| URN | urn:agi-llid:10544 |
|---|---|
| Total Entities | 0 |
| Connectivity | 335 |
| Name | Procr |
| Description | protein C receptor, endothelial |
| Notes | The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] |
| GO Molecular Function | receptor activity |
|---|---|
| protein C-terminus binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| centrosome |
| GO Biological Process | antigen processing and presentation |
|---|---|
| immune response | |
| negative regulation of coagulation | |
| hemostasis | |
| blood coagulation |
| Pathway | protein C anticoagulant pathway |
|---|
| Group | Receptors |
|---|---|
| antigen processing and presentation | |
| immune response | |
| negative regulation of coagulation | |
| hemostasis | |
| blood coagulation | |
| receptor activity | |
| protein C-terminus binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| centrosome | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 10544 |
|---|---|
| 19124 | |
| 362248 |
| Cell Localization | Plasma membrane |
|---|---|
| Membrane |
| GO ID | 0004872 |
|---|---|
| 0019882 | |
| 0007596 | |
| 0006955 | |
| 0050819 | |
| 0005813 | |
| 0005887 | |
| 0008022 | |
| 0007599 | |
| 0016021 | |
| 0016020 |
| Alias | CCCA |
|---|---|
| EPCR | |
| CCD41 | |
| endothelial protein C receptor | |
| APC receptor | |
| centrocyclin | |
| CD201 antigen | |
| activated protein C receptor | |
| cell cycle, centrosome-associated protein | |
| AI325044 | |
| RP23-388H13.2 | |
| CD antigen CD201 | |
| centrosomal protein CCD41 | |
| endothelial cell protein C receptor | |
| MGC23024 | |
| endothelial cell protein C/activated protein C receptors | |
| MGC114418 | |
| MGC116255 | |
| OTTHUMP00000030729 | |
| OTTMUSP00000017260 | |
| PROCR | |
| endothelial cell protein C/activated protein C receptor | |
| antigen CD201 | |
| OTTMUSP00000017261 | |
| protein C receptor | |
| Endothelial cell protein C receptors | |
| APC receptors | |
| bA42O4 | |
| bA42O4.2 | |
| CD201 | |
| Activated protein C receptors |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 600646 |
|---|
| Rat chromosome position | 3q42 |
|---|
| Hugo ID | 9452 |
|---|
| Human chromosome position | 20q11.2 |
|---|
| Swiss-Prot Accession | Q9UNN8 |
|---|---|
| Q64695 | |
| Q4V8I1 | |
| Q4FK76 | |
| Q9WV33 | |
| B2RC04 | |
| Q14218 | |
| Q6IB56 | |
| Q96CB3 | |
| Q9ULX1 |
| PIR ID | A55945 |
|---|---|
| S18948 | |
| A55365 |
| Unigene ID | Hs.647450 |
|---|---|
| Mm.3243 | |
| Rn.144312 |
| KEGG ID | hsa:10544 |
|---|---|
| mmu:19124 | |
| rno:362248 |
| Swiss-Prot ID | EPCR_MOUSE |
|---|---|
| EPCR_HUMAN | |
| EPCR_RAT |
| Ensembl ID | ENSG00000101000 |
|---|---|
| ENSP00000216968 | |
| ENST00000216968 | |
| ENSMUSG00000027611 | |
| ENSMUSP00000029140 | |
| ENSMUST00000029140 | |
| ENSRNOG00000019330 | |
| ENSRNOP00000052129 | |
| ENSRNOT00000055254 |
| Homologene ID | 4670 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104596 |
|---|
| RGD ID | 1305991 |
|---|
| MedScan ID | 10544 |
|---|