|
.003 |
.005 |
.0 |
.001 |
.001 |
.003 |
.0 |
.001 |
.013 |
.001 |
.0 |
.007 |
.0 |
.005 |
.001 |
.0 |
.002 |
.001 |
.009 |
.196 |
.847 |
.95 |
.159 |
.051 |
.005 |
.0 |
.216 |
.0 |
.141 |
.172 |
.996 |
.958 |
.11 |
.008 |
.437 |
.229 |
.001 |
.001 |
.0 |
.0 |
.0 |
.0 |
.003 |
.007 |
.036 |
.048 |
.711 |
.006 |
.083 |
.004 |
.003 |
.001 |
.007 |
.12 |
.308 |
.35 |
.765 |
.165 |
.171 |
.174 |
.176 |
.004 |
.002 |
.0 |
.003 |
.001 |
.071 |
.014 |
.832 |
.002 |
.001 |
.03 |
.0 |
.004 |
.001 |
.01 |
.695 |
.0 |
.999 |
.377 |
.001 |
.003 |
.0 |
.001 |
.0 |
.008 |
.009 |
.023 |
.0 |
.003 |
.387 |
.051 |
.014 |
.0 |
.256 |
.006 |
.127 |
.04 |
.0 |
.003 |
.002 |
.057 |
.402 |
.365 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.001 |
.037 |
.053 |
.57 |
.001 |
.033 |
.0 |
.001 |
.184 |
.0 |
.0 |
.005 |
.012 |
.625 |
.004 |
.0 |
.003 |
.001 |
.0 |
.0 |
.0 |
.084 |
.0 |
.006 |
.001 |
.0 |
.036 |
.007 |
.003 |
.152 |
.857 |
.0 |
.002 |
.0 |
.002 |
.001 |
.043 |
.09 |
.013 |
.001 |
.0 |
.01 |
.017 |
.084 |
.247 |
.02 |
-- |
-- |
.002 |
.103 |
.002 |
.0 |
.001 |
.001 |
.001 |
.002 |
.593 |
.366 |
.003 |
.007 |
.002 |
.002 |
.0 |
.0 |
.002 |
.013 |
.0 |
.0 |
.0 |
.06 |
-- |
.031 |
.127 |
.014 |
.003 |
.002 |
.001 |
.131 |
.003 |
.002 |
.01 |
.065 |
.028 |
.001 |
.007 |
.993 |
.076 |
.005 |
.466 |
.0 |
.227 |
.003 |
.0 |
.0 |
.0 |
.001 |
.0 |
.003 |
.002 |
.071 |
.004 |
.031 |
.011 |
.155 |
.001 |
.004 |
.001 |
.0 |
.008 |
.003 |
.005 |
.006 |
.008 |
.023 |
.053 |
.001 |
.174 |
.094 |
.006 |
.003 |
.001 |
.007 |
.006 |
.0 |
.0 |
.0 |
.003 |
.871 |
.095 |
.001 |
.226 |
.111 |
.018 |
.01 |
.02 |
.246 |
.013 |
.224 |
.984 |
.0 |
.132 |
.009 |
.0 |
.016 |
.003 |
.004 |
.008 |
-- |
-- |
-- |
.058 |
.008 |
.11 |
-- |
.001 |
.039 |
.002 |
.0 |
.998 |
.001 |
.0 |
.002 |
.02 |
.964 |
.764 |
.708 |
.001 |
.0 |
.0 |
.0 |
.005 |
.0 |
.029 |
.012 |
.012 |
.0 |
.001 |
.803 |
.003 |
.0 |
.009 |
.0 |
.0 |
.11 |
.033 |
.003 |
.002 |
.002 |
.0 |
.063 |
.093 |
.096 |
.096 |
.0 |
.0 |
.0 |
.0 |
.009 |
1.0 |
.998 |
.002 |
.0 |
.013 |
.999 |
.0 |
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
Dnmt3a
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
G |
- |
G |
C |
C |
- |
- |
- |
- |
C |
- |
- |
- |
- |
- |
G |
C |
C |
- |
- |
2 |
T |
2 |
2 |
C |
- |
C |
G |
C |
2 |
- |
T |
- |
C |
T |
C |
2 |
T |
G |
C |
G |
T |
G |
A |
T |
G |
A |
G |
G |
C |
C |
- |
2 |
C |
- |
- |
A |
- |
G |
12 |
A |
T |
G |
A |
G |
14 |
C |
32 |
