|
.221 |
.003 |
.007 |
.0 |
.457 |
.543 |
.211 |
.182 |
.056 |
.053 |
.007 |
.017 |
.302 |
.506 |
.006 |
.0 |
.0 |
.002 |
.024 |
.001 |
.102 |
.08 |
.359 |
.352 |
.352 |
.633 |
.01 |
.002 |
.001 |
.042 |
.961 |
.992 |
.008 |
.019 |
.001 |
.007 |
.018 |
.026 |
.228 |
.051 |
.211 |
.001 |
.087 |
.001 |
.248 |
.017 |
.002 |
.019 |
.006 |
.043 |
.002 |
.022 |
.006 |
.019 |
.0 |
.181 |
.002 |
.009 |
.001 |
.267 |
.347 |
.013 |
.008 |
.281 |
.043 |
.01 |
.159 |
.289 |
.061 |
.003 |
.405 |
.636 |
.0 |
.782 |
.672 |
.001 |
.0 |
.0 |
.011 |
.002 |
.019 |
.0 |
.001 |
.005 |
.001 |
.003 |
.005 |
.015 |
.011 |
.021 |
.003 |
.004 |
.002 |
.001 |
.001 |
.02 |
.021 |
.004 |
.009 |
.021 |
.006 |
.009 |
.005 |
.004 |
.01 |
.06 |
.074 |
-- |
-- |
.963 |
.346 |
.069 |
.055 |
.139 |
.399 |
.103 |
.0 |
.01 |
.04 |
.009 |
.043 |
.005 |
.001 |
.0 |
.0 |
.004 |
.002 |
.0 |
.0 |
.0 |
.002 |
.004 |
.001 |
.003 |
.0 |
.0 |
.001 |
.032 |
.038 |
.006 |
.206 |
.005 |
.999 |
.996 |
1.0 |
1.0 |
.999 |
1.0 |
1.0 |
.003 |
.0 |
.097 |
.0 |
.0 |
.0 |
.0 |
.003 |
.151 |
.136 |
.145 |
.001 |
.001 |
.051 |
.254 |
.412 |
.365 |
.094 |
.062 |
.143 |
.122 |
.044 |
.008 |
.012 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.008 |
.357 |
.24 |
.005 |
.015 |
.021 |
.046 |
.106 |
.003 |
.005 |
.001 |
.013 |
.0 |
.001 |
.0 |
.0 |
.002 |
.003 |
.049 |
.011 |
.008 |
.0 |
.329 |
.103 |
.112 |
.599 |
.659 |
.022 |
.001 |
.001 |
.001 |
.0 |
.001 |
.338 |
.044 |
-- |
-- |
.016 |
.0 |
.002 |
.006 |
.0 |
.0 |
.002 |
.008 |
.001 |
-- |
-- |
-- |
-- |
-- |
.128 |
.007 |
.984 |
.998 |
.003 |
.0 |
.001 |
.021 |
.023 |
.005 |
.0 |
.041 |
.037 |
.062 |
.002 |
.001 |
.226 |
.213 |
.127 |
-- |
.012 |
.058 |
.002 |
.002 |
.207 |
.303 |
.127 |
.026 |
.136 |
.167 |
.157 |
.166 |
.138 |
.02 |
.027 |
.578 |
.12 |
.016 |
.233 |
.0 |
.003 |
.191 |
.998 |
-- |
.168 |
.021 |
.0 |
.079 |
.009 |
.001 |
.03 |
.021 |
.02 |
.011 |
.0 |
.023 |
.091 |
-- |
.454 |
.999 |
.997 |
.146 |
.003 |
.009 |
.813 |
.0 |
.785 |
.079 |
.685 |
.001 |
.235 |
.001 |
.034 |
.0 |
.001 |
.023 |
.966 |
.552 |
.0 |
.011 |
.002 |
.023 |
.011 |
.0 |
.31 |
.09 |
1.0 |
.949 |
.018 |
.005 |
.07 |
.001 |
.874 |
.0 |
.884 |
.0 |
.032 |
.01 |
.464 |
.004 |
.005 |
.008 |
.01 |
.164 |
.249 |
.027 |
.117 |
.058 |
.001 |
.004 |
.019 |
.023 |
.001 |
.019 |
.052 |
-- |
.007 |
.01 |
.0 |
.037 |
.041 |
.013 |
.193 |
.003 |
.002 |
.508 |
.0 |
.041 |
.97 |
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
Atg4c
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
A |
C |
- |
6 |
A |
A |
A |
G |
A |
G |
T |
T |
C |
T |
G |
G |
A |
T |
G |
G |
T |
C |
A |
A |
C |
A |
C |
A |
C |
C |
A |
A |
C |
A |
T |
C |
C |
T |
C |
G |
T |
C |
T |
G |
G |
C |
G |
G |
G |
G |
C |
G |
C |
C |
C |
T |
C |
- |
C |
A |
C |
G |
C |
- |
C |
A |
G |
A |
T |
A |
104 |
T |
