| URN | urn:agi-llid:952 |
|---|---|
| Total Entities | 0 |
| Connectivity | 864 |
| Name | Cd38 |
| Description | CD38 molecule |
| Notes | CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | hydrolase activity |
|---|---|
| hydrolase activity, acting on glycosyl bonds | |
| NAD+ nucleosidase activity | |
| phosphorus-oxygen lyase activity |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| cell surface | |
| plasma membrane | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | female pregnancy |
|---|---|
| B cell receptor signaling pathway | |
| positive regulation of B cell proliferation | |
| negative regulation of bone resorption | |
| positive regulation of vasoconstriction | |
| signal transduction | |
| apoptotic signaling pathway | |
| long term synaptic depression | |
| positive regulation of insulin secretion | |
| positive regulation of cell growth | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of apoptotic process | |
| response to drug | |
| response to hydroperoxide | |
| response to retinoic acid | |
| response to estradiol | |
| response to progesterone | |
| response to cytokine | |
| response to hormone | |
| response to interleukin-1 | |
| response to hypoxia | |
| positive regulation of transcription, DNA-templated | |
| negative regulation of transcription, DNA-templated |
| Pathway | B-cell Chronic Lymphocytic Leukemia Overview |
|---|---|
| Proteins Involved in Pathogenesis of B-cell Chronic Lymphocytic Leukemia | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| CD38 -> NF-kB signaling | |
| TNF/STAT Expression Targets | |
| PECAM1 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| TNF/NF-kB Expression Targets | |
| IL1B Expression Targets | |
| nicotinamide adenine nucleotide utilization pathway |
| Group | CD38 |
|---|---|
| female pregnancy | |
| B cell receptor signaling pathway | |
| positive regulation of B cell proliferation | |
| negative regulation of bone resorption | |
| positive regulation of vasoconstriction | |
| signal transduction | |
| apoptotic signaling pathway | |
| long term synaptic depression | |
| positive regulation of insulin secretion | |
| positive regulation of cell growth | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of apoptotic process | |
| response to drug | |
| response to hydroperoxide | |
| response to retinoic acid | |
| response to estradiol | |
| response to progesterone | |
| response to cytokine | |
| response to hormone | |
| response to interleukin-1 | |
| response to hypoxia | |
| positive regulation of transcription, DNA-templated | |
| negative regulation of transcription, DNA-templated | |
| hydrolase activity | |
| hydrolase activity, acting on glycosyl bonds | |
| NAD+ nucleosidase activity | |
| phosphorus-oxygen lyase activity | |
| membrane | |
| integral component of membrane | |
| cell surface | |
| plasma membrane | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 952 |
|---|---|
| 12494 | |
| 25668 |
| Cell Localization | Plasma membrane |
|---|---|
| Membrane |
| GO ID | 0003953 |
|---|---|
| 0016849 | |
| 0050853 | |
| 0097190 | |
| 0007565 | |
| 0060292 | |
| 0043066 | |
| 0045779 | |
| 0045892 | |
| 0030890 | |
| 0030307 | |
| 0007204 | |
| 0032024 | |
| 0045893 | |
| 0045907 | |
| 0042493 | |
| 0032355 | |
| 0033194 | |
| 0001666 | |
| 0070555 | |
| 0032570 | |
| 0032526 | |
| 0007165 | |
| 0009986 | |
| 0016021 | |
| 0016020 | |
| 0005634 | |
| 0005886 | |
| 0016787 | |
| 0016798 | |
| 0009725 | |
| 0043231 | |
| 0034097 |
| Alias | T10 |
|---|---|
| ADP-ribosyl cyclase 1 | |
| cADPr hydrolase 1 | |
| CD38 antigen (p45) | |
| NAD(+) nucleosidase | |
| cyclic ADP-ribose hydrolase 1 | |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | |
| Cd38-rs1 | |
| I-19 | |
| NIM-R5 antigen | |
| CD38H | |
| CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase) | |
| t10 antigen | |
| Cd38-rs I | |
| cyclic ADP-ribose hydrolase | |
| leukocyte cell surface antigen CD38 | |
| Cyclic ADP-ribose hydrolase I | |
| Lymphocyte differentiating antigen CD38 | |
| OTTHUMP00000217743 | |
| CD38 leukocyte cell surface antigen | |
| Lymphocyte differentiation antigen CD38 | |
| CD38 antigen | |
| CD38 antigen (p45), ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | |
| antigen cd38 | |
| Acute lymphoblastic leukaemia cells antigen CD38 | |
| Acute lymphoblastic leukemia cells antigen CD38 | |
| ADP-ribosyl cyclase | |
| ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase | |
| ADP-ribosyl cyclase I | |
| CADPR hydrolase I | |
| CD38 |
| Mouse chromosome position | 5 23.85 cM |
|---|
| OMIM ID | 107270 |
|---|
| Rat chromosome position | 14q21 |
|---|
| Hugo ID | 1667 |
|---|
| Human chromosome position | 4p15 |
|---|
| Swiss-Prot Accession | P28907 |
|---|---|
| P56528 | |
| Q4FJL8 | |
| Q64244 | |
| O00121 | |
| O00122 | |
| Q96HY4 | |
| Q8BFY8 |
| PIR ID | A43521 |
|---|---|
| JC2410 | |
| I49586 |
| Unigene ID | Hs.479214 |
|---|---|
| Mm.249873 | |
| Rn.11414 |
| KEGG ID | hsa:952 |
|---|---|
| mmu:12494 | |
| rno:25668 |
| Swiss-Prot ID | CD38_HUMAN |
|---|---|
| CD38_RAT | |
| CD38_MOUSE |
| EC Number | 3.2.2.5 |
|---|
| Ensembl ID | ENSMUSG00000029084 |
|---|---|
| ENSMUSP00000030964 | |
| ENSMUST00000030964 | |
| ENSRNOG00000003069 | |
| ENSRNOP00000004121 | |
| ENSRNOT00000004121 |
| Homologene ID | 1345 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 107474 |
|---|
| RGD ID | 2303 |
|---|
| MedScan ID | 952 |
|---|