|
.016 |
.05 |
.002 |
.002 |
.032 |
.01 |
.0 |
.002 |
.0 |
.0 |
.007 |
.005 |
.003 |
.021 |
.0 |
.009 |
.007 |
.007 |
.002 |
.001 |
.004 |
.001 |
.004 |
.0 |
.945 |
.213 |
.284 |
.0 |
.0 |
.002 |
.785 |
.031 |
.02 |
.004 |
.0 |
.003 |
.388 |
.185 |
.118 |
.001 |
.001 |
.003 |
.001 |
.0 |
.007 |
.085 |
.235 |
.021 |
.019 |
.006 |
.014 |
.007 |
.001 |
.004 |
.0 |
.216 |
.082 |
.727 |
.255 |
.02 |
.169 |
.293 |
.049 |
.089 |
.0 |
.006 |
.25 |
.058 |
.02 |
.003 |
.0 |
.001 |
.006 |
.004 |
.003 |
.0 |
.003 |
.007 |
.012 |
.061 |
.045 |
.047 |
.004 |
.0 |
.003 |
.0 |
.0 |
.019 |
.092 |
.002 |
-- |
.0 |
.097 |
.0 |
.029 |
.03 |
.039 |
.0 |
.996 |
.0 |
.0 |
.079 |
.025 |
.012 |
.009 |
.043 |
.028 |
.036 |
.034 |
.04 |
.001 |
.192 |
.001 |
-- |
-- |
.044 |
.027 |
-- |
-- |
-- |
.0 |
.007 |
.001 |
.105 |
-- |
-- |
-- |
.001 |
.001 |
.057 |
.038 |
.003 |
.005 |
.0 |
.001 |
.047 |
.037 |
.294 |
.151 |
.008 |
.005 |
.348 |
.0 |
.003 |
.0 |
.0 |
.02 |
.002 |
.499 |
.002 |
.994 |
.0 |
.63 |
.0 |
.012 |
.298 |
.004 |
.0 |
.0 |
.001 |
.015 |
.299 |
.0 |
.002 |
.0 |
.001 |
.001 |
.0 |
.0 |
1.0 |
.005 |
.001 |
.0 |
.003 |
.003 |
.002 |
.0 |
.205 |
.0 |
.013 |
.001 |
.01 |
.138 |
.025 |
.076 |
.13 |
.002 |
.718 |
.013 |
.016 |
.061 |
.063 |
.001 |
.004 |
.005 |
.949 |
.113 |
.001 |
.069 |
.085 |
.11 |
-- |
.929 |
.042 |
.016 |
.104 |
.001 |
.001 |
.057 |
.0 |
.02 |
.001 |
.002 |
.001 |
.129 |
.003 |
.198 |
.007 |
.233 |
.005 |
.002 |
.02 |
-- |
.006 |
.0 |
.0 |
.007 |
.001 |
.002 |
.005 |
.0 |
.0 |
.079 |
.009 |
.001 |
.002 |
.002 |
.024 |
.0 |
1.0 |
.001 |
.013 |
.813 |
.001 |
.005 |
.0 |
.001 |
.017 |
.321 |
.016 |
.02 |
.0 |
.001 |
.006 |
.0 |
.004 |
.002 |
.001 |
.001 |
.001 |
.001 |
.007 |
.01 |
.003 |
.029 |
.001 |
.001 |
.001 |
.021 |
.3 |
.0 |
.402 |
.003 |
.014 |
.009 |
.001 |
1.0 |
.999 |
1.0 |
.015 |
.008 |
.038 |
.001 |
.001 |
.0 |
.0 |
.0 |
.022 |
.003 |
.0 |
.0 |
.002 |
.0 |
.0 |
.0 |
.015 |
.014 |
.0 |
.007 |
.005 |
.014 |
.338 |
.175 |
.002 |
.001 |
.014 |
.129 |
.188 |
.0 |
.004 |
.113 |
.0 |
.006 |
.001 |
.021 |
.05 |
.004 |
.015 |
.257 |
.0 |
.0 |
.002 |
.001 |
.002 |
.006 |
.003 |
.0 |
.038 |
.037 |
.125 |
.002 |
.009 |
.008 |
.992 |
.034 |
.002 |
.002 |
.083 |
.0 |
.0 |
.138 |
.017 |
.004 |
.779 |
.782 |
.136 |
.001 |
.122 |
.001 |
.0 |
.048 |
.011 |
1.0 |
.0 |
.001 |
.123 |
.001 |
.004 |
.037 |
.001 |
.001 |
.011 |
.0 |
.001 |
.0 |
.0 |
.001 |
.005 |
.012 |
.001 |
.003 |
.012 |
.012 |
.012 |
.007 |
.001 |
.999 |
1.0 |
.046 |
.001 |
.001 |
.002 |
.001 |
.001 |
.009 |
.0 |
.0 |
.082 |
.0 |
.219 |
.975 |
.937 |
.001 |
.008 |
.0 |
.022 |
.088 |
.002 |
.0 |
1.0 |
.001 |
.01 |
.0 |
.038 |
.094 |
.001 |
.045 |
.005 |
.015 |
.001 |
.026 |
.292 |
.055 |
.128 |
.001 |
.0 |
.0 |
1.0 |
.003 |
.0 |
.043 |
.005 |
.965 |
.304 |
.0 |
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
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Ap3b1
