| URN | urn:agi-llid:2147 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4370 |
| Name | F2 |
| Description | coagulation factor II (thrombin) |
| Notes | Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | thrombospondin receptor activity |
|---|---|
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| receptor binding | |
| growth factor activity | |
| calcium ion binding |
| GO Cellular Component | extracellular matrix |
|---|---|
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | leukocyte migration |
|---|---|
| positive regulation of collagen biosynthetic process | |
| blood coagulation, intrinsic pathway | |
| multicellular organismal development | |
| positive regulation of blood coagulation | |
| negative regulation of fibrinolysis | |
| negative regulation of platelet activation | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| platelet activation | |
| negative regulation of astrocyte differentiation | |
| regulation of cell shape | |
| cell surface receptor signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase signaling | |
| positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway | |
| thrombin receptor signaling pathway | |
| positive regulation of cell growth | |
| cytosolic calcium ion homeostasis | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of cell proliferation | |
| response to inactivity | |
| response to wounding | |
| acute-phase response | |
| wound healing | |
| cellular response to mechanical stimulus | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of protein phosphorylation | |
| negative regulation of proteolysis | |
| regulation of gene expression | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Systemic Lupus Erythematosus | |
| Proteins Involved in Pathogenesis of Vasospasm | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Astrocytoma | |
| Proteins Involved in Pathogenesis of Cataract | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Proteins Involved in Pathogenesis of Rheumatoid Arthritis | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Epilepsies Associated with Blood-Brain Barrier Disruption | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Vitamin K metabolism | |
| ThrombinR -> STAT1 signaling | |
| ThrombinR -> NF-kB signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| coagulation cascade pathway | |
| protein C anticoagulant pathway |
| Group | Coagulation factor |
|---|---|
| leukocyte migration | |
| positive regulation of collagen biosynthetic process | |
| blood coagulation, intrinsic pathway | |
| multicellular organismal development | |
| positive regulation of blood coagulation | |
| negative regulation of fibrinolysis | |
| negative regulation of platelet activation | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| platelet activation | |
| negative regulation of astrocyte differentiation | |
| regulation of cell shape | |
| cell surface receptor signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase signaling | |
| thrombospondin receptor activity | |
| positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway | |
| thrombin receptor signaling pathway | |
| positive regulation of cell growth | |
| cytosolic calcium ion homeostasis | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of cell proliferation | |
| response to inactivity | |
| response to wounding | |
| acute-phase response | |
| wound healing | |
| cellular response to mechanical stimulus | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of protein phosphorylation | |
| negative regulation of proteolysis | |
| regulation of gene expression | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| receptor binding | |
| growth factor activity | |
| calcium ion binding | |
| extracellular matrix | |
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space | |
| Genes with Mutations Associated with Hashimoto's Thyroiditis | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2147 |
|---|---|
| 14061 | |
| 29251 |
| Cell Localization | Extracellular |
|---|---|
| Secreted | |
| Extracellular space |
| GO ID | 0005509 |
|---|---|
| 0008083 | |
| 0005102 | |
| 0004252 | |
| 0070053 | |
| 0006953 | |
| 0007596 | |
| 0007597 | |
| 0007166 | |
| 0044267 | |
| 0051480 | |
| 0042730 | |
| 0050900 | |
| 0007275 | |
| 0048712 | |
| 0051918 | |
| 0010544 | |
| 0045861 | |
| 0017187 | |
| 0030168 | |
| 0030194 | |
| 0030307 | |
| 0008284 | |
| 0032967 | |
| 0014068 | |
| 1900738 | |
| 0001934 | |
| 2000379 | |
| 0051281 | |
| 0043687 | |
| 0006508 | |
| 0030193 | |
| 0008360 | |
| 0010468 | |
| 0009611 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0070493 | |
| 0031012 | |
| 0071260 | |
| 0014854 | |
| 0042060 |
| Alias | PT |
|---|---|
| THPH1 | |
| RPRGL2 | |
| prothrombin | |
| serine protease | |
| prothrombin B-chain | |
| prepro-coagulation factor II | |
| Cf2 | |
| FII | |
| Cf-2 | |
| thrombin | |
| RP23-176N9.4 | |
| coagulation factor 2 | |
| tropostasin | |
| blood-coagulating factor IIa | |
| beta-thrombins | |
| beta-thrombin | |
| activated blood-coagulation factor II | |
| activated blood-coagulating factor iis | |
| activated blood-coagulating factor II | |
| tropostasins | |
| thrombofort | |
| blood-coagulating factor iias | |
| serozyme | |
| activated blood-coagulating factor 2 | |
| blood-coagulation factor IIa | |
| coagulating factor II (thrombin) | |
| carboxylated prothrombin | |
| carboxyprothrombin | |
| factor ii | |
| proserozyme | |
| thrombogen | |
| blood clotting factor 2 | |
| thrombin activity | |
| plasmozyme | |
| Coagulation factor II | |
| thrombin-C | |
| thrombins | |
| blood clotting factor II | |
| bovine prothrombin | |
| clotting factor 2 | |
| plasma prothrombin | |
| prothrombin bovine | |
| thrombinogen | |
| coagulation factor II (thrombin) | |
| E thrombin | |
| E thrombins | |
| factor IIa | |
| prothrombine | |
| fibrinogenase | |
| THRB_HUMAN | |
| thrombases | |
| prothrombin b | |
| thrombase | |
| OTTMUSP00000015068 | |
| g-thrombins | |
| g-thrombin | |
| fibrinogenases |
| Mouse chromosome position | 2 50.63 cM |
|---|
| OMIM ID | 176930 |
|---|---|
| 601367 | |
| 614390 | |
| 613679 | |
| 188050 |
| Rat chromosome position | 3q24 |
|---|
| Hugo ID | 3535 |
|---|
| Human chromosome position | 11p11 |
|---|
| Swiss-Prot Accession | P00734 |
|---|---|
| P19221 | |
| Q3TJ94 | |
| G3V843 | |
| P18292 | |
| B2R7F7 | |
| B4E1A7 | |
| Q4QZ40 | |
| Q53H04 | |
| Q53H06 | |
| Q7Z7P3 | |
| Q9UCA1 |
| PIR ID | A29351 |
|---|---|
| A35827 |
| Unigene ID | Hs.655207 |
|---|---|
| Mm.89048 | |
| Rn.54498 |
| KEGG ID | hsa:2147 |
|---|---|
| mmu:14061 | |
| rno:29251 |
| Swiss-Prot ID | THRB_HUMAN |
|---|---|
| THRB_MOUSE |
| EC Number | 3.4.21.5 |
|---|
| Ensembl ID | ENSG00000180210 |
|---|---|
| ENSP00000308541 | |
| ENST00000311907 | |
| ENSMUSG00000027249 | |
| ENSMUSP00000028681 | |
| ENSMUST00000028681 | |
| ENSRNOG00000016325 | |
| ENSRNOP00000022233 | |
| ENSRNOT00000022233 |
| Homologene ID | 426 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88380 |
|---|
| RGD ID | 61996 |
|---|
| MedScan ID | 2147 |
|---|