chr start stop reference nuc variant nuc depth genic status zygosity variant ID 19 60829763 60829764 T A 14 GENIC homozygous 46180695 19 60831281 60831283 TT -- 7 GENIC homozygous 46432181 19 60831301 60831302 T - 10 GENIC homozygous 46472926 19 60831334 60831335 A G 13 GENIC homozygous 46472928 19 60832051 60832052 G C 28 GENIC homozygous 46472930 19 60832394 60832395 T TA 14 GENIC possibly homozygous 46472932 19 60832459 60832460 T C 23 GENIC homozygous 46472934 19 60832678 60832679 A - 19 GENIC homozygous 46472936 19 60833327 60833328 T C 19 GENIC homozygous 46180696 19 60833555 60833556 C G 17 GENIC homozygous 46472938 19 60834371 60834372 A AT 17 GENIC homozygous 46472940 19 60834382 60834383 G A 17 GENIC homozygous 46472942 19 60834851 60834852 A G 19 GENIC homozygous 46472944 19 60834852 60834853 T C 19 GENIC homozygous 46180698 19 60834891 60834892 A - 11 GENIC homozygous 46472946 19 60834963 60834964 C CCTGTTGG 19 GENIC homozygous 46180699 19 60834967 60834968 A - 20 GENIC homozygous 46180700 19 60835083 60835087 ATCT ---- 12 GENIC homozygous 46472948 19 60835425 60835426 A ATGTATGTATGACTGTATGTATGAC 15 GENIC homozygous 46472950 19 60835851 60835852 C T 22 GENIC homozygous 46472952 19 60836172 60836173 A G 20 GENIC homozygous 46180703 19 60838228 60838229 C CCG 1 GENIC homozygous 46472954 19 60838817 60838819 TG -- 44 GENIC homozygous 46472956 19 60838846 60838847 A ATG 38 GENIC homozygous 46472957 19 60838908 60838916 GTGTGTGA -------- 3 GENIC homozygous 46472959 19 60839838 60839839 G A 24 GENIC homozygous 46472961 19 60839857 60839858 G T 21 GENIC homozygous 46180707 19 60840108 60840109 A G 18 GENIC homozygous 46180710 19 60842116 60842117 A AAGAAGAGGAGGAAGG 8 GENIC homozygous 46472963 19 60844575 60844595 GTGTGTGTGTGTGTGTGTGC -------------------- 8 GENIC heterozygous 46472965 19 60844838 60844839 G A 13 GENIC homozygous 46472967 19 60847264 60847276 CATACATACATA ------------ 20 GENIC homozygous 46472969 19 60848147 60848148 T - 11 GENIC possibly homozygous 46180723 19 60849093 60849108 ACCTGGGCCCCTGTC --------------- 3 GENIC homozygous 46472971 19 60850001 60850002 A AT 22 GENIC homozygous 46180731 19 60850287 60850288 G A 26 GENIC homozygous 46472973 19 60850465 60850466 A ATGTGTGTATGTGTGTGTATGTGTGTATGTATGTATGTGTGTGTGTATGTTTGTGTGTGTGTATGTG 82 GENIC homozygous 46472975 19 60850823 60850824 T C 36 GENIC homozygous 46180738 19 60852403 60852405 TT -- 3 GENIC homozygous 46472977 19 60853258 60853259 T C 23 GENIC homozygous 46180745 19 60853306 60853325 CTATGTGTTCATCAGGGGG ------------------- 16 GENIC homozygous 46472979 19 60853381 60853382 C CG 17 GENIC homozygous 46472981 19 60853677 60853678 A G 34 GENIC homozygous 46180746 19 60853800 60853803 AAA --- 9 GENIC homozygous 46472983 19 60854555 60854556 C CG 20 GENIC homozygous 46180749 19 60854939 60854941 TT -- 7 GENIC heterozygous 46413050 19 60854938 60854941 TTT --- 7 GENIC heterozygous 46413048 19 60855043 60855044 G C 16 GENIC homozygous 46472985 19 60856464 60856465 C T 35 GENIC homozygous 46180757 19 60855421 60855422 C G 25 GENIC homozygous 46180755 19 60855907 60855908 C T 18 GENIC homozygous 46472987 19 60856286 60856287 A C 27 GENIC homozygous 46472989 19 60857021 60857022 T A 15 GENIC homozygous 46180767 19 60857614 