| URN | urn:agi-llid:2232 |
|---|---|
| Total Entities | 0 |
| Connectivity | 152 |
| Name | Fdxr |
| Description | ferredoxin reductase |
| Notes | This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined. [provided by RefSeq] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| NADPH-adrenodoxin reductase activity | |
| ferredoxin-NADP+ reductase activity | |
| NADPH binding |
| GO Cellular Component | mitochondrial inner membrane |
|---|---|
| mitochondrial matrix | |
| mitochondrion |
| GO Biological Process | lipid metabolic process |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| steroid biosynthetic process | |
| NADPH oxidation | |
| steroid metabolic process | |
| cholesterol metabolic process | |
| generation of precursor metabolites and energy | |
| transport |
| Pathway | AGT/TP53 Expression Targets |
|---|---|
| steroid hormone biosynthetic pathway | |
| testosterone biosynthetic pathway | |
| mitochondrial iron-sulfur cluster protein biogenesis pathway |
| Group | lipid metabolic process |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| steroid biosynthetic process | |
| NADPH oxidation | |
| oxidoreductase activity | |
| NADPH-adrenodoxin reductase activity | |
| ferredoxin-NADP+ reductase activity | |
| steroid metabolic process | |
| cholesterol metabolic process | |
| generation of precursor metabolites and energy | |
| transport | |
| NADPH binding | |
| mitochondrial inner membrane | |
| mitochondrial matrix | |
| mitochondrion |
| LocusLink ID | 2232 |
|---|---|
| 14149 | |
| 79122 |
| Cell Localization | Mitochondrion matrix |
|---|
| GO ID | 0070402 |
|---|---|
| 0015039 | |
| 0004324 | |
| 0070995 | |
| 0008203 | |
| 0006091 | |
| 0055114 | |
| 0044281 | |
| 0006694 | |
| 0005743 | |
| 0005759 | |
| 0005739 | |
| 0016491 | |
| 0006629 | |
| 0008202 | |
| 0006810 | |
| 0009055 | |
| 0005515 | |
| 0022900 |
| Alias | ADXR |
|---|---|
| NADPH:adrenodoxin oxidoreductase, mitochondrial | |
| AR | |
| adrenodoxin reductase | |
| adrenodoxin-NADP(+) reductase | |
| ferredoxin--NADP(+) reductase | |
| RP23-117K15.3 | |
| NADPH:ferredoxin oxidoreductases | |
| NADP(H)-adrenodoxin reductases | |
| NADP(H)-adrenodoxin reductase | |
| NADP:ferredoxin oxidoreductase | |
| NADP(H):ferredoxin oxidoreductases | |
| NADP:ferredoxin oxidoreductases | |
| NADPH:adrenodoxin oxidoreductase | |
| NADPH:ferredoxin oxidoreductase | |
| NADPH-adrenodoxin reductase | |
| NADPH-adrenodoxin reductases | |
| OTTMUSP00000003980 | |
| reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase | |
| reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductases | |
| TPNH-ferredoxin reductase | |
| TPNH-ferredoxin reductases | |
| NADP(H):ferredoxin oxidoreductase | |
| ferredoxin-NADP oxidoreductases | |
| adrenodoxin reductases | |
| ferredoxin reductase | |
| ferredoxin-NADP oxidoreductase | |
| NADP(H):adrenodoxin oxidoreductase | |
| Ferredoxin-NADP reductase | |
| Ferredoxin-NADP(+) reductase | |
| ferredoxin-nicotinamide adenine dinucleotide phosphate reductase | |
| ferredoxin-nicotinamide adenine dinucleotide phosphate reductases | |
| ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductases | |
| ferredoxin-TPN reductase | |
| ferredoxin-TPN reductases | |
| NAD(P)H:adrenodoxin oxidoreductase | |
| NAD(P)H:ferredoxin oxidoreductase | |
| NAD(P)H:ferredoxin oxidoreductases | |
| NAD(P)H-adrenodoxin reductase | |
| NAD(P)H-adrenodoxin reductases | |
| ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase | |
| FDXR | |
| Ferredoxin-NADP(+) reductase |
| Mouse chromosome position | 11 |
|---|---|
| 11 E2 |
| OMIM ID | 103270 |
|---|
| Rat chromosome position | 10q32.2 |
|---|
| Hugo ID | 3642 |
|---|
| Human chromosome position | 17q25.1 |
|---|---|
| 17q24-q25 |
| Swiss-Prot Accession | P22570 |
|---|---|
| Q6GSK2 | |
| Q61578 | |
| P56522 | |
| B4DDI7 | |
| B4DHX5 | |
| B4DQQ4 | |
| B4DX24 | |
| B7Z7G2 | |
| E7EQC1 | |
| Q13716 | |
| Q4PJI0 | |
| Q9BU12 | |
| A2A6S3 | |
| Q3UZ58 | |
| Q6IQY0 | |
| Q6PG98 |
| PIR ID | A40487 |
|---|---|
| S60028 |
| Unigene ID | Hs.69745 |
|---|---|
| Mm.4719 | |
| Rn.10860 |
| KEGG ID | hsa:2232 |
|---|---|
| mmu:14149 | |
| rno:79122 |
| Swiss-Prot ID | ADRO_RAT |
|---|---|
| ADRO_HUMAN | |
| ADRO_MOUSE | |
| Q6GSK2_HUMAN | |
| A2A6S3_MOUSE |
| EC Number | 1.18.1.6 |
|---|---|
| 1.18.1.2 |
| Ensembl ID | ENSG00000161513 |
|---|---|
| ENSP00000416515 | |
| ENST00000442102 | |
| ENSP00000408595 | |
| ENST00000413947 | |
| ENSP00000462183 | |
| ENST00000582944 | |
| ENSP00000414172 | |
| ENST00000420580 | |
| ENSP00000445432 | |
| ENST00000544854 | |
| ENSP00000462972 | |
| ENST00000581530 | |
| ENSP00000293195 | |
| ENST00000293195 | |
| ENSMUSG00000018861 | |
| ENSMUSP00000021078 | |
| ENSMUST00000021078 | |
| ENSRNOG00000003387 | |
| ENSRNOP00000004592 | |
| ENSRNOT00000004592 |
| Homologene ID | 3033 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104724 |
|---|
| RGD ID | 621648 |
|---|
| MedScan ID | 2232 |
|---|
| IPI ID | IPI00026958 |
|---|---|
| IPI00221118 | |
| IPI00790677 | |
| IPI00453981 | |
| IPI00193379 |