| URN | urn:agi-llid:80224 |
|---|---|
| Total Entities | 0 |
| Connectivity | 16 |
| Name | Nubpl |
| Description | nucleotide binding protein-like |
| Notes | This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. The respiratory complex I consists of 45 subunits and 8 iron-sulfur (Fe/S) clusters. This protein is an Fe/S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[provided by RefSeq, Jan 2011] |
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| metal ion binding | |
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding |
| GO Cellular Component | mitochondrion |
|---|
| GO Biological Process | mitochondrion morphogenesis |
|---|---|
| mitochondrial respiratory chain complex I assembly |
| Pathway | mitochondrial iron-sulfur cluster protein biogenesis pathway |
|---|
| Group | mitochondrion morphogenesis |
|---|---|
| mitochondrial respiratory chain complex I assembly | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| mitochondrion |
| LocusLink ID | 80224 |
|---|---|
| 76826 |
| Cell Localization | Mitochondrion |
|---|
| GO ID | 0051539 |
|---|---|
| 0005524 | |
| 0046872 | |
| 0032981 | |
| 0070584 | |
| 0005739 | |
| 0051536 | |
| 0000166 |
| Alias | IND1 |
|---|---|
| huInd1 | |
| C14orf127 | |
| iron-sulfur protein NUBPL | |
| IND1 homolog | |
| iron-sulfur protein required for NADH dehydrogenase | |
| 2410170E07Rik | |
| nucleotide-binding protein-like | |
| nubpl | |
| nucleotide binding protein-like | |
| FLJ12660 | |
| chromosome 14 open reading frame 127 | |
| 2410170E07 |
| Mouse chromosome position | 12 |
|---|
| OMIM ID | 613621 |
|---|---|
| 252010 |
| Hugo ID | 20278 |
|---|
| Human chromosome position | 14q12 |
|---|
| Swiss-Prot Accession | B4DWB0 |
|---|---|
| Q8TB37 | |
| B3KSK2 | |
| Q9CWD8 | |
| Q6P6K2 | |
| B4DHZ1 | |
| Q86TZ4 | |
| Q9H9M2 |
| Unigene ID | Hs.288981 |
|---|---|
| Mm.244781 |
| KEGG ID | hsa:80224 |
|---|---|
| mmu:76826 |
| Swiss-Prot ID | NUBPL_MOUSE |
|---|---|
| NUBPL_HUMAN |
| Ensembl ID | ENSG00000151413 |
|---|---|
| ENSP00000439286 | |
| ENST00000536705 | |
| ENSP00000281081 | |
| ENST00000281081 |
| Homologene ID | 11854 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 1924076 |
|---|
| RGD ID | 1307232 |
|---|
| MedScan ID | 80224 |
|---|