|
.676 |
.001 |
.001 |
.105 |
.002 |
.001 |
.001 |
.116 |
.0 |
.005 |
.066 |
.537 |
.001 |
.022 |
.002 |
.001 |
.104 |
.001 |
.187 |
.001 |
.0 |
.033 |
.0 |
.009 |
.025 |
.204 |
.165 |
.003 |
.0 |
.0 |
.001 |
.007 |
.001 |
.001 |
-- |
.598 |
.036 |
.002 |
.216 |
.099 |
.076 |
.04 |
.003 |
.012 |
.791 |
.002 |
.003 |
.003 |
.0 |
.0 |
.037 |
.0 |
.0 |
.0 |
.001 |
.0 |
.224 |
.44 |
.002 |
.004 |
.052 |
.006 |
.997 |
.985 |
.991 |
.554 |
.436 |
.918 |
-- |
.002 |
.012 |
.003 |
.016 |
.002 |
.0 |
.0 |
.0 |
.0 |
.001 |
.769 |
.01 |
.0 |
.001 |
.0 |
.017 |
.0 |
.135 |
1.0 |
.0 |
.001 |
.147 |
.153 |
.086 |
.001 |
.104 |
.112 |
.0 |
.01 |
.216 |
.0 |
.647 |
.011 |
.007 |
.001 |
.001 |
.118 |
.002 |
.009 |
.001 |
.001 |
.033 |
.05 |
.001 |
.004 |
.0 |
.001 |
.001 |
.001 |
.042 |
.033 |
.113 |
.047 |
.052 |
.166 |
.001 |
-- |
.0 |
.019 |
.003 |
.002 |
.952 |
.068 |
.008 |
.003 |
.056 |
.002 |
.006 |
.006 |
.243 |
.001 |
.983 |
.199 |
.001 |
.011 |
.0 |
.0 |
.0 |
.002 |
.0 |
.117 |
.004 |
.005 |
.003 |
.001 |
.159 |
.323 |
.001 |
.003 |
.0 |
.011 |
.011 |
.005 |
.177 |
.011 |
.425 |
.004 |
.001 |
.061 |
.133 |
.017 |
.16 |
.0 |
.0 |
.34 |
.052 |
.114 |
.178 |
.997 |
1.0 |
.0 |
.005 |
.004 |
.005 |
.003 |
.063 |
.003 |
.003 |
.001 |
.001 |
.0 |
.003 |
.0 |
.001 |
.006 |
.002 |
.002 |
.001 |
.0 |
.0 |
.012 |
.025 |
.003 |
.011 |
.02 |
.0 |
.004 |
.223 |
.001 |
.024 |
.001 |
.022 |
.506 |
.619 |
.0 |
.997 |
1.0 |
.0 |
.134 |
.352 |
.332 |
.377 |
.929 |
.847 |
.0 |
.002 |
.001 |
.059 |
.09 |
.001 |
.001 |
.0 |
.0 |
.002 |
.002 |
.0 |
.0 |
.003 |
.385 |
.0 |
.154 |
.001 |
.001 |
.0 |
-- |
-- |
-- |
.002 |
.001 |
.0 |
.003 |
.001 |
.008 |
.188 |
.0 |
.0 |
.0 |
.3 |
.001 |
.008 |
.029 |
.012 |
.001 |
.006 |
.012 |
.022 |
.069 |
.001 |
.073 |
.133 |
.157 |
.001 |
.624 |
.004 |
.035 |
.0 |
.0 |
.002 |
.003 |
.266 |
.038 |
.0 |
.0 |
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
Atg7
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
C |
C |
C |
A |
G |
C |
A |
A |
G |
G |
A |
A |
A |
T |
C |
G |
T |
A |
G |
C |
A |
C |
C |
C |
A |
C |
A |
A |
C |
T |
A |
A |
A |
G |
C |
G |
A |
C |
T |
T |
C |
G |
C |
T |
T |
G |
G |
