|
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.01 |
.004 |
.005 |
.009 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.019 |
.023 |
.039 |
.037 |
.022 |
.015 |
.001 |
.01 |
.003 |
.015 |
.123 |
.008 |
.002 |
.001 |
.014 |
.018 |
.015 |
.144 |
.503 |
.035 |
.086 |
.198 |
.123 |
.008 |
.131 |
.047 |
.027 |
.053 |
.017 |
.018 |
.011 |
.03 |
.032 |
.051 |
.004 |
.003 |
.041 |
.052 |
.054 |
.054 |
.005 |
.025 |
.068 |
.011 |
.055 |
.016 |
.005 |
.05 |
.005 |
.008 |
.062 |
.0 |
.012 |
.034 |
.003 |
.011 |
.005 |
.002 |
.005 |
.012 |
.002 |
.012 |
.032 |
.05 |
.003 |
.003 |
.015 |
.017 |
.008 |
.003 |
.001 |
.0 |
.0 |
.007 |
.003 |
.221 |
.026 |
.017 |
.022 |
.022 |
.143 |
.009 |
.017 |
.044 |
.081 |
.051 |
.008 |
.009 |
.002 |
.014 |
.014 |
.044 |
.007 |
.004 |
.007 |
.009 |
.017 |
.039 |
.029 |
.006 |
.003 |
.007 |
.008 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.001 |
.015 |
.931 |
.313 |
.002 |
.018 |
.312 |
.428 |
.772 |
.79 |
.58 |
.596 |
.048 |
.975 |
.896 |
.981 |
.788 |
.329 |
.094 |
.407 |
.009 |
.134 |
.115 |
.398 |
.949 |
.77 |
.747 |
.885 |
.802 |
.252 |
.234 |
.478 |
.76 |
.391 |
.024 |
.086 |
.004 |
.01 |
.009 |
.001 |
.002 |
.01 |
.053 |
.007 |
.048 |
.014 |
.03 |
.521 |
.525 |
.004 |
.001 |
.001 |
.063 |
.02 |
.01 |
.002 |
.002 |
.021 |
.004 |
.008 |
.001 |
.044 |
.004 |
.001 |
.001 |
.002 |
.004 |
.822 |
.898 |
.999 |
.179 |
.081 |
.991 |
.999 |
.105 |
.949 |
.955 |
.952 |
.31 |
.302 |
.257 |
.972 |
.982 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.017 |
.003 |
.002 |
.0 |
.004 |
.006 |
.004 |
.018 |
.165 |
.044 |
.019 |
.013 |
.001 |
.001 |
.004 |
.152 |
.03 |
.0 |
.015 |
.011 |
.283 |
.102 |
.124 |
.018 |
.033 |
.023 |
.64 |
.045 |
.072 |
.287 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.289 |
.082 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
|
Cyp2c66l
|
Cyp2c66l
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
Cyp2c6
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
Cyp2c7
|
|
A |
A |
C |
T |
T |
T |
T |
T |
G |
A |
A |
C |
C |
A |
C |
C |
A |
A |
C |
T |
T |
T |
T |
A |
A |
T |
C |
G |
G |
T |
C |
A |
G |
T |
A |
T |
A |
G |
G |
C |
G |
G |
A |
T |
G |
G |
A |
C |
G |
C |
G |
T |
T |
G |
G |
T |
C |
T |
G |
G |
G |
G |
C |
T |
C |
T |
A |
C |
C |
G |
G |
C |
T |
C |
G |
C |
A |
T |
G |
T |
G |
G |
C |
T |
G |
G |
T |
G |
G |
G |
G |
A |
C |
A |
A |
A |
A |
T |
T |
T |
T |
G |
C |
A |
A |
T |
T |
T |
A |
C |
C |
A |
T |
G |
C |
A |
G |
G |
G |
G |
T |
T |
C |
C |
G |
A |
C |
G |
G |
T |
G |
C |
T |
A |
C |
T |
G |
T |
A |
G |
A |
A |
G |
A |
G |
A |
A |
G |
C |
C |
G |
C |
G |
C |
T |
G |
C |
A |
T |
C |
T |
C |
C |
G |
A |
G |
T |
T |
A |
A |
T |
T |
T |
C |
T |
A |
A |
G |
C |
C |
A |
C |
C |
A |
G |
G |
C |
G |
A |
C |
A |
G |
A |
G |
T |
C |
G |
G |
G |
A |
A |
T |
