|
.0 |
.0 |
.009 |
.017 |
.005 |
.017 |
.386 |
.544 |
.644 |
.567 |
.002 |
.001 |
.001 |
.002 |
.001 |
.021 |
.0 |
.012 |
.001 |
.001 |
.002 |
.008 |
.0 |
.019 |
.043 |
.631 |
.0 |
.001 |
.008 |
.003 |
.03 |
.002 |
.024 |
.003 |
.003 |
.002 |
.003 |
.015 |
.002 |
.012 |
.013 |
.004 |
.002 |
.858 |
.081 |
.125 |
.262 |
.397 |
.169 |
.155 |
.025 |
.001 |
.036 |
.0 |
.025 |
.012 |
.001 |
.005 |
.002 |
.044 |
.0 |
.0 |
.072 |
.375 |
.273 |
.153 |
.041 |
.0 |
.0 |
.003 |
.0 |
.012 |
.0 |
.0 |
.0 |
.023 |
.0 |
.001 |
.01 |
.0 |
.001 |
.001 |
.001 |
.0 |
.0 |
.07 |
.033 |
.4 |
.059 |
.005 |
.206 |
.005 |
.008 |
.554 |
.717 |
.001 |
.003 |
.01 |
.001 |
.148 |
.018 |
.01 |
.183 |
.018 |
.0 |
.005 |
.008 |
.018 |
.061 |
.009 |
.016 |
.0 |
.045 |
.148 |
.036 |
.0 |
.0 |
.162 |
.0 |
.004 |
.0 |
.0 |
.388 |
.159 |
.021 |
.004 |
.001 |
.012 |
.028 |
.015 |
.002 |
.0 |
.001 |
.003 |
.0 |
.001 |
.0 |
.009 |
.056 |
.081 |
.144 |
.114 |
.025 |
.047 |
.003 |
.001 |
.0 |
.001 |
.021 |
.0 |
.001 |
.31 |
.0 |
.083 |
.124 |
.001 |
.003 |
.643 |
.003 |
.199 |
.0 |
.01 |
.031 |
.002 |
.002 |
.008 |
.097 |
.093 |
.046 |
.047 |
.004 |
.019 |
.17 |
.706 |
1.0 |
.208 |
.069 |
.168 |
.025 |
.008 |
.024 |
.007 |
.001 |
.003 |
.035 |
.012 |
.026 |
.324 |
.112 |
.139 |
.133 |
.176 |
.187 |
.272 |
.328 |
.06 |
.045 |
.013 |
.013 |
.092 |
.002 |
.692 |
.548 |
.798 |
.782 |
.053 |
.437 |
.003 |
.022 |
.023 |
.023 |
.134 |
.107 |
.013 |
.05 |
.078 |
.005 |
.321 |
.103 |
.005 |
.005 |
.007 |
.104 |
.048 |
.053 |
.007 |
.063 |
.028 |
.156 |
.631 |
.006 |
.015 |
.149 |
.001 |
.001 |
.096 |
.023 |
.013 |
.067 |
.607 |
.004 |
.002 |
.0 |
.0 |
.0 |
.02 |
.006 |
.0 |
.011 |
.698 |
.04 |
.418 |
.445 |
.04 |
.018 |
.006 |
.012 |
.002 |
.005 |
.001 |
.042 |
.001 |
.134 |
.063 |
.001 |
.003 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
.0 |
.026 |
.0 |
.0 |
.0 |
.015 |
.026 |
.089 |
.001 |
.001 |
.85 |
.99 |
.984 |
.019 |
.032 |
.003 |
.712 |
.007 |
.055 |
.017 |
.035 |
.004 |
-- |
.0 |
.45 |
.123 |
.007 |
.111 |
.001 |
.0 |
.013 |
.0 |
.001 |
.003 |
.001 |
.005 |
.0 |
.084 |
.033 |
.001 |
.005 |
.017 |
.004 |
.003 |
.0 |
.008 |
.0 |
.0 |
.005 |
.002 |
.003 |
.015 |
.026 |
.016 |
.243 |
.314 |
.016 |
.004 |
.0 |
.004 |
.001 |
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Cxcl11
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Cxcl10
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
Art3
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
C |
C |
G |
C |
C |
T |
T |
T |
C |
T |
A |
C |
C |
T |
A |
T |
T |
T |
A |
T |
C |
A |
T |
A |
C |
C |
C |
G |
T |
A |
A |
T |
C |
G |
T |
