| URN | urn:agi-llid:5624 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1708 |
| Name | Proc |
| Description | protein C (inactivator of coagulation factors Va and VIIIa) |
| Notes | This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| calcium ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | leukocyte migration |
|---|---|
| negative regulation of coagulation | |
| negative regulation of blood coagulation | |
| hemostasis | |
| blood coagulation | |
| negative regulation of apoptotic process | |
| negative regulation of inflammatory response | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Vasospasm | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Vitamin K metabolism | |
| protein C anticoagulant pathway |
| Group | leukocyte migration |
|---|---|
| negative regulation of coagulation | |
| negative regulation of blood coagulation | |
| hemostasis | |
| blood coagulation | |
| negative regulation of apoptotic process | |
| negative regulation of inflammatory response | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| calcium ion binding | |
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5624 |
|---|---|
| 19123 | |
| 25268 |
| GO ID | 0005509 |
|---|---|
| 0004252 | |
| 0007596 | |
| 0044267 | |
| 0050900 | |
| 0043066 | |
| 0030195 | |
| 0017187 | |
| 0043687 | |
| 0006508 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0005615 | |
| 0050819 | |
| 0050728 |
| Alias | PC |
|---|---|
| APC | |
| PROC1 | |
| THPH3 | |
| THPH4 | |
| vitamin K-dependent protein C | |
| autoprothrombin IIA | |
| anticoagulant protein C | |
| blood coagulation factor XIV | |
| inactivator of coagulation factors Va, VIII | |
| ceprotin | |
| OTTHUMP00000203827 | |
| PROC | |
| protein C | |
| protein C (inactivator of coagulating factors Va and VIIIa) | |
| protein C (inactivator of coagulation factors Va and VIIIa) | |
| Vitamin-K dependent protein C | |
| autoprothrombin iiia | |
| glycoprotein c | |
| human protein C | |
| Activated protein C | |
| inactivator of coagulating factors Va, 8 | |
| OTTHUMP00000203820 | |
| autoprothrombin 3a | |
| Autoprothrombin IIAs | |
| inactivator of coagulation factors Va and VIIIa | |
| activated blood coagulating factor XIV | |
| Activated blood coagulation factor XIV | |
| Blood coagulating factor XIV | |
| blood-coagulating factor XIVa | |
| inactivator of coagulation factors Va, 5 | |
| GSAPC | |
| inactivator of coagulating factors Va and VIIIa | |
| inactivator of coagulating factors Va, VIII | |
| Blood-coagulation factor XIVa | |
| inactivator of coagulation factors Va, V |
| Mouse chromosome position | 18 |
|---|
| OMIM ID | 612283 |
|---|---|
| 176860 | |
| 612304 |
| Rat chromosome position | 18p12 |
|---|
| Hugo ID | 9451 |
|---|
| Human chromosome position | 2q13-q14 |
|---|
| Swiss-Prot Accession | P04070 |
|---|---|
| B4DPQ7 | |
| P33587 | |
| P31394 | |
| Q15189 | |
| Q15190 | |
| Q16001 | |
| Q53S74 | |
| Q9UC55 | |
| O35498 | |
| Q91WN8 | |
| Q99PC6 |
| PIR ID | S18994 |
|---|---|
| A22331 | |
| JX0210 |
| Unigene ID | Hs.224698 |
|---|---|
| Mm.2786 | |
| Mm.489734 | |
| Rn.91064 |
| KEGG ID | hsa:5624 |
|---|---|
| mmu:19123 | |
| rno:25268 |
| Swiss-Prot ID | PROC_RAT |
|---|---|
| PROC_HUMAN | |
| PROC_MOUSE |
| EC Number | 3.4.21.69 |
|---|
| Ensembl ID | ENSG00000115718 |
|---|---|
| ENSP00000234071 | |
| ENST00000234071 | |
| ENSP00000404030 | |
| ENST00000453608 | |
| ENSMUSG00000024386 | |
| ENSMUSP00000132226 | |
| ENSMUST00000171765 | |
| ENSRNOG00000014376 | |
| ENSRNOP00000019596 | |
| ENSRNOT00000019596 |
| Homologene ID | 37288 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97771 |
|---|
| RGD ID | 3411 |
|---|
| MedScan ID | 5624 |
|---|