Elsevier Inc. protein C anticoagulant pathway coagulation cascade pathway Gla domain vitamin K-dependent proteins, anticoagulation vitamin K-dependent proteins, coagulation gamma-carboxyglutamic acid Vitamin K1 oxide phylloquinone glutamate vitamin K1 reduced vitamin K1 reduced ---> Vitamin K1 oxide Vitamin K1 oxide ---> phylloquinone Vkorc1 Ggcx Ggcx ---> vitamin K-dependent proteins, coagulation phylloquinone ---> vitamin K1 reduced vitamin K-dependent proteins, anticoagulation ---> protein C anticoagulant pathway vitamin K-dependent proteins, coagulation ---> coagulation cascade pathway Ggcx ---> vitamin K-dependent proteins, anticoagulation glutamate ---> gamma-carboxyglutamic acid