
A
|
T
|
T
|
C
|
C
|
T
|
A
|
C
|
C
|
T
|
-
|
G
|
G
|
T
|
T
|
A
|
-
|
-
|
6
|
C
|
T
|
-
|
2
|
6
|
2
|
T
|
C
|
C
|
A
|
-
|
G
|
T
|
T
|
G
|
T
|
T
|
A
|
T
|
C
|
T
|
G
|
C
|
-
|
-
|
-
|
2
|
-
|
A
|
C
|
-
|
-
|
-
|
-
|
C
|
G
|
A
|
C
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
G
|
-
|
-
|
-
|
G
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
A
|
T
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
A
|
-
|
-
|
G
|
2
|
C
|
A
|
A
|
G
|
-
|
T
|
G
|
T
|
-
|
T
|
-
|
-
|
-
|
-
|
-
|
G
|
G
|
G
|
-
|
G
|
-
|
-
|
-
|
A
|
3/A
|
-
|
G
|
A
|
G
|
A
|
G
|
G
|
G
|
3
|
-
|
C
|
C
|
G
|
G
|
T
|
T
|
G
|
T
|
G
|
-
|
T
|
-
|
T
|
A
|
T
|
T
|
T
|
C
|
A
|
A
|
C
|
G
|
-
|
-
|
A
|
-
|
C
|
-
|
-
|
G
|
A
|
-
|
-
|
-
|
T
|
-
|
-
|
C
|
G
|
-
|
-
|
G
|
2
|
-
|
A
|
-
|
-
|
-
|
G
|
-
|
C
|
A
|
A
|
A
|
A
|
C
|
T
|
2
|
C
|
2
|
C
|
6
|
A
|
T
|
T
|
T
|
2
|
A
|
-
|
T
|
-
|
-
|
G
|
-
|
-
|
2
|
G
|
G
|
-
|
C
|
-
|
T
|
T
|
G
|
-
|
T
|
T
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
G
|
G
|
-
|
C
|
3
|
-
|
-
|
-/2
|
20
|
16/-
|
C
|
C
|
C
|
G
|
G
|
T
|
C
|
C
|
G
|
A
|
-
|
-
|
A
|
A
|
A
|
T
|
A
|
A
|
C
|
A
|
A
|
-
|
-
|
T
|
G
|
C
|
G
|
21
|
5
|
C
|
G
|
T
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
C
|
-/2
|
G
|
T
|
C
|
C
|
C
|
-
|
G
|
G
|
-
|
G
|
G
|
G
|
C
|
G
|
C
|
C
|
G
|
G
|
G
|
T
|
4
|
A
|
C
|
G
|
-
|
T
|
C
|
G
|
T
|
C
|
A
|
C
|
G
|
T
|
C
|
C
|
G
|
T
|
C
|
C
|
C
|
T
|
T
|
C
|
C
|
C
|
A
|
T
|
-
|
G
|
C
|
C
|
T
|
T
|
G
|
T
|
-
|
-
|
T
|
A
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
T
|
-
|
C
|
T
|
C
|
-
|
4
|
A
|
T
|
A
|
A
|
T
|
T
|
A
|
-
|
C
|
T
|
-
|
G
|
T
|
A
|
T
|
T
|
A
|
C
|
G
|
-
|
-
|
G
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
T
|
C
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
C
|
C
|
A
|
C
|
C
|
G
|
C
|
G
|
G
|
G
|
C
|
A
|
-
|
T
|
5
|
G
|
C
|
A
|
4
|
A
|
T
|
A
|
T
|
A
|
C
|
T
|
A
|
-
|
C
|
-
|
T
|
-
|
G
|
C
|
G
|
T
|
G
|
A
|
A
|
G
|
A
|
G
|
A
|
G
|
C
|
G
|
-
|
C
|
A
|
A
|
T
|
10
|
G
|
-
|
T
|
4
|
T
|
T
|
-
|
3
|
A
|
T
|
G
|
|