Protein Fdx1

URN	urn:agi-llid:2230
Total Entities	0
Connectivity	409
Name	Fdx1
Description	ferredoxin 1
Notes	The product of this gene is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. This gene product has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific. [provided by RefSeq]

GO Molecular Function	NADPH-adrenodoxin reductase activity
	cholesterol monooxygenase (side-chain-cleaving) activity
	electron carrier activity
	enzyme binding
	metal ion binding
	iron ion binding
	iron-sulfur cluster binding
	2 iron, 2 sulfur cluster binding

GO Biological Process	lipid metabolic process
	small molecule metabolic process
	oxidation-reduction process
	steroid biosynthetic process
	NADPH oxidation
	positive regulation of oxidoreductase activity
	steroid metabolic process
	cholesterol metabolic process
	adrenal gland development
	cellular response to epinephrine stimulus
	cellular response to organic cyclic compound
	cellular response to leptin stimulus
	response to gonadotropin
	response to leptin
	regulation of catalytic activity
	hormone biosynthetic process
	transport

Pathway	steroid hormone biosynthetic pathway
	testosterone biosynthetic pathway
	mitochondrial iron-sulfur cluster protein biogenesis pathway

Group	Steroid metabolism
	Urea cycle
	lipid metabolic process
	small molecule metabolic process
	oxidation-reduction process
	steroid biosynthetic process
	NADPH oxidation
	positive regulation of oxidoreductase activity
	NADPH-adrenodoxin reductase activity
	cholesterol monooxygenase (side-chain-cleaving) activity
	steroid metabolic process
	cholesterol metabolic process
	adrenal gland development
	cellular response to epinephrine stimulus
	cellular response to organic cyclic compound
	cellular response to leptin stimulus
	response to gonadotropin
	response to leptin
	regulation of catalytic activity
	hormone biosynthetic process
	transport
	electron carrier activity
	enzyme binding
	metal ion binding
	iron ion binding
	iron-sulfur cluster binding
	2 iron, 2 sulfur cluster binding
	mitochondrial crista
	mitochondrial matrix
	mitochondrion
	Secreted proteins

Alias	ADX
	FDX
	LOH11CR1D
	adrenodoxin, mitochondrial
	ferredoxin-1
	hepatoredoxin
	adrenal ferredoxin
	mitochondrial adrenodoxin
	ferredoxin
	ferredoxin 1
	ferredoxin I
	FDX I
	CG4205-PA
	FDX1
	adrenodoxin
	Adrenodoxin, mitochondrial precursor

Mouse chromosome position	9
	9 B

OMIM ID	103260

Rat chromosome position	8q24

Hugo ID	3638

Human chromosome position	11q22

Homologene ID	31216

MGI ID	103224

RGD ID	62036

MedScan ID	2230