| URN | urn:agi-llid:23479 |
|---|---|
| Total Entities | 0 |
| Connectivity | 95 |
| Name | Iscu |
| Description | iron-sulfur cluster assembly enzyme |
| Notes | Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | protein complex scaffold |
|---|---|
| metal ion binding | |
| iron ion binding | |
| iron-sulfur cluster binding |
| GO Cellular Component | mitochondrial matrix |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| iron-sulfur cluster assembly | |
| nitrogen fixation |
| Pathway | mitochondrial iron-sulfur cluster protein biogenesis pathway |
|---|
| Group | small molecule metabolic process |
|---|---|
| iron-sulfur cluster assembly | |
| nitrogen fixation | |
| protein complex scaffold | |
| metal ion binding | |
| iron ion binding | |
| iron-sulfur cluster binding | |
| mitochondrial matrix | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus | |
| Biofluids assayable substances |
| LocusLink ID | 23479 |
|---|---|
| 66383 | |
| 288740 |
| Cell Localization | Mitochondrion |
|---|---|
| Cytoplasm | |
| Nucleus |
| GO ID | 0005506 |
|---|---|
| 0051536 | |
| 0032947 | |
| 0016226 | |
| 0009399 | |
| 0044281 | |
| 0005737 | |
| 0005829 | |
| 0005759 | |
| 0005739 | |
| 0005634 | |
| 0046872 |
| Alias | HML |
|---|---|
| ISU2 | |
| NIFU | |
| NIFUN | |
| hnifU | |
| 2310020H20Rik | |
| iron-sulfur cluster assembly enzyme ISCU, mitochondrial | |
| nifU-like protein | |
| iron-sulfur cluster scaffold homolog | |
| NifU-like N-terminal domain containing | |
| IscU iron-sulfur cluster scaffold homolog | |
| nifU-like N-terminal domain-containing protein | |
| AA407971 | |
| ISCU2 | |
| RGD1309562 | |
| nitrogen fixation cluster-like | |
| LOC91850 | |
| MGC74517 | |
| OTTMUSP00000031461 | |
| OTTMUSP00000031462 | |
| OTTMUSP00000031465 | |
| OTTMUSP00000031469 | |
| LOC433217 | |
| human nifU-like protein | |
| iron-sulfur cluster assembly enzyme | |
| 2310020H20 | |
| LOC231631 | |
| ISCU | |
| IscU iron-sulfur cluster scaffold homolog (E. coli) | |
| IscU iron-sulfur cluster scaffold homolog pseudogene | |
| iron-sulfur cluster scaffold homolog (E. coli) |
| Mouse chromosome position | 5 |
|---|
| OMIM ID | 611911 |
|---|---|
| 255125 |
| Rat chromosome position | 12q16 |
|---|
| Hugo ID | 29882 |
|---|
| Human chromosome position | 12q24.1 |
|---|
| Swiss-Prot Accession | Q9H1K1 |
|---|---|
| B3KQ30 | |
| B4DNC9 | |
| Q9D7P6 | |
| B2RZ79 | |
| Q4VBC7 | |
| Q8K344 | |
| Q6P713 | |
| Q99617 | |
| Q9H1K2 |
| Unigene ID | Hs.615131 |
|---|---|
| Mm.29497 | |
| Rn.121 |
| KEGG ID | hsa:23479 |
|---|---|
| mmu:66383 | |
| rno:288740 |
| Swiss-Prot ID | ISCU_MOUSE |
|---|---|
| ISCU_HUMAN |
| Ensembl ID | ENSG00000136003 |
|---|---|
| ENSP00000376554 | |
| ENST00000392807 | |
| ENSP00000310623 | |
| ENST00000311893 | |
| ENSMUSG00000025825 | |
| ENSMUSP00000026937 | |
| ENSMUST00000026937 | |
| ENSRNOG00000000701 | |
| ENSRNOP00000000890 | |
| ENSRNOT00000000890 |
| Homologene ID | 6991 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913633 |
|---|
| RGD ID | 1309562 |
|---|
| MedScan ID | 23479 |
|---|