T |
C |
G |
T |
T |
A |
T |
T |
A |
C |
A |
T |
C |
G |
G |
A |
T |
C |
G |
A |
C |
C |
A |
A |
C |
A |
C |
A |
A |
C |
T |
A |
C |
T |
T |
A |
G |
T |
T |
G |
C |
T |
G |
T |
G |
A |
A |
A |
T |
T |
G |
C |
G |
C |
T |
T |
A |
T |
G |
A |
G |
C |
C |
C |
T |
A |
A |
T |
A |
G |
A |
G |
C |
C |
C |
C |
A |
G |
C |
A |
C |
C |
A |
G |
C |
A |
C |
G |
G |
G |
C |
A |
C |
C |
C |
C |
T |
A |
A |
G |
T |
C |
G |
G |
A |
A |
C |
T |
G |
A |
G |
G |
C |
C |
T |
T |
C |
C |
T |
G |
A |
T |
C |
G |
G |
G |
C |
C |
G |
G |
A |
A |
C |
T |
A |
C |
A |
G |
T |
T |
T |
C |
A |
A |
A |
A |
G |
T |
A |
G |
T |
A |
T |
T |
T |
A |
A |
C |
G |
A |
A |
A |
T |
C |
G |
A |
G |
T |
A |
A |
C |
T |
A |
A |
G |
A |
C |
C |
A |
G |
A |
A |
G |
C |
C |
G |
G |
T |
G |
G |
A |
T |
T |
G |
C |
C |
T |
A |
A |
T |
G |
A |
C |
C |
A |
T |
C |
A |
A |
G |
T |
A |
A |
T |
C |
C |
T |
A |
T |
G |
G |
A |
A |
T |
C |
T |
A |
A |
A |
T |
G |
A |
A |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
T
|
T
|
T
|
G
|
T
|
T
|
T
|
T
|
A
|
A
|
C
|
G
|
G
|
A
|
T
|
A
|
C
|
G
|
A
|
T
|
G
|
T
|
T
|
T
|
G
|
T
|
T
|
G
|
T
|
C
|
G
|
G
|
G
|
T
|
T
|
C
|
G
|
T
|
C
|
C
|
T
|
A
|
C/T
|
C
|
A
|
A
|
G/C
|
C
|
T
|
A
|
C
|
C
|
C
|
C
|
C
|
C
|
T
|
T
|
C
|
T
|
A
|
A
|
T
|
C
|
C/T
|
G/A
|
G
|
C/T
|
T
|
T
|
T
|
T
|
T
|
T
|
A/T
|
G
|
T
|
C
|
G
|
T
|
C
|
C
|
G
|
T
|
C
|
C
|
A
|
G
|
T/C
|
T
|
A
|
T
|
T
|
G
|
G
|
C
|
C
|
A
|
T
|
A
|
T
|
C
|
C
|
G
|
C
|
A
|
G
|
A
|
T
|
T
|
T
|
C
|
G
|
G
|
T/G
|
A/G
|
C
|
C
|
A
|
T
|
T
|
T
|
T
|
G
|
A
|
T
|
G
|
G
|
C/T
|
A/G
|
C
|
T
|
G
|
G
|
T
|
A
|
T
|
T
|
G
|
T
|
T
|
A
|
T
|
C
|
G
|
G
|
A
|
C
|
T
|
C
|
A
|
G
|
G
|
A
|
A
|
A
|
T
|
T
|
A
|
T
|
G
|
A
|
A
|
A
|
C/T
|
C
|
A
|
G
|
C
|
A
|
A
|
A
|
A
|
T
|
T
|
T
|
T
|
T
|
G
|
T
|
C
|
T
|
A
|
C
|
A
|
C
|
C
|
C
|
T
|
G
|
C
|
G
|
G
|
A
|
C
|
G
|
A
|
A
|
G
|
A
|
G
|
C
|
G
|
G
|
G
|
A
|
G
|
G
|
G
|
G
|
T
|
A
|
G
|
A
|
T/A
|
C
|
T
|
G
|
G
|
A/C
|
C
|
A
|
C
|
T
|
T
|
G
|
A
|
C
|
G
|
A
|
T
|
T
|
A
|
A
|
C
|
A
|
A
|
G
|
C
|
C
|
A
|
G
|
G
|
T/C
|
G
|
G
|
C
|
A
|
G
|
T
|
T
|
G
|
C
|
G
|
G
|
T
|
A
|
C
|
T
|
G
|
G
|
T
|
T
|
A
|
G
|
C
|
C
|
T
|
T
|
G
|
T/G
|
G
|
C
|
A/G
|
A/G
|
G
|
C
|
A
|
G
|
T
|
G
|
|