| URN | urn:agi-llid:7056 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1138 |
| Name | Thbd |
| Description | thrombomodulin |
| Notes | The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transmembrane signaling receptor activity |
|---|---|
| receptor activity | |
| carbohydrate binding | |
| calcium ion binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| cell surface | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | female pregnancy |
|---|---|
| leukocyte migration | |
| negative regulation of fibrinolysis | |
| negative regulation of coagulation | |
| negative regulation of blood coagulation | |
| negative regulation of platelet activation | |
| hemostasis | |
| blood coagulation | |
| embryo development | |
| response to cAMP | |
| response to lipopolysaccharide | |
| response to X-ray |
| Pathway | Coagulation Cascade |
|---|---|
| Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| TGFB1-TGFBR2 Expression Targets | |
| protein C anticoagulant pathway |
| Group | Scavenger receptor |
|---|---|
| female pregnancy | |
| leukocyte migration | |
| negative regulation of fibrinolysis | |
| negative regulation of coagulation | |
| negative regulation of blood coagulation | |
| negative regulation of platelet activation | |
| hemostasis | |
| blood coagulation | |
| embryo development | |
| transmembrane signaling receptor activity | |
| response to cAMP | |
| response to lipopolysaccharide | |
| response to X-ray | |
| receptor activity | |
| carbohydrate binding | |
| calcium ion binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| cell surface | |
| plasma membrane | |
| extracellular space | |
| Genes Hypermethylated in Melanoma | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7056 |
|---|---|
| 21824 | |
| 83580 |
| Cell Localization | Plasma membrane |
|---|---|
| Membrane |
| GO ID | 0005509 |
|---|---|
| 0030246 | |
| 0004872 | |
| 0004888 | |
| 0007596 | |
| 0009790 | |
| 0007565 | |
| 0050900 | |
| 0030195 | |
| 0051918 | |
| 0010544 | |
| 0009986 | |
| 0005887 | |
| 0005886 | |
| 0007599 | |
| 0050819 | |
| 0005615 | |
| 0016021 | |
| 0016020 | |
| 0010165 | |
| 0051591 | |
| 0032496 |
| Alias | TM |
|---|---|
| THRM | |
| AHUS6 | |
| BDCA3 | |
| CD141 | |
| THPH12 | |
| thrombomodulin | |
| fetomodulin | |
| CD141 antigen | |
| AI385582 | |
| RP23-70N3.2 | |
| snoRNA MBII-339 | |
| thrombomdulin | |
| OTTMUSP00000016721 | |
| THBD | |
| OTTHUMP00000030415 |
| Mouse chromosome position | 2 73.45 cM |
|---|
| OMIM ID | 188040 |
|---|---|
| 612926 | |
| 614486 |
| Rat chromosome position | 3q41 |
|---|
| Hugo ID | 11784 |
|---|
| Human chromosome position | 20p11.2 |
|---|
| Swiss-Prot Accession | P07204 |
|---|---|
| P15306 | |
| Q543W3 | |
| O35370 | |
| Q8IV29 | |
| Q9UC32 |
| PIR ID | S08488 |
|---|---|
| A41442 |
| Unigene ID | Hs.2030 |
|---|---|
| Mm.24096 | |
| Rn.88295 |
| KEGG ID | hsa:7056 |
|---|---|
| mmu:21824 | |
| rno:83580 |
| Swiss-Prot ID | TRBM_MOUSE |
|---|---|
| TRBM_HUMAN |
| Ensembl ID | ENSG00000178726 |
|---|---|
| ENSP00000366307 | |
| ENST00000377103 | |
| ENSMUSG00000074743 | |
| ENSMUSP00000096877 | |
| ENSMUST00000099270 |
| Homologene ID | 308 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98736 |
|---|
| RGD ID | 621299 |
|---|
| MedScan ID | 7056 |
|---|