| URN | urn:agi-llid:1915 |
|---|---|
| Total Entities | 0 |
| Connectivity | 710 |
| Name | Eef1a1 |
| Description | eukaryotic translation elongation factor 1 alpha 1 |
| Notes | This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | GTPase activity |
|---|---|
| translation elongation factor activity | |
| protein kinase binding | |
| GTP binding |
| GO Cellular Component | eukaryotic translation elongation factor 1 complex |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | regulation of transcription, DNA-templated |
|---|---|
| transcription, DNA-templated | |
| cellular protein metabolic process | |
| translation | |
| translational elongation | |
| gene expression |
| Pathway | Translation |
|---|---|
| chaperone mediated autophagy pathway |
| Group | Translation |
|---|---|
| Oncogenes | |
| GTPase activity | |
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| cellular protein metabolic process | |
| translation | |
| translational elongation | |
| translation elongation factor activity | |
| gene expression | |
| protein kinase binding | |
| GTP binding | |
| eukaryotic translation elongation factor 1 complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| LocusLink ID | 1915 |
|---|---|
| 100360413 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0019901 | |
| 0003746 | |
| 0044267 | |
| 0010467 | |
| 0006355 | |
| 0006351 | |
| 0006412 | |
| 0006414 | |
| 0005737 | |
| 0005829 | |
| 0005853 | |
| 0005634 | |
| 0005886 |
| Alias | CCS3 |
|---|---|
| EF1A | |
| PTI1 | |
| CCS-3 | |
| EE1A1 | |
| EEF-1 | |
| EEF1A | |
| EF-Tu | |
| LENG7 | |
| eEF1A-1 | |
| GRAF-1EF | |
| HNGC:16303 | |
| RP11-505P4.2 | |
| elongation factor 1-alpha 1 | |
| EF-1-alpha-1 | |
| EF1a-like protein | |
| CTCL tumor antigen | |
| elongation factor Tu | |
| cervical cancer suppressor 3 | |
| elongation factor 1 alpha subunit | |
| prostate tumor-inducing protein 1 | |
| eukaryotic elongation factor 1 A-1 | |
| leukocyte receptor cluster member 7 | |
| leukocyte receptor cluster (LRC) member 7 | |
| translation elongation factor 1 alpha 1-like 14 | |
| glucocorticoid receptor AF-1 specific elongation factor | |
| eukaryotic translation elongation factor 1 alpha 1-like 14 | |
| eukaryotic translation elongation factor 1 alpha 1-like | |
| MGC102687 | |
| MGC7551 | |
| MGC27859 | |
| MGC18758 | |
| MGC16224 | |
| MGC131894 | |
| MGC125172 | |
| MGC103271 | |
| prostate tumour-inducing protein I | |
| MGC102592 | |
| LOC96648 | |
| leukocyte receptor cluster (LRC) member VII | |
| MGC8115 | |
| MGC118397 | |
| prostate tumour-inducing protein 1 | |
| LOC100360413 | |
| translation elongating factor 1 alpha 1-like 14 | |
| prostate tumor-inducing protein I | |
| MGC8209 | |
| OTTMUSP00000021291 | |
| OTTHUMP00000063805 | |
| OTTHUMP00000063804 | |
| OTTHUMP00000016736 | |
| oncogene PTI-1 - human | |
| PTI I | |
| Eef1a1 | |
| EF-1-alpha I | |
| EF1a-like | |
| EF1 alpha | |
| eEF-1-alpha-1 | |
| eEF-1-alpha I | |
| EEF1A1L14 | |
| Eef1a I | |
| glucocorticoid receptor AF-1 specific elongating factor | |
| CTCL tumour antigen | |
| Eef1a2l1 | |
| EEF I | |
| FLJ25721 | |
| eukaryotic translation elongation factor 1 alpha 2 like 1 | |
| eukaryotic translation elongation factor 1 alpha 1 | |
| eukaryotic translation elongating factor 1 alpha 1 | |
| elongation factor 1-alpha | |
| Elongation factor 1 A-1 | |
| Elongation factor 1 A I | |
| elongating factor 1-alpha | |
| elongating factor 1 alpha subunit | |
| eukaryotic translation elongating factor 1 alpha I |
| OMIM ID | 130590 |
|---|
| Rat chromosome position | 1 |
|---|
| Hugo ID | 3189 |
|---|
| Human chromosome position | 6q14.1 |
|---|
| Swiss-Prot Accession | P68104 |
|---|---|
| Q6IPS9 | |
| M0R757 | |
| P04719 | |
| P04720 |
| PIR ID | B24977 |
|---|
| Unigene ID | Hs.535192 |
|---|---|
| Hs.586423 | |
| Hs.745122 |
| KEGG ID | hsa:1915 |
|---|---|
| rno:100360413 |
| Swiss-Prot ID | EF1A1_HUMAN |
|---|
| Ensembl ID | ENSG00000156508 |
|---|---|
| ENSP00000330054 | |
| ENST00000331523 |
| Homologene ID | 68181 |
|---|
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| RGD ID | 2322143 |
|---|
| MedScan ID | 1915 |
|---|