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Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
Ap3b1
|
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--
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|
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|
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|
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|
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--
|
--
|
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|
--
|
--
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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--
|
--
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--
|
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|
--
|
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|
--
|
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|
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|
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|
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|
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|
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|
--
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--
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--
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|
--
|
--
|
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|
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|
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|
--
|
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|
--
|
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|
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|
--
|
--
|
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|
--
|
--
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--
|
--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
G |
T |
C |
C |
G |
C |
A |
T |
T |
C |
G |
G |
T |
A |
T |
A |
- |
T |
G |
- |
C |
G |
T |
C |
T |
G |
C |
T |
T |
A |
G |
G |
C |
G |
C |
C |
G |
2 |
G |
T |
T |
G |
C |
A |
2 |
T |
A |
T |
C |
C |
A |
T |
C |
9 |
17 |
G |
G |
A |
A |
C |
C |
A |
G |
G |
C |
G |
G |
G |
T |
- |
- |
13 |
G |
G |
21 |
14 |
C |
- |
2 |
G |
G |
C |
T |
T |
A |
G |
T |
T |
C |
A |
T |
G |
A |
- |
T |
A |
A |
T |
T |
A |
A |
C |
C |
- |
T |
- |
A |
T |
A |
G |
T |
A |
G |
- |
G |
- |
T |
G |
G |
C |
A |
T |
A |
C |
C |
16 |
T |
A |
A |
G |
T |
C |
C |
T |
T |
G |
9 |
5 |
C |
T |
G |
G |
T |
A |
C |
G |
G |
C |
- |
G |
T |
A |
G |
A |
C |
C |
T |
T |
C |
T |
A |
T |
T |
G |
A |
T |
T |
C |
16 |
T |
G |
A |
T |
G |
A |
C |
C |
T |
- |
T |
C |
- |
G |
A |
T |
T |
T |
- |
G |
A |
T |
A |
C |
C |
A |
T |
C |
T |
T |
A |
G |
G |
T |
C |
A |
A |
T |
G |
G |
C |
A |
T |
A |
A |
A |
T |
C |
A |
T |
C |
A |
- |
G |
2 |
C |
A |
T |
A |
T |
T |
A |
A |
C |
G |
T |
C |
- |
- |
A |
A |
A |
A |
G |
G |
T |
G |
G |
A |
G |
C |
G |
T |
T |
C |
C |
C |
C |
A |
A |
A |
T |
G |
