| URN | urn:agi-llid:23530 |
|---|---|
| Total Entities | 0 |
| Connectivity | 100 |
| Name | Nnt |
| Description | nicotinamide nucleotide transhydrogenase |
| Notes | This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | NAD(P)+ transhydrogenase activity |
|---|---|
| NAD(P)+ transhydrogenase (AB-specific) activity | |
| NAD(P)+ transhydrogenase (B-specific) activity | |
| NAD binding | |
| NADP binding |
| GO Cellular Component | integral component of membrane |
|---|---|
| mitochondrial respiratory chain | |
| mitochondrial inner membrane | |
| mitochondrion |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| tricarboxylic acid cycle | |
| proton transport | |
| cellular metabolic process | |
| reactive oxygen species metabolic process |
| Pathway | nicotinamide adenine dinucleotide metabolic pathway |
|---|
| Group | Other transport proteins |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| NAD(P)+ transhydrogenase activity | |
| NAD(P)+ transhydrogenase (AB-specific) activity | |
| NAD(P)+ transhydrogenase (B-specific) activity | |
| tricarboxylic acid cycle | |
| proton transport | |
| cellular metabolic process | |
| reactive oxygen species metabolic process | |
| NAD binding | |
| NADP binding | |
| integral component of membrane | |
| mitochondrial respiratory chain | |
| mitochondrial inner membrane | |
| mitochondrion | |
| Secreted proteins |
| LocusLink ID | 23530 |
|---|---|
| 310378 |
| Cell Localization | Plasma membrane |
|---|---|
| Mitochondrion inner membrane |
| GO ID | 0051287 |
|---|---|
| 0008750 | |
| 0003957 | |
| 0008746 | |
| 0050661 | |
| 0044237 | |
| 0055114 | |
| 0015992 | |
| 0072593 | |
| 0044281 | |
| 0006099 | |
| 0016021 | |
| 0005743 | |
| 0005746 | |
| 0005739 |
| Alias | GCCD4 |
|---|---|
| hCG_17428 | |
| NAD(P) transhydrogenase, mitochondrial | |
| pyridine nucleotide transhydrogenase | |
| Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase) | |
| nicotinamide nucleotide transhydrogenase | |
| OTTHUMP00000122433 | |
| OTTMUSP00000023154 | |
| Nnt | |
| Nicotinamide nucleotide transhydrogenase (NAD(P) transhydrogenase) | |
| nicotinamide nucleotide transhydrogenase (nad | |
| NAD(P) transhydrogenase | |
| mitochondrial NAD(P) transhydrogenase | |
| MGC126503 | |
| MGC126502 | |
| 4930423F13 | |
| MGC109126 |
| OMIM ID | 607878 |
|---|---|
| 614736 |
| Rat chromosome position | 2q16 |
|---|
| Hugo ID | 7863 |
|---|
| Human chromosome position | 5p12 |
|---|
| Swiss-Prot Accession | Q13423 |
|---|---|
| Q5BJZ3 | |
| Q16796 | |
| Q2TB60 | |
| Q8N3V4 |
| PIR ID | G02257 |
|---|
| Unigene ID | Hs.482043 |
|---|---|
| Rn.3128 |
| KEGG ID | hsa:23530 |
|---|---|
| rno:310378 |
| Swiss-Prot ID | NNTM_HUMAN |
|---|
| EC Number | 1.6.1.2 |
|---|
| Ensembl ID | ENSG00000112992 |
|---|---|
| ENSP00000343873 | |
| ENST00000344920 | |
| ENSRNOG00000026842 | |
| ENSRNOP00000029578 | |
| ENSRNOT00000033627 |
| Homologene ID | 7445 |
|---|
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| RGD ID | 1587346 |
|---|
| MedScan ID | 23530 |
|---|