C |
T |
C |
A |
C |
G |
T |
G |
C |
C |
G |
T |
G |
T |
T |
C |
C |
T |
T |
A |
T |
T |
G |
A |
T |
C |
A |
G |
C |
C |
C |
T |
A |
A |
G |
C |
T |
T |
A |
T |
G |
G |
G |
C |
A |
T |
T |
C |
G |
G |
G |
T |
C |
G |
T |
A |
C |
T |
C |
G |
A |
A |
G |
G |
C |
G |
G |
A |
C |
G |
G |
A |
G |
T |
C |
C |
C |
G |
C |
A |
G |
C |
C |
G |
A |
T |
G |
C |
G |
C |
C |
A |
T |
G |
G |
C |
A |
T |
C |
A |
A |
G |
C |
T |
G |
G |
T |
C |
A |
C |
A |
C |
C |
A |
T |
G |
G |
T |
G |
T |
G |
A |
G |
T |
C |
T |
C |
G |
C |
G |
T |
A |
G |
C |
A |
T |
C |
A |
A |
G |
C |
A |
A |
T |
T |
G |
T |
A |
C |
A |
C |
T |
T |
G |
T |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A/C
|
A/G
|
C/G
|
T/C
|
T/A
|
T/C
|
T/C
|
T/C
|
G/A
|
A/G
|
A/G
|
T
|
T
|
C
|
C/T
|
C/A
|
A/G
|
A/C
|
C/T
|
T/C
|
T/C
|
G
|
T/C
|
C
|
A/G
|
T/A
|
C/T
|
G/T
|
G/A
|
T/G
|
C/G
|
A/G
|
T
|
G
|
A/C
|
T/C
|
A/G
|
G/T
|
G/T
|
C/G
|
G/T
|
G/T
|
A/G
|
T/C
|
G/A
|
G/A
|
A/T
|
C/A
|
G/T
|
C/T
|
G/A
|
T/C
|
T/A
|
G/A
|
G/A
|
T/A
|
C/T
|
T/C
|
G/A
|
G/A
|
G/A
|
G/T
|
C/T
|
T/G
|
C/T
|
T/C
|
A/T
|
C/G
|
C/A
|
G/A
|
G/C
|
C/A
|
T/A
|
C/A
|
G/A
|
C/A
|
A/G
|
T/C
|
G/A
|
T/A
|
G/C
|
G/T
|
C/T
|
T/G
|
G/A
|
G/A
|
T/G
|
G/A
|
G/C
|
G/A
|
G/A
|
A/G
|
C/T
|
A/T
|
A/T
|
A/G
|
A/G
|
T/C
|
T/G
|
T/C
|
T/C
|
G/C
|
C/T
|
A/C
|
A/G
|
T/A
|
T/C
|
T/C
|
A/T
|
C/T
|
C/T
|
A/T
|
T/C
|
G/C
|
C/T
|
A/C
|
G/A
|
G/T
|
G/A
|
G/T
|
T/G
|
T/C
|
C/A
|
C/T
|
G/A
|
A/T
|
C/T
|
G/A
|
G/A
|
T/G
|
G/A
|
C/T
|
T/C
|
C/T
|
C/T
|
T/C
|
G/A
|
T/C
|
A/G
|
G/T
|
A/T
|
A/C
|
G/T
|
A/C
|
G/C
|
A/T
|
A/T
|
G/C
|
C/T
|
C/T
|
G/T
|
C/T
|
G/A
|
C/A
|
T/C
|
G/A
|
C/A
|
A/T
|
T/C
|
C/A
|
T/G
|
C/G
|
C/T
|
G/A
|
A/T
|
G/A
|
T/A
|
T/C
|
A/C
|
A/G
|
T/C
|
T/C
|
T/A
|
C/T
|
T/A
|
A/C
|
A/C
|
G/A
|
C/A
|
C/T
|
A/G
|
C/A
|
C/T
|
A/C
|
G/C
|
G/A
|
C/T
|
G/A
|
A/G
|
C/T
|
A/C
|
G/A
|
A/G
|
G/A
|
T/A
|
C/G
|
G/C
|
G/A
|
G/A
|
A/G
|
A/G
|
T/C
|
C/G
|
T/C
|
C/T
|
A/G
|
C/T
|
G/A
|
T/G
|
G/C
|
C/T
|
C/G
|
G/A
|
T/C
|
G/A
|
T/C
|
T/G
|
C/T
|
C/A
|
T/G
|
T/C
|
A/G
|
T/C
|
T/C
|
G/A
|
A/T
|
T/C
|
C/T
|
A/G
|
G/A
|
C/T
|
C/T
|
C/T
|
T/C
|
A/G
|
A/G
|
G/A
|
C/T
|
T/C
|
T/C
|
A/G
|
T/C
|
G/A
|
G/A
|
G/A
|
C/T
|
A/C
|
T/G
|
T/C
|
C/A
|
G/T
|
G/T
|
G/C
|
T/A
|
C/T
|
G/T
|
T/C
|
A/C
|
C/A
|
T/C
|
C/T
|
G/A
|
A/G
|
A/G
|
G/A
|
G/A
|
C/T
|
G/T
|
G/A
|
A/G
|
C/T
|
G/A
|
G/A
|
A/T
|
G/A
|
T/C
|
C/A
|
C/A
|
C/T
|
G/T
|
C/T
|
A/C
|
G/C
|
C/T
|
C/A
|
G/T
|
A/G
|
T/C
|
G/T
|
C/T
|
G/C
|
C/T
|
C/A
|
A/T
|
T/G
|
G/C
|
G/A
|
C/A
|
A/G
|
T/C
|
C/T
|
A/G
|
A/T
|
G/T
|
C/T
|
T/A
|
G/A
|
G/A
|
T/G
|
C/A
|
A/G
|
C/T
|
A/C
|
C/A
|
C/T
|
A/T
|
T/C
|
G/A
|
G/T
|
T/G
|
G/A
|
T/G
|
G/C
|
A/G
|
G/A
|
T/G
|
C/T
|
T/C
|
C/A
|
G/A
|
C/G
|
G/A
|
T/C
|
A/T
|
G/T
|
C/T
|
A/T
|
C
|
A
|
A/C
|
G
|
A
|
C/T
|
A/C
|
A/G
|
T/A
|
T/C
|
G/T
|
T/A
|
A/G
|
C/T
|
A/G
|
C/T
|
T/A
|
T/A
|
G/C
|
A
|
A/G
|
|