60857615 T TCTAGC 28 GENIC homozygous 46180775 19 60858548 60858549 C T 30 GENIC homozygous 46472991 19 60858690 60858691 T C 27 GENIC homozygous 46180779 19 60858913 60858914 G A 19 GENIC homozygous 46472993 19 60859288 60859289 C CG 4 GENIC homozygous 46472995 19 60859295 60859296 T TG 5 GENIC homozygous 46472997 19 60859496 60859497 G A 19 GENIC homozygous 46472999 19 60860094 60860095 G A 36 GENIC homozygous 46180788 19 60860676 60860677 C T 14 GENIC homozygous 46473001 19 60861297 60861299 GT -- 7 GENIC homozygous 46413052 19 60861828 60861829 C CA 13 GENIC heterozygous 46473003 19 60862201 60862202 G A 25 GENIC homozygous 46473005 19 60862818 60862819 G T 31 GENIC homozygous 46473007 19 60863097 60863129 TGGTGTGAGCAGTTGTCCAGGCTGTGTGGAGC -------------------------------- 14 GENIC homozygous 46473009 19 60863400 60863401 G GCCAGGCTGTGTGGAGCTGGTGTGAGCATGTGC 7 GENIC homozygous 46473011 19 60863889 60863890 A ATGTGTG 26 GENIC heterozygous 46180815 19 60863889 60863890 A ATGTGTGTG 26 GENIC possibly homozygous 46473013 19 60865283 60865294 GGGGGGGGGGG ----------- 16 GENIC homozygous 46473015 19 60865294 60865295 G C 13 GENIC homozygous 46473017 19 60865722 60865723 A G 21 GENIC homozygous 46180820 19 60866057 60866058 A C 31 GENIC homozygous 46180821 19 60866598 60866599 G GCACA 14 GENIC homozygous 46180822 19 60866656 60866657 T C 32 GENIC homozygous 46180823 19 60866751 60866752 T C 27 GENIC homozygous 46180824 19 60866756 60866766 ACACACACAC ---------- 14 GENIC homozygous 46473019 19 60867015 60867016 C - 19 GENIC homozygous 46473021 19 60867017 60867018 T A 19 GENIC homozygous 46473023 19 60867219 60867220 T C 15 GENIC homozygous 46180825 19 60868159 60868160 G A 14 GENIC homozygous 46473025 19 60868426 60868427 A G 13 GENIC homozygous 46473027 19 60868666 60868667 T C 23 GENIC homozygous 46473029 19 60868729 60868730 C T 24 GENIC homozygous 46473031 19 60868754 60868755 T A 24 GENIC homozygous 46473033 19 60868812 60868813 A G 29 GENIC homozygous 46473035 19 60868842 60868843 G A 28 GENIC homozygous 46473037 19 60868846 60868847 A G 27 GENIC homozygous 46473039 19 60869147 60869148 A G 12 GENIC homozygous 46473041 19 60870609 60870610 A AC 27 GENIC homozygous 46180829 19 60865300 60865301 G GCC 13 GENIC homozygous 46383233 19 60871982 60871983 T G 23 GENIC homozygous 46180838 19 60872177 60872181 GAGA ---- 35 GENIC homozygous 46473043 19 60873007 60873009 AA -- 26 GENIC homozygous 46180856 19 60873429 60873430 A C 25 GENIC homozygous 46180858 19 60873680 60873681 A G 20 GENIC homozygous 46180859 19 60873804 60873824 TGTGTGTGTGTGTGTGTGTG -------------------- 4 GENIC heterozygous 46473045 19 60874078 60874079 T - 14 GENIC possibly homozygous 46413058 19 60874183 60874184 C CA 16 GENIC homozygous 46180862 19 60875209 60875210 T C 24 GENIC homozygous 46180866 19 60875469 60875470 T C 25 GENIC homozygous 46473047 19 60875470 60875471 G A 25 GENIC homozygous 46473049 19 60875910 60875911 T C 26 GENIC homozygous 46473051 19 60875986 60875996 GTGTGTGTGC ---------- 15 GENIC possibly homozygous 46473053 19 60876003 60876004 G A 19 GENIC homozygous 46473055 19 60876037 60876038 T C 19 GENIC homozygous 46473057 19 60876058 60876059 A ATG 20 GENIC homozygous 46180869 19 60876270 60876271 C A 