Elsevier Inc. Proc_act_diss ---| coagulation cascade pathway coagulation cascade pathway Gla domain Thbd Procr F2 Proc Proc_act Proc_act_diss Pros1 protease mediated signaling pathway vitamin K-dependent proteins, anticoagulation vitamin K cycle pathway Proc_act_diss ---- Pros1 F2 ---- Thbd Proc ---- Procr F2 --+> Proc_act F2 ---> Proc Proc_act ---- Procr Proc_act --+> protease mediated signaling pathway