| URN | urn:agi-llid:27247 |
|---|---|
| Total Entities | 0 |
| Connectivity | 25 |
| Name | Nfu1 |
| Description | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) |
| Notes | This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| GO Molecular Function | iron ion binding |
|---|---|
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding |
| GO Cellular Component | centrosome |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | iron-sulfur cluster assembly |
|---|
| Pathway | mitochondrial iron-sulfur cluster protein biogenesis pathway |
|---|
| Group | iron-sulfur cluster assembly |
|---|---|
| iron ion binding | |
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| centrosome | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| LocusLink ID | 27247 |
|---|---|
| 56748 | |
| 297416 |
| Cell Localization | Mitochondrion |
|---|---|
| Cytoplasm | |
| Cytosol |
| GO ID | 0051539 |
|---|---|
| 0005506 | |
| 0016226 | |
| 0005813 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005634 | |
| 0051536 |
| Alias | Nfu |
|---|---|
| NifU | |
| HIRIP | |
| MMDS1 | |
| NIFUC | |
| CGI-33 | |
| HIRIP5 | |
| NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | |
| HIRA-interacting protein 5 | |
| iron-sulfur cluster scaffold protein | |
| NifU-like C-terminal domain containing | |
| 0610006G17Rik | |
| mHIRIP5 | |
| histone cell cycle regulation defective interacting protein 5 | |
| NFU1 iron-sulfur cluster scaffold homolog | |
| NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) | |
| MGC142254 | |
| Nfu1 | |
| OTTHUMP00000214466 | |
| histone cell cycle regulation defective interactive protein V | |
| MGC142252 | |
| OTTHUMP00000214438 | |
| OTTHUMP00000214465 | |
| OTTMUSP00000038171 | |
| OTTMUSP00000038172 | |
| RIKEN cDNA 0610006G17 gene | |
| histone cell cycle regulation defective interactive protein 5 | |
| OTTHUMP00000214439 | |
| HIRA interacting protein V | |
| histone cell cycle regulation defective interacting protein V | |
| 0610006G17 | |
| HIRA interacting protein 5 | |
| HIRA interactive protein 5 | |
| HIRA interactive protein V | |
| HIRA-interacting protein | |
| HIRIP5 protein, HIRA-interactive protein V | |
| HIRA-interactive protein 5 (CGI-33) | |
| HIRIP5 protein, HIRA-interacting protein 5 | |
| HIRIP5 protein, HIRA-interacting protein V | |
| HIRIP5 protein, HIRA-interactive protein 5 | |
| HIRA-interacting protein 5 (CGI-33) | |
| HIRIP5 proteins |
| Mouse chromosome position | 6 |
|---|
| OMIM ID | 608100 |
|---|---|
| 605711 |
| Rat chromosome position | 4q34 |
|---|
| Hugo ID | 16287 |
|---|
| Human chromosome position | 2p15-p13 |
|---|
| Swiss-Prot Accession | Q9UMS0 |
|---|---|
| Q9QZ23 | |
| D3ZA85 | |
| B4DUL9 | |
| Q53QE5 | |
| Q6VNZ8 | |
| Q7Z5B1 | |
| Q7Z5B2 | |
| Q9Y322 | |
| Q3ULE0 | |
| Q6VNZ7 | |
| Q8CF80 | |
| Q9D1B7 |
| Unigene ID | Hs.430439 |
|---|---|
| Mm.23809 | |
| Rn.161843 |
| KEGG ID | hsa:27247 |
|---|---|
| mmu:56748 | |
| rno:297416 |
| Swiss-Prot ID | NFU1_HUMAN |
|---|---|
| NFU1_MOUSE |
| Ensembl ID | ENSG00000169599 |
|---|---|
| ENSP00000377842 | |
| ENST00000394305 | |
| ENSP00000306965 | |
| ENST00000303698 | |
| ENSMUSG00000029993 | |
| ENSMUSP00000032060 | |
| ENSMUST00000032060 | |
| ENSRNOG00000018410 | |
| ENSRNOP00000024884 | |
| ENSRNOT00000024884 |
| Homologene ID | 6369 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913290 |
|---|
| RGD ID | 1307823 |
|---|
| MedScan ID | 27247 |
|---|