17 GENIC homozygous 46473059 19 60876490 60876491 G A 24 GENIC homozygous 46473061 19 60876611 60876612 A AT 23 GENIC homozygous 46473063 19 60876688 60876689 G A 16 GENIC homozygous 46473065 19 60876750 60876751 A T 19 GENIC homozygous 46473067 19 60876879 60876880 A G 27 GENIC homozygous 46473069 19 60877389 60877390 A G 18 GENIC homozygous 46473075 19 60877085 60877086 C G 19 GENIC homozygous 46473071 19 60877273 60877274 C T 20 GENIC homozygous 46473073 19 60877575 60877576 G A 14 GENIC homozygous 46473077 19 60877902 60877903 C T 24 GENIC homozygous 46473079 19 60878758 60878759 C CCACACACACACACACACACACA 6 GENIC homozygous 46473081 19 60878778 60878779 T A 19 GENIC homozygous 46180879 19 60878783 60878784 C CACACTCAT 20 GENIC homozygous 46473083 19 60879077 60879078 T C 29 GENIC homozygous 46180881 19 60879518 60879519 A C 22 GENIC homozygous 46180882 19 60879818 60879819 T C 35 GENIC homozygous 46180883 19 60879826 60879827 T C 36 GENIC homozygous 46180884 19 60880080 60880081 T C 29 GENIC homozygous 46473085 19 60880760 60880761 G A 23 GENIC homozygous 46473087 19 60880956 60880957 A G 22 GENIC homozygous 46180885 19 60880971 60880972 A G 25 GENIC homozygous 46180886 19 60880976 60880977 A G 25 GENIC homozygous 46383239 19 60880977 60880978 G A 25 GENIC homozygous 46383241 19 60880987 60880988 G A 28 GENIC homozygous 46383243 19 60880997 60880998 T TC 27 GENIC homozygous 46180887 19 60881077 60881078 A G 21 GENIC homozygous 46473089 19 60881535 60881536 C T 31 GENIC homozygous 46473091 19 60881740 60881741 A G 35 GENIC homozygous 46473093 19 60882445 60882446 C CGT 35 GENIC heterozygous 46180889 19 60882445 60882446 C CGTGT 35 GENIC possibly homozygous 46473095 19 60883448 60883449 G A 20 GENIC homozygous 46473097 19 60883856 60883857 T C 17 GENIC homozygous 46473099 19 60884621 60884622 A AT 9 GENIC homozygous 46473101 19 60885190 60885191 C CACAT 14 GENIC homozygous 46473103 19 60885288 60885289 C A 19 GENIC homozygous 46473105 19 60885336 60885337 C T 20 GENIC homozygous 46473107 19 60885615 60885616 T TAACC 19 GENIC homozygous 46180893 19 60886070 60886071 C T 38 GENIC homozygous 46473109 19 60886490 60886491 G A 24 GENIC homozygous 46473111 19 60886708 60886709 T - 7 GENIC homozygous 46473113 19 60886870 60886871 G T 21 GENIC homozygous 46180895 19 60887149 60887150 G A 27 GENIC homozygous 46473115 19 60887523 60887524 A G 24 GENIC homozygous 46180896 19 60887635 60887636 C T 23 GENIC homozygous 46473117 19 60887666 60887667 T - 19 GENIC homozygous 46180897 19 60888279 60888280 T C 40 GENIC homozygous 46473119 19 60888390 60888391 G GCA 18 GENIC heterozygous 46413062 19 60888401 60888403 CA -- 18 GENIC heterozygous 46413064 19 60888650 60888651 C T 26 GENIC homozygous 46473121 19 60888947 60888948 A G 30 GENIC homozygous 46473129 19 60888719 60888720 C CT 9 GENIC possibly homozygous 46473123 19 60888830 60888831 C A 15 GENIC possibly homozygous 46473125 19 60888843 60888844 G GTT 7 GENIC heterozygous 46180905 19 60888843 60888844 G GTTTT 7 GENIC possibly homozygous 46473127 19 60880986 60880987 A G 28 GENIC homozygous 46267076 19 60889381 60889382 A C 21 GENIC homozygous 46473131 19 60889652 60889653 C T 22 GENIC homozygous 46473133 19 60889754 60889755 A G 20 GENIC homozygous 