| URN | urn:agi-llid:9054 |
|---|---|
| Total Entities | 0 |
| Connectivity | 79 |
| Name | Nfs1 |
| Description | NFS1 cysteine desulfurase |
| Notes | Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| cysteine desulfurase activity | |
| protein homodimerization activity | |
| pyridoxal phosphate binding |
| GO Cellular Component | mitochondrial matrix |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| vitamin metabolic process | |
| sulfur amino acid metabolic process | |
| cysteine metabolic process | |
| water-soluble vitamin metabolic process | |
| molybdopterin cofactor biosynthetic process | |
| Mo-molybdopterin cofactor biosynthetic process | |
| iron incorporation into metallo-sulfur cluster | |
| protein complex assembly |
| Pathway | mitochondrial iron-sulfur cluster protein biogenesis pathway |
|---|
| Group | metabolic process |
|---|---|
| small molecule metabolic process | |
| vitamin metabolic process | |
| sulfur amino acid metabolic process | |
| cysteine metabolic process | |
| water-soluble vitamin metabolic process | |
| catalytic activity | |
| transferase activity | |
| cysteine desulfurase activity | |
| molybdopterin cofactor biosynthetic process | |
| Mo-molybdopterin cofactor biosynthetic process | |
| iron incorporation into metallo-sulfur cluster | |
| protein complex assembly | |
| protein homodimerization activity | |
| pyridoxal phosphate binding | |
| mitochondrial matrix | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| LocusLink ID | 9054 |
|---|---|
| 18041 | |
| 84594 |
| Cell Localization | Mitochondrion |
|---|---|
| Cytoplasm | |
| Nucleus |
| GO ID | 0031071 |
|---|---|
| 0042803 | |
| 0030170 | |
| 0006777 | |
| 0006534 | |
| 0018283 | |
| 0032324 | |
| 0006461 | |
| 0044281 | |
| 0000096 | |
| 0006766 | |
| 0006767 | |
| 0005829 | |
| 0005759 | |
| 0005739 | |
| 0005634 | |
| 0003824 | |
| 0016740 | |
| 0008152 | |
| 0005737 |
| Alias | IscS |
|---|---|
| NIFS | |
| HUSSY-08 | |
| cysteine desulfurase, mitochondrial | |
| NFS1 nitrogen fixation 1 homolog | |
| nitrogen-fixing bacteria S-like protein | |
| nitrogen fixation 1 (S. cerevisiae, homolog) | |
| m-Nfs1 | |
| m-Nfsl | |
| AA987187 | |
| RP23-220D12.8 | |
| nifS-like (sic) | |
| nitrogen fixation gene, yeast homolog 1 | |
| nitrogen fixation gene 1 | |
| nifs-like | |
| nitrogen fixation gene 1 (S. cerevisiae) | |
| NFS1 nitrogen fixation I | |
| nitrogen fixation gene I | |
| nitrogen fixation gene, yeast homolog | |
| NFS1 nitrogen fixation 1 homolog (S. cerevisiae) | |
| OTTHUMP00000030799 | |
| OTTHUMP00000030800 | |
| OTTMUSP00000017220 | |
| NFS1 cysteine desulfurase | |
| nitrogen fixation gene, yeast homolog I | |
| LOC96810 | |
| OTTHUMP00000179026 | |
| cysteine desulfurase | |
| HUSSY VIII | |
| MGC124952 | |
| NFS nitrogen fixation 1 (S. cerevisiae) | |
| NFS1 nitrogen fixation 1 (S. cerevisiae) | |
| NFS1 nitrogen fixation 1 | |
| HUSSY-8 | |
| NFS nitrogen fixation I | |
| mitochondrial Cysteine desulfurase | |
| NFS nitrogen fixation 1 | |
| Nfs I | |
| Nfs1 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 603485 |
|---|
| Rat chromosome position | 3q42 |
|---|
| Hugo ID | 15910 |
|---|
| Human chromosome position | 20q11.22 |
|---|
| Swiss-Prot Accession | Q53FP3 |
|---|---|
| Q9Y697 | |
| Q5QP19 | |
| Q9CTB2 | |
| Q9Z1J3 | |
| Q3MHT2 | |
| Q99P39 | |
| Q8C6I5 | |
| B3KMA5 | |
| B4DXK9 | |
| E1P5R8 | |
| F5GYK5 | |
| Q6P0L8 | |
| Q9NTZ5 | |
| Q9Y481 |
| Unigene ID | Hs.194692 |
|---|---|
| Mm.283604 | |
| Rn.3151 |
| KEGG ID | hsa:9054 |
|---|---|
| mmu:18041 | |
| rno:84594 |
| Swiss-Prot ID | NFS1_MOUSE |
|---|---|
| NFS1_HUMAN |
| EC Number | 2.8.1.7 |
|---|
| Ensembl ID | ENSG00000244005 |
|---|---|
| ENSP00000380570 | |
| ENST00000397425 | |
| ENSP00000438594 | |
| ENST00000540053 | |
| ENSP00000363198 | |
| ENST00000374085 | |
| ENSMUSG00000027618 | |
| ENSMUSP00000029147 | |
| ENSMUST00000029147 |
| Homologene ID | 5463 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1316706 |
|---|
| RGD ID | 620912 |
|---|
| MedScan ID | 9054 |
|---|