C |
C |
- |
G |
3 |
A |
G |
T |
A |
A |
G |
G |
G |
G |
C |
G |
C |
T |
T |
G |
C |
- |
G |
A |
C |
T |
A |
G |
2 |
C |
T |
A |
C |
G |
C |
2 |
- |
- |
2 |
C |
C |
A |
- |
- |
- |
A |
T |
- |
G |
- |
A |
C |
G |
- |
- |
2 |
G |
A |
3 |
G |
G |
C |
- |
- |
C |
T |
T |
G |
G |
- |
G |
T |
- |
C |
A |
G |
A |
C |
T |
- |
T |
G |
- |
C |
- |
A |
A |
A |
C |
C |
- |
G |
C |
C |
A |
T |
2 |
C |
T |
T |
13 |
T |
A |
G |
C |
A |
G |
C |
C |
T |
T |
C |
T |
- |
C |
A |
A |
A |
T |
T |
T |
G |
T |
A |
A |
T |
A |
T |
G |
A |
A |
A |
- |
T |
C |
C |
C |
14 |
C |
T |
A |
G |
C |
A |
A |
C |
G |
A |
T |
G |
24 |
- |
C |
T |
A |
T |
A |
C |
22 |
A |
G |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
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|
|
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|
|
|
|
|
|
|
|
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|
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|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
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|
|
|
|
|
|
|
|
|
|
|
|
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|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
C
|
A
|
T
|
T
|
T
|
G
|
G
|
T/C
|
T/C
|
-
|
A
|
A
|
A
|
C
|
G
|
T
|
12
|
-
|
A
|
C
|
T
|
A
|
C
|
T
|
C
|
A
|
T
|
-
|
C
|
G
|
A
|
A
|
T
|
C
|
A
|
T
|
A
|
-
|
C
|
C
|
A
|
A
|
G
|
G
|
-
|
A
|
G
|
T/C
|
T
|
T
|
G
|
-
|
T
|
-
|
-
|
A
|
-
|
G
|
G
|
G
|
A
|
G
|
A
|
T
|
T
|
-
|
-
|
-
|
C
|
G
|
2
|
-
|
A
|
C
|
-
|
-
|
T
|
20
|
-
|
A
|
-
|
T
|
C
|
C
|
G
|
A
|
C
|
-
|
T
|
T
|
A
|
A
|
G
|
G
|
C
|
G
|
G
|
C
|
C
|
G
|
G
|
-
|
-
|
G
|
C
|
G
|
G
|
C
|
G
|
A
|
G
|
G
|
A
|
48
|
-
|
AA/G
|
C
|
T
|
T
|
A
|
G
|
C
|
C
|
T
|
T
|
16/-
|
C
|
G
|
C
|
T
|
C
|
A
|
A
|
C
|
C
|
A
|
-
|
-
|
G
|
C
|
A
|
A
|
C
|
G
|
A
|
A
|
A
|
T
|
C
|
A
|
G
|
T
|
A
|
T
|
A
|
T
|
C
|
G
|
T
|
G
|
G
|
C
|
C
|
A
|
G
|
G
|
A
|
T
|
-
|
C
|
A
|
T
|
C
|
A
|
T
|
A
|
T
|
C
|
3
|
C
|
T
|
3
|
A
|
T
|
C
|
C
|
C
|
T
|
A
|
G
|
A
|
G
|
T
|
A
|
T
|
C
|
T
|
C
|
C
|
G
|
A
|
G/A
|
A
|
T
|
G
|
G
|
C
|
T
|
A
|
T
|
G
|
C
|
G
|
-
|
G
|
C
|
G
|
G
|
G
|
G
|
G
|
8
|
A
|
-
|
T
|
G
|
C
|
T
|
C
|
C
|
G
|
T
|
T
|
T
|
C
|
T
|
A
|
5
|
C
|
G
|
G
|
G
|
A
|
A
|
C
|
A
|
A
|
C
|
A
|
T
|
A
|
C
|
-
|
T
|
T
|
T
|
T
|
G
|
G
|
G
|
-
|
T
|
G
|
A
|
A
|
A
|
-
|
G
|
A
|
C
|
G
|
G
|
A
|
A
|
A
|
A
|
T
|
A
|
T
|
C
|
C
|
T
|
G
|
C
|
T
|
C
|
T
|
G
|
G
|
-
|
-
|
A
|
G
|
T
|
T
|
-
|
T
|
-
|
T
|
T
|
-
|
-
|
T
|
-
|
G
|
T
|
T
|
-
|
-
|
T
|
-
|
T
|
-
|
T
|
C
|
T
|
2
|
-
|
A
|
G
|
-
|
-
|
C
|
-
|
A
|
G
|
T
|
C
|
-
|
-
|
-
|
T
|
-
|
-
|
12
|
T
|
G
|
C
|
G
|
G
|
C
|
C
|
C
|
A
|
-/2
|
T
|
4
|
G
|
G
|
G
|
T
|
A
|
5
|
A
|
T
|
T
|
T
|
C
|
-
|
T
|
C
|
A
|
-
|
G
|
G
|
A
|
T
|
G
|
A
|
T
|
T
|
A
|
-
|
T
|
C
|
C
|
-
|
G
|
G
|
G
|
C
|
C
|
A
|
T
|
C
|
G
|
-
|
A
|
T
|
C
|
A
|
G
|
G
|
G
|
G
|
G
|
T
|
G
|
T
|
-
|
T
|
-
|
C
|
C
|
T
|
G
|
T
|
T
|
A
|
G
|
C
|
A
|
-
|
T
|
A
|
-
|
G
|
C
|
G
|
A
|
-
|
G
|
A
|
-
|
|