46180906 19 60889776 60889777 A G 19 GENIC homozygous 46180907 19 60890142 60890143 C T 16 GENIC homozygous 46180908 19 60890150 60890151 C T 16 GENIC homozygous 46180909 19 60890387 60890388 C A 13 GENIC homozygous 46180910 19 60891557 60891558 G A 35 GENIC homozygous 46180911 19 60891677 60891678 G C 24 GENIC homozygous 46473135 19 60891903 60891904 C - 20 GENIC homozygous 46473137 19 60892166 60892167 C CT 29 GENIC homozygous 46180912 19 60892232 60892233 T TA 21 GENIC homozygous 46180914 19 60892514 60892515 A - 11 GENIC homozygous 46180915 19 60893259 60893260 C A 25 GENIC homozygous 46473139 19 60893802 60893803 A G 23 GENIC homozygous 46180916 19 60893913 60893914 C T 9 GENIC homozygous 46180917 19 60894647 60894648 T TG 18 GENIC homozygous 46473141 19 60894819 60894820 A G 22 GENIC homozygous 46180919 19 60894897 60894899 GT -- 31 GENIC homozygous 46473143 19 60894932 60894936 GTGA ---- 35 GENIC homozygous 46473145 19 60894989 60894991 TG -- 28 GENIC homozygous 46473147 19 60895017 60895018 G T 38 GENIC homozygous 46180923 19 60895099 60895101 GT -- 1 GENIC homozygous 46180924 19 60895333 60895334 T TTG 39 GENIC homozygous 46180927 19 60895375 60895379 GTGA ---- 56 GENIC homozygous 46180928 19 60896271 60896272 C T 19 GENIC homozygous 46473149 19 60897806 60897807 C T 48 GENIC homozygous 46473151 19 60896983 60896984 G C 22 GENIC homozygous 46180933 19 60897405 60897406 T TC 35 GENIC homozygous 46180934 19 60897473 60897474 T C 27 GENIC homozygous 46180935 19 60898158 60898159 A G 17 GENIC homozygous 46180936 19 60898164 60898165 T C 15 GENIC homozygous 46180937 19 60898304 60898305 T A 24 GENIC homozygous 46180938 19 60898416 60898417 T A 26 GENIC homozygous 46473153 19 60899178 60899179 A G 32 GENIC homozygous 46180940 19 60899250 60899251 A G 38 GENIC homozygous 46180941 19 60899265 60899266 C T 42 GENIC homozygous 46180942 19 60899703 60899713 GTGTGTGTGT ---------- 12 GENIC homozygous 46473155 19 60900586 60900587 T C 6 GENIC homozygous 46180946 19 60900589 60900590 T C 6 GENIC homozygous 46180947 19 60900762 60900763 A C 11 GENIC homozygous 46473157 19 60901588 60901589 A T 23 GENIC homozygous 46180951 19 60901773 60901774 G GTCTGTCTT 16 GENIC heterozygous 46473159 19 60902152 60902153 T G 40 GENIC homozygous 46180961 19 60902155 60902156 T A 38 GENIC homozygous 46180962 19 60902187 60902188 C G 41 GENIC homozygous 46180963 19 60902237 60902238 G A 23 GENIC homozygous 46180964 19 60902243 60902244 G A 24 GENIC homozygous 46180965 19 60902247 60902248 C A 23 GENIC homozygous 46180966 19 60902257 60902258 T A 26 GENIC homozygous 46180967 19 60902268 60902269 G A 30 GENIC homozygous 46180968 19 60902274 60902275 G C 30 GENIC homozygous 46180969 19 60902725 60902726 C CTGTG 15 GENIC homozygous 46473161 19 60903054 60903055 T C 33 GENIC homozygous 46180971 19 60903407 60903408 G A 29 GENIC homozygous 46180972 19 60903620 60903621 T C 27 GENIC homozygous 46473163 19 60903689 60903690 A G 26 GENIC homozygous 46180973 19 60904193 60904194 T C 21 GENIC homozygous 46180974 19 60905679 60905680 C A 29 GENIC homozygous 46180979 19 60905850 60905851 A G 20 GENIC homozygous 46180981 19 60906595 60906596 T C 19 GENIC homozygous 46180982 19 60906928 60906929 G A 25 GENIC homozygous 