T |
C |
C |
G |
A |
G |
A |
C |
C |
T |
G |
G |
G |
T |
T |
G |
A |
A |
G |
T |
A |
T |
C |
G |
T |
T |
G |
C |
G |
T |
A |
A |
T |
G |
G |
C |
T |
T |
T |
C |
T |
C |
G |
T |
C |
T |
A |
C |
C |
G |
A |
A |
A |
G |
G |
T |
C |
C |
G |
G |
A |
C |
T |
A |
T |
G |
C |
G |
T |
T |
T |
C |
T |
C |
C |
T |
T |
A |
A |
A |
A |
C |
T |
A |
A |
T |
C |
C |
A |
C |
C |
A |
A |
C |
A |
G |
A |
A |
C |
A |
A |
T |
A |
T |
G |
G |
A |
G |
A |
T |
A |
G |
A |
C |
G |
G |
C |
G |
C |
A |
T |
C |
T |
G |
A |
A |
A |
T |
G |
C |
A |
A |
G |
C |
T |
G |
G |
C |
A |
A |
T |
C |
T |
A |
A |
C |
A |
A |
A |
T |
T |
C |
G |
G |
G |
A |
C |
G |
G |
G |
T |
A |
G |
C |
T |
A |
G |
G |
C |
G |
A |
G |
G |
G |
T |
C |
A |
T |
G |
C |
G |
A |
C |
G |
T |
C |
A |
C |
A |
T |
A |
C |
T |
T |
A |
C |
G |
A |
C |
C |
A |
C |
T |
G |
T |
G |
T |
G |
G |
A |
A |
A |
A |
T |
T |
G |
C |
T |
G |
C |
G |
C |
A |
T |
G |
A |
T |
C |
A |
C |
T |
T |
G |
A |
G |
C |
T |
T |
G |
C |
A |
T |
C |
G |
A |
A |
A |
G |
C |
G |
C |
G |
C |
C |
A |
A |
C |
A |
A |
G |
A |
A |
T |
G |
T |
G |
G |
A |
C |
G |
C |
A |
A |
T |
T |
A |
G |
T |
A |
A |
G |
T |
G |
A |
T |
T |
T |
A |
C |
G |
C |
A |
G |
C |
T |
C |
G |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
T
|
A
|
T
|
C/T
|
C/T
|
T/C
|
T/C
|
T/C
|
T
|
C
|
G
|
T
|
G
|
C
|
G
|
C
|
C
|
C
|
G
|
C
|
T
|
G
|
C
|
C
|
T
|
T
|
T
|
A
|
C
|
G
|
G
|
C
|
G
|
A
|
C
|
C
|
T
|
T
|
A
|
G
|
C
|
G
|
T
|
G
|
C
|
A
|
A
|
T
|
C
|
C
|
C
|
G
|
G
|
T
|
A
|
G
|
C
|
T
|
A
|
C
|
C
|
A
|
T
|
A
|
G
|
G
|
G
|
C
|
A
|
A
|
T
|
C
|
C
|
C
|
T
|
C
|
T
|
A
|
C
|
T
|
A
|
G
|
T
|
T
|
T
|
G
|
G
|
G
|
A
|
A
|
C
|
T
|
C/G
|
C
|
A
|
G
|
T
|
C
|
G
|
C
|
A
|
T
|
A
|
C
|
C
|
C
|
A
|
A
|
T
|
T
|
G
|
C
|
G
|
G
|
G
|
G
|
T
|
G
|
A/C
|
A/C
|
C
|
G
|
G
|
G
|
T
|
A
|
G
|
G
|
T
|
C
|
A
|
G
|
T
|
G
|
G
|
G
|
C
|
G
|
C
|
T
|
A
|
G
|
A
|
G
|
C
|
G
|
A
|
T
|
T
|
A
|
A
|
T
|
A
|
T
|
G
|
C
|
G
|
C
|
A
|
G
|
T
|
C
|
C
|
A
|
G
|
G
|
G
|
A
|
T
|
A
|
A
|
A
|
T
|
G
|
C
|
C
|
T
|
C
|
G
|
G
|
T
|
G
|
G
|
G
|
C
|
C
|
T
|
A
|
A
|
A
|
T
|
T
|
T
|
C
|
A
|
C
|
C
|
A
|
T
|
C
|
G
|
A
|
A
|
T
|
C
|
G
|
A
|
A
|
A
|
C
|
T
|
C
|
C
|
A
|
G
|
T
|
G
|
T
|
C
|
C
|
G
|
G
|
A
|
G
|
C
|
G
|
T
|
G
|
C
|
G
|
T
|
C
|
G
|
A
|
T
|
G
|
T
|
C
|
A
|
C
|
A
|
C
|
A
|
A
|
G
|
C
|
G
|
G
|
G
|
A
|
G/C
|
C/T
|
C
|
A
|
G
|
A
|
T
|
C
|
C
|
A
|
G
|
G
|
A
|
G
|
T
|
A
|
A
|
A
|
G
|
A
|
G
|
C
|
A
|
A
|
T
|
G
|
G
|
A
|
A
|
T
|
G
|
G
|
T
|
A
|
A
|
T
|
A
|
T
|
A
|
G
|
G
|
G
|
G
|
G
|
G/C
|
G
|
C
|
C
|
T
|
C
|
T
|
A
|
T
|
G
|
T
|
T
|
G
|
G
|
C
|
A
|
G
|
C
|
C
|
G
|
G
|
A
|
C
|
A
|
T
|
A
|
C
|
G
|
C
|
C/T
|
A
|
T
|
G
|
A
|
T
|
A
|
T
|
A
|
A
|
|