| URN | urn:agi-llid:3312 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1057 |
| Name | Hspa8 |
| Description | heat shock 70kDa protein 8 |
| Notes | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| GO Molecular Function | ATPase activity, coupled |
|---|---|
| unfolded protein binding | |
| receptor binding | |
| nucleotide binding | |
| ATP binding | |
| ADP binding |
| GO Cellular Component | clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
|---|---|
| spliceosomal complex | |
| nucleolus | |
| ribonucleoprotein complex | |
| protein complex | |
| Prp19 complex | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| synaptic vesicle | |
| melanosome | |
| nucleus | |
| neuron projection | |
| neuronal cell body | |
| extracellular vesicular exosome |
| GO Biological Process | ATP catabolic process |
|---|---|
| axon guidance | |
| regulation of cell cycle | |
| synaptic transmission | |
| neurotransmitter secretion | |
| post-Golgi vesicle-mediated transport | |
| response to stress | |
| response to unfolded protein | |
| negative regulation of transcription, DNA-templated | |
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| RNA metabolic process | |
| mRNA metabolic process | |
| RNA splicing | |
| mRNA processing | |
| protein folding | |
| chaperone-mediated protein folding | |
| chaperone mediated protein folding requiring cofactor | |
| gene expression | |
| modulation by virus of host morphology or physiology |
| Pathway | Transcytosis |
|---|---|
| Protein Folding | |
| Macrophage Function in Crohn's Disease | |
| Class II Mutations Cause CFTR Misfolding and Degradation in Cystic Fibrosis | |
| ADORA1/2A -> exocytosis | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| chaperone mediated autophagy pathway |
| Group | Endocytosis |
|---|---|
| Protein folding | |
| ATP catabolic process | |
| ATPase activity, coupled | |
| axon guidance | |
| regulation of cell cycle | |
| synaptic transmission | |
| neurotransmitter secretion | |
| post-Golgi vesicle-mediated transport | |
| response to stress | |
| response to unfolded protein | |
| negative regulation of transcription, DNA-templated | |
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| RNA metabolic process | |
| mRNA metabolic process | |
| RNA splicing | |
| mRNA processing | |
| protein folding | |
| chaperone-mediated protein folding | |
| chaperone mediated protein folding requiring cofactor | |
| gene expression | |
| modulation by virus of host morphology or physiology | |
| unfolded protein binding | |
| receptor binding | |
| nucleotide binding | |
| ATP binding | |
| ADP binding | |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane | |
| spliceosomal complex | |
| nucleolus | |
| ribonucleoprotein complex | |
| protein complex | |
| Prp19 complex | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| synaptic vesicle | |
| melanosome | |
| nucleus | |
| neuron projection | |
| neuronal cell body | |
| extracellular vesicular exosome | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 3312 |
|---|---|
| 15481 | |
| 24468 |
| Cell Localization | Cytoplasm |
|---|---|
| Plasma membrane | |
| Melanosome | |
| Nucleus | |
| Nucleolus |
| GO ID | 0005524 |
|---|---|
| 0042623 | |
| 0051082 | |
| 0016070 | |