G |
A |
A |
5 |
G |
C |
G |
C |
A |
G |
G |
A |
C |
G |
2 |
- |
A |
T |
- |
- |
C |
A |
A |
T |
C |
T |
- |
- |
- |
- |
G |
C |
- |
- |
- |
C |
- |
C |
T |
C |
C |
A |
A |
T |
A |
G |
5 |
T |
A |
G |
G |
A |
T |
C |
2 |
- |
T |
G |
A |
G |
C |
A |
G |
T |
A |
T |
- |
C |
A |
2 |
A |
G |
2 |
T |
4 |
G |
T |
- |
C |
2 |
- |
T |
A |
G |
G |
G |
C |
5 |
3 |
C |
2 |
C |
3 |
T |
C |
T |
T |
G |
G |
4 |
G |
2 |
A |
T |
C |
G |
- |
2 |
G |
- |
2 |
- |
A |
2 |
T |
- |
- |
- |
G |
A |
3 |
C |
- |
C |
G |
G |
G |
- |
G |
A |
T |
4 |
- |
G |
C |
T |
17 |
2 |
11 |
T |
C |
G |
G |
A |
A |
C |
C |
G |
C |
6 |
- |
3 |
T |
G |
T |
C |
- |
G |
C |
T |
T |
C |
C |
A |
T |
T |
2 |
C |
T |
- |
A |
T |
G |
A |
- |
G |
T |
C |
2 |
G |
C |
T |
T |
- |
T |
T |
C |
G |
A |
G |
G |
C |
C |
G |
2 |
C |
G |
A |
T |
23 |
A |
T |
T |
C |
G |
T |
C |
G |
T |
T |
A |
T |
C |
C |
T |
T |
T |
T |
G |
C |
- |
C |
A |
A |
C |
C |
T |
C |
C |
G |
G |
T |
T |
G |
G |
G |
T |
G |
G |
G |
C |
T |
C |
G |
A |
G |
A |
C |
C |
A |
G |
C |
C |
12 |
A |
G |
A |
C |
40 |
C |
G |
T |
G |
C |
- |
G |
A |
G |
A |
T |
T |
A |
T |
T |
T |
C |
C |
C |
A |
C |
T |
T |
C |
A |
A |
G |
G |
T |
T |
C |
A |
C |
C |
G |
A |
T |
A |
G |
G |
3 |
A |
T |
G |
- |
G |
G |
A |
A |
G |
C |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C
|
G
|
G
|
-
|
T
|
G
|
C
|
A
|
G
|
C
|
A
|
C
|
T
|
G
|
A
|
A
|
C
|
G
|
A
|
T
|
G
|
T
|
G
|
G
|
G
|
C
|
T
|
G
|
A
|
A
|
G
|
G
|
A
|
G
|
C
|
A
|
T
|
A
|
G
|
T
|
C
|
A
|
C
|
A
|
A
|
T
|
A
|
A
|
A
|
A
|
T
|
T
|
A
|
T
|
G
|
G
|
T
|
5
|
T
|
C
|
T
|
A
|
A
|
13
|
-
|
G
|
A
|
G
|
C
|
C
|
-
|
C
|
A
|
G
|
G
|
-
|
A
|
A
|
A
|
A
|
C
|
A
|
A
|
G
|
A
|
A
|
-
|
G
|
-
|
C
|
G
|
T
|
G
|
C
|
C
|
-
|
T
|
-
|
G
|
T
|
G
|
A
|
C
|
A
|
T
|
G
|
A
|
-
|
2
|
A
|
C
|
T
|
T
|
G
|
T
|
A
|
C
|
T
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
T
|
A
|
-
|
-
|
-
|
C
|
T
|
-
|
T
|
-
|
-
|
-
|
-
|
C
|
-
|
-
|
-
|
A
|
A
|
G
|
T
|
-
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
2
|
-
|
T
|
A
|
-
|
T
|
-
|
-
|
-
|
T
|
T
|
T
|
-
|
G
|
-
|
G
|
G
|
-
|
-
|
A
|
T
|
A
|
-
|
-
|
-
|
-
|
12/A
|
A
|
T
|
C
|
-
|
-
|
-
|
C
|
T
|
A
|
T
|
C
|
T
|
G
|
T
|
A
|
T
|
-
|
8
|
-
|
G
|
A
|
G
|
T
|
G
|
C
|
T
|
C
|
C
|
T
|
G
|
G
|
A
|
G
|
-
|
T
|
G
|
2
|
G
|
C
|
C
|
G
|
G
|
A
|
G
|
-
|
-
|
A
|
T
|
A
|
C
|
5
|
C
|
-
|
T
|
A
|
G
|
A
|
A
|
T
|
T
|
A
|
-
|
T
|
A
|
G
|
C
|
-
|
T
|
-
|
C
|
T
|
A
|
C
|
G
|
T
|
C
|
C
|
A/G
|
T/A
|
T
|
C/A
|
A
|
C
|
C
|
C
|
A
|
A
|
A
|
T
|
G
|
T
|
T
|
T
|
-
|
T
|
T
|
A
|
A
|
A
|
C
|
A
|
A
|
A
|
A
|
A
|
A
|
T
|
T
|
C
|
T
|
T
|
G
|
-
|
T
|
-
|
-
|
G
|
A
|
T
|
T
|
-
|
G
|
A
|
G
|
A
|
40/-
|
T
|
A
|
C
|
A
|
T
|
G
|
A
|
G
|
A
|
G
|
-
|
C
|
G
|
G
|
C
|
-
|
T
|
G
|
T
|
G
|
T
|
A
|
C
|
T
|
G
|
G
|
A
|
-
|
G
|
C
|
A
|
T
|
A
|
T
|
A
|
T
|
-
|
G
|
A
|
C
|
-
|
G
|
A
|
-
|
T
|
A
|
-
|
-
|
T
|
A
|
T
|
C
|
|