A |
T |
G |
A |
T |
T |
A |
C |
4 |
T |
G |
T |
G |
T |
A |
A |
G |
C |
- |
C |
4 |
C |
C |
T |
A |
G |
A |
C |
- |
G |
T |
G |
A |
T |
- |
A |
C |
T |
A |
C |
A |
- |
C |
A |
A |
A |
T |
C |
A |
9 |
T |
C |
G |
- |
C |
G |
T |
T |
A |
A |
A |
A |
T |
C |
T |
C |
C |
C |
C |
A |
C |
C |
G |
A |
T |
G |
A |
C |
A |
A |
A |
A |
T |
C |
2 |
A |
G |
A |
T |
A |
T |
C |
18 |
- |
C |
C |
A |
A |
2 |
6 |
- |
- |
C |
A |
2 |
A |
G |
G |
3 |
9 |
G |
A |
A |
T |
C |
C |
G |
G |
A |
A |
C |
C |
- |
G |
T |
A |
G |
C |
A |
A |
T |
A |
C |
T |
G |
- |
A |
A |
G |
G |
T |
A |
T |
A |
A |
C |
C |
C |
C |
G |
G |
C |
2 |
G |
C |
G |
4 |
T |
C |
T |
A |
G |
12 |
G |
T |
C |
C |
T |
T |
T |
C |
G |
5 |
C |
G |
T |
A |
G |
T |
A |
A |
C |
- |
C |
G |
G |
- |
G |
G |
A |
T |
A |
T |
T |
A |
A |
G |
T |
A |
- |
- |
C |
A |
T |
A |
- |
A |
G |
A |
A |
C |
C |
G |
T |
T |
- |
T |
2 |
C |
A |
A |
T |
T |
C |
- |
A |
G |
T |
C |
C |
A |
C |
C |
T |
A |
T |
T |
T |
T |
A |
C |
C |
C |
C |
T |
- |
G |
A |
A |
C |
C |
G |
A |
T |
C |
T |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C/G
|
-
|
2
|
-
|
-
|
-
|
C
|
C
|
C
|
G
|
-
|
3
|
G
|
G
|
G
|
T
|
C
|
G
|
-
|
G
|
G
|
-
|
G
|
-
|
-
|
-
|
2
|
-
|
C
|
T
|
-
|
G
|
-
|
C
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
C
|
-
|
-
|
T
|
C
|
-
|
-
|
-
|
C
|
T
|
-
|
G
|
-
|
-
|
2
|
C
|
G
|
2
|
C
|
-
|
G
|
G
|
T
|
C
|
A
|
-
|
T
|
-
|
G
|
C
|
A
|
G
|
G
|
C
|
G
|
T
|
-
|
-
|
A
|
C
|
A
|
A
|
-
|
G
|
A
|
T
|
6
|
T
|
-
|
T
|
T
|
C
|
C
|
A
|
A/G
|
A
|
-/G
|
T
|
C
|
A
|
G
|
C
|
5
|
G
|
C/T
|
T/C
|
A/G
|
C/T
|
-
|
3
|
C/G
|
A/G
|
A/G
|
A/C
|
T/C
|
C/T
|
A/T
|
9/-
|
A
|
T
|
A
|
4
|
T
|
C
|
A
|
C
|
G/G
|
T
|
G
|
T
|
C
|
A
|
C
|
T
|
T
|
T
|
T
|
G
|
A
|
G
|
C
|
G
|
-
|
G/-
|
G
|
T
|
T
|
G
|
G
|
-
|
C
|
A
|
-
|
G
|
A
|
C
|
-
|
T
|
C
|
-
|
-
|
T
|
A
|
T
|
G
|
G
|
-
|
-
|
-/T
|
C
|
T
|
G
|
-
|
G
|
T
|
A
|
-
|
-
|
A
|
C
|
G
|
C
|
T
|
G
|
A
|
T
|
G
|
C
|
T
|
G
|
T
|
T
|
A
|
G
|
T
|
T
|
G
|
G
|
C
|
G
|
T
|
C
|
C
|
2
|
G
|
C
|
A
|
A
|
C
|
G
|
C
|
G
|
T
|
T
|
A
|
-
|
T
|
A
|
A
|
A
|
-
|
A
|
T
|
A
|
4/-
|
C
|
T
|
C
|
T
|
A
|
-
|
A
|
C
|
A
|
T
|
C
|
A
|
G
|
T
|
T
|
-
|
T
|
C
|
C
|
C
|
T
|
C
|
G
|
G
|
T
|
G
|
T
|
T
|
A
|
C
|
-
|
C
|
G
|
C
|
T
|
C
|
C
|
G
|
T
|
T
|
C
|
G
|
T
|
3
|
T
|
G
|
C
|
G
|
A
|
G
|
T
|
G
|
G
|
T
|
T
|
T
|
C
|
G
|
C
|
-
|
-
|
T
|
C
|
T
|
C
|
C
|
T
|
4
|
G
|
T
|
C
|
T
|
T
|
G
|
-
|
T
|
C
|
C
|
C
|
C
|
C
|
G
|
T
|
G
|
G
|
G
|
A
|
G
|
2
|
A
|
G
|
G
|
T
|
T
|
A
|
G
|
G
|
-
|
C
|
A
|
|