| 0008380 | |
| 0007411 | |
| 0051085 | |
| 0010467 | |
| 0016071 | |
| 0006397 | |
| 0019048 | |
| 0045892 | |
| 0007269 | |
| 0006892 | |
| 0006457 | |
| 0051726 | |
| 0006986 | |
| 0007268 | |
| 0006351 | |
| 0000974 | |
| 0061202 | |
| 0005829 | |
| 0070062 | |
| 0005622 | |
| 0042470 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0030529 | |
| 0005681 | |
| 0043531 | |
| 0000166 | |
| 0005102 | |
| 0006200 | |
| 0061077 | |
| 0006355 | |
| 0006950 | |
| 0005737 | |
| 0043005 | |
| 0043025 | |
| 0043234 | |
| 0008021 |
| Alias | LAP1 |
|---|---|
| HSC54 | |
| HSC70 | |
| HSC71 | |
| HSP71 | |
| HSP73 | |
| NIP71 | |
| HEL-33 | |
| HSPA10 | |
| HEL-S-72p | |
| heat shock cognate 71 kDa protein | |
| LPS-associated protein 1 | |
| heat shock 70kd protein 10 | |
| epididymis luminal protein 33 | |
| heat shock cognate protein 54 | |
| constitutive heat shock protein 70 | |
| lipopolysaccharide-associated protein 1 | |
| N-myristoyltransferase inhibitor protein 71 | |
| epididymis secretory sperm binding protein Li 72p | |
| Hsc73 | |
| 2410008N15Rik | |
| heat shock cognate hsc73 | |
| heat shock 70kD protein 8 | |
| heat shock 70 kDa protein 8 | |
| heat shock protein cognate 70 | |
| heat shock protein 8 | |
| heat shock protein A8 | |
| Heat shock cognate protein 70 | |
| Hspa8 | |
| MGC106514 | |
| LPS-associated protein I | |
| lipopolysaccharide-associated protein I | |
| MGC118485 | |
| Hspa8* | |
| MGC131511 | |
| MGC102007 | |
| OTTMUSP00000039134 | |
| uncharacterized bone marrow protein bm034 | |
| LOC624853 | |
| RIKEN cDNA 2410008N15 gene | |
| MGC29929 | |
| MGC114311 | |
| 2410008N15 | |
| dnaK-type molecular chaperone hsc73 | |
| dnaK-type molecular chaperone hsp72-ps I | |
| dnaK-type molecular chaperone hsp72-ps1 | |
| heat shock 70kd protein 10 (HSC71) | |
| heat shock 70kD protein VIII | |
| heat shock 70kDa protein 8 | |
| heat shock 70kDa protein VIII | |
| heat shock protein VIII | |
| heat shock cognate protein | |
| Heat shock cognate 71 kDa protein (Hsc70.1) |
| Mouse chromosome position | 9 21.55 cM |
|---|
| OMIM ID | 600816 |
|---|
| Rat chromosome position | 8q22 |
|---|
| Hugo ID | 5241 |
|---|
| Human chromosome position | 11q24.1 |
|---|
| Swiss-Prot Accession | P11142 |
|---|---|
| Q53HF2 | |
| P63017 | |
| P63018 | |
| P08109 | |
| P12225 | |
| Q4FZY7 | |
| Q62373 | |
| Q62374 | |
| Q62375 | |
| Q9H3R6 | |
| Q3U6R0 | |
| Q3U764 | |
| Q3U7D7 | |
| Q3U7E2 | |
| Q3U9B4 | |
| Q3U9G0 | |
| Q3UGM0 | |
| Q5FWJ6 | |
| Q6NZD0 |
| PIR ID | S07197 |
|---|---|
| A27077 | |
| A45935 | |
| JC4853 |
| Unigene ID | Hs.180414 |
|---|---|
| Mm.290774 | |
| Mm.336743 | |
| Mm.351377 | |
| Mm.412745 | |
| Mm.485345 | |
| Rn.120392 | |
| Rn.129299 | |
| Rn.201298 |
| KEGG ID | hsa:3312 |
|---|---|
| mmu:15481 | |
| rno:24468 |
| Swiss-Prot ID | HSP7C_RAT |
|---|---|
| HSP7C_HUMAN | |
| HSP7C_MOUSE |
| Ensembl ID | ENSG00000109971 |
|---|---|
| ENSP00000432083 | |
| ENST00000534624 | |
| ENSP00000404372 | |
| ENST00000453788 | |
| ENSP00000227378 | |
| ENST00000227378 | |
| ENSMUSG00000015656 | |
| ENSMUSP00000015800 | |
| ENSMUST00000015800 |
| Homologene ID | 68524 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 105384 |
|---|
| RGD ID | 621725 |
|---|
| MedScan ID | 3312 |
|---|