| URN | urn:agi-llid:2670 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2060 |
| Name | Gfap |
| Description | glial fibrillary acidic protein |
| Notes | This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
| GO Molecular Function | structural molecule activity |
|---|---|
| integrin binding | |
| kinase binding | |
| structural constituent of cytoskeleton |
| GO Cellular Component | membrane |
|---|---|
| intermediate filament | |
| cell body | |
| cell projection | |
| cytoplasm | |
| cytosol | |
| astrocyte projection |
| GO Biological Process | Bergmann glial cell differentiation |
|---|---|
| astrocyte development | |
| positive regulation of glial cell proliferation | |
| positive regulation of Schwann cell proliferation | |
| negative regulation of neuron projection development | |
| neuron projection regeneration | |
| intermediate filament-based process | |
| intermediate filament organization | |
| regulation of neurotransmitter uptake | |
| long-term synaptic potentiation | |
| extracellular matrix organization | |
| response to wounding |
| Pathway | Intermediate Filament Polymerization |
|---|---|
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Astrocytoma | |
| DLL1 Expression Targets | |
| DLL3 Expression Targets | |
| IL6 Expression Targets | |
| IL11 Expression Targets | |
| Erythropoietin/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| CNTF Expression Targets | |
| CLCF1 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| TGFA/STAT Expression Targets | |
| IGF2/STAT Expression Targets | |
| Morphine Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| NOTCH Expression Targets | |
| chaperone mediated autophagy pathway |
| Group | Intermediate filament polymerization |
|---|---|
| Bergmann glial cell differentiation | |
| astrocyte development | |
| positive regulation of glial cell proliferation | |
| positive regulation of Schwann cell proliferation | |
| negative regulation of neuron projection development | |
| neuron projection regeneration | |
| intermediate filament-based process | |
| intermediate filament organization | |
| regulation of neurotransmitter uptake | |
| long-term synaptic potentiation | |
| extracellular matrix organization | |
| response to wounding | |
| structural molecule activity | |
| integrin binding | |
| kinase binding | |
| structural constituent of cytoskeleton | |
| membrane | |
| intermediate filament | |
| cell body | |
| cell projection | |
| cytoplasm | |
| cytosol | |
| astrocyte projection | |
| Proteins Involved in Pathogenesis of Mental Retardation Caused by Hypothyroidism | |
| Disease Genes Identified in Syndromic Epilepsy | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2670 |
|---|---|
| 14580 | |
| 24387 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005178 |
|---|---|
| 0019900 | |
| 0005200 | |
| 0060020 | |
| 0014002 | |
| 0030198 | |
| 0045109 | |
| 0060291 | |
| 0010977 | |
| 0031102 | |
| 0010625 | |
| 0051580 | |
| 0009611 | |
| 0097449 | |
| 0044297 | |
| 0005737 | |
| 0005829 | |
| 0005882 | |
| 0016020 | |
| 0005198 | |
| 0045103 | |
| 0060252 | |
| 0042995 |
| Alias | glial fibrillary acidic protein |
|---|---|
| AI836096 | |
| intermediate filament protein | |
| intermediate filament | |
| glial fibrillary acidic protein alpha | |
| Glial fibrillary acidic protein, astrocyte | |
| glia filament protein | |
| glial filament protein | |
| glia fibrillary acidic protein | |
| OTTMUSP00000002989 | |
| glial fibrillary acid protein | |
| GFAP | |
| FLJ45472 | |
| glial acidic fibrillary protein |
| Mouse chromosome position | 11 66.48 cM |
|---|
| OMIM ID | 137780 |
|---|---|
| 203450 |
| Rat chromosome position | 10q32.1 |
|---|
| Hugo ID | 4235 |
|---|
| Human chromosome position | 17q21 |
|---|
| Swiss-Prot Accession | P14136 |
|---|---|
| A7REI1 | |
| P03995 | |
| P47819 | |
| Q7TQ31 | |
| Q9R1Q3 | |
| Q9Z2S0 | |
| A1E2H7 | |
| A2AH87 | |
| B2RTI7 | |
| Q09J71 | |
| Q3USS4 | |
| Q496R4 | |
| Q496S3 | |
| Q7TQ30 | |
| Q80VX6 | |
| Q925K2 | |
| Q925K3 | |
| B2RD44 | |
| D3DX59 | |
| E9PAX3 | |
| Q53H98 | |
| Q5D055 | |
| Q6ZQS3 | |
| Q7Z5J6 | |
| Q7Z5J7 | |
| Q96KS4 | |
| Q96P18 | |
| Q9UFD0 |
| PIR ID | I56572 |
|---|---|
| B60052 | |
| A32936 | |
| T42645 |
| Unigene ID | Hs.514227 |
|---|---|
| Mm.1239 | |
| Rn.91512 |
| KEGG ID | hsa:2670 |
|---|---|
| mmu:14580 | |
| rno:24387 |
| Swiss-Prot ID | GFAP_RAT |
|---|---|
| GFAP_MOUSE | |
| GFAP_HUMAN |
| Ensembl ID | ENSG00000131095 |
|---|---|
| ENSP00000403962 | |
| ENST00000435360 | |
| ENSP00000253408 | |
| ENST00000253408 | |
| ENSMUSG00000020932 | |
| ENSMUSP00000077061 | |
| ENSMUST00000077902 | |
| ENSMUSP00000064691 | |
| ENSMUST00000067444 | |
| ENSRNOG00000002919 | |
| ENSRNOP00000032389 | |
| ENSRNOT00000034401 |
| Homologene ID | 1554 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 95697 |
|---|
| RGD ID | 2679 |
|---|
| MedScan ID | 2670 |
|---|