46473165 19 60907544 60907545 G A 40 GENIC homozygous 46180985 19 60908421 60908422 T TCAGC 35 GENIC homozygous 46180986 19 60908903 60908904 G A 26 GENIC homozygous 46473167 19 60908972 60908973 T C 21 GENIC homozygous 46473169 19 60909227 60909228 A - 11 GENIC possibly homozygous 46413076 19 60909278 60909279 A G 15 GENIC homozygous 46473171 19 60909330 60909331 T C 20 GENIC homozygous 46473173 19 60909337 60909338 T G 19 GENIC homozygous 46473175 19 60909339 60909340 A G 18 GENIC homozygous 46180988 19 60909378 60909379 A G 13 GENIC homozygous 46473177 19 60909494 60909495 T C 20 GENIC homozygous 46473179 19 60909508 60909509 T C 22 GENIC homozygous 46473181 19 60909550 60909551 A C 27 GENIC homozygous 46473183 19 60909671 60909672 C T 38 GENIC homozygous 46473185 19 60909701 60909702 A G 27 GENIC homozygous 46473187 19 60909707 60909708 A G 27 GENIC homozygous 46473189 19 60909731 60909732 C T 24 GENIC homozygous 46473191 19 60910152 60910153 A AGTCT 31 GENIC homozygous 46473193 19 60910154 60910155 G GATA 33 GENIC homozygous 46473195 19 60910165 60910166 C G 34 GENIC homozygous 46473197 19 60910292 60910293 G T 25 GENIC homozygous 46473199 19 60910582 60910583 A G 14 GENIC homozygous 46473201 19 60910671 60910672 G A 25 GENIC homozygous 46473203 19 60910758 60910759 C T 14 GENIC homozygous 46473205 19 60910808 60910809 G GC 11 GENIC homozygous 46180990 19 60911586 60911587 T C 18 GENIC homozygous 46180991 19 60911788 60911789 T C 31 GENIC homozygous 46473207 19 60912037 60912038 A C 17 GENIC homozygous 46180992 19 60912203 60912204 A AGT 9 GENIC heterozygous 46473209 19 60912575 60912577 AC -- 22 GENIC homozygous 46180994 19 60913072 60913073 T C 31 GENIC homozygous 46180995 19 60913710 60913711 C A 23 GENIC homozygous 46180997 19 60914025 60914026 T C 30 GENIC homozygous 46473211 19 60915293 60915294 G C 25 GENIC homozygous 46473213 19 60916361 60916362 G GTAT 5 GENIC homozygous 46181009 19 60916777 60916778 G A 16 GENIC homozygous 46473215 19 60916846 60916847 A G 9 GENIC homozygous 46181012 19 60916878 60916894 CGCACACACACGCACA ---------------- 3 GENIC homozygous 46473217 19 60917564 60917565 C CCTT 20 GENIC homozygous 46181018 19 60917876 60917890 GGTTTCTGGTACTG -------------- 16 GENIC homozygous 46181019 19 60918141 60918142 C T 23 GENIC homozygous 46181020 19 60918174 60918175 C T 25 GENIC homozygous 46181021 19 60918429 60918430 C G 26 GENIC homozygous 46473219 19 60918442 60918443 A T 27 GENIC homozygous 46473221 19 60918488 60918489 T G 17 GENIC homozygous 46473223 19 60918513 60918514 G A 9 GENIC homozygous 46473225 19 60918679 60918723 TTATTTATTTATTTATTTATTTACTTACTTACTTACTTACTTAC -------------------------------------------- 6 GENIC homozygous 46473227 19 60918795 60918796 G A 10 GENIC homozygous 46473229 19 60918957 60918958 A G 17 GENIC homozygous 46473231 19 60919040 60919041 T G 9 GENIC homozygous 46473233 19 60919066 60919067 C G 12 GENIC homozygous 46473235 19 60919084 60919085 C G 12 GENIC homozygous 46473237 19 60919168 60919169 C T 12 GENIC homozygous 46473239 19 60919190 60919191 A C 9 GENIC homozygous 46473241 19 60919227 60919228 G T 11 GENIC heterozygous 46383247 19 60919232 60919233 G GTTT 10 GENIC homozygous 46473243 19 60919237 60919238 G GTTTTTT 14 GENIC