| URN | urn:agi-llid:5627 |
|---|---|
| Total Entities | 0 |
| Connectivity | 723 |
| Name | Pros1 |
| Description | protein S (alpha) |
| Notes | This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009] |
| GO Molecular Function | endopeptidase inhibitor activity |
|---|---|
| protein complex binding | |
| calcium ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| endoplasmic reticulum membrane | |
| Golgi membrane | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| protein complex | |
| extracellular space |
| GO Biological Process | leukocyte migration |
|---|---|
| regulation of complement activation | |
| innate immune response | |
| negative regulation of coagulation | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| platelet degranulation | |
| positive regulation of phagocytosis | |
| response to lipopolysaccharide | |
| negative regulation of endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Vitamin K metabolism | |
| IL6 Expression Targets | |
| protein C anticoagulant pathway |
| Group | leukocyte migration |
|---|---|
| regulation of complement activation | |
| innate immune response | |
| negative regulation of coagulation | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| platelet degranulation | |
| positive regulation of phagocytosis | |
| response to lipopolysaccharide | |
| endopeptidase inhibitor activity | |
| negative regulation of endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| protein complex binding | |
| calcium ion binding | |
| extracellular region | |
| endoplasmic reticulum membrane | |
| Golgi membrane | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| protein complex | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5627 |
|---|---|
| 19128 | |
| 81750 |
| Cell Localization | Secreted |
|---|
| GO ID | 0005509 |
|---|---|
| 0004866 | |
| 0007596 | |
| 0044267 | |
| 0042730 | |
| 0045087 | |
| 0050900 | |
| 0010951 | |
| 0017187 | |
| 0030168 | |
| 0002576 | |
| 0043687 | |
| 0006508 | |
| 0030449 | |
| 0005796 | |
| 0000139 | |
| 0005789 | |
| 0005576 | |
| 0031093 | |
| 0032403 | |
| 0007599 | |
| 0050819 | |
| 0050766 | |
| 0005615 | |
| 0043234 | |
| 0032496 |
| Alias | PSA |
|---|---|
| PROS | |
| PS21 | |
| PS22 | |
| PS23 | |
| PS24 | |
| PS25 | |
| THPH5 | |
| THPH6 | |
| vitamin K-dependent protein S | |
| protein Sa | |
| vitamin K-dependent plasma protein S | |
| AW214361 | |
| PS-23 | |
| PS-24 | |
| PS-25 | |
| PS26 | |
| protein S | |
| PS-26 | |
| PS-21 | |
| protein S (alpha) | |
| PROS1 | |
| PROS I | |
| OTTHUMP00000197146 | |
| protein S alpha | |
| PS-22 |
| Mouse chromosome position | 16 |
|---|
| OMIM ID | 176880 |
|---|---|
| 612336 | |
| 614514 |
| Rat chromosome position | 7 |
|---|
| Hugo ID | 9456 |
|---|
| Human chromosome position | 3q11.2 |
|---|
| Swiss-Prot Accession | P07225 |
|---|---|
| Q08761 | |
| Q3TR66 | |
| M0R5R0 | |
| P53813 | |
| A8KAC9 | |
| D3DN28 | |
| Q15518 | |
| Q7Z715 | |
| Q9UCZ8 | |
| P43483 |
| PIR ID | A35610 |
|---|---|
| S43504 |
| Unigene ID | Hs.64016 |
|---|---|
| Mm.127156 | |
| Rn.2888 |
| KEGG ID | hsa:5627 |
|---|---|
| mmu:19128 | |
| rno:81750 |
| Swiss-Prot ID | PROS_HUMAN |
|---|---|
| PROS_MOUSE |
| Ensembl ID | ENSG00000184500 |
|---|---|
| ENSP00000377783 | |
| ENST00000394236 | |
| ENSMUSG00000022912 | |
| ENSMUSP00000023629 | |
| ENSMUST00000023629 | |
| ENSRNOG00000048723 | |
| ENSRNOP00000064737 | |
| ENSRNOT00000073689 |
| Homologene ID | 264 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1095733 |
|---|
| RGD ID | 620971 |
|---|
| MedScan ID | 5627 |
|---|