homozygous 46473245 19 60919337 60919338 T C 28 GENIC homozygous 46473247 19 60919458 60919459 T A 34 GENIC possibly homozygous 46473249 19 60919794 60919795 T C 23 GENIC homozygous 46473251 19 60919841 60919842 T C 28 GENIC homozygous 46473253 19 60919901 60919902 C T 22 GENIC homozygous 46473255 19 60920303 60920304 T C 22 GENIC homozygous 46473257 19 60920330 60920331 C T 26 GENIC homozygous 46473259 19 60920378 60920379 G GC 33 GENIC homozygous 46473261 19 60920379 60920380 T C 33 GENIC homozygous 46473263 19 60920387 60920388 A G 29 GENIC homozygous 46473265 19 60920783 60920784 A G 12 GENIC homozygous 46473267 19 60920844 60920845 C CT 10 GENIC homozygous 46473269 19 60920847 60920848 C CTTTCTTT 13 GENIC homozygous 46473270 19 60920897 60920898 T C 10 GENIC homozygous 46473272 19 60920997 60920998 T C 10 GENIC homozygous 46473274 19 60921049 60921050 C T 11 GENIC homozygous 46473276 19 60921309 60921310 T C 21 GENIC homozygous 46473278 19 60921310 60921311 G A 21 GENIC homozygous 46473280 19 60922225 60922226 A ATCTC 13 GENIC homozygous 46473282 19 60922283 60922295 ATCTATCTATCT ------------ 14 GENIC homozygous 46473284 19 60922432 60922443 TCATCTATCAA ----------- 24 GENIC homozygous 46181028 19 60922468 60922470 TC -- 34 GENIC homozygous 46473286 19 60922482 60922483 T C 35 GENIC homozygous 46473288 19 60922541 60922542 T TATCTATCAATC 29 GENIC homozygous 46473290 19 60922677 60922685 TCTGTCTA -------- 7 GENIC homozygous 46473292 19 60922952 60922953 C T 24 GENIC homozygous 46473294 19 60923570 60923571 C T 27 GENIC homozygous 46473296 19 60924276 60924277 A - 18 GENIC possibly homozygous 46473298 19 60926593 60926594 T C 31 GENIC homozygous 46181031 19 60924692 60924693 G A 36 GENIC homozygous 46473300 19 60924705 60924706 C A 36 GENIC homozygous 46473302 19 60926135 60926136 C G 22 GENIC homozygous 46473304 19 60926609 60926610 T G 30 GENIC homozygous 46473306 19 60926747 60926748 A G 21 GENIC homozygous 46473308 19 60926794 60926795 T C 19 GENIC homozygous 46473310 19 60926957 60926959 TT -- 13 GENIC possibly homozygous 46446725 19 60926958 60926959 T - 13 GENIC heterozygous 46446727 19 60928842 60928844 GG -- 22 GENIC homozygous 46473312 19 60929576 60929577 A G 19 GENIC homozygous 46181040 19 60929674 60929675 A G 18 GENIC homozygous 46473314 19 60929681 60929682 G GCA 19 GENIC homozygous 46473316 19 60929705 60929706 C G 19 GENIC homozygous 46473318 19 60929738 60929739 T C 21 GENIC homozygous 46473320 19 60929912 60929917 TTGTA ----- 39 GENIC homozygous 46473322 19 60929951 60929952 C T 39 GENIC homozygous 46473324 19 60930037 60930038 C CG 31 GENIC homozygous 46473326 19 60930066 60930067 T C 37 GENIC homozygous 46473328 19 60930118 60930119 C CCCA 23 GENIC homozygous 46473330 19 60930124 60930125 T C 24 GENIC homozygous 46473332 19 60930152 60930153 T C 28 GENIC homozygous 46473334 19 60954527 60954528 C CA 26 GENIC homozygous 46181147 19 60930259 60930260 C T 30 GENIC homozygous 46473336 19 60940317 60940321 CTCT ---- 6 GENIC homozygous 46473338 19 60940383 60940384 C G 23 GENIC homozygous 46181105 19 60949525 60949527 AT -- 11 GENIC heterozygous 46181138 19 60957069 60957070 A AACAC 7 GENIC possibly homozygous 46473340 19 60961463 60961464 A - 25 GENIC homozygous 46181160